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SEBASTIAN ACOSTA

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
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    Collapse Biography 
    Collapse education and training
    Rice University, Houston TXPhD05/2014Computational and Applied Mathematics
    Brigham Young University, Provo UTMS05/2011Mathematics
    Brigham Young University, Provo UTBS05/2009Mechanical Engineering
    Collapse awards and honors
    2017 - 2020NSF - DMS, Baylor College of Medicine
    2015 - 2017AMS-Simons Travel Grant, Baylor College of Medicine
    2012 - 2013BP Scholarship Award in Science, Rice University
    2011SIAM Summer School on Waves and Imaging
    2011Graduate Research Award, BYU Math
    2010Graduate Research Fellowship, BYU Math
    2009Orson Pratt Prize for most outstanding graduating senior, BYU Math
    Brigham Young Bicentennial Scholar, BYU

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    1R56HL131574     (Craig Rusin)Jul 1, 2018 - Jul 1, 2023
    National Institute of Health - National Heart Lung and Blood Institute
    Multi-site validation study of the HLHS arrest predictor
    Role: Research Faculty
    NSF-DMS 1712725     (Sebastian Acosta)Jul 15, 2017 - Jul 15, 2020
    National Science Foundation
    Collaborative Research: Improved Algorithms for Multiwave Imaging in Complex Media: Theory and Computation
    Role: PI
    16BGIA27490024     (Craig Rusin)Jan 1, 2016 - Jan 1, 2017
    American Heart Association Beginning-Grant-In-Aid
    Real-time prediction of acute arrest in infants with single ventricle physiology
    Role: Research Staff

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McOmber BG, Moreira AG, Kirkman K, Acosta S, Rusin C, Shivanna B. Predictive analytics in bronchopulmonary dysplasia: past, present, and future. Front Pediatr. 2024; 12:1483940. PMID: 39633818; PMCID: PMC11615574.
      Citations:    
    2. Loomba RS, Savorgnan F, Acosta S, Elhoff JJ, Farias JS, Villarreal EG, Flores S. Clinical Interventions and Hemodynamic Monitoring in the Setting of Left Ventricular Systolic Heart Failure in Children: Insights From a Physiologic Simulator. Am J Ther. 2024 Sep-Oct 01; 31(5):e531-e540. PMID: 39292830.
      Citations:    Fields:    Translation:Humans
    3. Gilg S, Acosta S, Loomba RS, Rizk C, Stapleton GE, Faraoni D, Savorgnan F. Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates. Pediatr Investig. 2024 Jun; 8(2):135-138. PMID: 38910849; PMCID: PMC11193373.
      Citations: 1     
    4. Elhoff JJ, Acosta S, Flores S, LaSalle J, Loomba R, McGetrick M, McKinney C, Ostrom M, Pande CK, Schlosser R, Schwab S, Savorgnan F. Parental holding of infants improves haemodynamics in the cardiac ICU. Cardiol Young. 2024 May; 34(5):1004-1009. PMID: 38014584.
      Citations:    Fields:    
    5. Acosta S, Hassan AM, Gugala Z, Karagoli Z, Hochstetler J, Kiskaddon AL, Checchia P, Faraoni D, Zheng F, Savorgnan F. Higher Cumulative Dose of Opioids and Other Sedatives are Associated with Extubation Failure in Norwood Patients. Pediatr Cardiol. 2024 Jan; 45(1):8-13. PMID: 37880385.
      Citations:    Fields:    Translation:Humans
    6. Subramanian D, Vittala A, Chen X, Julien C, Acosta S, Rusin C, Allen C, Rider N, Starosolski Z, Annapragada A, Devaraj S. Stratification of Pediatric COVID-19 Cases Using Inflammatory Biomarker Profiling and Machine Learning. J Clin Med. 2023 Aug 22; 12(17). PMID: 37685502; PMCID: PMC10487951.
      Citations:    
    7. Chao H, Acosta S, Rusin C, Rhee C. Comparison of Near-Infrared Spectroscopy-Based Cerebral Autoregulatory Indices in Extremely Low Birth Weight Infants. Children (Basel). 2023 Aug 09; 10(8). PMID: 37628360; PMCID: PMC10453436.
      Citations:    
    8. Rusin CG, Acosta SI, Brady KM, Vu E, Scahill C, Fonseca B, Barrett C, Simsic J, Yates AR, Klepczynski B, Gaynor WJ, Penny DJ. Automated prediction of cardiorespiratory deterioration in patients with single-ventricle parallel circulation: A?multicenter validation study. JTCVS Open. 2023 Sep; 15:406-411. PMID: 37808061; PMCID: PMC10556807.
