TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentTherapeutic Innovation Center
    DivisionTherapeutic Innovation Center

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frazier MN, Dillard LB, Krahn JM, Perera L, Williams JG, Wilson IM, Stewart ZD, Pillon MC, Deterding LJ, Borgnia MJ, Stanley RE. Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res. 2021 09 27; 49(17):10136-10149. PMID: 34403466; PMCID: PMC8385992.
      Citations: 11     Fields:    Translation:HumansCells
    2. Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun. 2021 01 27; 12(1):636. PMID: 33504779; PMCID: PMC7840905.
      Citations: 23     Fields:    Translation:Cells
    3. Pillon MC, Gordon J, Frazier MN, Stanley RE. HEPN RNases - an emerging class of functionally distinct RNA processing and degradation enzymes. Crit Rev Biochem Mol Biol. 2021 02; 56(1):88-108. PMID: 33349060; PMCID: PMC7856873.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Frazier MN, Pillon MC, Kocaman S, Gordon J, Stanley RE. Structural overview of macromolecular machines involved in ribosome biogenesis. Curr Opin Struct Biol. 2021 04; 67:51-60. PMID: 33099228; PMCID: PMC8058114.
      Citations: 6     Fields:    Translation:Cells
    5. Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15. bioRxiv. 2020 Aug 11. PMID: 32803198; PMCID: PMC7427136.
    6. Pillon MC, Stanley RE. Nonradioactive Assay to Measure Polynucleotide Phosphorylation of Small Nucleotide Substrates. J Vis Exp. 2020 05 08; (159). PMID: 32449708; PMCID: PMC7389563.
      Citations:    Fields:    Translation:Cells
    7. Pillon MC, Goslen KH, Gordon J, Wells ML, Williams JG, Stanley RE. It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly. J Biol Chem. 2020 05 01; 295(18):5857-5870. PMID: 32220933; PMCID: PMC7196650.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Pillon MC, Hsu AL, Krahn JM, Williams JG, Goslen KH, Sobhany M, Borgnia MJ, Stanley RE. Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat Struct Mol Biol. 2019 09; 26(9):830-839. PMID: 31488907; PMCID: PMC6733591.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Pillon MC, Lo YH, Stanley RE. IT'S 2 for the price of 1: Multifaceted ITS2 processing machines in RNA and DNA maintenance. DNA Repair (Amst). 2019 09; 81:102653. PMID: 31324529; PMCID: PMC6764878.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Gordon J, Pillon MC, Stanley RE. Nol9 Is a Spatial Regulator for the Human ITS2 Pre-rRNA Endonuclease-Kinase Complex. J Mol Biol. 2019 09 06; 431(19):3771-3786. PMID: 31288032; PMCID: PMC6733650.
      Citations: 2     Fields:    Translation:HumansCells
    11. Almawi AW, Randall JR, Liu L, Martin HK, Sacre L, Shen Y, Pillon MC, Simmons LA, Scotland MK, Sutton MD, Guarn? A. Binding of the regulatory domain of MutL to the sliding ?-clamp is species specific. Nucleic Acids Res. 2019 05 21; 47(9):4831-4842. PMID: 30916336; PMCID: PMC6511837.
      Citations: 4     Fields:    Translation:Cells
    12. Mok MCY, Campalans A, Pillon MC, Radicella JP, Junop MS, Guarn? A. Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage. Sci Rep. 2019 02 28; 9(1):3095. PMID: 30816207; PMCID: PMC6395731.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    13. Liu L, Ortiz Castro MC, Pillon MC, Rodr?guez Gonz?lez J, Guarn? A. The endonuclease domain of Bacillus subtilis MutL is functionally asymmetric. DNA Repair (Amst). 2019 01; 73:1-6. PMID: 30391220.
      Citations: 2     Fields:    Translation:Cells
    14. Pillon MC, Sobhany M, Stanley RE. Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex. RNA. 2018 05; 24(5):721-738. PMID: 29440475; PMCID: PMC5900568.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Lo YH, Pillon MC, Stanley RE. Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae. J Vis Exp. 2018 Jan 10; (131). PMID: 29364241; PMCID: PMC5820766.
