"Convulsants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.
| Descriptor ID |
D003292
|
| MeSH Number(s) |
D27.505.696.282.224 D27.505.954.427.220.224
|
| Concept/Terms |
Convulsant Effect- Convulsant Effect
- Effect, Convulsant
- Convulsant Effects
- Effects, Convulsant
|
Below are MeSH descriptors whose meaning is more general than "Convulsants".
Below are MeSH descriptors whose meaning is more specific than "Convulsants".
This graph shows the total number of publications written about "Convulsants" by people in this website by year, and whether "Convulsants" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 2 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Convulsants" by people in Profiles.
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Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor. Sci Rep. 2020 08 19; 10(1):13999.
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Early a-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva. Prostaglandins Leukot Essent Fatty Acids. 2019 04; 143:15-20.
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Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation. J Med Chem. 2018 04 12; 61(7):3151-3165.
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Wortmannin Attenuates Seizure-Induced Hyperactive PI3K/Akt/mTOR Signaling, Impaired Memory, and Spine Dysmorphology in Rats. eNeuro. 2017 May-Jun; 4(3).
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Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy. Exp Neurol. 2015 Nov; 273:92-104.
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Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. Epilepsia. 2014 Dec; 55(12):1944-52.
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Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid. Epilepsy Behav. 2011 Nov; 22(3):461-8.
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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep; 13(9):1056-8.
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Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide. J Med Chem. 2010 May 27; 53(10):4177-86.
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Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. Epilepsia. 2009 Jul; 50(7):1741-51.