TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
Houston, TX 77030
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    R01DK067324     (NG, PHILIP)Apr 1, 2004 - Jun 30, 2015
    Improving Safety and Efficacy of Gene Therapy with HDAd
    Role: Principal Investigator

    R01HL083047     (NG, PHILIP)Apr 1, 2007 - Sep 30, 2011
    Aerosol delivery of HDAd into Primate Lungs: Preclinical CF Gene Therapy Studies
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jin Z, Kho J, Dawson B, Jiang MM, Chen Y, Ali S, Burrage LC, Grover M, Palmer DJ, Turner DL, Ng P, Nagamani SC, Lee B. Nitric oxide modulates bone anabolism through regulation of osteoblast glycolysis and differentiation. J Clin Invest. 2021 03 01; 131(5). PMID: 33373331.
      Citations: 1     Fields:    
    2. Palmer DJ, Turner DL, Ng P. A Single "All-in-One" Helper-Dependent Adenovirus to Deliver Donor DNA and CRISPR/Cas9 for Efficient Homology-Directed Repair. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:441-447. PMID: 32154329.
      Citations: 9     
    3. Hamdan H, Lim BC, Torii T, Joshi A, Konning M, Smith C, Palmer DJ, Ng P, Leterrier C, Oses-Prieto JA, Burlingame AL, Rasband MN. Mapping axon initial segment structure and function by multiplexed proximity biotinylation. Nat Commun. 2020 01 03; 11(1):100. PMID: 31900387.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    4. Palmer DJ, Turner DL, Ng P. Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses. Mol Ther Methods Clin Dev. 2019 Dec 13; 15:285-293. PMID: 31890728.
      Citations: 3     
    5. Palmer DJ, Turner DL, Ng P. Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses. Mol Ther Methods Clin Dev. 2019 Jun 14; 13:432-439. PMID: 31080846.
      Citations: 6     
    6. Soria LR, Nitzahn M, De Angelis A, Khoja S, Attanasio S, Annunziata P, Palmer DJ, Ng P, Lipshutz GS, Brunetti-Pierri N. Hepatic glutamine synthetase augmentation enhances ammonia detoxification. J Inherit Metab Dis. 2019 11; 42(6):1128-1135. PMID: 30724386.
      Citations: 1     Fields:    Translation:Animals
    7. Stamatikos A, Dronadula N, Ng P, Palmer D, Knight E, Wacker BK, Tang C, Kim F, Dichek DA. ABCA1 Overexpression in Endothelial Cells In Vitro Enhances ApoAI-Mediated Cholesterol Efflux and Decreases Inflammation. Hum Gene Ther. 2019 02; 30(2):236-248. PMID: 30079772.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. Khoja S, Nitzahn M, Hermann K, Truong B, Borzone R, Willis B, Rudd M, Palmer DJ, Ng P, Brunetti-Pierri N, Lipshutz GS. Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy. Mol Genet Metab. 2018 08; 124(4):243-253. PMID: 29801986.
      Citations: 5     Fields:    Translation:HumansAnimals
    9. Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A. A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice. Mol Ther Methods Clin Dev. 2018 Mar 16; 8:52-64. PMID: 29255741.
      Citations: 13     
    10. Brunetti-Pierri N, Ng P. Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models. Virus Genes. 2017 Oct; 53(5):684-691. PMID: 28593513.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Palmer DJ, Grove NC, Turner DL, Ng P. Gene Editing with Helper-Dependent Adenovirus Can Efficiently Introduce Multiple Changes Simultaneously over a Large Genomic Region. Mol Ther Nucleic Acids. 2017 Sep 15; 8:101-110. PMID: 28918012.
      Citations: 5     
    12. Palmer DJ, Grove NC, Ing J, Crane AM, Venken K, Davis BR, Ng P. Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors. Mol Ther Nucleic Acids. 2016 Oct 11; 5(10):e372. PMID: 27727248.
      Citations: 9     
    13. Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A. In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors. Blood. 2016 11 03; 128(18):2206-2217. PMID: 27554082.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    14. Palmer DJ, Grove NC, Ng P. Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector. Mol Ther Methods Clin Dev. 2016; 3:16039. PMID: 27331077.
