Cortical Spreading Depression
"Cortical Spreading Depression" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)
| Descriptor ID |
D013181
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| MeSH Number(s) |
G11.561.200.500.300
|
| Concept/Terms |
Cortical Spreading Depression- Cortical Spreading Depression
- Cortical Spreading Depressions
- Depression, Cortical Spreading
- Depressions, Cortical Spreading
- Spreading Depression, Cortical
- Spreading Depressions, Cortical
- Spreading Depression of Leao
- Leao Spreading Depression
- Cortical Depression, Spreading
- Cortical Depressions, Spreading
- Depression, Spreading Cortical
- Depressions, Spreading Cortical
- Spreading Cortical Depressions
- Spreading Cortical Depression
|
Below are MeSH descriptors whose meaning is more general than "Cortical Spreading Depression".
Below are MeSH descriptors whose meaning is more specific than "Cortical Spreading Depression".
This graph shows the total number of publications written about "Cortical Spreading Depression" by people in this website by year, and whether "Cortical Spreading Depression" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cortical Spreading Depression" by people in Profiles.
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Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization. Brain. 2021 10 22; 144(9):2863-2878.
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Hypoxia limits inhibitory effects of Zn2+ on spreading depolarizations. PLoS One. 2013; 8(11):e75739.
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Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons. J Physiol. 2012 Nov 15; 590(22):5877-93.
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Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo. J Neurophysiol. 2012 Feb; 107(3):1032-41.
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Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation. J Cereb Blood Flow Metab. 2011 Apr; 31(4):1073-84.
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Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling. J Biomed Opt. 2005 Jan-Feb; 10(1):11004.
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Astrocytes contribute to regulation of extracellular calcium and potassium in the rat cerebral cortex during spreading depression. Brain Res. 2004 Jun 25; 1012(1-2):177-84.
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Energy failure in astrocytes increases the vulnerability of neurons to spreading depression. Eur J Neurosci. 2004 May; 19(9):2446-54.
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Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression. J Neurophysiol. 2000 Jun; 83(6):3519-24.
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Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. 2000; 95(3):639-45.