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HAMED JAFAR-NEJAD

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
AddressOne Baylor Plaza, 919E
Houston TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01GM084135     (JAFAR-NEJAD, HAMED)Apr 1, 2008 - Dec 31, 2017
    NIH/NIGMS
    Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Role: Principal Investigator

    R01DK109982     (JAFAR-NEJAD, HAMED)Jul 15, 2016 - Jun 30, 2020
    NIH/NIDDK
    Negative regulation of Jagged1 by glycosylation: towards a mechanism-based therapy for Alagille syndrome
    Role: Principal Investigator

    R35GM130317     (JAFAR-NEJAD, HAMED)Feb 1, 2019 - Jan 31, 2024
    NIH/NIGMS
    Regulation of developmental signaling pathways by glycosylation and deglycosylation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Niknejad N, Jafar-Nejad H. Unbiased glycomics: a powerful tool in rare disease diagnosis and research. Transl Res. 2019 04; 206:1-4. PMID: 30528322.
      View in: PubMed
    2. Pandey A, Li-Kroeger D, Sethi MK, Lee TV, Buettner FF, Bakker H, Jafar-Nejad H. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Glycobiology. 2018 11 01; 28(11):849-859. PMID: 30169771.
      View in: PubMed
    3. Adams JM, Jafar-Nejad H. A New Model of Alagille Syndrome With Broad Phenotypic Representation. Gastroenterology. 2018 03; 154(4):803-806. PMID: 29425927.
      View in: PubMed
    4. Pandey A, Jafar-Nejad H. Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands. J Vis Exp. 2018 01 02; (131). PMID: 29364239.
      View in: PubMed
    5. Wu J, Hunt SD, Matthias N, Servián-Morilla E, Lo J, Jafar-Nejad H, Paradas C, Darabi R. Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi). Stem Cell Res. 2017 10; 24:102-105. PMID: 29034878.
      View in: PubMed
    6. Galeone A, Han SY, Huang C, Hosomi A, Suzuki T, Jafar-Nejad H. Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1. Elife. 2017 08 04; 6. PMID: 28826503.
      View in: PubMed
    7. Lee TV, Pandey A, Jafar-Nejad H. Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila. PLoS Genet. 2017 04; 13(4):e1006723. PMID: 28394891.
      View in: PubMed
    8. Servián-Morilla E, Takeuchi H, Lee TV, Clarimon J, Mavillard F, Area-Gómez E, Rivas E, Nieto-González JL, Rivero MC, Cabrera-Serrano M, Gómez-Sánchez L, Martínez-López JA, Estrada B, Márquez C, Morgado Y, Suárez-Calvet X, Pita G, Bigot A, Gallardo E, Fernández-Chacón R, Hirano M, Haltiwanger RS, Jafar-Nejad H, Paradas C. A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med. 2016 11; 8(11):1289-1309. PMID: 27807076.
      View in: PubMed
    9. Harvey BM, Rana NA, Moss H, Leonardi J, Jafar-Nejad H, Haltiwanger RS. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. J Biol Chem. 2016 07 29; 291(31):16348-60. PMID: 27268051.
      View in: PubMed
    10. Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad H. Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology. 2016 Feb; 63(2):550-65. PMID: 26235536.
      View in: PubMed
    11. Haltom AR, Jafar-Nejad H. The multiple roles of epidermal growth factor repeat O-glycans in animal development. Glycobiology. 2015 Oct; 25(10):1027-42. PMID: 26175457.
      View in: PubMed
    12. He P, Grotzke JE, Ng BG, Gunel M, Jafar-Nejad H, Cresswell P, Enns GM, Freeze HH. A congenital disorder of deglycosylation: Biochemical characterization of N-glycanase 1 deficiency in patient fibroblasts. Glycobiology. 2015 Aug; 25(8):836-44. PMID: 25900930.
      View in: PubMed
    13. Haltom AR, Lee TV, Harvey BM, Leonardi J, Chen YJ, Hong Y, Haltiwanger RS, Jafar-Nejad H. The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 2014 Nov; 10(11):e1004795. PMID: 25412384.
      View in: PubMed
    14. LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 2014 Sep 25; 3:e02950. PMID: 25255098.
      View in: PubMed
    15. Leonardi J, Jafar-Nejad H. Structure-function analysis of Drosophila Notch using genomic rescue transgenes. Methods Mol Biol. 2014; 1187:29-46. PMID: 25053479.
      View in: PubMed