      Citations: 6     
    15. VanderVeen N, Raja N, Yi E, Appelman H, Ng P, Palmer D, Zamler D, Dzaman M, Lowenstein PR, Castro MG. Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model. Hum Gene Ther Methods. 2016 06; 27(3):98-111. PMID: 27056322.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    16. Hu Y, O'Boyle K, Palmer D, Ng P, Sutton RE. High-level production of replication-defective human immunodeficiency type 1 virus vector particles using helper-dependent adenovirus vectors. Mol Ther Methods Clin Dev. 2015; 2:15004. PMID: 26029715.
    17. Saydaminova K, Ye X, Wang H, Richter M, Ho M, Chen H, Xu N, Kim JS, Papapetrou E, Holmes MC, Gregory PD, Palmer D, Ng P, Ehrhardt A, Lieber A. Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation. Mol Ther Methods Clin Dev. 2015; 1:14057. PMID: 26052525.
      Citations: 28     
    18. VanderVeen N, Paran C, Appelhans A, Krasinkiewicz J, Lemons R, Appelman H, Doherty R, Palmer D, Ng P, Lowenstein PR, Castro MG. Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Mol Ther Methods Clin Dev. 2014 Feb 05; 1. PMID: 25068145.
      Citations: 4     
    19. Pastore N, Nusco E, Piccolo P, Castaldo S, Vaníkova J, Vetrini F, Palmer DJ, Vitek L, Ng P, Brunetti-Pierri N. Improved efficacy and reduced toxicity by ultrasound-guided intrahepatic injections of helper-dependent adenoviral vector in Gunn rats. Hum Gene Ther Methods. 2013 Oct; 24(5):321-7. PMID: 23947957.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. VanderVeen N, Paran C, Krasinkiewicz J, Zhao L, Palmer D, Hervey-Jumper S, Ng P, Lowenstein PR, Castro MG. Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma. Hum Gene Ther Clin Dev. 2013 Sep; 24(3):116-26. PMID: 24007469.
      Citations: 8     Fields:    Translation:Animals
    21. Brunetti-Pierri N, Ng T, Iannitti D, Cioffi W, Stapleton G, Law M, Breinholt J, Palmer D, Grove N, Rice K, Bauer C, Finegold M, Beaudet A, Mullins C, Ng P. Transgene expression up to 7 years in nonhuman primates following hepatic transduction with helper-dependent adenoviral vectors. Hum Gene Ther. 2013 Aug; 24(8):761-5. PMID: 23902403.
      Citations: 30     Fields:    Translation:AnimalsCells
    22. Weaver EA, Nehete PN, Nehete BP, Yang G, Buchl SJ, Hanley PW, Palmer D, Montefiori DC, Ferrari G, Ng P, Sastry KJ, Barry MA. Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV. PLoS One. 2013; 8(7):e67574. PMID: 23844034.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Brunetti-Pierri N, Ng P. Adenoviral Vectors for Hemophilia Gene Therapy. J Genet Syndr Gene Ther. 2013 Apr 30; 2(Suppl 1):017. PMID: 24883229.
    24. Puntel M, A K M GM, Farrokhi C, Vanderveen N, Paran C, Appelhans A, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Kaur S, Kennedy S, Palmer D, Ng P, Liu C, Krasinkiewicz J, Lowenstein PR, Castro MG. Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma. Toxicol Appl Pharmacol. 2013 May 01; 268(3):318-30. PMID: 23403069.
      Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    25. Pastore N, Blomenkamp K, Annunziata F, Piccolo P, Mithbaokar P, Maria Sepe R, Vetrini F, Palmer D, Ng P, Polishchuk E, Iacobacci S, Polishchuk R, Teckman J, Ballabio A, Brunetti-Pierri N. Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency. EMBO Mol Med. 2013 Mar; 5(3):397-412. PMID: 23381957.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    26. Piccolo P, Vetrini F, Mithbaokar P, Grove NC, Bertin T, Palmer D, Ng P, Brunetti-Pierri N. SR-A and SREC-I are Kupffer and endothelial cell receptors for helper-dependent adenoviral vectors. Mol Ther. 2013 Apr; 21(4):767-74. PMID: 23358188.
