Leukocyte-Adhesion Deficiency Syndrome
"Leukocyte-Adhesion Deficiency Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.
| Descriptor ID |
D018370
|
| MeSH Number(s) |
C20.673.600
|
| Concept/Terms |
Leukocyte-Adhesion Deficiency Syndrome- Leukocyte-Adhesion Deficiency Syndrome
- Leukocyte Adhesion Deficiency Syndrome
- Deficiency Syndrome, Leukocyte-Adhesion
- Deficiency Syndrome, Leukocyte Adhesion
- Deficiency Syndromes, Leukocyte-Adhesion
- Leukocyte-Adhesion Deficiency Syndromes
- Syndrome, Leukocyte-Adhesion Deficiency
- Syndromes, Leukocyte-Adhesion Deficiency
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte-Adhesion Deficiency Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte-Adhesion Deficiency Syndrome".
This graph shows the total number of publications written about "Leukocyte-Adhesion Deficiency Syndrome" by people in this website by year, and whether "Leukocyte-Adhesion Deficiency Syndrome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukocyte-Adhesion Deficiency Syndrome" by people in Profiles.
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Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III. J Thromb Haemost. 2012 Jul; 10(7):1397-408.
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Mary Allen Engle Award: The glue of life--a career retrospective. Trans Am Clin Climatol Assoc. 2011; 122:138-49.
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Rectal ulcer with an elusive diagnosis: all that ulcers is not Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Sep; 51(3):367-9.
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Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice. J Clin Invest. 2000 Dec; 106(12):1457-66.
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Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med. 1998 Jul 06; 188(1):119-31.
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Recognition of leukochimerism during genotyping for bovine leukocyte adhesion deficiency (BLAD) by polymerase-chain-reaction-amplified DNA extracted from blood. J Vet Diagn Invest. 1995 Oct; 7(4):569-72.
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Correction of CD18-deficient lymphocytes by retrovirus-mediated gene transfer. Science. 1990 Jun 15; 248(4961):1413-6.