TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
Houston, TX 77030
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    R01HL083047     (NG, PHILIP)Apr 1, 2007 - Sep 30, 2011
    Aerosol delivery of HDAd into Primate Lungs: Preclinical CF Gene Therapy Studies
    Role: Principal Investigator

    R01DK067324     (NG, PHILIP)Apr 1, 2004 - Jun 30, 2015
    Improving Safety and Efficacy of Gene Therapy with HDAd
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou J, Hamdan H, Yalamanchili HK, Pang K, Pohodich AE, Lopez J, Shao Y, Oses-Prieto JA, Li L, Kim W, Durham MA, Bajikar SS, Palmer DJ, Ng P, Thompson ML, Bebin EM, Burlingame AL, Liu Z, Rasband MN, Zoghbi HY, M?ller AJ, Kuechler A, Kampmeier A, Haack TB. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Proc Natl Acad Sci U S A. 2022 01 25; 119(4). PMID: 35074918; PMCID: PMC8794850.
      Citations:    Fields:    Translation:AnimalsCells
    2. Jin Z, Kho J, Dawson B, Jiang MM, Chen Y, Ali S, Burrage LC, Grover M, Palmer DJ, Turner DL, Ng P, Nagamani SC, Lee B. Nitric oxide modulates bone anabolism through regulation of osteoblast glycolysis and differentiation. J Clin Invest. 2021 03 01; 131(5). PMID: 33373331; PMCID: PMC7919726.
      Citations: 4     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    3. Palmer DJ, Turner DL, Ng P. A Single "All-in-One" Helper-Dependent Adenovirus to Deliver Donor DNA and CRISPR/Cas9 for Efficient Homology-Directed Repair. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:441-447. PMID: 32154329; PMCID: PMC7058846.
      Citations: 12     
    4. Hamdan H, Lim BC, Torii T, Joshi A, Konning M, Smith C, Palmer DJ, Ng P, Leterrier C, Oses-Prieto JA, Burlingame AL, Rasband MN. Mapping axon initial segment structure and function by multiplexed proximity biotinylation. Nat Commun. 2020 01 03; 11(1):100. PMID: 31900387; PMCID: PMC6941957.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    5. Palmer DJ, Turner DL, Ng P. Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses. Mol Ther Methods Clin Dev. 2019 Dec 13; 15:285-293. PMID: 31890728; PMCID: PMC6923503.
      Citations: 3     
    6. Palmer DJ, Turner DL, Ng P. Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses. Mol Ther Methods Clin Dev. 2019 Jun 14; 13:432-439. PMID: 31080846; PMCID: PMC6506437.
      Citations: 9     
    7. Palmer DJ, Grove NC, Turner DL, Ng P. Gene Editing with Helper-Dependent Adenovirus Can Efficiently Introduce Multiple Changes Simultaneously over a Large Genomic Region. Mol Ther Nucleic Acids. 2017 Sep 15; 8:101-110. PMID: 28918012; PMCID: PMC5493818.
      Citations: 5     
    8. Palmer DJ, Grove NC, Ing J, Crane AM, Venken K, Davis BR, Ng P. Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors. Mol Ther Nucleic Acids. 2016 Oct 11; 5(10):e372. PMID: 27727248; PMCID: PMC5095686.
      Citations: 10     
    9. Palmer DJ, Grove NC, Ng P. Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector. Mol Ther Methods Clin Dev. 2016; 3:16039. PMID: 27331077; PMCID: PMC4898405.
      Citations: 6     
    10. Brunetti-Pierri N, Ng T, Iannitti D, Cioffi W, Stapleton G, Law M, Breinholt J, Palmer D, Grove N, Rice K, Bauer C, Finegold M, Beaudet A, Mullins C, Ng P. Transgene expression up to 7 years in nonhuman primates following hepatic transduction with helper-dependent adenoviral vectors. Hum Gene Ther. 2013 Aug; 24(8):761-5. PMID: 23902403; PMCID: PMC3746245.
      Citations: 32     Fields:    Translation:AnimalsCells
    11. Suzuki M, Bertin TK, Rogers GL, Cela RG, Zolotukhin I, Palmer DJ, Ng P, Herzog RW, Lee B. Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo. Mol Ther. 2013 Apr; 21(4):796-805. PMID: 23319058; PMCID: PMC3616533.