      Citations: 23     Fields:    Translation:AnimalsCells
    27. Suzuki M, Bertin TK, Rogers GL, Cela RG, Zolotukhin I, Palmer DJ, Ng P, Herzog RW, Lee B. Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo. Mol Ther. 2013 Apr; 21(4):796-805. PMID: 23319058.
      Citations: 27     Fields:    Translation:AnimalsCells
    28. Muhammad AK, Xiong W, Puntel M, Farrokhi C, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Palmer D, Ng P, Liu C, Lowenstein PR, Castro MG. Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial. Hum Gene Ther Methods. 2012 Aug; 23(4):271-84. PMID: 22950971.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    29. Guse K, Suzuki M, Sule G, Bertin TK, Tyynismaa H, Ahola-Erkkilä S, Palmer D, Suomalainen A, Ng P, Cerullo V, Hemminki A, Lee B. Capsid-modified adenoviral vectors for improved muscle-directed gene therapy. Hum Gene Ther. 2012 Oct; 23(10):1065-70. PMID: 22888960.
      Citations: 10     Fields:    Translation:AnimalsCells
    30. Brunetti-Pierri N, Liou A, Patel P, Palmer D, Grove N, Finegold M, Piccolo P, Donnachie E, Rice K, Beaudet A, Mullins C, Ng P. Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques. Mol Ther. 2012 Oct; 20(10):1863-70. PMID: 22828499.
      Citations: 19     Fields:    Translation:AnimalsCells
    31. Rosewell A, Vetrini F, Ng P. Helper-Dependent Adenoviral Vectors. J Genet Syndr Gene Ther. 2011 Oct 29; Suppl 5. PMID: 24533227.
      Citations: 7     
    32. Smith JS, Xu Z, Tian J, Palmer DJ, Ng P, Byrnes AP. The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response. PLoS One. 2011; 6(10):e26755. PMID: 22046344.
      Citations: 8     Fields:    Translation:AnimalsCells
    33. Palmer DJ, Ng P. Rescue, amplification, and large-scale production of helper-dependent adenoviral vectors. Cold Spring Harb Protoc. 2011 Jul 01; 2011(7):857-66. PMID: 21724821.
      Citations: 5     Fields:    Translation:Cells
    34. Palmer DJ, Ng P. Characterization of helper-dependent adenoviral vectors. Cold Spring Harb Protoc. 2011 Jul 01; 2011(7):867-70. PMID: 21724820.
      Citations: 2     Fields:    Translation:Cells
    35. Khare R, May SM, Vetrini F, Weaver EA, Palmer D, Rosewell A, Grove N, Ng P, Barry MA. Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer. Mol Ther. 2011 Jul; 19(7):1254-62. PMID: 21505422.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    36. Brunetti-Pierri N, Ng P. Helper-dependent adenoviral vectors for liver-directed gene therapy. Hum Mol Genet. 2011 Apr 15; 20(R1):R7-13. PMID: 21470977.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    37. Dimmock D, Brunetti-Pierri N, Palmer DJ, Beaudet AL, Ng P. Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors. Hum Gene Ther. 2011 Apr; 22(4):483-8. PMID: 20973621.
      Citations: 7     Fields:    Translation:AnimalsCells
    38. Weaver EA, Hillestad ML, Khare R, Palmer D, Ng P, Barry MA. Characterization of species C human adenovirus serotype 6 (Ad6). Virology. 2011 Mar 30; 412(1):19-27. PMID: 21251688.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    39. Vetrini F, Ng P. Liver-directed gene therapy with helper-dependent adenoviral vectors: current state of the art and future challenges. Curr Pharm Des. 2011; 17(24):2488-99. PMID: 21774769.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    40. Prill JM, Espenlaub S, Samen U, Engler T, Schmidt E, Vetrini F, Rosewell A, Grove N, Palmer D, Ng P, Kochanek S, Kreppel F. Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells. Mol Ther. 2011 Jan; 19(1):83-92. PMID: 20959811.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    41. Lee BH, Kushwah R, Wu J, Ng P, Palaniyar N, Grinstein S, Philpott DJ, Hu J. Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells. Immunol Lett. 2010 Nov 30; 134(1):93-102. PMID: 20850478.