      Citations:    
    9. Savorgnan F, Crouthamel DI, Heroy A, Santerre J, Acosta S. Markov model for detection of ECG instability prior to cardiac arrest in single-ventricle patients. J Electrocardiol. 2023 Sep-Oct; 80:106-110. PMID: 37311367.
      Citations:    Fields:    Translation:Humans
    10. Weld J, Kim E, Chandra P, Savorgnan F, Acosta S, Flores S, Loomba RS. Fluid Overload and AKI After the Norwood Operation: The Correlation and Characterization of Routine Clinical Markers. Pediatr Cardiol. 2024 Oct; 45(7):1440-1447. PMID: 37129600.
      Citations:    Fields:    
    11. Subramanian D, Vittala A, Chen X, Julien C, Acosta S, Rusin C, Allen C, Rider N, Starosolski Z, Annapragada A, Devaraj S. Stratification of Pediatric COVID-19 cases by inflammatory biomarker profiling and machine learning. medRxiv. 2023 Apr 04. PMID: 37066407; PMCID: PMC10104220.
      Citations:    
    12. Farias JS, Villarreal EG, Savorgnan F, Acosta S, Flores S, Loomba RS. The use of neutrophil-lymphocyte ratio for the prediction of refractory disease and coronary artery lesions in patients with Kawasaki disease. Cardiol Young. 2023 Aug; 33(8):1409-1417. PMID: 37012661.
      Citations:    Fields:    Translation:HumansCells
    13. Savorgnan F, Hassan A, Borges N, Acosta S. Pulse Oximetry and Arterial Saturation Difference in Pediatric COVID-19 Patients: Retrospective Analysis by Race. Pediatr Crit Care Med. 2023 06 01; 24(6):458-462. PMID: 36825900; PMCID: PMC10226388.
      Citations:    Fields:    Translation:Humans
    14. Suresh S, Acosta S, Ettinger AK, Savorgnan F, Annapragada A, Kannikeswaran N, Sethuraman U. Association of Area Deprivation Index With Severity of COVID-19 in Pediatric Patients: A Multisite Study of Racially and Ethnically Diverse Children. Pediatr Infect Dis J. 2023 06 01; 42(6):e197-e200. PMID: 36854096.
      Citations:    Fields:    Translation:Humans
    15. Savorgnan F, Loomba RS, Flores S, Rusin CG, Zheng F, Hassan AM, Acosta S. Descriptors of Failed Extubation in Norwood Patients Using Physiologic Data Streaming. Pediatr Cardiol. 2023 Feb; 44(2):396-403. PMID: 36562780.
      Citations:    Fields:    Translation:Humans
    16. Loomba RS, Dyamenahalli U, Savorgnan F, Acosta S, Elhoff JJ, Farias JS, Villarreal E, Flores S. The effect of clinical and haemodynamic variables on post-operative length of stay immediately upon admission after biventricular repair with Yasui operation following an earlier Norwood operation. Cardiol Young. 2023 Oct; 33(10):2066-2071. PMID: 36537282.
      Citations:    Fields:    
    17. Loomba RS, Dyamenahalli U, Savorgnan F, Acosta S, Villarreal E, Farias JS, Wong J, Flores S. Association of Immediate Postoperative Hemodynamic and Laboratory Values in Predicting Norwood Admission Outcomes. Pediatr Cardiol. 2024 Aug; 45(6):1232-1241. PMID: 36350339.
      Citations:    Fields:    
    18. Savorgnan F, Acosta S. Calcium Chloride Is Given to Sicker Patients During Cardiopulmonary Resuscitation Events. Pediatr Crit Care Med. 2022 11 01; 23(11):938-940. PMID: 36326457.
      Citations:    Fields:    Translation:Humans
    19. Hassan AM, Acosta S, Zheng F, Rusin C, Savorgnan F. Noninvasive Respiratory Support Does Not Prevent Extubation Failure in High-Risk Norwood Patients. Crit Care Explor. 2022 Oct; 4(10):e0782. PMID: 36311558; PMCID: PMC9605742.
      Citations:    
    20. Ahmed M, Acosta SI, Hoffman GM, Tweddell JS, Ghanayem NS. Mathematical analysis of hemoglobin target in univentricular parallel circulation. J Thorac Cardiovasc Surg. 2023 07; 166(1):214-220. PMID: 36357224.
