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CHRISTOPHE HERMAN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    DP1AI152073     (HERMAN, CHRISTOPHE)Sep 30, 2019 - Jul 31, 2024
    NIH
    A Synthetic Platform for Non-Antibiotic Eradication of Bacterial Infections
    Role: Principal Investigator
    R01GM088653     (HERMAN, CHRISTOPHE)Aug 1, 2010 - Jan 31, 2021
    NIH
    Molecular Noise, Transcription Errors and Heritable Phenotypic Change
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cooke MB, Herman C, Sivaramakrishnan P. Clues to transcription/replication collision-induced DNA damage: it was RNAP, in the chromosome, with the fork. FEBS Lett. 2024 Nov 24. PMID: 39582266.
      Citations:    Fields:    
    2. Wen AX, Herman C. Horizontal gene transfer and beyond: the delivery of biological matter by bacterial membrane vesicles to host and bacterial cells. Curr Opin Microbiol. 2024 Oct; 81:102525. PMID: 39190937; PMCID: PMC11444307.
      Citations:    Fields:    Translation:Cells
    3. Hu G, Cooke MB, Wen AX, Yu X, Wang J, Herman C, Wang MC. Chemical Induction of Longevity-Promoting Colanic Acid in the Host's Microbiota. bioRxiv. 2024 Jul 24. PMID: 39211270; PMCID: PMC11360898.
      Citations:    
    4. Bradley CC, Wang C, Gordon AJE, Wen AX, Luna PN, Cooke MB, Kohrn BF, Kennedy SR, Avadhanula V, Piedra PA, Lichtarge O, Shaw CA, Ronca SE, Herman C. Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence. Nat Microbiol. 2024 May; 9(5):1382-1392. PMID: 38649410; PMCID: PMC11384275.
      Citations: 3     Fields:    Translation:HumansCells
    5. Zhai Y, Pribis JP, Dooling SW, Garcia-Villada L, Minnick PJ, Xia J, Liu J, Mei Q, Fitzgerald DM, Herman C, Hastings PJ, Costa-Mattioli M, Rosenberg SM. Drugging evolution of antibiotic resistance at a regulatory network hub. Sci Adv. 2023 06 23; 9(25):eadg0188. PMID: 37352342; PMCID: PMC10289659.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Zhai Y, Minnick PJ, Pribis JP, Garcia-Villada L, Hastings PJ, Herman C, Rosenberg SM. ppGpp and RNA-polymerase backtracking guide antibiotic-induced mutable gambler cells. Mol Cell. 2023 04 20; 83(8):1298-1310.e4. PMID: 36965481; PMCID: PMC10317147.
      Citations: 1     Fields:    Translation:Cells
    7. Cooke MB, Herman C. Conjugation's Toolkit: the Roles of Nonstructural Proteins in Bacterial Sex. J Bacteriol. 2023 03 21; 205(3):e0043822. PMID: 36847532; PMCID: PMC10029717.
      Citations:    Fields:    
    8. Marciano DC, Wang C, Hsu TK, Bourquard T, Atri B, Nehring RB, Abel NS, Bowling EA, Chen TJ, Lurie PD, Katsonis P, Rosenberg SM, Herman C, Lichtarge O. Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli. Nat Commun. 2022 06 09; 13(1):3189. PMID: 35680894; PMCID: PMC9184624.
      Citations: 1     Fields:    Translation:Cells
    9. Bradley CC, Gordon AJE, Wang C, Cooke MB, Kohrn BF, Kennedy SR, Lichtarge O, Ronca SE, Herman C. RNA polymerase inaccuracy underlies SARS-CoV-2 variants and vaccine heterogeneity. Res Sq. 2022 Jun 02. PMID: 35677076; PMCID: PMC9176646.
      Citations:    
    10. Neve IAA, Sowa JN, Lin CJ, Sivaramakrishnan P, Herman C, Ye Y, Han L, Wang MC. Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans. G3 (Bethesda). 2020 01 07; 10(1):189-198. PMID: 31712257; PMCID: PMC6945014.
