"4-Quinolones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
| Descriptor ID |
D042462
|
| MeSH Number(s) |
D03.633.100.810.835.055
|
| Concept/Terms |
4-Quinolones- 4-Quinolones
- 4 Quinolones
- 4-Quinolinones
- 4 Quinolinones
- 4-Oxoquinolines
- 4 Oxoquinolines
|
Below are MeSH descriptors whose meaning is more general than "4-Quinolones".
Below are MeSH descriptors whose meaning is more specific than "4-Quinolones".
This graph shows the total number of publications written about "4-Quinolones" by people in this website by year, and whether "4-Quinolones" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
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Below are the most recent publications written about "4-Quinolones" by people in Profiles.
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Molecular mechanisms of drug inhibition of DNA gyrase. Bioessays. 1996 Aug; 18(8):661-71.