"GTP Cyclohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
| Descriptor ID |
D006136
|
| MeSH Number(s) |
D08.811.277.151.300
|
| Concept/Terms |
GTP Cyclohydrolase- GTP Cyclohydrolase
- Cyclohydrolase, GTP
- GTP 8-Formylhydrolase
- 8-Formylhydrolase, GTP
- GTP 8 Formylhydrolase
- GTP Ring-Opening Enzyme
- GTP Ring Opening Enzyme
- Ring-Opening Enzyme, GTP
- GTP Dihydrolase
- Dihydrolase, GTP
- 7,8-Dihydroneopterintriphosphate Synthetase
- 7,8 Dihydroneopterintriphosphate Synthetase
- Synthetase, 7,8-Dihydroneopterintriphosphate
|
Below are MeSH descriptors whose meaning is more general than "GTP Cyclohydrolase".
Below are MeSH descriptors whose meaning is more specific than "GTP Cyclohydrolase".
This graph shows the total number of publications written about "GTP Cyclohydrolase" by people in this website by year, and whether "GTP Cyclohydrolase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "GTP Cyclohydrolase" by people in Profiles.
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Mitochondrial regulation of ferroptosis. J Cell Biol. 2021 09 06; 220(9).
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Dystonia. Nat Rev Dis Primers. 2018 09 20; 4(1):25.
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Elevated levels of plasma phenylalanine in schizophrenia: a guanosine triphosphate cyclohydrolase-1 metabolic pathway abnormality? PLoS One. 2014; 9(1):e85945.
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A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study. Mol Genet Metab. 2012 Nov; 107(3):592-5.
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C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling. J Mol Cell Cardiol. 2007 Dec; 43(6):780-91.