TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Precision Environmental Health
    DivisionCenter for Precision Env Health

    Collapse Research 
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    R01HD109780     (BUFFINGTON, SHELLY A)Aug 15, 2023 - Jun 30, 2028
    Maternal gut microbiota in fetal programming of neurodevelopment and related disorders
    Role: Principal Investigator

    R01HD109095     (BUFFINGTON, SHELLY A)Jul 25, 2022 - May 31, 2027
    Targeting opportunistic pathogens to improve maternal obesity-associated health outcomes in offspring
    Role: Principal Investigator

    F31NS073295     (BUFFINGTON, SHELLY)Apr 7, 2011 - Apr 6, 2014
    Elucidating the role of UBXD4 at the axon initial segment
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stephens GS, Park J, Eagle A, You J, Silva-P?rez M, Fu CH, Choi S, Romain CPS, Sugimoto C, Buffington SA, Zheng Y, Costa-Mattioli M, Liu Y, Robison AJ, Chin J. Persistent ?FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. Prog Neurobiol. 2024 Jun; 237:102612. PMID: 38642602.
      Citations:    Fields:    Translation:HumansAnimals
    2. Matz LM, Shah NS, Porterfield L, Stuyck OM, Jochum MD, Kayed R, Taglialatela G, Urban RJ, Buffington SA. Microbial determinants of dementia risk in subjects of Mexican descent with type 2 diabetes living in South Texas. medRxiv. 2024 Mar 22. PMID: 38562743; PMCID: PMC10984044.
    3. Di Ges? CM, Matz LM, Fultz R, Bolding IJ, Buffington SA. Monospecies probiotic preparation and administration with downstream analysis of sex-specific effects on gut microbiome composition in mice. STAR Protoc. 2023 Sep 15; 4(3):102386. PMID: 37379217; PMCID: PMC10331592.
      Citations:    Fields:    Translation:AnimalsCells
    4. Di Ges? CM, Matz LM, Bolding IJ, Fultz R, Hoffman KL, Gammazza AM, Petrosino JF, Buffington SA. Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior. Cell Rep. 2023 May 30; 42(5):112498. PMID: 37133995; PMCID: PMC10399135.
      Citations:    Fields:    
    5. Di Ges? CM, Matz LM, Bolding IJ, Fultz R, Hoffman KL, Gammazza AM, Petrosino JF, Buffington SA. Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior. Cell Rep. 2022 10 11; 41(2):111461. PMID: 36223744; PMCID: PMC9597666.
      Citations: 5     Fields:    Translation:Animals
    6. Fultz R, Ticer T, Ihekweazu FD, Horvath TD, Haidacher SJ, Hoch KM, Bajaj M, Spinler JK, Haag AM, Buffington SA, Engevik MA. Unraveling the Metabolic Requirements of the Gut Commensal Bacteroides ovatus. Front Microbiol. 2021; 12:745469. PMID: 34899632; PMCID: PMC8656163.
      Citations: 1     
    7. Ash RT, Buffington SA, Park J, Suter B, Costa-Mattioli M, Zoghbi HY, Smirnakis SM. Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jul-Aug; 8(4). PMID: 34021030; PMCID: PMC8260274.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Di Ges? CM, Matz LM, Buffington SA. Diet-induced dysbiosis of the maternal gut microbiome in early life programming of neurodevelopmental disorders. Neurosci Res. 2021 Jul; 168:3-19. PMID: 33992660; PMCID: PMC9158738.
    9. Schlagal CR, Dunn TJ, Xu P, Felsing DE, Merritt CR, Manja S, Fox RG, Buffington SA, Saade G, Dineley KT, Yu Y, Cunningham KA, Wu P. Maternal Opioid Exposure Culminates in Perturbed Murine Neurodevelopment and Hyperactive Phenotype in Adolescence. Neuroscience. 2021 05 21; 463:272-287. PMID: 33811940; PMCID: PMC9233450.