      Citations: 10     Fields:    Translation:AnimalsCells
    11. Bradley CC, Gordon AJE, Halliday JA, Herman C. Transcription fidelity: New paradigms in epigenetic inheritance, genome instability and disease. DNA Repair (Amst). 2019 09; 81:102652. PMID: 31326363; PMCID: PMC6764924.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    12. Pribis JP, Zhai Y, Lewin-Epstein O, Wang AZ, Liu J, Xia J, Mei Q, Fitzgerald DM, Bos J, Austin RH, Herman C, Bates D, Hadany L, Hastings PJ, Rosenberg SM, Garc?a-Villada L. Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response. Mol Cell. 2019 05 16; 74(4):785-800.e7. PMID: 30948267; PMCID: PMC6553487.
      Citations: 40     Fields:    Translation:Cells
    13. Xia J, Chiu LY, Nehring RB, Mei Q, Perez M, Zhai Y, Fitzgerald DM, Pribis JP, Wang Y, Hu CW, Powell RT, LaBonte SA, Jalali A, Lentzsch AM, Szafran AT, Joshi MC, Richters M, Gibson JL, Frisch RL, Hastings PJ, Bates D, Queitsch C, Hilsenbeck SG, Coarfa C, Hu JC, Siegele DA, Scott KL, Liang H, Mancini MA, Herman C, Miller KM, Rosenberg SM, Bravo N??ez MA, Matadamas Guzm?n ML. Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. Cell. 2019 01 10; 176(1-2):127-143.e24. PMID: 30633903; PMCID: PMC6344048.
      Citations: 35     Fields:    Translation:HumansCells
    14. Kotlajich MV, Xia J, Zhai Y, Lin HY, Bradley CC, Shen X, Mei Q, Wang AZ, Lynn EJ, Shee C, Chen LT, Li L, Miller KM, Herman C, Hastings PJ, Rosenberg SM. Fluorescent fusions of the N protein of phage Mu label DNA damage in living cells. DNA Repair (Amst). 2018 12; 72:86-92. PMID: 30268364; PMCID: PMC6287932.
      Citations: 2     Fields:    Translation:Cells
    15. Gordon AJE, Sivaramakrishnan P, Halliday JA, Herman C. Transcription infidelity and genome integrity: the parallax view. Transcription. 2018; 9(5):315-320. PMID: 29929421; PMCID: PMC6150618.
      Citations:    Fields:    Translation:Cells
    16. Sivaramakrishnan P, Gordon AJE, Halliday JA, Herman C. How Acts of Infidelity Promote DNA Break Repair: Collision and Collusion Between DNA Repair and Transcription. Bioessays. 2018 10; 40(10):e1800045. PMID: 30091472; PMCID: PMC6334755.
      Citations:    Fields:    Translation:Cells
    17. Swings T, Marciano DC, Atri B, Bosserman RE, Wang C, Leysen M, Bonte C, Schalck T, Furey I, Van den Bergh B, Verstraeten N, Christie PJ, Herman C, Lichtarge O, Michiels J. CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing. Nat Commun. 2018 Jun 08; 9(1):2231. PMID: 29884781; PMCID: PMC5993718.
      Citations: 2     Fields:    Translation:Cells
    18. Han B, Sivaramakrishnan P, Lin CJ, Neve IAA, He J, Tay LWR, Sowa JN, Sizovs A, Du G, Wang J, Herman C, Wang MC. Microbial Genetic Composition Tunes Host Longevity. Cell. 2018 05 03; 173(4):1058. PMID: 29727664; PMCID: PMC6240461.
      Citations: 4     Fields:    
    19. Girard ME, Gopalkrishnan S, Grace ED, Halliday JA, Gourse RL, Herman C. DksA and ppGpp Regulate the sS Stress Response by Activating Promoters for the Small RNA DsrA and the Anti-Adapter Protein IraP. J Bacteriol. 2018 01 15; 200(2). PMID: 29061665; PMCID: PMC5738727.
      Citations: 23     Fields:    Translation:Cells
    20. Sivaramakrishnan P, Halliday JA, Liu J, Golding I, Rosenberg SM, Herman C, Sep?lveda LA, N??ez MAB. The transcription fidelity factor GreA impedes DNA break repair. Nature. 2017 10 12; 550(7675):214-218. PMID: 28976965; PMCID: PMC5654330.
      Citations: 27     Fields:    Translation:Cells
    21. Han B, Sivaramakrishnan P, Lin CJ, Neve IAA, He J, Tay LWR, Sowa JN, Sizovs A, Du G, Wang J, Herman C, Wang MC. Microbial Genetic Composition Tunes Host Longevity. Cell. 2017 Jun 15; 169(7):1249-1262.e13. PMID: 28622510; PMCID: PMC5635830.
