"Calgranulin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
| Descriptor ID |
D040501
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| MeSH Number(s) |
D12.776.157.125.750.500.100 D12.776.631.655.500.100 D23.050.301.562.100
|
| Concept/Terms |
Calgranulin A- Calgranulin A
- 60B8-B Antigen
- 60B8 B Antigen
- Antigen, 60B8-B
- CABP-P8
- MRP8 Protein
- Leukocyte L1 Protein Light Chain
- Myeloid Calcium-Binding Protein P8
- Myeloid Calcium Binding Protein P8
- MRP-8 Protein
- MRP 8 Protein
- S100 A8 Protein
- A8 Protein, S100
- S100A8 Protein
- Cystic Fibrosis Antigen
- Antigen, Cystic Fibrosis
- Macrophage-Related Protein-8
- Macrophage Related Protein 8
|
Below are MeSH descriptors whose meaning is more general than "Calgranulin A".
Below are MeSH descriptors whose meaning is more specific than "Calgranulin A".
This graph shows the total number of publications written about "Calgranulin A" by people in this website by year, and whether "Calgranulin A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calgranulin A" by people in Profiles.
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S100A8/A9 as a therapeutic target in myocardial infarction: cellular mechanisms, molecular interactions, and translational challenges. Eur Heart J. 2019 08 21; 40(32):2724-2726.
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Biomarkers in the early diagnosis of sepsis: the quest continues. Am J Emerg Med. 2015 Nov; 33(11):1671.
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Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD. Blood. 2014 Sep 18; 124(12):1976-86.
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S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1137-46.
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Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells. Blood. 2012 Sep 13; 120(11):2203-13.
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Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene. 2012 Oct 18; 31(42):4550-8.
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Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov; 21(11):1564-77.
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Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. Int J Cancer. 2011 Jul 15; 129(2):331-45.
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Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS One. 2009 Oct 16; 4(10):e7475.
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Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2009 Mar; 136(3):953-66.