      Citations: 11     Fields:    Translation:AnimalsCells
    42. Vetrini F, Ng P. Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives. Viruses. 2010 Sep; 2(9):1886-917. PMID: 21994713.
      Citations: 15     Fields:    
    43. Kubo S, Haga K, Tamamoto A, Palmer DJ, Ng P, Okamura H, Kasahara N. Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo. Mol Ther. 2011 Jan; 19(1):76-82. PMID: 20808291.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    44. Vetrini F, Brunetti-Pierri N, Palmer DJ, Bertin T, Grove NC, Finegold MJ, Ng P. Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad. Mol Ther. 2010 Jul; 18(7):1339-45. PMID: 20461064.
      Citations: 6     Fields:    Translation:AnimalsCells
    45. Puntel M, Muhammad AK, Candolfi M, Salem A, Yagiz K, Farrokhi C, Kroeger KM, Xiong W, Curtin JF, Liu C, Bondale NS, Lerner J, Pechnick RN, Palmer D, Ng P, Lowenstein PR, Castro MG. A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics. J Virol. 2010 Jun; 84(12):6007-17. PMID: 20375153.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    46. Kubo S, Kataoka M, Tateno C, Yoshizato K, Kawasaki Y, Kimura T, Faure-Kumar E, Palmer DJ, Ng P, Okamura H, Kasahara N. In vivo stable transduction of humanized liver tissue in chimeric mice via high-capacity adenovirus-lentivirus hybrid vector. Hum Gene Ther. 2010 Jan; 21(1):40-50. PMID: 19725756.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    47. Weaver EA, Nehete PN, Nehete BP, Buchl SJ, Palmer D, Montefiori DC, Ng P, Sastry KJ, Barry MA. Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines. Viruses. 2009 Dec 01; 1(3):920. PMID: 20107521.
      Citations: 17     Fields:    
    48. Brunetti-Pierri N, Ng P. Progress towards liver and lung-directed gene therapy with helper-dependent adenoviral vectors. Curr Gene Ther. 2009 Oct; 9(5):329-40. PMID: 19860648.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    49. Brunetti-Pierri N, Grove NC, Zuo Y, Edwards R, Palmer D, Cerullo V, Teruya J, Ng P. Bioengineered factor IX molecules with increased catalytic activity improve the therapeutic index of gene therapy vectors for hemophilia B. Hum Gene Ther. 2009 May; 20(5):479-85. PMID: 19196177.
      Citations: 12     Fields:    Translation:AnimalsCells
    50. Weaver EA, Nehete PN, Buchl SS, Senac JS, Palmer D, Ng P, Sastry KJ, Barry MA. Comparison of replication-competent, first generation, and helper-dependent adenoviral vaccines. PLoS One. 2009; 4(3):e5059. PMID: 19333387.
      Citations: 37     Fields:    Translation:AnimalsCells
    51. Hofherr SE, Senac JS, Chen CY, Palmer DJ, Ng P, Barry MA. Short-term rescue of neonatal lethality in a mouse model of propionic acidemia by gene therapy. Hum Gene Ther. 2009 Feb; 20(2):169-80. PMID: 19025475.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    52. Brunetti-Pierri N, Stapleton GE, Law M, Breinholt J, Palmer DJ, Zuo Y, Grove NC, Finegold MJ, Rice K, Beaudet AL, Mullins CE, Ng P. Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates. Mol Ther. 2009 Feb; 17(2):327-33. PMID: 19050700.
      Citations: 44     Fields:    Translation:Animals
    53. Xia A, Wooltorton JR, Palmer DJ, Ng P, Pereira FA, Eatock RA, Oghalai JS. Functional prestin transduction of immature outer hair cells from normal and prestin-null mice. J Assoc Res Otolaryngol. 2008 Sep; 9(3):307-20. PMID: 18506528.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    54. Lin Y, Kwon T, Polo J, Zhu YF, Coates S, Crawford K, Dong C, Wininger M, Hall J, Selby M, Coit D, Medina-Selby A, McCoin C, Ng P, Drane D, Chien D, Han J, Vajdy M, Houghton M. Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. J Virol. 2008 Aug; 82(15):7492-503. PMID: 18508900.
