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LYNNETTE AVERILL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Psychiatry & Behavioral Sciences
Address1977 BUTLER BOULEVARD
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. O'Brien B, Lee J, Kim S, Nandra GS, Pannu P, Tamman A, Amarneh D, Swann AC, Murphy N, Averill L, Jha M, Mathew SJ. Anti-suicidal effects of IV ketamine in a real-world setting. Psychiatry Res. 2024 Jan; 331:115604. PMID: 38064911.
      Citations:    Fields:    Translation:Humans
    2. Murphy N, Tamman AJF, Lijffijt M, Amarneh D, Iqbal S, Swann A, Averill LA, O'Brien B, Mathew SJ. Correction: Neural complexity EEG biomarkers of rapid and post-rapid ketamine effects in late-life treatment-resistant depression: a randomized control trial. Neuropsychopharmacology. 2023 Oct; 48(11):1699. PMID: 37349477; PMCID: PMC10517107.
      Citations:    Fields:    
    3. Davis AK, Xin Y, Sepeda N, Averill LA. Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico. Am J Drug Alcohol Abuse. 2023 09 03; 49(5):587-596. PMID: 37734158.
      Citations: 1     Fields:    Translation:Humans
    4. Murphy N, Tamman AJF, Lijffijt M, Amarneh D, Iqbal S, Swann A, Averill LA, O'Brien B, Mathew SJ. Neural complexity EEG biomarkers of rapid and post-rapid ketamine effects in late-life treatment-resistant depression: a randomized control trial. Neuropsychopharmacology. 2023 10; 48(11):1586-1593. PMID: 37076582; PMCID: PMC10516885.
      Citations:    Fields:    Translation:Humans
    5. Ragnhildstveit A, Roscoe J, Bass LC, Averill CL, Abdallah CG, Averill LA. The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence. Ther Adv Psychopharmacol. 2023; 13:20451253231154125. PMID: 36895431; PMCID: PMC9989422.
      Citations: 1     
    6. Ragnhildstveit A, Kaiyo M, Snyder MB, Jackson LK, Lopez A, Mayo C, Miranda AC, August RJ, Seli P, Robison R, Averill LA. Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report. Front Psychiatry. 2023; 14:1051542. PMID: 36846226; PMCID: PMC9947284.
      Citations: 1     
    7. Armstrong SB, Xin Y, Sepeda ND, Polanco M, Averill LA, Davis AK. Prospective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans. Mil Psychol. 2024 Mar-Apr; 36(2):184-191. PMID: 38377244; PMCID: PMC10880491.
      Citations:    Translation:Humans
    8. Tamman AJF, Jiang L, Averill CL, Mason GF, Averill LA, Abdallah CG. Biological embedding of early trauma: the role of higher prefrontal synaptic strength. Eur J Psychotraumatol. 2023; 14(2):2246338. PMID: 37642398; PMCID: PMC10467533.
      Citations:    Fields:    Translation:Humans
    9. O'Brien B, Lee J, Kim S, Nandra GS, Pannu P, Swann AC, Murphy N, Tamman AJF, Amarneh D, Lijffijt M, Averill LA, Mathew SJ. Replication of distinct trajectories of antidepressant response to intravenous ketamine. J Affect Disord. 2023 01 15; 321:140-146. PMID: 36302492.
      Citations: 1     Fields:    Translation:Humans
    10. Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, Purohit P, Brundige A, Murff W, Ahn KH, Sherif MA, Baltutis EJ, Ranganathan M, D'Souza D, Martini B, Southwick SM, Petrakis IL, Burson RR, Guthmiller KB, Lautenschlager KA, McCallin JP, Hoch MB, Timchenko A, Souza SE, Bryant CE, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH, L?pez-Roca AL. Correction to: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology. 2022 Jul; 47(8):1583-1584. PMID: 35545665; PMCID: PMC9205895.
      Citations:    Fields:    
    11. Averill LA, Jiang L, Purohit P, Coppoli A, Averill CL, Roscoe J, Kelmendi B, De Feyter HM, de Graaf RA, Gueorguieva R, Sanacora G, Krystal JH, Rothman DL, Mason GF, Abdallah CG. Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans. Chronic Stress (Thousand Oaks). 2022 Jan-Dec; 6:24705470221092734. PMID: 35434443; PMCID: PMC9008809.
      Citations:    
    12. Averill LA, Abdallah CG. Investigational drugs for assisting psychotherapy for posttraumatic stress disorder (PTSD): emerging approaches and shifting paradigms in the era of psychedelic medicine. Expert Opin Investig Drugs. 2022 02; 31(2):133-137. PMID: 35188023.
