"Osteoprotegerin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
| Descriptor ID |
D053244
|
| MeSH Number(s) |
D12.776.543.750.705.852.760.949.249
|
| Concept/Terms |
Osteoprotegerin- Osteoprotegerin
- Osteoclastogenesis Inhibitory Factor
- Receptors, Tumor Necrosis Factor, Member 11b
- Follicular Dendritic Cell-Derived Receptor-1
- Follicular Dendritic Cell Derived Receptor 1
- Tumor Necrosis Factor Receptor Superfamily, Member 11b
- FDCR-1 Protein
- FDCR 1 Protein
- OCIF Protein
- Tumor Necrosis Factor Receptor 11b
|
Below are MeSH descriptors whose meaning is more general than "Osteoprotegerin".
Below are MeSH descriptors whose meaning is more specific than "Osteoprotegerin".
This graph shows the total number of publications written about "Osteoprotegerin" by people in this website by year, and whether "Osteoprotegerin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 2 | 3 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Osteoprotegerin" by people in Profiles.
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Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress? Clin Sci (Lond). 2022 03 18; 136(5):379-382.
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Distribution of alkaline phosphatase, osteopontin, RANK ligand and osteoprotegerin in calcified human carotid atheroma. Protein J. 2015 Oct; 34(5):315-28.
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Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Apr 15; 29(8):817-31.
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Bone biology and the role of the RANK ligand pathway. Oncology (Williston Park). 2009 Dec; 23(14 Suppl 5):9-15.
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Direct effects of osteoprotegerin on human bone cell metabolism. Biochem Biophys Res Commun. 2009 Nov 20; 389(3):550-5.
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ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev. 2009 Aug 15; 23(16):1882-94.
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Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome. Bone. 2009 Aug; 45(2):346-56.
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A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North American travelers to Mexico. J Infect Dis. 2009 Feb 15; 199(4):477-85.
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Bone markers and their prognostic value in metastatic bone disease: clinical evidence and future directions. Cancer Treat Rev. 2008 Nov; 34(7):629-39.
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Intensive lipid-lowering therapy ameliorates novel calcification markers and GSM score in patients with carotid stenosis. Eur J Vasc Endovasc Surg. 2008 Jun; 35(6):661-8.