      Citations: 104     Fields:    Translation:AnimalsCells
    22. Xia J, Chen LT, Mei Q, Ma CH, Halliday JA, Lin HY, Magnan D, Pribis JP, Fitzgerald DM, Hamilton HM, Richters M, Nehring RB, Shen X, Li L, Bates D, Hastings PJ, Herman C, Jayaram M, Rosenberg SM. Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase. Sci Adv. 2016 Nov; 2(11):e1601605. PMID: 28090586; PMCID: PMC5222578.
      Citations: 17     Fields:    Translation:HumansCells
    23. Marciano DC, Lua RC, Herman C, Lichtarge O. Cooperativity of Negative Autoregulation Confers Increased Mutational Robustness. Phys Rev Lett. 2016 Jun 24; 116(25):258104. PMID: 27391757; PMCID: PMC5152588.
      Citations: 2     Fields:    Translation:Cells
    24. Satory D, Gordon AJ, Wang M, Halliday JA, Golding I, Herman C. DksA involvement in transcription fidelity buffers stochastic epigenetic change. Nucleic Acids Res. 2015 Dec 02; 43(21):10190-9. PMID: 26304546; PMCID: PMC4666387.
      Citations: 15     Fields:    Translation:Cells
    25. Gordon AJ, Satory D, Halliday JA, Herman C. Lost in transcription: transient errors in information transfer. Curr Opin Microbiol. 2015 Apr; 24:80-7. PMID: 25637723; PMCID: PMC4380820.
      Citations: 23     Fields:    Translation:Cells
    26. Grace ED, Gopalkrishnan S, Girard ME, Blankschien MD, Ross W, Gourse RL, Herman C. Activation of the sE-dependent stress pathway by conjugative TraR may anticipate conjugational stress. J Bacteriol. 2015 Mar; 197(5):924-31. PMID: 25535270; PMCID: PMC4325106.
      Citations: 7     Fields:    Translation:Cells
    27. Gordon AJ, Satory D, Wang M, Halliday JA, Golding I, Herman C. Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity. Nucleic Acids Res. 2014 Oct 29; 42(19):12015-26. PMID: 25294823; PMCID: PMC4231768.
      Citations: 7     Fields:    Translation:Cells
    28. Bednarz M, Halliday JA, Herman C, Golding I. Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda. PLoS One. 2014; 9(6):e100876. PMID: 24963924; PMCID: PMC4070997.
      Citations: 18     Fields:    Translation:Cells
    29. Marciano DC, Lua RC, Katsonis P, Amin SR, Herman C, Lichtarge O. Negative feedback in genetic circuits confers evolutionary resilience and capacitance. Cell Rep. 2014 Jun 26; 7(6):1789-95. PMID: 24910431; PMCID: PMC4103627.
      Citations: 11     Fields:    
    30. Zhang Y, Mooney RA, Grass JA, Sivaramakrishnan P, Herman C, Landick R, Wang JD. DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest. Mol Cell. 2014 Mar 06; 53(5):766-78. PMID: 24606919; PMCID: PMC4023959.
      Citations: 40     Fields:    Translation:Cells
    31. Shee C, Cox BD, Gu F, Luengas EM, Joshi MC, Chiu LY, Magnan D, Halliday JA, Frisch RL, Gibson JL, Nehring RB, Do HG, Hernandez M, Li L, Herman C, Hastings PJ, Bates D, Harris RS, Miller KM, Rosenberg SM. Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife. 2013 Oct 29; 2:e01222. PMID: 24171103; PMCID: PMC3809393.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    32. Satory D, Halliday JA, Sivaramakrishnan P, Lua RC, Herman C. Characterization of a novel RNA polymerase mutant that alters DksA activity. J Bacteriol. 2013 Sep; 195(18):4187-94. PMID: 23852871; PMCID: PMC3754754.
      Citations: 9     Fields:    Translation:Cells
    33. Gordon AJ, Satory D, Halliday JA, Herman C. Heritable change caused by transient transcription errors. PLoS Genet. 2013 Jun; 9(6):e1003595. PMID: 23825966; PMCID: PMC3694819.