      Citations:    Fields:    Translation:AnimalsCells
    16. Pillon MC, Stanley RE. Nuclease integrated kinase super assemblies (NiKs) and their role in RNA processing. Curr Genet. 2018 Feb; 64(1):183-190. PMID: 28929238; PMCID: PMC5820773.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Pillon MC, Guarn? A. Complementary uses of small angle X-ray scattering and X-ray crystallography. Biochim Biophys Acta Proteins Proteom. 2017 Nov; 1865(11 Pt B):1623-1630. PMID: 28743534.
      Citations:    Fields:    Translation:Cells
    18. Pillon MC, Sobhany M, Borgnia MJ, Williams JG, Stanley RE. Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5530-E5538. PMID: 28652339; PMCID: PMC5514736.
      Citations: 17     Fields:    Translation:AnimalsCells
    19. Lo YH, Romes EM, Pillon MC, Sobhany M, Stanley RE. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Structure. 2017 05 02; 25(5):762-772.e4. PMID: 28416111; PMCID: PMC5415421.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Kurinov I, Durocher D, Sicheri F, Guarn? A. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Nucleic Acids Res. 2016 08 19; 44(14):6971-80. PMID: 27302132; PMCID: PMC5001605.
      Citations: 13     Fields:    Translation:Cells
    21. Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Savchenko A, Wright GD, Guarn? A. Rifampin phosphotransferase is an unusual antibiotic resistance kinase. Nat Commun. 2016 Apr 22; 7:11343. PMID: 27103605; PMCID: PMC4844700.
      Citations: 17     Fields:    Translation:Cells
    22. Pillon MC, Babu VM, Randall JR, Cai J, Simmons LA, Sutton MD, Guarn? A. The sliding clamp tethers the endonuclease domain of MutL to DNA. Nucleic Acids Res. 2015 Dec 15; 43(22):10746-59. PMID: 26384423; PMCID: PMC4678855.
      Citations: 21     Fields:    Translation:Cells
    23. Lenhart JS, Pillon MC, Biteen JS, Simmons LA, Guarn? A. Mismatch repair in Gram-positive bacteria. Res Microbiol. 2016 Jan; 167(1):4-12. PMID: 26343983.
      Citations: 23     Fields:    Translation:AnimalsCells
    24. Tian L, Pillon MC, Kurinov I, Heck AJ, Greenberg RA, Zeqiraj E, Piggott CA, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Orlicky S, Gish GD, Guarn? A, Sicheri F. Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 2015 Sep 17; 59(6):970-83. PMID: 26344097; PMCID: PMC4579573.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Dong B, Jha BK, Pillon MC, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Silverman RH, Huang H, Zeqiraj E, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Guarn? A, Sicheri F. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol Cell. 2014 Jan 23; 53(2):221-34. PMID: 24462203; PMCID: PMC3974923.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    26. Lenhart JS, Pillon MC, Simmons LA, Guarn? A. Trapping and visualizing intermediate steps in the mismatch repair pathway in vivo. Mol Microbiol. 2013 Nov; 90(4):680-98. PMID: 23998896.
      Citations: 16     Fields:    Translation:Cells
    27. Pillon MC, Dubinsky M, Johnston RN, Liu SL, Guarn? A. Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability. DNA Repair (Amst). 2013 Oct; 12(10):864-9. PMID: 23916559.
      Citations: 2     Fields:    Translation:Cells
    28. Pillon MC, Miller JH, Guarn? A. The endonuclease domain of MutL interacts with the ? sliding clamp. DNA Repair (Amst). 2011 Jan 02; 10(1):87-93. PMID: 21050827; PMCID: PMC3028594.
      Citations: 29     Fields:    Translation:Cells
    29. Pillon MC, Lorenowicz JJ, Uckelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC, Simmons LA, Friedhoff P, Guarn? A. Structure of the endonuclease domain of MutL: unlicensed to cut. Mol Cell. 2010 Jul 09; 39(1):145-51. PMID: 20603082; PMCID: PMC2933357.
      Citations: 65     Fields:    Translation:Cells
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