      Citations:    Fields:    Translation:Humans
    21. Savorgnan F, Moreira A, Moreira A, Annapragada A, Sexson Tejtel SK, Flores S, Rusin CG, Shekerdemian L, Acosta S. Physiologic profile associated with severe multisystem inflammatory syndrome in children: a retrospective study. Pediatr Res. 2023 01; 93(1):102-109. PMID: 35568731; PMCID: PMC9106980.
      Citations:    Fields:    
    22. Savorgnan F, Crouthamel DI, Heroy A, Santerre J, Acosta S. Quantification of electrocardiogram instability prior to cardiac arrest in patients with single-ventricle physiology. J Electrocardiol. 2022 Jul-Aug; 73:29-33. PMID: 35580481.
      Citations:    Fields:    
    23. Savorgnan F, Acosta S, Alali A, Moreira A, Annapragada A, Rusin CG, Flores S, Loomba RS, Moreira A. Social and Demographic Disparities in the Severity of Multisystem Inflammatory Syndrome in Children. Pediatr Infect Dis J. 2022 06 01; 41(6):e256-e258. PMID: 35537132; PMCID: PMC9083307.
      Citations:    Fields:    Translation:Humans
    24. Savorgnan F, Flores S, Loomba RS, Acosta S. Hemodynamic Response to Fluid Boluses in Patients with Single-Ventricle Parallel Circulation. Pediatr Cardiol. 2022 Dec; 43(8):1784-1791. PMID: 35511283.
      Citations:    Fields:    
    25. Jain PN, Acosta S, Annapragada A, Checchia PA, Moreira A, Muscal E, Sartain SE, Tejtel SKS, Vogel TP, Shekerdemian L, Rusin CG. Comparison of Laboratory and Hemodynamic Time Series Data Across Original, Alpha, and Delta Variants in Patients With Multisystem Inflammatory Syndrome in Children. Pediatr Crit Care Med. 2022 08 01; 23(8):e372-e381. PMID: 35507775; PMCID: PMC9345524.
      Citations:    Fields:    
    26. Alali A, Acosta S, Ahmed M, Spinner J, Akcan-Arikan A, Morris SA, Jain PN. Postoperative physiological parameters associated with severe acute kidney injury after pediatric heart transplant. Pediatr Transplant. 2022 08; 26(5):e14267. PMID: 35279933.
      Citations:    Fields:    Translation:Humans
    27. Loomba RS, Farias JS, Savorgnan F, Acosta S, Flores S, Villarreal EG. Veno-Arterial Partial Pressure of Carbon Dioxide Difference as a Metric of Systemic Oxygen Delivery: Insights from a Correlative Meta-Analysis. J Pediatr Intensive Care. 2024 Dec; 13(4):372-378. PMID: 39629341; PMCID: PMC11584265.
      Citations:    
    28. Bronicki RA, Acosta S, Savorgnan F, Flores S, Achuff BJ, Loomba R, Ahmed M, Ghanayem N, Heinle JS, Asadourian V, Lasa JJ. The acute influence of vasopressin on hemodynamic status and tissue oxygenation following the Norwood procedure. JTCVS Open. 2022 Mar; 9:217-224. PMID: 36003471; PMCID: PMC9390553.
      Citations:    
    29. Loomba RS, Rausa J, Farias JS, Villarreal EG, Acosta S, Savorgnan F, Flores S. Impact of Medical Interventions and Comorbidities on Norwood Admission for Patients with Hypoplastic Left Heart Syndrome. Pediatr Cardiol. 2022 Feb; 43(2):267-278. PMID: 35034159.
      Citations:    Fields:    Translation:Humans
    30. Savorgnan F, Flores S, Loomba RS, Checchia PA, Bronicki RA, Farias JS, Acosta S. Hemodynamic Response to Calcium Chloride Boluses in Single-Ventricle Patients with Parallel Circulation. Pediatr Cardiol. 2022 Mar; 43(3):554-560. PMID: 34652494.
      Citations: 1     Fields:    Translation:Humans
    31. Rusin CG, Acosta SI, Vu EL, Ahmed M, Brady KM, Penny DJ. Automated Prediction of Cardiorespiratory Deterioration in Patients With Single Ventricle. J Am Coll Cardiol. 2021 06 29; 77(25):3184-3192. PMID: 34167643; PMCID: PMC8091451.
      Citations: 2     Fields:    Translation:Humans
    32. Savorgnan F, Bhat PN, Checchia PA, Acosta S, Tume SC, Lasa JJ, Asadourian V, Achuff BJ, Flores S, Ahmed M, Crouthamel DI, Loomba RS, Bronicki RA. RBC Transfusion Induced ST Segment Variability Following the Norwood Procedure. Crit Care Explor. 2021 May; 3(5):e0417. PMID: 34036271; PMCID: PMC8140762.