      Citations: 31     Fields:    Translation:AnimalsCells
    12. Guse K, Suzuki M, Sule G, Bertin TK, Tyynismaa H, Palmer D, Suomalainen A, Ng P, Cerullo V, Hemminki A, Lee B, Ahola-Erkkil? S. Capsid-modified adenoviral vectors for improved muscle-directed gene therapy. Hum Gene Ther. 2012 Oct; 23(10):1065-70. PMID: 22888960; PMCID: PMC3472516.
      Citations: 15     Fields:    Translation:AnimalsCells
    13. Brunetti-Pierri N, Liou A, Patel P, Palmer D, Grove N, Finegold M, Piccolo P, Donnachie E, Rice K, Beaudet A, Mullins C, Ng P. Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques. Mol Ther. 2012 Oct; 20(10):1863-70. PMID: 22828499; PMCID: PMC3464633.
      Citations: 20     Fields:    Translation:AnimalsCells
    14. Rosewell A, Vetrini F, Ng P. Helper-Dependent Adenoviral Vectors. J Genet Syndr Gene Ther. 2011 Oct 29; Suppl 5. PMID: 24533227; PMCID: PMC3923448.
      Citations: 8     
    15. Dimmock D, Brunetti-Pierri N, Palmer DJ, Beaudet AL, Ng P. Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors. Hum Gene Ther. 2011 Apr; 22(4):483-8. PMID: 20973621; PMCID: PMC3073075.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Vetrini F, Ng P. Liver-directed gene therapy with helper-dependent adenoviral vectors: current state of the art and future challenges. Curr Pharm Des. 2011; 17(24):2488-99. PMID: 21774769.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    17. Vetrini F, Ng P. Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives. Viruses. 2010 Sep; 2(9):1886-1917. PMID: 21994713; PMCID: PMC3186006.
      Citations: 18     Fields:    
    18. Vetrini F, Brunetti-Pierri N, Palmer DJ, Bertin T, Grove NC, Finegold MJ, Ng P. Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad. Mol Ther. 2010 Jul; 18(7):1339-45. PMID: 20461064; PMCID: PMC2911263.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Brunetti-Pierri N, Ng P. Progress towards liver and lung-directed gene therapy with helper-dependent adenoviral vectors. Curr Gene Ther. 2009 Oct; 9(5):329-40. PMID: 19860648.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    20. Brunetti-Pierri N, Grove NC, Zuo Y, Edwards R, Palmer D, Cerullo V, Teruya J, Ng P. Bioengineered factor IX molecules with increased catalytic activity improve the therapeutic index of gene therapy vectors for hemophilia B. Hum Gene Ther. 2009 May; 20(5):479-85. PMID: 19196177; PMCID: PMC2861950.
      Citations: 12     Fields:    Translation:AnimalsCells
    21. Brunetti-Pierri N, Stapleton GE, Law M, Breinholt J, Palmer DJ, Zuo Y, Grove NC, Finegold MJ, Rice K, Beaudet AL, Mullins CE, Ng P. Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates. Mol Ther. 2009 Feb; 17(2):327-33. PMID: 19050700; PMCID: PMC2835071.
      Citations: 45     Fields:    Translation:Animals
    22. Xia A, Wooltorton JR, Palmer DJ, Ng P, Pereira FA, Eatock RA, Oghalai JS. Functional prestin transduction of immature outer hair cells from normal and prestin-null mice. J Assoc Res Otolaryngol. 2008 Sep; 9(3):307-20. PMID: 18506528; PMCID: PMC2538149.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    23. Palmer DJ, Ng P. Methods for the production of first generation adenoviral vectors. Methods Mol Biol. 2008; 433:55-78. PMID: 18679617.
      Citations: 7     Fields:    Translation:HumansCells
    24. Palmer DJ, Ng P. Methods for the production of helper-dependent adenoviral vectors. Methods Mol Biol. 2008; 433:33-53. PMID: 18679616.
      Citations: 26     Fields:    Translation:HumansCells
    25. Wenzel GI, Xia A, Funk E, Evans MB, Palmer DJ, Ng P, Pereira FA, Oghalai JS. Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea. Otol Neurotol. 2007 Dec; 28(8):1100-8. PMID: 18043435.
