"Promegestone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.
| Descriptor ID |
D011397
|
| MeSH Number(s) |
D04.210.500.668.651.443.680
|
| Concept/Terms |
Promegestone- Promegestone
- Promestone
- 17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione
R-5020- R-5020
- R 5020
- R5020
- RU5020
- RU-5020
- RU 5020
|
Below are MeSH descriptors whose meaning is more general than "Promegestone".
Below are MeSH descriptors whose meaning is more specific than "Promegestone".
This graph shows the total number of publications written about "Promegestone" by people in this website by year, and whether "Promegestone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 3 | 4 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Promegestone" by people in Profiles.
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Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells. Oncogene. 2016 09 29; 35(39):5191-201.
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Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Mol Endocrinol. 2016 Feb; 30(2):158-72.
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GATA2 is expressed at critical times in the mouse uterus during pregnancy. Gene Expr Patterns. 2012 May-Jun; 12(5-6):196-203.
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Progesterone receptor directly inhibits ?-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications. Mol Endocrinol. 2011 Jun; 25(6):955-68.
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Multimodal regulation of E2F1 gene expression by progestins. Mol Cell Biol. 2010 Apr; 30(8):1866-77.
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Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400. Mol Endocrinol. 2010 Feb; 24(2):335-45.
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Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures. Biol Reprod. 2010 Feb; 82(2):402-12.
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Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. Mol Cell Biol. 2005 Apr; 25(8):2885-98.
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The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol. 2000 May; 20(9):3102-15.
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Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Mol Endocrinol. 2000 Jan; 14(1):52-65.