      Citations:    Fields:    Translation:Humans
    13. Averill LA, Averill CL, Gueorguieva R, Fouda S, Sherif M, Ahn KH, Ranganathan M, D'Souza DC, Southwick SM, Sanacora G, Duman RS, Krystal JH, Abdallah CG. mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression. J Affect Disord. 2022 04 15; 303:91-97. PMID: 35101523.
      Citations:    Fields:    Translation:Humans
    14. Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, Purohit P, Brundige A, Murff W, Ahn KH, Sherif MA, Baltutis EJ, Ranganathan M, D'Souza D, Martini B, Southwick SM, Petrakis IL, Burson RR, Guthmiller KB, Lautenschlager KA, McCallin JP, Hoch MB, Timchenko A, Souza SE, Bryant CE, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH, L?pez-Roca AL. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology. 2022 07; 47(8):1574-1581. PMID: 35046508; PMCID: PMC8767037.
      Citations: 3     Fields:    Translation:Humans
    15. Peterson AL, Young-McCaughan S, Roache JD, Mintz J, Litz BT, Williamson DE, Resick PA, Foa EB, McGeary DD, Dondanville KA, Taylor DJ, Wachen JS, Fox PT, Bryan CJ, McLean CP, Pruiksma KE, Yarvis JS, Niles BL, Abdallah CG, Averill LA, Back SE, Baker MT, Blount TH, Borah AM, Borah EV, Brock MS, Brown LA, Burg MM, Cigrang JA, DeBeer BB, DeVoe ER, Fina BA, Flanagan JC, Fredman SJ, Gardner CL, Gatchel RR, Goodie JL, Gueorguieva R, Higgs JB, Jacoby VM, Kelly KM, Krystal JH, Lapiz-Bluhm MD, Marx BP, Maurer DM, McDevitt-Murphy ME, McGeary CA, Meyer EC, Miles SR, Monson CM, Morilak DA, Moring JC, Mysliwiec V, Nicholson KL, Rauch SAM, Riggs DS, Rosen CS, Rudd MD, Schobitz RP, Schrader CC, Shinn AM, Shiroma PR, Sloan DM, Stern SL, Strong R, Vannoy SD, Young KA, Keane TM, STRONG STAR Consortium and the Consortium to Alleviate PTSD, L?pez-Roca AL. STRONG STAR and the Consortium to Alleviate PTSD: Shaping the future of combat PTSD and related conditions in military and veteran populations. Contemp Clin Trials. 2021 11; 110:106583. PMID: 34600107.
      Citations: 1     Fields:    Translation:Humans
    16. Fan S, Nemati S, Akiki TJ, Roscoe J, Averill CL, Fouda S, Averill LA, Abdallah CG. Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder. Chronic Stress (Thousand Oaks). 2020 Jan-Dec; 4:2470547020984726. PMID: 33458556; PMCID: PMC7783890.
      Citations: 3     
    17. Abdallah CG, Ahn KH, Averill LA, Nemati S, Averill CL, Fouda S, Ranganathan M, Morgan PT, D'Souza DC, Mathalon DH, Krystal JH, Driesen NR. A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants. Neuropsychopharmacology. 2021 01; 46(2):478-485. PMID: 32967000; PMCID: PMC7852889.
      Citations: 6     Fields:    Translation:Humans
    18. Averill LA, Abdallah CG, Fenton LR, Fasula MK, Jiang L, Rothman DL, Mason GF, Sanacora G. Early life stress and glutamate neurotransmission in major depressive disorder. Eur Neuropsychopharmacol. 2020 06; 35:71-80. PMID: 32418842; PMCID: PMC7913468.
      Citations: 2     Fields:    Translation:HumansCells
    19. Averill LA, Fouda S, Murrough JW, Abdallah CG. Chronic stress pathology and ketamine-induced alterations in functional connectivity in major depressive disorder: An abridged review of the clinical evidence. Adv Pharmacol. 2020; 89:163-194. PMID: 32616206.
      Citations: 1     Fields:    Translation:Humans
    20. Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D'Souza DC, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology. 2020 05; 45(6):990-997. PMID: 32092760; PMCID: PMC7162891.
      Citations: 33     Fields:    Translation:Humans
    21. Averill CL, Averill LA, Fan S, Abdallah CG. Of Forests and Trees: Bridging the Gap Between Neurobiology and Behavior in Posttraumatic Stress Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 02; 5(2):135-137. PMID: 32035611.
