Solute Carrier Family 22 Member 5
"Solute Carrier Family 22 Member 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.
| Descriptor ID |
D000074058
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| MeSH Number(s) |
D12.776.157.530.450.250.812.750 D12.776.157.530.937.612.750 D12.776.543.585.450.250.812.750 D12.776.543.585.937.701.750
|
| Concept/Terms |
Solute Carrier Family 22 Member 5- Solute Carrier Family 22 Member 5
- High-Affinity Carnitine Transporter
- Carnitine Transporter, High-Affinity
- High Affinity Carnitine Transporter
- Transporter, High-Affinity Carnitine
- OCTN2 Protein
- Sodium-Dependent Carnitine Cotransporter
- Carnitine Cotransporter, Sodium-Dependent
- Sodium Dependent Carnitine Cotransporter
- Organic Cation-Carnitine Transporter 2
- Organic Cation Carnitine Transporter 2
- SLC22A5 Protein
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Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 22 Member 5".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 22 Member 5".
This graph shows the total number of publications written about "Solute Carrier Family 22 Member 5" by people in this website by year, and whether "Solute Carrier Family 22 Member 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Solute Carrier Family 22 Member 5" by people in Profiles.
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SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE). Breast Cancer Res Treat. 2012 Jul; 134(1):101-15.
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Molecular spectrum of SLC22A5 (OCTN2) gene mutations detected in 143 subjects evaluated for systemic carnitine deficiency. Hum Mutat. 2010 Aug; 31(8):E1632-51.
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Maternal systemic primary carnitine deficiency uncovered by newborn screening: clinical, biochemical, and molecular aspects. Genet Med. 2010 Jan; 12(1):19-24.
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A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. Gastroenterology. 2005 Feb; 128(2):260-9.
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Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet. 2004 May; 36(5):471-5.
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Functional characterization of the carnitine transporter defective in primary carnitine deficiency. Arch Biochem Biophys. 1999 Apr 01; 364(1):99-106.