      Citations: 20     Fields:    Translation:AnimalsCells
    55. King GD, Muhammad AK, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG. High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity. J Virol. 2008 May; 82(9):4680-4. PMID: 18287240.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    56. Xiong W, Candolfi M, Kroeger KM, Puntel M, Mondkar S, Larocque D, Liu C, Curtin JF, Palmer D, Ng P, Lowenstein PR, Castro MG. Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain. Mol Ther. 2008 Feb; 16(2):343-51. PMID: 18180781.
      Citations: 22     Fields:    Translation:AnimalsCellsPHPublic Health
    57. Palmer DJ, Ng P. Methods for the production of first generation adenoviral vectors. Methods Mol Biol. 2008; 433:55-78. PMID: 18679617.
      Citations: 7     Fields:    Translation:HumansCells
    58. Palmer DJ, Ng P. Methods for the production of helper-dependent adenoviral vectors. Methods Mol Biol. 2008; 433:33-53. PMID: 18679616.
      Citations: 24     Fields:    Translation:HumansCells
    59. Wenzel GI, Xia A, Funk E, Evans MB, Palmer DJ, Ng P, Pereira FA, Oghalai JS. Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea. Otol Neurotol. 2007 Dec; 28(8):1100-8. PMID: 18043435.
      Citations: 18     Fields:    Translation:AnimalsCells
    60. Barcia C, Jimenez-Dalmaroni M, Kroeger KM, Puntel M, Rapaport AJ, Larocque D, King GD, Johnson SA, Liu C, Xiong W, Candolfi M, Mondkar S, Ng P, Palmer D, Castro MG, Lowenstein PR. One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. Mol Ther. 2007 Dec; 15(12):2154-63. PMID: 17895861.
      Citations: 44     Fields:    Translation:AnimalsCells
    61. Brunetti-Pierri N, Stapleton GE, Palmer DJ, Zuo Y, Mane VP, Finegold MJ, Beaudet AL, Leland MM, Mullins CE, Ng P. Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy. Mol Ther. 2007 Apr; 15(4):732-40. PMID: 17285138.
      Citations: 44     Fields:    Translation:AnimalsCells
    62. Seiler MP, Gottschalk S, Cerullo V, Ratnayake M, Mane VP, Clarke C, Palmer DJ, Ng P, Rooney CM, Lee B. Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates. Mol Ther. 2007 Feb; 15(2):386-92. PMID: 17235318.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    63. Flotte TR, Ng P, Dylla DE, McCray PB, Wang G, Kolls JK, Hu J. Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis. Mol Ther. 2007 Feb; 15(2):229-41. PMID: 17235299.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    64. Chaudhuri SR, Mallam JN, Chévez-Barrios P, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL. Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Mol Ther. 2007 Mar; 15(3):566-70. PMID: 17180120.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    65. Brunetti-Pierri N, Ng P. Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy. Curr Opin Mol Ther. 2006 Oct; 8(5):446-54. PMID: 17078387.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    66. Candolfi M, Curtin JF, Xiong WD, Kroeger KM, Liu C, Rentsendorj A, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells. Mol Ther. 2006 Sep; 14(3):371-81. PMID: 16798098.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    67. Brunetti-Pierri N, Ng T, Iannitti DA, Palmer DJ, Beaudet AL, Finegold MJ, Carey KD, Cioffi WG, Ng P. Improved hepatic transduction, reduced systemic vector dissemination, and long-term transgene expression by delivering helper-dependent adenoviral vectors into the surgically isolated liver of nonhuman primates. Hum Gene Ther. 2006 Apr; 17(4):391-404. PMID: 16610927.
      Citations: 32     Fields:    Translation:AnimalsCells
    68. Xiong W, Goverdhana S, Sciascia SA, Candolfi M, Zirger JM, Barcia C, Curtin JF, King GD, Jaita G, Liu C, Kroeger K, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. J Virol. 2006 Jan; 80(1):27-37. PMID: 16352528.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    69. Koehler DR, Frndova H, Leung K, Louca E, Palmer D, Ng P, McKerlie C, Cox P, Coates AL, Hu J. Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter. J Gene Med. 2005 Nov; 7(11):1409-20. PMID: 15999396.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    70. Kiang A, Hartman ZC, Liao S, Xu F, Serra D, Palmer DJ, Ng P, Amalfitano A. Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice. Mol Ther. 2006 Jan; 13(1):127-34. PMID: 16169280.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    71. Farmen SL, Karp PH, Ng P, Palmer DJ, Koehler DR, Hu J, Beaudet AL, Zabner J, Welsh MJ. Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR. Am J Physiol Lung Cell Mol Physiol. 2005 Dec; 289(6):L1123-30. PMID: 16085675.
