"Orotic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
| Descriptor ID |
D009963
|
| MeSH Number(s) |
D03.066.627 D03.383.742.698.875.660
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Orotic Acid".
Below are MeSH descriptors whose meaning is more specific than "Orotic Acid".
This graph shows the total number of publications written about "Orotic Acid" by people in this website by year, and whether "Orotic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Orotic Acid" by people in Profiles.
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Arginase I deficiency: severe infantile presentation with hyperammonemia: more common than reported? Mol Genet Metab. 2011 Sep-Oct; 104(1-2):107-11.
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A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function. FEBS J. 2010 Mar; 277(6):1420-39.
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Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors. J Gene Med. 2008 Aug; 10(8):890-6.
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Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism. BMC Pediatr. 2002 Dec 30; 2:12.
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Cycloheximide sensitivity of orotic acid biosynthesis induced by ammonia and glycine administration. Eur J Biochem. 1998 Feb 01; 251(3):597-604.
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Nucleotide pool imbalances in the livers of patients with urea cycle disorders associated with increased levels of orotic aciduria. Biochem Mol Biol Int. 1995 Mar; 35(3):685-90.
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Perturbations of endogenous levels of orotic acid and carcinogenesis: effect of an arginine-deficient diet and carbamyl aspartate on hepatocarcinogenesis in the rat and the mouse. Carcinogenesis. 1994 Nov; 15(11):2497-500.
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An earlier proliferative response of hepatocytes in gamma-glutamyl transferase positive foci to partial hepatectomy. Cancer Lett. 1994 Jun 30; 81(2):229-35.
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The development of hepatocellular carcinoma in initiated rat liver after a brief exposure to orotic acid coupled with partial hepatectomy. Carcinogenesis. 1993 Dec; 14(12):2527-30.
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The effect of long-term feeding of orotic acid on the incidence of foci of enzyme-altered hepatocytes and hepatic nodules in Fischer 344 rats. Carcinogenesis. 1993 Sep; 14(9):1901-5.