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Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine.
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.
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Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine.
Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine. Nat Commun. 2025 Apr 07; 16(1):2898.
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PubMed
subject areas
Animals
Antibodies, Bacterial
Antibodies, Monoclonal
Antigens, Bacterial
Bacterial Proteins
Borrelia burgdorferi
Complement Factor H
Crystallography, X-Ray
Female
Humans
Lyme Disease
Lyme Disease Vaccines
Mice
Models, Molecular
authors with profiles
WEN-HSIANG CHEN
MARIA BOTTAZZI
ULRICH STRYCH