Glucose-6-Phosphate Isomerase
"Glucose-6-Phosphate Isomerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
| Descriptor ID |
D005956
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| MeSH Number(s) |
D08.811.399.475.200.350
|
| Concept/Terms |
Glucose-6-Phosphate Isomerase- Glucose-6-Phosphate Isomerase
- Glucose 6 Phosphate Isomerase
- Isomerase, Glucose-6-Phosphate
- Isomerase, Glucose 6 Phosphate
- Phosphohexose Isomerase
- Isomerase, Phosphohexose
- Glucosephosphate Isomerase
- Isomerase, Glucosephosphate
- Phosphoglucose Isomerase
- Isomerase, Phosphoglucose
Autocrine Motility Factor- Autocrine Motility Factor
- Motility Factor, Autocrine
- Tumor Autocrine Motility Factor
- Tumor-Cell Autocrine Motility Factor
- Tumor Cell Autocrine Motility Factor
- Neuroleukin
|
Below are MeSH descriptors whose meaning is more general than "Glucose-6-Phosphate Isomerase".
Below are MeSH descriptors whose meaning is more specific than "Glucose-6-Phosphate Isomerase".
This graph shows the total number of publications written about "Glucose-6-Phosphate Isomerase" by people in this website by year, and whether "Glucose-6-Phosphate Isomerase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 3 | 0 | 3 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glucose-6-Phosphate Isomerase" by people in Profiles.
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2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019 Dec 29; 21(1).
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Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle. Circ Res. 2020 01 03; 126(1):60-74.
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Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep. 2015 Dec 22; 13(11):2395-2402.
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Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol. 2012 Jan 01; 188(1):170-81.
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Glucose metabolism gene variants modulate the risk of pancreatic cancer. Cancer Prev Res (Phila). 2011 May; 4(5):758-66.
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Expression of autocrine motility factor correlates with the angiogenic phenotype of and poor prognosis for human gastric cancer. Clin Cancer Res. 2005 Aug 15; 11(16):5778-83.
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Substrate preferences and glucose uptake in glibenclamide-resistant Leishmania parasites. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Mar-Apr; 140(3-4):395-402.
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Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Cancer Res. 2003 Sep 01; 63(17):5446-53.
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Antihuman epidermal growth factor receptor 2 antibody herceptin inhibits autocrine motility factor (AMF) expression and potentiates antitumor effects of AMF inhibitors. Clin Cancer Res. 2002 Oct; 8(10):3285-9.
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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol. 2002 Jul 22; 158(2):227-33.