"Orotic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
| Descriptor ID |
D009963
|
| MeSH Number(s) |
D03.066.627 D03.383.742.698.875.660
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Orotic Acid".
Below are MeSH descriptors whose meaning is more specific than "Orotic Acid".
This graph shows the total number of publications written about "Orotic Acid" by people in this website by year, and whether "Orotic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Orotic Acid" by people in Profiles.
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Arginase I deficiency: severe infantile presentation with hyperammonemia: more common than reported? Mol Genet Metab. 2011 Sep-Oct; 104(1-2):107-11.
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A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function. FEBS J. 2010 Mar; 277(6):1420-39.
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Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors. J Gene Med. 2008 Aug; 10(8):890-6.
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Orotic acid excretion and arginine metabolism. J Nutr. 2007 06; 137(6 Suppl 2):1656S-1661S.
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Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism. BMC Pediatr. 2002 Dec 30; 2:12.
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Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes. J Clin Invest. 1996 Feb 01; 97(3):826-32.