      Citations: 1     Fields:    Translation:Humans
    22. Nemati S, Akiki TJ, Roscoe J, Ju Y, Averill CL, Fouda S, Dutta A, McKie S, Krystal JH, Deakin JFW, Averill LA, Abdallah CG. A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. iScience. 2020 Jan 24; 23(1):100800. PMID: 31918047; PMCID: PMC6992944.
      Citations: 7     
    23. Schmaal L, van Harmelen AL, Chatzi V, Lippard ETC, Toenders YJ, Averill LA, Mazure CM, Blumberg HP. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies. Mol Psychiatry. 2020 02; 25(2):408-427. PMID: 31787757; PMCID: PMC6974434.
      Citations:    
    24. Averill CL, Abdallah CG, Averill LA. When the "Golden Chain" Breaks: Sleep Disturbance and the Vicious Cycle of Chronic Stress. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 12; 4(12):1018-1020. PMID: 31812223.
      Citations:    Fields:    Translation:HumansAnimals
    25. Averill LA, Abdallah CG, Levey DF, Han S, Harpaz-Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depress Anxiety. 2019 09; 36(9):834-845. PMID: 31385647.
      Citations: 6     Fields:    Translation:Humans
    26. Abdallah CG, Averill CL, Ramage AE, Averill LA, Goktas S, Nemati S, Krystal JH, Roache JD, Resick PA, Young-McCaughan S, Peterson AL, Fox P, STRONG STAR Consortium. Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder. Chronic Stress (Thousand Oaks). 2019 Jan-Dec; 3. PMID: 31131337; PMCID: PMC6529942.
      Citations: 10     
    27. Abdallah CG, Averill CL, Ramage AE, Averill LA, Alkin E, Nemati S, Krystal JH, Roache JD, Resick P, Young-McCaughan S, Peterson AL, Fox P, STRONG STAR Consortium. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment. Chronic Stress (Thousand Oaks). 2019 Jan-Feb; 3. PMID: 31008419; PMCID: PMC6469713.
      Citations: 13     
    28. Abdallah CG, Roache JD, Averill LA, Young-McCaughan S, Martini B, Gueorguieva R, Amoroso T, Southwick SM, Guthmiller K, Lautenschlager K, Mintz J, Litz BT, Williamson DE, Keane TM, Peterson AL, Krystal JH, Consortium to Alleviate PTSD, L?pez-Roca AL. Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial. Contemp Clin Trials. 2019 06; 81:11-18. PMID: 30999057.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    29. Akiki TJ, Averill LA, Abdallah CG. Neurobiological studies of trauma-related psychopathology: a public health perspective. Eur J Psychotraumatol. 2018; 9(1):1556554. PMID: 30637093; PMCID: PMC6319465.
      Citations: 2     Fields:    
    30. Abdallah CG, Dutta A, Averill CL, McKie S, Akiki TJ, Averill LA, Deakin JFW. Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients. Chronic Stress (Thousand Oaks). 2018 Jan-Dec; 2. PMID: 30263977; PMCID: PMC6154502.
      Citations: 25     
    31. Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder. Annu Rev Pharmacol Toxicol. 2019 01 06; 59:171-189. PMID: 30216745; PMCID: PMC6326888.
      Citations: 25     Fields:    Translation:HumansAnimals
    32. Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Topology of brain functional connectivity networks in posttraumatic stress disorder. Data Brief. 2018 Oct; 20:1658-1675. PMID: 30364328; PMCID: PMC6195053.
      Citations: 1     
    33. Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG. Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder. Mol Neuropsychiatry. 2018 Oct; 4(2):75-82. PMID: 30397595; PMCID: PMC6206974.
      Citations: 8     
    34. Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology. 2018 09; 43(10):2154-2160. PMID: 29977074; PMCID: PMC6098048.
      Citations: 58     Fields:    Translation:HumansCells
    35. Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach. Neuroimage. 2018 08 01; 176:489-498. PMID: 29730491; PMCID: PMC5976548.
      Citations: 62     Fields:    Translation:Humans
    36. Averill LA, Averill CL, Kelmendi B, Abdallah CG, Southwick SM. Stress Response Modulation Underlying the Psychobiology of Resilience. Curr Psychiatry Rep. 2018 03 28; 20(4):27. PMID: 29594808.
      Citations: 14     Fields:    Translation:Humans
    37. Krystal JH, Abdallah CG, Pietrzak RH, Averill LA, Harpaz-Rotem I, Levy I, Kelmendi B, Southwick SM. Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions. Biol Psychiatry. 2018 02 01; 83(3):197-199. PMID: 29277190.