      Citations: 46     Translation:HumansCells
    72. Brunetti-Pierri N, Nichols TC, McCorquodale S, Merricks E, Palmer DJ, Beaudet AL, Ng P. Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector. Hum Gene Ther. 2005 Jul; 16(7):811-20. PMID: 16000063.
      Citations: 39     Fields:    Translation:AnimalsCells
    73. Brunetti-Pierri N, Palmer DJ, Mane V, Finegold M, Beaudet AL, Ng P. Increased hepatic transduction with reduced systemic dissemination and proinflammatory cytokines following hydrodynamic injection of helper-dependent adenoviral vectors. Mol Ther. 2005 Jul; 12(1):99-106. PMID: 15963925.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    74. Toietta G, Mane VP, Norona WS, Finegold MJ, Ng P, McDonagh AF, Beaudet AL, Lee B. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):3930-5. PMID: 15753292.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    75. Palmer DJ, Ng P. Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther. 2005 Jan; 16(1):1-16. PMID: 15703484.
      Citations: 57     Fields:    Translation:HumansCells
    76. Mok H, Palmer DJ, Ng P, Barry MA. Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses. Mol Ther. 2005 Jan; 11(1):66-79. PMID: 15585407.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    77. Mian A, Guenther M, Finegold M, Ng P, Rodgers J, Lee B. Toxicity and adaptive immune response to intracellular transgenes delivered by helper-dependent vs. first generation adenoviral vectors. Mol Genet Metab. 2005 Mar; 84(3):278-88. PMID: 15694178.
      Citations: 10     Fields:    Translation:AnimalsCells
    78. Palmer DJ, Ng P. Physical and infectious titers of helper-dependent adenoviral vectors: a method of direct comparison to the adenovirus reference material. Mol Ther. 2004 Oct; 10(4):792-8. PMID: 15451463.
      Citations: 36     Fields:    Translation:HumansCells
    79. Mian A, McCormack WM, Mane V, Kleppe S, Ng P, Finegold M, O'Brien WE, Rodgers JR, Beaudet AL, Lee B. Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus. Mol Ther. 2004 Sep; 10(3):492-9. PMID: 15336649.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    80. Brunetti-Pierri N, Palmer DJ, Beaudet AL, Carey KD, Finegold M, Ng P. Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum Gene Ther. 2004 Jan; 15(1):35-46. PMID: 14965376.
      Citations: 102     Fields:    Translation:AnimalsCells
    81. Palmer D, Ng P. Improved system for helper-dependent adenoviral vector production. Mol Ther. 2003 Nov; 8(5):846-52. PMID: 14599819.
      Citations: 141     Fields:    Translation:HumansCells
    82. Ng P, Evelegh C, Cummings D, Graham FL. Cre levels limit packaging signal excision efficiency in the Cre/loxP helper-dependent adenoviral vector system. J Virol. 2002 May; 76(9):4181-9. PMID: 11932383.
      Citations: 15     Fields:    Translation:Cells
    83. Shi CX, Hitt M, Ng P, Graham FL. Superior tissue-specific expression from tyrosinase and prostate-specific antigen promoters/enhancers in helper-dependent compared with first-generation adenoviral vectors. Hum Gene Ther. 2002 Jan 20; 13(2):211-24. PMID: 11812278.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    84. Ng P, Graham FL. Construction of first-generation adenoviral vectors. Methods Mol Med. 2002; 69:389-414. PMID: 11987791.
      Citations: 32     Fields:    Translation:Cells
    85. Ng P, Parks RJ, Graham FL. Preparation of helper-dependent adenoviral vectors. Methods Mol Med. 2002; 69:371-88. PMID: 11987790.
      Citations: 32     Fields:    Translation:Cells
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