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WILLIAM HUDSON

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patel R, Saab K, Luo L, Ma Y, Osman RA, Williams NT, Everitt J, Zelazowski MJ, Castro P, Decker WK, Hudson WH, Myers JN, Sandulache VC, Frederick MJ, Mowery YM, Kirsch DG, Patel R, Saab K, Luo L, Ma Y, Osman RA, Williams NT, Everitt J, Zelazowski MJ, Castro P, Decker WK, Hudson WH, Myers JN, Sandulache VC, Frederick MJ, Mowery YM, Kirsch DG. Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2025 Oct 01; 31(19):4184-4195. PMID: 40742317; PMCID: PMC12428276.
      Citations:    Fields:    
    2. Hyslop S, Hofferek CJ, Stegantseva MV, Kan E, McCord KA, Alvarez VM, Xia AY, Conarty JP, Wieland A, Hudson WH. CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection. Cell Rep. 2025 Sep 18; 44(10):116316. PMID: 40974572; PMCID: PMC12509300.
      Citations:    Fields:    
    3. Li Y, Yadollahi P, Essien FN, Putluri V, Ambati CSR, Kami Reddy KR, Kamal AHM, Putluri N, Abdurrahman LM, Ruiz Echartea ME, Ernste KJ, Trivedi AJ, Vazquez-Perez J, Hudson WH, Decker WK, Patel R, Osman AA, Kheradmand F, Lai SY, Myers JN, Skinner HD, Coarfa C, Lee K, Jain A, Malovannaya A, Frederick MJ, Sandulache VC. Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer. J Transl Med. 2025 Apr 05; 23(1):403. PMID: 40188338; PMCID: PMC11971752.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Gill AL, Wang PH, Lee J, Hudson WH, Ando S, Araki K, Hu Y, Wieland A, Im S, Gavora A, Medina CB, Freeman GJ, Hashimoto M, Reiner SL, Ahmed R. PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Sci Immunol. 2023 08 04; 8(86):eadg0539. PMID: 37624909; PMCID: PMC10798572.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Hudson WH, Olson JJ, Sudmeier LJ. Immune microenvironment remodeling after radiation of a progressing brain metastasis. Cell Rep Med. 2023 06 20; 4(6):101054. PMID: 37209684; PMCID: PMC10313918.
      Citations: 1     Fields:    Translation:HumansCells
    6. Ando S, Perkins CM, Sajiki Y, Chastain C, Valanparambil RM, Wieland A, Hudson WH, Hashimoto M, Ramalingam SS, Freeman GJ, Ahmed R, Araki K. mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection. J Clin Invest. 2023 01 17; 133(2). PMID: 36378537; PMCID: PMC9843061.
      Citations: 6     Fields:    Translation:Cells
    7. Gill AL, Hudson WH, Valanparambil RM, Ahn E, McGuire DJ, Wieland A, McManus DT, Kissick HT, Akondy RS, Ahmed R. Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection. J Virol. 2023 01 31; 97(1):e0155622. PMID: 36541799; PMCID: PMC9888238.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    8. Hudson WH, Wieland A. Technology meets TILs: Deciphering T?cell function in the -omics era. Cancer Cell. 2023 01 09; 41(1):41-57. PMID: 36206755; PMCID: PMC9839604.
      Citations: 9     Fields:    Translation:HumansCells
    9. Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgr?ber V, Greenleaf WJ, Klein C, Goronzy JJ, Uma?a P, Leonard WJ, Smith KA, Ahmed R. PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program. Nature. 2022 10; 610(7930):173-181. PMID: 36171288; PMCID: PMC9793890.
      Citations: 38     Fields:    Translation:HumansCells
    10. Frank F, Keen MM, Rao A, Bassit L, Liu X, Bowers HB, Patel AB, Cato ML, Sullivan JA, Greenleaf M, Piantadosi A, Lam WA, Hudson WH, Ortlund EA. Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests. Cell. 2022 09 15; 185(19):3603-3616.e13. PMID: 36084631; PMCID: PMC9420710.
      Citations:    
    11. Hu Y, Hudson WH, Kissick HT, Medina CB, Baptista AP, Ma C, Liao W, Germain RN, Turley SJ, Zhang N, Ahmed R. TGF-? regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection. J Exp Med. 2022 10 03; 219(10). PMID: 35980386; PMCID: PMC9393409.
      Citations:    
    12. Hudson WH, Sudmeier LJ. Localization of T?cell clonotypes using the Visium spatial transcriptomics platform. STAR Protoc. 2022 06 17; 3(2):101391. PMID: 35707680; PMCID: PMC9189629.
