E01 W81WH-19-1-0689 (Kanwal; Chhatwal)Sep 1, 2022 - Aug 1, 2023 Department of Defense office of the Congressionally Directed Medical Research Programs (CDMRP) Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award
Risk of hepatocellular cancer after virological cure with direct acting antiviral agents in individuals with hepatitis C
Role Description: The goal of this study is to examine the risk and determinants of hepatocellular carcinoma
(HCC) in patients with chronic hepatitis C (CHC) virologically cured with new direct acting antiviral agent (DAA)
regimens and to identify cost-effective strategies for early detection of HCC in those patients.
Role: Co-Investigator |
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1P01CA263025-01 (Kanwal)Apr 1, 2022 - Mar 1, 2027 NIH
Prevention of Hepatocellular Carcinoma Related to Metabolic Syndrome, Project 2
Role Description: The overarching goal of this project is to reduce the burden of hepatocellular carcinoma (HCC)-
related mortality through better understanding of contemporary risk factors (e.g., phenotypic, biochemical and
genetic markers of metabolic dysfunction) and protective factors (e.g., chemoprevention, HCC surveillance) of
HCC related to metabolic (dysfunction) fatty liver disease (MAFLD), and identifying the comparative
effectiveness of prevention strategies in individuals with MAFLD. The goal of Project 2 is to reduce
hepatocellular cancer (HCC)-related mortality by investigating personalized chemoprevention in individuals
with metabolic-associated fatty liver disease (MAFLD).
Role: Co-Investigator |
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NIH 1R01-CA260689 01 (Silverberg; Chiao)Jun 15, 2021 - May 31, 2026 NIH/NCI
(PQ3) Addressing Cancer Treatment Disparities for Persons with HIV, Project 2
Role Description: This project will address these critical knowledge gaps for the four most common NADCs in
PWH treated with CRT/RT (anal, head and neck, lung, or prostate cancer): Aim 1: To evaluate differences in
the timing of cancer treatment initiation between PWH and matched uninfected patients, and risk factors for
delayed treatment in PWH. Aim 2: To evaluate disparities in short-term SAEs and cancer treatment.
*Status of Support: Active
Role: Co-Investigator |
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HSR&D IIR 19-365 Application #I01 HX003127 (Massarweh)May 1, 2021 - Apr 30, 2025 Department of Veterans Affairs Health Services Research & Development (HSR&D)
Enhancing the Efficiency of Data Collection for Surgical Quality Improvement
Role Description: The primary objective of this study is to identify in a large racial/ethnically and socioeconomically
diverse cohort of patients with cirrhosis the multi-level factors that explain racial and ethnic disparities in HCC
risk/incidence and tumor stage at diagnosis, as well as a set of potentially actionable (identifiable, preventable
or treatable) determinants of HCC disparities in Texas
Role: Co-Investigator |
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NIH 1R01 CA256977-01 (Kanwal; Singal)Mar 1, 2021 - Feb 1, 2026 NIH/NCI
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease Outcomes
Role Description: The goal of this study is to conduct a comprehensive evaluation of multilevel factors
hypothesized to play important roles in causing racial/ethnic and SES disparities in three key measures of
cirrhosis prognosis: a) hepatic decompensation, including HCC, b) liver-related hospitalization, and c) overall
surviva
Role: Co-Investigator |
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RP200633 (Kanwal)Aug 1, 2020 - Aug 1, 2025 RP200633
Reducing Disparities in the Risk of Hepatocellular Cancer
Role Description: The primary objective of this study is to identify in a large racial/ethnically and socioeconomically
diverse cohort of patients with cirrhosis the multi-level factors that explain racial and ethnic disparities in HCC
risk/incidence and tumor stage at diagnosis, as well as a set of potentially actionable (identifiable, preventable
or treatable) determinants of HCC disparities in Texas
Role: Co-Investigator |
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5P30DK056338-19 (El-Serag)May 1, 2018 - Feb 1, 2023 NIH/NIDDK
Center for Gastrointestinal Development, Infection and Injury
Role Description: This Center supports four scientific cores, conferences, and a pilot project program to facilitate
on-going Digestive Disease research of center members, promote interactions and translational research
between basic and clinical areas, develop new projects, nurture new investigators, and provide GI educational
activities.
Role: Co-Investigator |
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NIH 1R01CA212008-01A1 (Singal)Aug 1, 2017 - Jul 1, 2023 NIH/NCI
Harms of Hepatocellular Carcinoma Screening in Patients with Cirrhosis
Role Description: The purpose of this study is to investigate the harms that may be associated with screening for
HCC in patients with cirrhosis recruited from 4 medical centers in Texas.
Role: Co-Investigator |
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R01CA206476 (KRAMER, JENNIFER R)Jun 10, 2016 - May 31, 2021 NIH
(PQ3) Identifying Novel Pharmacologic Risk factors for Common Non-AIDS Defining Cancers in Individuals with Well-controlled HIV Infection
Role Description: This project will address these critical knowledge gaps for the four most common NADCs in
PWH treated with CRT/RT (anal, head and neck, lung, or prostate cancer): Aim 1: To evaluate differences in
the timing of cancer treatment initiation between PWH and matched uninfected patients, and risk factors for
delayed treatment in PWH. Aim 2: To evaluate disparities in short-term SAEs and cancer treatment.
Role: Co-Investigator |