      Citations:    
    33. ACOSTA S. Local on-surface radiation condition for multiple scattering of waves from convex obstacles. Comput. Methods Appl. Mech. Engrg. 2021; 378:113697. View Publication.
    34. Foughty ZC, Tavaslioglu O, Rhee CJ, Elizondo LI, Rusin CG, Penny DJ, Acosta S, Rios DR. Novel Method of Calculating Pulse Pressure Variation to Predict Fluid Responsiveness to Transfusion in Very Low Birth Weight Infants. J Pediatr. 2021 Jul; 234:265-268.e1. PMID: 33865859; PMCID: PMC8238876.
      Citations:    Fields:    Translation:Humans
    35. Elizondo LI, Vu EL, Kibler KK, Rios DR, Easley RB, Andropoulos D, Acosta S, Rusin C, Brady K, Rhee CJ. Critical Closing Pressure by Diffuse Correlation Spectroscopy in a Neonatal Piglet Model. Acta Neurochir Suppl. 2021; 131:295-299. PMID: 33839861.
      Citations:    Fields:    Translation:Animals
    36. ACOSTA S. Solvability for photoacoustic imaging with idealized piezoelectric sensors. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2020; 67(11):2413-2422. View Publication.
    37. . A weight-adjusted discontinuous Galerkin method for wave propagation in coupled elastic-acoustic media. Journal of Computational Physics. 2020; 418:109632. View Publication.
    38. Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K, Acosta S, Naqvi R, Burmeister-Morton F, Burmeister F, Tarriela A, Petershack M, Evans M, Hoang A, Rajasekaran K, Ahuja S, Moreira A. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine. 2020 Sep; 26:100527. PMID: 32923992; PMCID: PMC7473262.
      Citations: 145     
    39. Kala S, Dunk C, Acosta S, Serghides L. Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies. Hum Reprod. 2020 08 01; 35(8):1781-1796. PMID: 32712670; PMCID: PMC7398624.
      Citations:    
    40. Rios DR, Rhee CJ, Elizondo L, Brady KM, Rusin CG, Acosta S. Creatinine filtration kinetics in critically Ill neonates. Pediatr Res. 2021 03; 89(4):952-957. PMID: 32454515; PMCID: PMC7688479.
      Citations:    Fields:    Translation:Humans
    41. Acosta S, Ahmed M, Yin SM, Brady KM, Penny DJ, Rusin CG. A robust Fourier-based method to measure pulse pressure variability. Biomed Signal Process Control. 2020 Jul; 60. PMID: 32719724; PMCID: PMC7384614.
      Citations: 1     
    42. . High order methods for acoustic scattering: Coupling farfield expansions ABC with deferred-correction methods. Wave Motion. 2020; 95:102529. View Publication.
    43. . Recovery of pressure and wave speed for photoacoustic imaging under a condition of relative uncertainty. Inverse Problems. 2019; 35(11):115013. View Publication.
    44. . Well-posedness for photoacoustic tomography with Fabry-Perot sensors. SIAM J. Imag. Sciences. 2019; 12(4):1669-1685. View Publication.
    45. Achuff BJ, Moffett BS, Acosta S, Lasa JJ, Checchia PA, Rusin CG. The authors reply. Pediatr Crit Care Med. 2019 10; 20(10):1004-1005. PMID: 31580284.
      Citations:    Fields:    Translation:Humans
    46. Achuff BJ, Moffett BS, Acosta S, Lasa JJ, Checchia PA, Rusin CG. Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients. Pediatr Crit Care Med. 2019 06; 20(6):527-533. PMID: 30676493.
      Citations: 4     Fields:    Translation:Humans
    47. Elizondo LI, Rios DR, Vu E, Kibler K, Easley RB, Andropoulos DB, Acosta S, Rusin CG, Kaiser JR, Brady KM, Rhee CJ. Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants. Pediatr Res. 2019 08; 86(2):242-246. PMID: 31003233; PMCID: PMC6658334.
      Citations: 1     Fields:    Translation:Humans
    48. ACOSTA S, Palacios B. Thermoacoustic tomography for an integro-differential wave equation modeling attenuation. J. Differential Equations. 2018; 264(3):1984-2010. View Publication.
