GTP-Binding Protein alpha Subunit, Gi2
"GTP-Binding Protein alpha Subunit, Gi2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.
| Descriptor ID |
D051960
|
| MeSH Number(s) |
D08.811.277.040.330.300.200.100.200.500 D12.644.360.360.100.200.500 D12.776.157.325.332.100.200.500 D12.776.476.375.100.200.500 D12.776.543.325.100.200.500
|
| Concept/Terms |
GTP-Binding Protein alpha Subunit, Gi2- GTP-Binding Protein alpha Subunit, Gi2
- GTP Binding Protein alpha Subunit, Gi2
- Galphai2 Protein
- Gi2-alpha Protein
- Gi2 alpha Protein
- G Protein Subunit alpha I2
- Galpha(i2) Protein
|
Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunit, Gi2".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Acid Anhydride Hydrolases [D08.811.277.040]
- GTP Phosphohydrolases [D08.811.277.040.330]
- GTP-Binding Proteins [D08.811.277.040.330.300]
- Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
- GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D08.811.277.040.330.300.200.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D08.811.277.040.330.300.200.100.200.500]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
- GTP-Binding Protein alpha Subunits [D12.644.360.360.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.644.360.360.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.644.360.360.100.200.500]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- GTP-Binding Proteins [D12.776.157.325]
- Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
- GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.157.325.332.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.157.325.332.100.200.500]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
- GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.476.375.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.476.375.100.200.500]
- Membrane Proteins [D12.776.543]
- Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
- GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.543.325.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.543.325.100.200.500]
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunit, Gi2".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunit, Gi2" by people in this website by year, and whether "GTP-Binding Protein alpha Subunit, Gi2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
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click here.
Below are the most recent publications written about "GTP-Binding Protein alpha Subunit, Gi2" by people in Profiles.
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Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 Sep 20; 385(6715):eadd8947.
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Targeting Gai2 in neutrophils protects from myocardial ischemia reperfusion injury. Basic Res Cardiol. 2024 10; 119(5):717-732.
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An essential role for Ga(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. Sci Signal. 2015 Sep 15; 8(394):ra92.
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Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood. 2013 Mar 07; 121(10):1875-85.
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Alterations in myeloid dendritic cell innate immune responses in the Galphai2-deficient mouse model of colitis. Inflamm Bowel Dis. 2009 Feb; 15(2):248-60.
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Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. J Cell Sci. 2007 Jul 01; 120(Pt 13):2171-8.
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Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice. J Immunol. 2005 May 15; 174(10):6122-8.
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Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice. Int Immunol. 2005 Mar; 17(3):233-43.
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Galpha12 differentially regulates Na+-H+ exchanger isoforms. J Biol Chem. 1996 Sep 13; 271(37):22604-10.
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Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet. 1995 Jun; 10(2):143-50.