"Microbial Collagenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
| Descriptor ID |
D003012
|
| MeSH Number(s) |
D08.811.277.656.300.480.205.500 D08.811.277.656.675.374.205.500
|
| Concept/Terms |
Microbial Collagenase- Microbial Collagenase
- Clostridium histolyticum Collagenase
- Collagenase, Clostridium histolyticum
- Nucleolysin
- Collagenase, Microbial
- Collalysine
- Clostridiopeptidase A
- Collagenase Clostridium histolyticum
- Clostridium histolyticum, Collagenase
- histolyticum, Collagenase Clostridium
|
Below are MeSH descriptors whose meaning is more general than "Microbial Collagenase".
Below are MeSH descriptors whose meaning is more specific than "Microbial Collagenase".
This graph shows the total number of publications written about "Microbial Collagenase" by people in this website by year, and whether "Microbial Collagenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Microbial Collagenase" by people in Profiles.
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Impact of testosterone therapy and hypogonadism on treatment outcomes in Peyronie's disease: a multicenter retrospective analysis of collagenase clostridium histolyticum therapy. J Sex Med. 2026 Jun 05; 23(7).
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Long-Term Satisfaction With Collagenase Clostridium Histolyticum for Peyronie's Disease: Clinical Predictors and Side Effect Profile. Urol Pract. 2025 01; 12(1):168-175.
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Clinical Significance of Shortened Penile Length and Alterations in Penile Length Following Treatment for Peyronie's Disease. Sex Med Rev. 2022 07; 10(3):409-420.
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Trends in treatment of Peyronie's disease in adult men in the United States from 2008 to 2017-results from an encounter and claims database. Int J Impot Res. 2022 Apr; 34(3):280-288.
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Long-Term Safety and Curvature Deformity Characterization in Patients Previously Treated with Collagenase clostridium Histolyticum for Peyronie's Disease. J Urol. 2020 06; 203(6):1191-1197.
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Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie's disease by subgroup: results from two large, double-blind, randomized, placebo-controlled, phase III studies. BJU Int. 2015 Oct; 116(4):650-6.
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Minimally invasive treatment of Peyronie's disease: evidence-based progress. BJU Int. 2014 Jul; 114(1):16-24.
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Phase 2b study of the clinical efficacy and safety of collagenase Clostridium histolyticum in patients with Peyronie disease. J Urol. 2012 Jun; 187(6):2268-74.
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Establishment of a calcitonin-producing rat medullary thyroid carcinoma cell line. I. Morphological studies of the tumor and cells in culture. Endocrinology. 1980 Aug; 107(2):509-15.
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Comparison of alpha- and beta-cell secretory responses in islets isolated with collagenase and in the isolated perfused pancreas of rats. Diabetes. 1975 Nov; 24(11):961-70.