"Giant Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
| Descriptor ID |
D015726
|
| MeSH Number(s) |
A11.500
|
| Concept/Terms |
Giant Cells- Giant Cells
- Cell, Giant
- Cells, Giant
- Giant Cell
- Syncytium
- Polykaryocytes
- Polykaryocyte
- Syncytia
- Giant Cells, Multinucleated
- Cell, Multinucleated Giant
- Cells, Multinucleated Giant
- Giant Cell, Multinucleated
- Multinucleated Giant Cell
- Multinucleated Giant Cells
|
Below are MeSH descriptors whose meaning is more general than "Giant Cells".
Below are MeSH descriptors whose meaning is more specific than "Giant Cells".
This graph shows the total number of publications written about "Giant Cells" by people in this website by year, and whether "Giant Cells" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 0 | 1 | 1 |
| 2004 | 2 | 0 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Giant Cells" by people in Profiles.
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Xanthogranulomatous epithelial tumors/keratin-positive giant cell-rich tumors involving the head and neck: report of seven cases and review of the literature. Virchows Arch. 2024 Oct; 485(4):605-613.
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Cutaneous Atypical Fibroxanthoma With Osteoclast-Like Giant Cell: A Rare but Diagnostic Pitfall. Am J Dermatopathol. 2023 10 01; 45(10):704-707.
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Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells. Oncogene. 2023 02; 42(9):665-678.
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Polyploid giant cancer cells: An emerging new field of cancer biology. Semin Cancer Biol. 2022 06; 81:1-4.
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The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventions. Semin Cancer Biol. 2022 06; 81:132-144.
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Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy?. Biol Reprod. 2021 08 03; 105(2):305-316.
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Giant cells: Linking McClintock's heredity to early embryogenesis and tumor origin throughout millennia of evolution on Earth. Semin Cancer Biol. 2022 06; 81:176-192.
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Skin and superficial soft tissue neoplasms with multinucleated giant cells: Clinical, histologic, phenotypic, and molecular differentiating features. Ann Diagn Pathol. 2019 Oct; 42:18-32.
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Osteoclast-like giant cell-rich carcinomas of the lung: a clinicopathological, immunohistochemical, and molecular study of 3 cases. Hum Pathol. 2019 03; 85:168-173.
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Poorly differentiated osteoclast-like giant cell variant of cutaneous squamous cell carcinoma: Uncovering its mutational landscape through massive parallel sequencing. Pathol Res Pract. 2018 11; 214(11):1898-1903.