    16. Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad H. Negative regulation of notch signaling by xylose. PLoS Genet. 2013 Jun; 9(6):e1003547. PMID: 23754965.
      View in: PubMed
    17. Takeuchi H, Fernández-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, Weldeghiorghis TK, Macnaughtan MA, Jafar-Nejad H, Haltiwanger RS. Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16600-5. PMID: 21949356.
      View in: PubMed
    18. Leonardi J, Fernandez-Valdivia R, Li YD, Simcox AA, Jafar-Nejad H. Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development. 2011 Aug; 138(16):3569-78. PMID: 21771811.
      View in: PubMed
    19. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development. 2011 May; 138(10):1925-34. PMID: 21490058.
      View in: PubMed
    20. Jafar-Nejad H, Leonardi J, Fernandez-Valdivia R. Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology. 2010 Aug; 20(8):931-49. PMID: 20368670.
      View in: PubMed
    21. Lee TV, Takeuchi H, Jafar-Nejad H. Regulation of notch signaling via O-glucosylation insights from Drosophila studies. Methods Enzymol. 2010; 480:375-98. PMID: 20816218.
      View in: PubMed
    22. Simcox AA, Austin CL, Jacobsen TL, Jafar-Nejad H. Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Fly (Austin). 2008 Nov-Dec; 2(6):306-9. PMID: 19077546.
      View in: PubMed
    23. Lim J, Jafar-Nejad H, Hsu YC, Choi KW. Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep. 2008 Nov; 9(11):1128-33. PMID: 18758436.
      View in: PubMed
    24. Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell. 2008 Jan 25; 132(2):247-58. PMID: 18243100.
      View in: PubMed
    25. Rogaeva A, Ou XM, Jafar-Nejad H, Lemonde S, Albert PR. Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. J Biol Chem. 2007 Jul 20; 282(29):20897-905. PMID: 17535813.
      View in: PubMed
    26. Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ. Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development. 2006 May; 133(10):1979-89. PMID: 16624856.
      View in: PubMed
    27. Jafar-Nejad H, Tien AC, Acar M, Bellen HJ. Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development. 2006 May; 133(9):1683-92. PMID: 16554363.
      View in: PubMed
    28. Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006 Jan; 8(1):27-36. PMID: 16341207.
      View in: PubMed
    29. Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005 Sep; 9(3):351-63. PMID: 16137928.
      View in: PubMed
    30. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44. PMID: 16122429.
      View in: PubMed
    31. Jafar-Nejad H, Bellen HJ. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol Cell Biol. 2004 Oct; 24(20):8803-12. PMID: 15456856.
      View in: PubMed
    32. Quan XJ, Denayer T, Yan J, Jafar-Nejad H, Philippi A, Lichtarge O, Vleminckx K, Hassan BA. Evolution of neural precursor selection: functional divergence of proneural proteins. Development. 2004 Apr; 131(8):1679-89. PMID: 15084454.
      View in: PubMed
    33. Jafar-Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJ. Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 2003 Dec 01; 17(23):2966-78. PMID: 14665671.
      View in: PubMed
    34. Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ. Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10860-5. PMID: 12960394.
      View in: PubMed
    35. Ou XM, Lemonde S, Jafar-Nejad H, Bown CD, Goto A, Rogaeva A, Albert PR. Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene. J Neurosci. 2003 Aug 13; 23(19):7415-25. PMID: 12917378.
      View in: PubMed
    36. Jafar-Nejad H, Norga K, Bellen H. Numb: "Adapting" notch for endocytosis. Dev Cell. 2002 Aug; 3(2):155-6. PMID: 12194846.
      View in: PubMed
    37. Ou XM, Jafar-Nejad H, Storring JM, Meng JH, Lemonde S, Albert PR. Novel dual repressor elements for neuronal cell-specific transcription of the rat 5-HT1A receptor gene. J Biol Chem. 2000 Mar 17; 275(11):8161-8. PMID: 10713139.
      View in: PubMed
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