"Reserpine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
| Descriptor ID |
D012110
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| MeSH Number(s) |
D03.132.436.681.933.500 D03.633.100.473.402.681.933.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Reserpine".
Below are MeSH descriptors whose meaning is more specific than "Reserpine".
This graph shows the total number of publications written about "Reserpine" by people in this website by year, and whether "Reserpine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Reserpine" by people in Profiles.
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An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell. 2019 01 14; 35(1):33-45.e6.
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VMAT2 identified as a regulator of late-stage ?-cell differentiation. Nat Chem Biol. 2014 Feb; 10(2):141-8.
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Reserpine-induced central effects: pharmacological evidence for the lack of central effects of reserpine methiodide. Can J Physiol Pharmacol. 2005 Jun; 83(6):509-15.
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Indirect biochemical evidence that reserpine methiodide produces selective depletion of peripheral biogenic amines in rats. Pharmazie. 2005 Apr; 60(4):294-7.
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Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. BMC Pharmacol. 2004 Nov 16; 4:30.
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Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus. Neuropharmacology. 1991 Jan; 30(1):59-65.
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Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives. Pol J Pharmacol Pharm. 1990 Jan-Feb; 42(1):49-58.
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Combined in situ hybridization and immunocytochemistry in the assay of pharmacological effects on tyrosine hydroxylase mRNA concentration. Pharmacol Res. 1989 May-Jun; 21(3):299-311.
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Norepinephrine and (Na+, K+)-ATPase: evidence for stabilization by lithium or imipramine. Neuropharmacology. 1988 Mar; 27(3):261-7.
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Coexistent tardive dyskinesia and parkinsonism. Clin Neuropharmacol. 1987 Dec; 10(6):511-21.