    10. Buffington SA, Dooling SW, Sgritta M, Noecker C, Murillo OD, Felice DF, Turnbaugh PJ, Costa-Mattioli M. Dissecting the contribution of host genetics and the microbiome in complex behaviors. Cell. 2021 04 01; 184(7):1740-1756.e16. PMID: 33705688; PMCID: PMC8996745.
      Citations: 19     Fields:    Translation:AnimalsCells
    11. Johnson JL, Stoica L, Liu Y, Zhu PJ, Bhattacharya A, Buffington SA, Huq R, Eissa NT, Larsson O, Porse BT, Domingo D, Nawaz U, Carroll R, Jolly L, Scerri TS, Kim HG, Brignell A, Coleman MJ, Braden R, Kini U, Jackson V, Baxter A, Bahlo M, Scheffer IE, Amor DJ, Hildebrand MS, Bonnen PE, Beeton C, Gecz J, Morgan AT, Costa-Mattioli M. Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Neuron. 2019 11 20; 104(4):665-679.e8. PMID: 31585809; PMCID: PMC7312756.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    12. Sgritta M, Dooling SW, Buffington SA, Momin EN, Francis MB, Britton RA, Costa-Mattioli M. Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron. 2019 01 16; 101(2):246-259.e6. PMID: 30522820; PMCID: PMC6645363.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    13. Buffington SA, Di Prisco GV, Auchtung TA, Ajami NJ, Petrosino JF, Costa-Mattioli M. Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell. 2016 Jun 16; 165(7):1762-1775. PMID: 27315483; PMCID: PMC5102250.
      Citations: 321     Fields:    Translation:AnimalsCells
    14. Pitcher MR, Buffington SA, Kochukov MY, Merritt JK, Fisher AR, Schanen NC, Costa-Mattioli M, Neul JL, Herrera JA. Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene. Hum Mol Genet. 2015 May 01; 24(9):2662-72. PMID: 25634563; PMCID: PMC4383870.
      Citations: 22     Fields:    Translation:AnimalsCells
    15. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Kaufman RJ, Walter P, Costa-Mattioli M, Krnjevic K. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nat Neurosci. 2014 Aug; 17(8):1073-82. PMID: 24974795; PMCID: PMC4340591.
      Citations: 95     Fields:    Translation:AnimalsCells
    16. Buffington SA, Huang W, Costa-Mattioli M. Translational control in synaptic plasticity and cognitive dysfunction. Annu Rev Neurosci. 2014; 37:17-38. PMID: 25032491; PMCID: PMC4721605.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    17. Kaphzan H, Buffington SA, Ramaraj AB, Lingrel JB, Rasband MN, Santini E, Klann E. Genetic reduction of the a1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome. Cell Rep. 2013 Aug 15; 4(3):405-12. PMID: 23911285; PMCID: PMC3756897.
      Citations: 34     Fields:    Translation:AnimalsCells
    18. Buffington SA, Rasband MN. Na+ channel-dependent recruitment of Nav?4 to axon initial segments and nodes of Ranvier. J Neurosci. 2013 Apr 03; 33(14):6191-202. PMID: 23554500; PMCID: PMC3643000.
      Citations: 31     Fields:    Translation:AnimalsCells
    19. Buffington SA, Schultz C, Rasband MN, Sobotzik JM. I?Ba is not required for axon initial segment assembly. Mol Cell Neurosci. 2012 May; 50(1):1-9. PMID: 22445657; PMCID: PMC3383875.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Kaphzan H, Buffington SA, Jung JI, Rasband MN, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011 Nov 30; 31(48):17637-48. PMID: 22131424; PMCID: PMC3483031.
      Citations: 69     Fields:    Translation:AnimalsCells
    21. Buffington SA, Rasband MN. The axon initial segment in nervous system disease and injury. Eur J Neurosci. 2011 Nov; 34(10):1609-19. PMID: 22103418; PMCID: PMC3482160.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
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