      Citations:    
    13. Sudmeier LJ, Hoang KB, Nduom EK, Wieland A, Neill SG, Schniederjan MJ, Ramalingam SS, Olson JJ, Ahmed R, Hudson WH. Distinct phenotypic states and spatial distribution of CD8+ T?cell clonotypes in human brain metastases. Cell Rep Med. 2022 05 17; 3(5):100620. PMID: 35584630; PMCID: PMC9133402.
      Citations:    
    14. Morrison TA, Hudson WH, Chisolm DA, Kanno Y, Shih HY, Ahmed R, Henao-Mejia J, Hafner M, O'Shea JJ. Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory. Cold Spring Harb Perspect Biol. 2022 01 04; 14(1). PMID: 34001528; PMCID: PMC8725624.
      Citations:    
    15. Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Sch?rch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunol Res. 2021 11; 9(11):1245-1251. PMID: 34544686; PMCID: PMC9644410.
      Citations:    
    16. Edara VV, Hudson WH, Xie X, Ahmed R, Suthar MS. Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination. JAMA. 2021 05 11; 325(18):1896-1898. PMID: 33739374; PMCID: PMC7980146.
      Citations:    
    17. Edara VV, Norwood C, Floyd K, Lai L, Davis-Gardner ME, Hudson WH, Mantus G, Nyhoff LE, Adelman MW, Fineman R, Patel S, Byram R, Gomes DN, Michael G, Abdullahi H, Beydoun N, Panganiban B, McNair N, Hellmeister K, Pitts J, Winters J, Kleinhenz J, Usher J, O'Keefe JB, Piantadosi A, Waggoner JJ, Babiker A, Stephens DS, Anderson EJ, Edupuganti S, Rouphael N, Ahmed R, Wrammert J, Suthar MS. Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant. Cell Host Microbe. 2021 04 14; 29(4):516-521.e3. PMID: 33798491; PMCID: PMC7980225.
      Citations:    
    18. Edara VV, Norwood C, Floyd K, Lai L, Davis-Gardner ME, Hudson WH, Mantus G, Nyhoff LE, Adelman MW, Fineman R, Patel S, Byram R, Gomes DN, Michael G, Abdullahi H, Beydoun N, Panganiban B, McNair N, Hellmeister K, Pitts J, Winters J, Kleinhenz J, Usher J, O'Keefe JB, Piantadosi A, Waggoner JJ, Babiker A, Stephens DS, Anderson EJ, Edupuganti S, Rouphael N, Ahmed R, Wrammert J, Suthar MS. Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant. bioRxiv. 2021 Feb 22. PMID: 33655254; PMCID: PMC7924283.
      Citations:    
    19. Wieland A, Patel MR, Cardenas MA, Eberhardt CS, Hudson WH, Obeng RC, Griffith CC, Wang X, Chen ZG, Kissick HT, Saba NF, Ahmed R. Defining HPV-specific B cell responses in patients with head and neck cancer. Nature. 2021 09; 597(7875):274-278. PMID: 33208941; PMCID: PMC9462833.
      Citations:    
    20. Suthar MS, Zimmerman MG, Kauffman RC, Mantus G, Linderman SL, Hudson WH, Vanderheiden A, Nyhoff L, Davis CW, Adekunle O, Affer M, Sherman M, Reynolds S, Verkerke HP, Alter DN, Guarner J, Bryksin J, Horwath MC, Arthur CM, Saakadze N, Smith GH, Edupuganti S, Scherer EM, Hellmeister K, Cheng A, Morales JA, Neish AS, Stowell SR, Frank F, Ortlund E, Anderson EJ, Menachery VD, Rouphael N, Mehta AK, Stephens DS, Ahmed R, Roback JD, Wrammert J. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Rep Med. 2020 06 23; 1(3):100040. PMID: 32835303; PMCID: PMC7276302.
      Citations:    
    21. Im SJ, Konieczny BT, Hudson WH, Masopust D, Ahmed R. PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4292-4299. PMID: 32034098; PMCID: PMC7049149.
      Citations:    
    22. Jansen CS, Prokhnevska N, Master VA, Sanda MG, Carlisle JW, Bilen MA, Cardenas M, Wilkinson S, Lake R, Sowalsky AG, Valanparambil RM, Hudson WH, McGuire D, Melnick K, Khan AI, Kim K, Chang YM, Kim A, Filson CP, Alemozaffar M, Osunkoya AO, Mullane P, Ellis C, Akondy R, Im SJ, Kamphorst AO, Reyes A, Liu Y, Kissick H. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature. 2019 12; 576(7787):465-470. PMID: 31827286; PMCID: PMC7108171.
