JOHN TAINER to Substrate Specificity
This is a "connection" page, showing publications JOHN TAINER has written about Substrate Specificity.
Connection Strength
1.869
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X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. Protein Sci. 2021 09; 30(9):1735-1756.
Score: 0.174
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Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase. Biochemistry. 2018 12 04; 57(48):6688-6700.
Score: 0.146
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Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes. Methods Enzymol. 2018; 599:157-196.
Score: 0.137
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Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun. 2017 06 27; 8:15855.
Score: 0.132
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Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily. Mech Ageing Dev. 2012 Apr; 133(4):195-202.
Score: 0.091
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Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases. Trends Biochem Sci. 2012 Feb; 37(2):74-84.
Score: 0.090
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Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. Cell. 2011 Apr 15; 145(2):198-211.
Score: 0.086
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DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst). 2007 Aug 01; 6(8):1100-15.
Score: 0.065
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WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol. 2006 May; 13(5):414-22.
Score: 0.061
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Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Mol Cell. 2006 Apr 07; 22(1):27-37.
Score: 0.061
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DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol. 2004 Aug; 11(8):714-20.
Score: 0.054
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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell. 2004 Jan 09; 116(1):39-50.
Score: 0.052
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Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii. J Mol Biol. 2003 Aug 22; 331(4):885-96.
Score: 0.051
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Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum. Proteins. 2003 Apr 01; 51(1):137-46.
Score: 0.049
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Structure and mechanism of the RuvB Holliday junction branch migration motor. J Mol Biol. 2001 Aug 10; 311(2):297-310.
Score: 0.044
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Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis. J Mol Biol. 2001 Jan 05; 305(1):95-107.
Score: 0.042
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Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means. Mutat Res. 2000 Aug 30; 460(3-4):211-29.
Score: 0.041
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Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. EMBO J. 2000 Apr 03; 19(7):1719-30.
Score: 0.040
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Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J Mol Biol. 2000 Feb 11; 296(1):295-309.
Score: 0.040
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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. Nature. 2000 Jan 27; 403(6768):451-6.
Score: 0.040
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MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol. 1998 Dec; 5(12):1058-64.
Score: 0.037
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Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1. Elife. 2017 02 23; 6.
Score: 0.032
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Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Mol Cell. 2016 11 17; 64(4):688-703.
Score: 0.032
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Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis. Cell. 1995 Mar 24; 80(6):869-78.
Score: 0.028
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Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends. Nucleic Acids Res. 2012 May; 40(10):4507-19.
Score: 0.023
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Solution structure of RNase P RNA. RNA. 2011 Jun; 17(6):1159-71.
Score: 0.022
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Substrate recognition and catalysis by flap endonucleases and related enzymes. Biochem Soc Trans. 2010 Apr; 38(2):433-7.
Score: 0.020
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Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase. Nucleic Acids Res. 2009 Oct; 37(18):6161-73.
Score: 0.019
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The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure. 2009 Jan 14; 17(1):96-104.
Score: 0.018
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Three metal ions participate in the reaction catalyzed by T5 flap endonuclease. J Biol Chem. 2008 Oct 17; 283(42):28741-6.
Score: 0.018
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Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease. J Mol Biol. 2007 Aug 03; 371(1):34-48.
Score: 0.016
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Synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction. Nucleic Acids Res. 2006; 34(5):1540-51.
Score: 0.015
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Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel. Biochemistry. 2003 Mar 18; 42(10):2781-9.
Score: 0.012
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Identification of a new cryptochrome class. Structure, function, and evolution. Mol Cell. 2003 Jan; 11(1):59-67.
Score: 0.012
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Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein. Protein Eng. 2002 Oct; 15(10):827-34.
Score: 0.012
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Repair activities of 8-oxoguanine DNA glycosylase from Archaeoglobus fulgidus, a hyperthermophilic archaeon. Mutat Res. 2001 Jul 12; 486(2):99-111.
Score: 0.011
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Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis. Biochemistry. 1999 Apr 13; 38(15):4834-45.
Score: 0.009
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Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1. J Biol Chem. 1998 Oct 16; 273(42):27154-61.
Score: 0.009
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Substrate specificity of prostate-specific antigen (PSA). Chem Biol. 1998 Sep; 5(9):475-88.
Score: 0.009
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Glubodies: randomized libraries of glutathione transferase enzymes. Chem Biol. 1996 May; 3(5):359-67.
Score: 0.008
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Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nat Struct Biol. 1995 Jul; 2(7):561-8.
Score: 0.007
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Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase. Free Radic Res Commun. 1991; 12-13 Pt 1:287-96.
Score: 0.005