"Adenovirus E4 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.
| Descriptor ID |
D017504
|
| MeSH Number(s) |
D12.776.624.664.520.045.080 D12.776.964.700.045.080 D23.050.327.045.080
|
| Concept/Terms |
Adenovirus E4 Proteins- Adenovirus E4 Proteins
- E4 Proteins, Adenovirus
- E4 Protein, Adenovirus
- Adenovirus E4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Adenovirus E4 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Adenovirus E4 Proteins".
This graph shows the total number of publications written about "Adenovirus E4 Proteins" by people in this website by year, and whether "Adenovirus E4 Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 2 | 0 | 2 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Adenovirus E4 Proteins" by people in Profiles.
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Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression. J Virol. 2015 Nov; 89(21):10774-85.
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Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins. J Virol. 2014 Dec; 88(24):14268-77.
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Effects of the deletion of early region 4 (E4) open reading frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on virus-host cell interaction, transgene expression, and immunogenicity of replicating adenovirus HIV vaccine vectors. PLoS One. 2013; 8(10):e76344.
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Functionally distinct monomers and trimers produced by a viral oncoprotein. Oncogene. 2008 Feb 28; 27(10):1412-20.
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A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles. J Virol. 2007 May; 81(9):4787-97.
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Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci. 2005 Sep 15; 118(Pt 18):4283-93.
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Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells. Gene Ther. 2004 Dec; 11(23):1694-702.
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Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. Oncogene. 2003 May 01; 22(17):2541-7.
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Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Oncogene. 2003 Feb 06; 22(5):710-21.
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Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2. EMBO J. 2001 Oct 15; 20(20):5578-86.