      Citations:    
    23. Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin JX, Konieczny BT, Im SJ, Freeman GJ, Leonard WJ, Kissick HT, Ahmed R. Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection. Immunity. 2019 12 17; 51(6):1043-1058.e4. PMID: 31810882; PMCID: PMC6920571.
      Citations:    
    24. Petermann F, Pekowska A, Johnson CA, Jankovic D, Shih HY, Jiang K, Hudson WH, Brooks SR, Sun HW, Villarino AV, Yao C, Singleton K, Akondy RS, Kanno Y, Sher A, Casellas R, Ahmed R, O'Shea JJ. The Magnitude of IFN-? Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1. Mol Cell. 2019 09 19; 75(6):1229-1242.e5. PMID: 31377117; PMCID: PMC6754279.
      Citations:    
    25. Hudson WH, Prokhnevska N, Gensheimer J, Akondy R, McGuire DJ, Ahmed R, Kissick HT. Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells. Nat Commun. 2019 01 14; 10(1):196. PMID: 30643116; PMCID: PMC6331603.
      Citations:    
    26. Hudson LE, Mendoza P, Hudson WH, Ziesel A, Hubbard GB, Wells J, Dwivedi B, Kowalski J, Seby S, Patel V, Geisert E, Specht C, Grossniklaus HE. Distinct Gene Expression Profiles Define Anaplastic Grade in Retinoblastoma. Am J Pathol. 2018 10; 188(10):2328-2338. PMID: 30036517; PMCID: PMC6168968.
      Citations:    
    27. Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-?B response elements. Nat Commun. 2018 04 06; 9(1):1337. PMID: 29626214; PMCID: PMC5889392.
      Citations:    
    28. Paunovska K, Sago CD, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE. A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation. Nano Lett. 2018 03 14; 18(3):2148-2157. PMID: 29489381; PMCID: PMC6054134.
      Citations:    
    29. Weikum ER, de Vera IMS, Nwachukwu JC, Hudson WH, Nettles KW, Kojetin DJ, Ortlund EA. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res. 2017 Aug 21; 45(14):8596-8608. PMID: 28591827; PMCID: PMC5737878.
      Citations:    
    30. Priyamvada L, Quicke KM, Hudson WH, Onlamoon N, Sewatanon J, Edupuganti S, Pattanapanyasat K, Chokephaibulkit K, Mulligan MJ, Wilson PC, Ahmed R, Suthar MS, Wrammert J. Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7852-7. PMID: 27354515; PMCID: PMC4948328.
      Citations:    
    31. Hudson LE, McDermott CD, Stewart TP, Hudson WH, Rios D, Fasken MB, Corbett AH, Lamb TJ. Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System. PLoS One. 2016; 11(4):e0153351. PMID: 27064405; PMCID: PMC4827847.
      Citations:    
    32. Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):326-31. PMID: 26715749; PMCID: PMC4720311.
      Citations:    
    33. Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nat Commun. 2014 Nov 07; 5:5395. PMID: 25377354; PMCID: PMC4280027.
      Citations:    
    34. Hudson WH, Ortlund EA. The structure, function and evolution of proteins that bind DNA and RNA. Nat Rev Mol Cell Biol. 2014 Nov; 15(11):749-60. PMID: 25269475; PMCID: PMC4280011.
      Citations:    
    35. Hudson WH, Youn C, Ortlund EA. Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PLoS One. 2014; 9(9):e107000. PMID: 25188500; PMCID: PMC4154765.
      Citations:    
    36. Horton BM, Hudson WH, Ortlund EA, Shirk S, Thomas JW, Young ER, Zinzow-Kramer WM, Maney DL. Estrogen receptor a polymorphism in a species with alternative behavioral phenotypes. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1443-8. PMID: 24474771; PMCID: PMC3910653.
      Citations:    
    37. Hudson WH, Youn C, Ortlund EA. The structural basis of direct glucocorticoid-mediated transrepression. Nat Struct Mol Biol. 2013 Jan; 20(1):53-8. PMID: 23222642; PMCID: PMC3539207.
      Citations:    
    38. Musille PM, Pathak M, Lauer JL, Hudson WH, Griffin PR, Ortlund EA. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. Nat Struct Mol Biol. 2012 Apr 15; 19(5):532-S2. PMID: 22504882; PMCID: PMC3960984.
      Citations:    
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