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JAMES ALANSON THOMAS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Critical Care
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    Collapse Biography 
    Collapse education and training
    Princeton University, Princeton, NJAB06/1981Romance Languages and Literature
    Stanford University School of Medicine, Stanford, CAMD05/1989Medicine
    Children's Hospital of Los Angeles, Los Angeles, CA06/1992Pediatrics Residency
    University of Texas Southwestern Medical Center, Dallas, TX06/1995Pediatric Critical Care Medicine Fellowship

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Coleman RD, Goldman J, Moffett B, Guffey D, Loftis L, Thomas J, Shekerdemian LS. Extracorporeal Membrane Oxygenation Mortality in High-Risk Populations: An Analysis of the Pediatric Health Information System Database. ASAIO J. 2019 Apr 15. PMID: 31045920.
      View in: PubMed
    2. Labarinas S, Meulmester K, Greene S, Thomas J, Virk M, Erkonen G. Extracorporeal Cardiopulmonary Resuscitation After Diphenhydramine Ingestion. J Med Toxicol. 2018 09; 14(3):253-256. PMID: 29956117.
      View in: PubMed
    3. Yu YR, Carpenter JL, DeMello AS, Keswani SG, Cass DL, Olutoye OO, Vogel AM, Thomas JA, Burgman C, Fernandes CJ, Lee TC. Evaluating quality of life of extracorporeal membrane oxygenation survivors using the pediatric quality of life inventory survey. J Pediatr Surg. 2018 May; 53(5):1060-1064. PMID: 29551243.
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    4. Carpenter JL, Yu YR, Cass DL, Olutoye OO, Thomas JA, Burgman C, Fernandes CJ, Lee TC. Use of venovenous ECMO for neonatal and pediatric ECMO: a decade of experience at a tertiary children's hospital. Pediatr Surg Int. 2018 Mar; 34(3):263-268. PMID: 29349617.
      View in: PubMed
    5. Thomas J, Kostousov V, Teruya J. Bleeding and Thrombotic Complications in the Use of Extracorporeal Membrane Oxygenation. Semin Thromb Hemost. 2018 Feb; 44(1):20-29. PMID: 28898902.
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    6. Sheeran PD, Anton-Martin P, Thompson MT, Fischer AC, Taylor D, Thomas JA. The authors reply. Pediatr Crit Care Med. 2015 Jun; 16(5):494-5. PMID: 26039438.
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    7. Anton-Martin P, Thompson MT, Sheeran PD, Fischer AC, Taylor D, Thomas JA. Extubation during pediatric extracorporeal membrane oxygenation: a single-center experience. Pediatr Crit Care Med. 2014 Nov; 15(9):861-9. PMID: 25251516.
      View in: PubMed
    8. Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. IKKa negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977. PMID: 25266676.
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    9. Lin KM, Hu W, Troutman TD, Jennings M, Brewer T, Li X, Nanda S, Cohen P, Thomas JA, Pasare C. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):775-80. PMID: 24379360.
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    10. Chandra R, Federici S, Bishwas T, Németh ZH, Deitch EA, Thomas JA, Spolarics Z. IRAK1-dependent signaling mediates mortality in polymicrobial sepsis. Inflammation. 2013 Dec; 36(6):1503-12. PMID: 23856940.
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    11. Chandra R, Federici S, Németh ZH, Csóka B, Thomas JA, Donnelly R, Spolarics Z. Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis. J Leukoc Biol. 2014 Mar; 95(3):497-507. PMID: 24193737.
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    12. Benosman S, Ravanan P, Correa RG, Hou YC, Yu M, Gulen MF, Li X, Thomas J, Cuddy M, Matsuzawa Y, Sano R, Diaz P, Matsuzawa S, Reed JC. Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling. PLoS One. 2013; 8(5):e64256. PMID: 23724040.
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    13. Zhou H, Yu M, Fukuda K, Im J, Yao P, Cui W, Bulek K, Zepp J, Wan Y, Kim TW, Yin W, Ma V, Thomas J, Gu J, Wang JA, DiCorleto PE, Fox PL, Qin J, Li X. IRAK-M mediates Toll-like receptor/IL-1R-induced NF?B activation and cytokine production. EMBO J. 2013 Feb 20; 32(4):583-96. PMID: 23376919.
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    14. Joffe AR, Carcillo J, Anton N, deCaen A, Han YY, Bell MJ, Maffei FA, Sullivan J, Thomas J, Garcia-Guerra G. Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent. Philos Ethics Humanit Med. 2011 Dec 29; 6:17. PMID: 22206616.
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    15. Evans J, Thomas J. Understanding family requirements in the intensive care room. Crit Care Nurs Q. 2011 Oct-Dec; 34(4):290-6. PMID: 21921714.
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    16. Wan Y, Kim TW, Yu M, Zhou H, Yamashita M, Kang Z, Yin W, Wang JA, Thomas J, Sen GC, Stark GR, Li X. The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production. J Immunol. 2011 Mar 01; 186(5):3006-14. PMID: 21270393.
