"Amitriptyline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
| Descriptor ID |
D000639
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.100 D04.615.181.384.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amitriptyline".
Below are MeSH descriptors whose meaning is more specific than "Amitriptyline".
This graph shows the total number of publications written about "Amitriptyline" by people in this website by year, and whether "Amitriptyline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Amitriptyline" by people in Profiles.
-
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism. EBioMedicine. 2022 Jul; 81:104130.
-
Current use of drugs affecting the central nervous system for chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review. Support Care Cancer. 2015 Feb; 23(2):513-24.
-
The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg. 1998 Dec; 87(6):1360-6.
-
A method for the determination of amitriptyline and its metabolites nortriptyline, 10-hydroxyamitriptyline, and 10-hydroxynortriptyline in human plasma using stable isotope dilution and gas chromatography-chemical ionization mass spectrometry (GC-CIMS). Clin Pharmacol Ther. 1979 Jun; 25(6):844-56.