      Citations: 33     Fields:    Translation:HumansCells
    34. Adikesavan AK, Katsonis P, Marciano DC, Lua R, Herman C, Lichtarge O. Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites. PLoS Genet. 2011 Sep; 7(9):e1002244. PMID: 21912525; PMCID: PMC3164682.
      Citations: 40     Fields:    Translation:Cells
    35. Satory D, Gordon AJ, Halliday JA, Herman C. Epigenetic switches: can infidelity govern fate in microbes? Curr Opin Microbiol. 2011 Apr; 14(2):212-7. PMID: 21496764.
      Citations: 19     Fields:    Translation:Cells
    36. Gibson JL, Lombardo MJ, Thornton PC, Hu KH, Galhardo RS, Beadle B, Habib A, Magner DB, Frost LS, Herman C, Hastings PJ, Rosenberg SM. The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli. Mol Microbiol. 2010 Jul; 77(2):415-30. PMID: 20497332; PMCID: PMC2909356.
      Citations: 35     Fields:    Translation:Cells
    37. Tehranchi AK, Blankschien MD, Zhang Y, Halliday JA, Srivatsan A, Peng J, Herman C, Wang JD. The transcription factor DksA prevents conflicts between DNA replication and transcription machinery. Cell. 2010 May 14; 141(4):595-605. PMID: 20478253; PMCID: PMC2919171.
      Citations: 101     Fields:    Translation:Cells
    38. Blankschien MD, Lee JH, Grace ED, Lennon CW, Halliday JA, Ross W, Gourse RL, Herman C. Super DksAs: substitutions in DksA enhancing its effects on transcription initiation. EMBO J. 2009 Jun 17; 28(12):1720-31. PMID: 19424178; PMCID: PMC2699356.
      Citations: 26     Fields:    Translation:Cells
    39. Gordon AJ, Halliday JA, Blankschien MD, Burns PA, Yatagai F, Herman C. Transcriptional infidelity promotes heritable phenotypic change in a bistable gene network. PLoS Biol. 2009 Feb 24; 7(2):e44. PMID: 19243224; PMCID: PMC2652393.
      Citations: 57     Fields:    Translation:Cells
    40. Blankschien MD, Potrykus K, Grace E, Choudhary A, Vinella D, Cashel M, Herman C. TraR, a homolog of a RNAP secondary channel interactor, modulates transcription. PLoS Genet. 2009 Jan; 5(1):e1000345. PMID: 19148274; PMCID: PMC2613031.
      Citations: 36     Fields:    Translation:Cells
    41. Nonaka G, Blankschien M, Herman C, Gross CA, Rhodius VA. Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress. Genes Dev. 2006 Jul 01; 20(13):1776-89. PMID: 16818608; PMCID: PMC1522074.
      Citations: 148     Fields:    Translation:Cells
    42. Guisbert E, Herman C, Lu CZ, Gross CA. A chaperone network controls the heat shock response in E. coli. Genes Dev. 2004 Nov 15; 18(22):2812-21. PMID: 15545634; PMCID: PMC528900.
      Citations: 78     Fields:    Translation:Cells
    43. Grigorova IL, Chaba R, Zhong HJ, Alba BM, Rhodius V, Herman C, Gross CA. Fine-tuning of the Escherichia coli sigmaE envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA. Genes Dev. 2004 Nov 01; 18(21):2686-97. PMID: 15520285; PMCID: PMC525548.
      Citations: 60     Fields:    Translation:Cells
    44. Herman C, Prakash S, Lu CZ, Matouschek A, Gross CA. Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH. Mol Cell. 2003 Mar; 11(3):659-69. PMID: 12667449.
      Citations: 73     Fields:    Translation:Cells
    45. Wang JD, Herman C, Tipton KA, Gross CA, Weissman JS. Directed evolution of substrate-optimized GroEL/S chaperonins. Cell. 2002 Dec 27; 111(7):1027-39. PMID: 12507429.
      Citations: 62     Fields:    Translation:Cells
    46. Herman CM, Kattan MW, Ohori M, Scardino PT, Wheeler TM. Primary Gleason pattern as a predictor of disease progression in gleason score 7 prostate cancer: a multivariate analysis of 823 men treated with radical prostatectomy. Am J Surg Pathol. 2001 May; 25(5):657-60. PMID: 11342779.
      Citations: 14     Fields:    Translation:Humans
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