"MPTP Poisoning" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
| Descriptor ID |
D020267
|
| MeSH Number(s) |
C10.228.140.079.862.800.300 C10.228.662.600.700.250 C10.720.606 C25.723.705.400
|
| Concept/Terms |
MPTP Poisoning- MPTP Poisoning
- Poisoning, MPTP
- Neurotoxicity Syndrome, MPTP
- MPTP-Induced Parkinsonism
- MPTP Induced Parkinsonism
- Parkinsonism, MPTP-Induced
- Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- MPTP Neurotoxicity Syndrome
- MPTP Neurotoxicity Syndromes
- Neurotoxicity Syndromes, MPTP
|
Below are MeSH descriptors whose meaning is more general than "MPTP Poisoning".
Below are MeSH descriptors whose meaning is more specific than "MPTP Poisoning".
This graph shows the total number of publications written about "MPTP Poisoning" by people in this website by year, and whether "MPTP Poisoning" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "MPTP Poisoning" by people in Profiles.
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Neuroprotection by Orexin-A via HIF-1a induction in a cellular model of Parkinson's disease. Neurosci Lett. 2014 Sep 05; 579:35-40.
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Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. J Neuroinflammation. 2012 Oct 23; 9:241.
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A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient mice. Brain Res Mol Brain Res. 2005 May 20; 136(1-2):267-70.
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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science. 2004 May 28; 304(5675):1328-31.