      Citations: 20     Fields:    Translation:AnimalsCells
    26. Brunetti-Pierri N, Stapleton GE, Palmer DJ, Zuo Y, Mane VP, Finegold MJ, Beaudet AL, Leland MM, Mullins CE, Ng P. Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy. Mol Ther. 2007 Apr; 15(4):732-40. PMID: 17285138.
      Citations: 44     Fields:    Translation:AnimalsCells
    27. Seiler MP, Gottschalk S, Cerullo V, Ratnayake M, Mane VP, Clarke C, Palmer DJ, Ng P, Rooney CM, Lee B. Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates. Mol Ther. 2007 Feb; 15(2):386-92. PMID: 17235318.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    28. Chaudhuri SR, Mallam JN, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Mol Ther. 2007 Mar; 15(3):566-70. PMID: 17180120.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    29. Brunetti-Pierri N, Ng P. Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy. Curr Opin Mol Ther. 2006 Oct; 8(5):446-54. PMID: 17078387.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    30. Brunetti-Pierri N, Ng T, Iannitti DA, Palmer DJ, Beaudet AL, Finegold MJ, Carey KD, Cioffi WG, Ng P. Improved hepatic transduction, reduced systemic vector dissemination, and long-term transgene expression by delivering helper-dependent adenoviral vectors into the surgically isolated liver of nonhuman primates. Hum Gene Ther. 2006 Apr; 17(4):391-404. PMID: 16610927.
      Citations: 32     Fields:    Translation:AnimalsCells
    31. Brunetti-Pierri N, Palmer DJ, Mane V, Finegold M, Beaudet AL, Ng P. Increased hepatic transduction with reduced systemic dissemination and proinflammatory cytokines following hydrodynamic injection of helper-dependent adenoviral vectors. Mol Ther. 2005 Jul; 12(1):99-106. PMID: 15963925.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    32. Brunetti-Pierri N, Nichols TC, McCorquodale S, Merricks E, Palmer DJ, Beaudet AL, Ng P. Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector. Hum Gene Ther. 2005 Jul; 16(7):811-20. PMID: 16000063.
      Citations: 39     Fields:    Translation:AnimalsCells
    33. Toietta G, Mane VP, Norona WS, Finegold MJ, Ng P, McDonagh AF, Beaudet AL, Lee B. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):3930-5. PMID: 15753292; PMCID: PMC554836.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    34. Palmer DJ, Ng P. Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther. 2005 Jan; 16(1):1-16. PMID: 15703484.
      Citations: 59     Fields:    Translation:HumansCells
    35. Mok H, Palmer DJ, Ng P, Barry MA. Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses. Mol Ther. 2005 Jan; 11(1):66-79. PMID: 15585407.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    36. Mian A, Guenther M, Finegold M, Ng P, Rodgers J, Lee B. Toxicity and adaptive immune response to intracellular transgenes delivered by helper-dependent vs. first generation adenoviral vectors. Mol Genet Metab. 2005 Mar; 84(3):278-88. PMID: 15694178.
      Citations: 10     Fields:    Translation:AnimalsCells
    37. Palmer DJ, Ng P. Physical and infectious titers of helper-dependent adenoviral vectors: a method of direct comparison to the adenovirus reference material. Mol Ther. 2004 Oct; 10(4):792-8. PMID: 15451463.
      Citations: 37     Fields:    Translation:HumansCells
    38. Mian A, McCormack WM, Mane V, Kleppe S, Ng P, Finegold M, O'Brien WE, Rodgers JR, Beaudet AL, Lee B. Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus. Mol Ther. 2004 Sep; 10(3):492-9. PMID: 15336649.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    39. Brunetti-Pierri N, Palmer DJ, Beaudet AL, Carey KD, Finegold M, Ng P. Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum Gene Ther. 2004 Jan; 15(1):35-46. PMID: 14965376.
      Citations: 110     Fields:    Translation:AnimalsCells
    40. Palmer D, Ng P. Improved system for helper-dependent adenoviral vector production. Mol Ther. 2003 Nov; 8(5):846-52. PMID: 14599819.
      Citations: 150     Fields:    Translation:HumansCells
    41. Ng P, Evelegh C, Cummings D, Graham FL. Cre levels limit packaging signal excision efficiency in the Cre/loxP helper-dependent adenoviral vector system. J Virol. 2002 May; 76(9):4181-9. PMID: 11932383; PMCID: PMC155107.
      Citations: 15     Fields:    Translation:Cells
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