"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 1 | 3 |
| 2002 | 2 | 0 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 3 | 3 |
| 2017 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process. Neurosci Lett. 2023 01 10; 793:136970.
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Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of NMDA receptor function. Psychopharmacology (Berl). 2020 Jan; 237(1):199-208.
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Early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by MK-801: Role of hippocampal BDNF. Brain Res. 2019 05 15; 1711:115-119.
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Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. Brain Res. 2018 03 01; 1682:14-23.
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NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016 10; 65(10):3139-50.
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Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system. J Neurosci. 2011 Jun 01; 31(22):8025-36.
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NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Antioxid Redox Signal. 2010 Oct 01; 13(7):975-86.
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Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C22-32.
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Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci. 2010 Mar 24; 30(12):4460-6.
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Ionotropic glutamate receptors contribute to maintained neuronal hyperexcitability following spinal cord injury in rats. Exp Neurol. 2010 Jul; 224(1):321-4.