      Citations: 3     Fields:    Translation:Humans
    38. Averill LA, Averill CL, Staley LA, Ozawa-Kirk JL, Kauwe JS, Henrie-Barrus P. The Opioid Abuse Risk Screener predicts aberrant same-day urine drug tests and 1-year controlled substance database checks: A brief report. Health Psychol Open. 2017 Jul-Dec; 4(2):2055102917748459. PMID: 29379630; PMCID: PMC5779942.
      Citations: 1     
    39. Averill CL, Satodiya RM, Scott JC, Wrocklage KM, Schweinsburg B, Averill LA, Akiki TJ, Amoroso T, Southwick SM, Krystal JH, Abdallah CG. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic Stress (Thousand Oaks). 2017 Jan-Dec; 1. PMID: 29520395; PMCID: PMC5839647.
      Citations: 10     
    40. Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct; 2(7):566-574. PMID: 29034354; PMCID: PMC5635826.
      Citations: 48     Fields:    
    41. Averill LA, Abdallah CG, Pietrzak RH, Averill CL, Southwick SM, Krystal JH, Harpaz-Rotem I. Combat Exposure Severity is Associated with Reduced Cortical Thickness in Combat Veterans: A Preliminary Report. Chronic Stress (Thousand Oaks). 2017 Jan; 1. PMID: 28845475; PMCID: PMC5568834.
      Citations: 13     
    42. Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG. The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities. Chronic Stress (Thousand Oaks). 2017 Feb; 1. PMID: 28825050; PMCID: PMC5562232.
      Citations: 23     
    43. Wrocklage KM, Averill LA, Cobb Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. Eur Neuropsychopharmacol. 2017 05; 27(5):515-525. PMID: 28279623; PMCID: PMC5429865.
      Citations: 39     Fields:    Translation:Humans
    44. Abdallah CG, Averill LA, Krystal JH. A New Journal: Addressing the Behavioral and Biological Effects of Chronic Stress. Chronic Stress (Thousand Oaks). 2017 Jan-Dec; 1:2470547016683296. PMID: 32440577; PMCID: PMC7219917.
      Citations:    
    45. Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG. Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. Neurosci Lett. 2017 05 10; 649:147-155. PMID: 27916636; PMCID: PMC5482215.
      Citations: 55     Fields:    Translation:HumansCells
    46. Abdallah CG, Averill LA, Collins KA, Geha P, Schwartz J, Averill C, DeWilde KE, Wong E, Anticevic A, Tang CY, Iosifescu DV, Charney DS, Murrough JW. Ketamine Treatment and Global Brain Connectivity in Major Depression. Neuropsychopharmacology. 2017 May; 42(6):1210-1219. PMID: 27604566; PMCID: PMC5437875.
      Citations: 94     Fields:    Translation:Humans
    47. Murrough JW, Abdallah CG, Anticevic A, Collins KA, Geha P, Averill LA, Schwartz J, DeWilde KE, Averill C, Jia-Wei Yang G, Wong E, Tang CY, Krystal JH, Iosifescu DV, Charney DS. Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder. Hum Brain Mapp. 2016 09; 37(9):3214-23. PMID: 27144347; PMCID: PMC4980239.
      Citations: 55     Fields:    Translation:Humans
    48. Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology. Behav Brain Sci. 2016 Jan; 39:e201. PMID: 28347382; PMCID: PMC5485236.
      Citations: 4     Fields:    Translation:Humans
    49. Averill LA, Eubanks Fleming CJ, Holens PL, Larsen SE. Research on PTSD prevalence in OEF/OIF Veterans: expanding investigation of demographic variables. Eur J Psychotraumatol. 2015; 6:27322. PMID: 25971312; PMCID: PMC4430556.
      Citations:    Fields:    
    50. Pietrzak RH, Averill LA, Abdallah CG, Neumeister A, Krystal JH, Levy I, Harpaz-Rotem I. Amygdala-hippocampal volume and the phenotypic heterogeneity of posttraumatic stress disorder: a cross-sectional study. JAMA Psychiatry. 2015 Apr; 72(4):396-8. PMID: 25692480; PMCID: PMC5134909.
      Citations: 11     Fields:    Translation:Humans
    51. Abdallah CG, Averill LA, Krystal JH. Ketamine as a promising prototype for a new generation of rapid-acting antidepressants. Ann N Y Acad Sci. 2015 May; 1344:66-77. PMID: 25727103; PMCID: PMC4412785.
      Citations: 48     Fields:    Translation:HumansAnimals
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