"Isoxazoles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
| Descriptor ID |
D007555
|
| MeSH Number(s) |
D03.383.129.385
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Isoxazoles".
Below are MeSH descriptors whose meaning is more specific than "Isoxazoles".
This graph shows the total number of publications written about "Isoxazoles" by people in this website by year, and whether "Isoxazoles" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2011 | 3 | 1 | 4 |
| 2013 | 3 | 0 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Isoxazoles" by people in Profiles.
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Tulane virus protease as a structural surrogate for inhibitor screening of human norovirus proteases. J Virol. 2026 03 24; 100(3):e0217625.
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Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors. J Virol. 2025 02 25; 99(2):e0175724.
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Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial. Nat Med. 2023 02; 29(2):392-400.
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Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524.
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Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 06 08; 60(11):4594-4610.
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Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice. Biochem Biophys Res Commun. 2017 03 25; 485(1):195-200.
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Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor. Drug Metab Dispos. 2015 Dec; 43(12):1966-70.
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Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting. Cell. 2015 Jun 18; 161(7):1656-67.
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Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress. Neoplasia. 2014 Oct; 16(10):824-34.
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Asenapine, blonanserin, iloperidone, lurasidone, and sertindole: distinctive clinical characteristics of 5 novel atypical antipsychotics. Clin Neuropharmacol. 2013 Nov-Dec; 36(6):223-38.