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    17. Raymond TT, Cunnyngham CB, Thompson MT, Thomas JA, Dalton HJ, Nadkarni VM. Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: a report from the National Registry of Cardiopulmonary Resuscitation. Pediatr Crit Care Med. 2010 May; 11(3):362-71. PMID: 19924027.
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    18. Dong JW, Vallejo JG, Tzeng HP, Thomas JA, Mann DL. Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H1079-87. PMID: 20061547.
      View in: PubMed
    19. Wang L, Quan J, Johnston WE, Maass DL, Horton JW, Thomas JA, Tao W. Age-dependent differences of interleukin-6 activity in cardiac function after burn complicated by sepsis. Burns. 2010 Mar; 36(2):232-8. PMID: 19501973.
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    20. Berglund M, Thomas JA, Fredin MF, Melgar S, Hörnquist EH, Hultgren OH. Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis. Cell Immunol. 2009; 259(1):27-32. PMID: 19540456.
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    21. Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6256-61. PMID: 19329491.
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    22. Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. Mol Cell Biol. 2008 May; 28(10):3538-47. PMID: 18347055.
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    23. Zhande R, Dauphinee SM, Thomas JA, Yamamoto M, Akira S, Karsan A. FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction. Mol Cell Biol. 2007 Nov; 27(21):7394-404. PMID: 17785432.
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    24. Fu Y, Xie C, Chen J, Zhu J, Zhou H, Thomas J, Zhou XJ, Mohan C. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol. 2006 Jan 01; 176(1):632-9. PMID: 16365459.
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    25. Hansen BS, Hussain RZ, Lovett-Racke AE, Thomas JA, Racke MK. Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity. J Neuroimmunol. 2006 Mar; 172(1-2):94-103. PMID: 16360885.
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    26. Li T, Hu J, Thomas JA, Li L. Differential induction of apoptosis by LPS and taxol in monocytic cells. Mol Immunol. 2005 May; 42(9):1049-55. PMID: 15829295.
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    27. Verdrengh M, Thomas JA, Hultgren OH. IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection. Microbes Infect. 2004 Nov; 6(14):1268-72. PMID: 15555532.
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    28. Binck BW, Tsen MF, Islas M, White DJ, Schultz RA, Willis MS, Garcia JV, Horton JW, Thomas JA. Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock. Am J Physiol Heart Circ Physiol. 2005 Feb; 288(2):H577-83. PMID: 15458952.
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    29. Horton JW, Tan J, White DJ, Maass DL, Thomas JA. Selective decontamination of the digestive tract attenuated the myocardial inflammation and dysfunction that occur with burn injury. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H2241-51. PMID: 15256371.
      View in: PubMed
    30. Thomas JA, Haudek SB, Koroglu T, Tsen MF, Bryant DD, White DJ, Kusewitt DF, Horton JW, Giroir BP. IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H597-606. PMID: 12860565.
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    31. Deng C, Radu C, Diab A, Tsen MF, Hussain R, Cowdery JS, Racke MK, Thomas JA. IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. J Immunol. 2003 Mar 15; 170(6):2833-42. PMID: 12626533.
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    32. White J, Thomas J, Maass DL, Horton JW. Cardiac effects of burn injury complicated by aspiration pneumonia-induced sepsis. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1):H47-58. PMID: 12637356.
      View in: PubMed
    33. Thomas JA, Tsen MF, White DJ, Horton JW. IRAK contributes to burn-triggered myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H829-36. PMID: 12124233.
      View in: PubMed
    34. Thomas JA, Tsen MF, White DJ, Horton JW. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1645-55. PMID: 12234819.
      View in: PubMed
    35. Swantek JL, Tsen MF, Cobb MH, Thomas JA. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol. 2000 Apr 15; 164(8):4301-6. PMID: 10754329.
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    36. Thomas JA, Allen JL, Tsen M, Dubnicoff T, Danao J, Liao XC, Cao Z, Wasserman SA. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol. 1999 Jul 15; 163(2):978-84. PMID: 10395695.
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    37. Greely HT, Hamm T, Johnson R, Price CR, Weingarten R, Raffin T. The ethical use of human fetal tissue in medicine. Stanford University Medical Center Committee on Ethics. N Engl J Med. 1989 Apr 20; 320(16):1093-6. PMID: 2535632.
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    38. Wilson DM, Perkins SN, Thomas JA, Seelig S, Berry SA, Hamm TE, Hoffman AR, Hintz RL, Rosenfeld RG. Effects of elevated serum insulinlike growth factor-II on growth hormone and insulinlike growth factor-I mRNA and secretion. Metabolism. 1989 Jan; 38(1):57-62. PMID: 2491900.
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    39. Thomas JA, Hamm TE, Perkins PL, Raffin TA. Animal research at Stanford University. Principles, policies, and practices. N Engl J Med. 1988 Jun 16; 318(24):1630-2. PMID: 3374537.
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    40. Ruark JE, Raffin TA. Initiating and withdrawing life support. Principles and practice in adult medicine. N Engl J Med. 1988 Jan 07; 318(1):25-30. PMID: 3275889.
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    41. Wilson DM, Thomas JA, Hamm TE, Wyche J, Hintz RL, Rosenfeld RG. Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents. Endocrinology. 1987 May; 120(5):1896-901. PMID: 3569119.
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