    49. Achuff BJ, Achuff JC, Park HH, Moffett B, Acosta S, Rusin CG, Checchia PA. Epinephrine syringe exchange events in a paediatric cardiovascular ICU: analysing the storm. Cardiol Young. 2018 Mar; 28(3):409-415. PMID: 29198222.
      Citations:    Fields:    Translation:Humans
    50. . A computational study of the Fontan circulation with fenestration or hepatic vein exclusion. Computers in Biology and Medicine. 2017; 89:405-418. View Publication.
    51. Penny DJ, Brady KM, Rusin CG, Acosta S. An effective model of cerebrovascular pressure reactivity and blood flow autoregulation. Microvasc Res. 2018 01; 115:34-43. PMID: 28847705.
      Citations:    Fields:    Translation:Humans
    52. ACOSTA S. High order surface radiation conditions for time-harmonic waves in exterior domains. Comput. Methods Appl. Mech. Engrg. 2017; 322:296-310. View Publication.
    53. Puelz C, Penny DJ, Brady KM, Rusin CG, Acosta S, Rivi?re B. Cardiovascular mechanics in the early stages of pulmonary hypertension: a computational study. Biomech Model Mechanobiol. 2017 Dec; 16(6):2093-2112. PMID: 28733923.
      Citations: 5     Fields:    Translation:Humans
    54. Villamizar V, ACOSTA S, Dastrup B. High order local absorbing boundary conditions for acoustic waves in terms of farfield expansions. Journal of Computational Physics. 2017; 333(3):331-351. View Publication.
    55. ACOSTA S, Montalto C. Photoacoustic imaging taking into account thermodynamic attenuation. Inverse Problems. 2016; 32(11):115001. View Publication.
    56. Rusin CG, Acosta SI, Shekerdemian LS, Vu EL, Bavare AC, Myers RB, Patterson LW, Brady KM, Penny DJ. Prediction of imminent, severe deterioration of children with parallel circulations using real-time processing of physiologic data. J Thorac Cardiovasc Surg. 2016 Jul; 152(1):171-7. PMID: 27174513; PMCID: PMC4921264.
      Citations: 14     Fields:    Translation:Humans
    57. Acosta S, Puelz C, Penny DJ, Rusin CG, Rivi?re B. Numerical Method of Characteristics for One-Dimensional Blood Flow. J Comput Phys. 2015 Aug 01; 294:96-109. PMID: 25931614; PMCID: PMC4410450.
      Citations: 3     
    58. . Multiwave imaging in an enclosure with variable wave speed. Inverse Problems. 2015; 31:065009. View Publication.
    59. . A control approach to recover the wave speed (conformal factor) from one measurement. Inverse Problems and Imaging. 2015; 9:301-315. View Publication.
    60. ACOSTA S. Recovery of the absorption coefficient in radiative transport from a single measurement. Inverse Problems and Imaging. 2015; 9(2):289-300. View Publication.
    61. Acosta S, Penny DJ, Rusin CG. An effective model of blood flow in capillary beds. Microvasc Res. 2015 Jul; 100:40-7. PMID: 25936622.
      Citations: 1     Fields:    Translation:HumansAnimals
    62. . Source estimation with incoherent waves in random waveguides. Inverse Problems. 2015; 31:035013. View Publication.
    63. . On-surface radiation condition for multiple scattering of waves. Comput. Meth. Appl. Mech. Engrg. 2015; 283:1296-1309. View Publication.
    64. . Time reversal for radiative transport with applications to inverse and control problems. Inverse Problems. 2013; 29:085014. View Publication.
    65. ACOSTA S, Chow S, Villamizar V. Contemporary Mathematics. Multifrequency inverse source problem for elastic waves. 2013; 586:1-8. View Publication.
    66. . On the multi-frequency inverse source problem in heterogeneous media. Inverse Problems. 2012; 28:075013. View Publication.
    67. Wagner R, ACOSTA S, Glasgow S, Su Q, Grobe R. Quantum fluctuations in the dressed vacuum of a bosonic model system. Journal of Physics A: Mathematical and Theoretical. 2012; 45:275303. View Publication.
    68. ACOSTA S, Villamizar V, Malone B. The DtN nonreflecting boundary condition for multiple scattering problems in the half-plane. Computer Methods in Applied Mechanics and Engineering. 2012; 217-220:1-11. View Publication.
    69. ACOSTA S, Villamizar V. Coupling of Dirichlet-to-Neumann boundary condition and finite difference methods in curvilinear coordinates for multiple scattering. Journal of Computational Physics. 2010; 229(15):5498-5517. View Publication.
    70. ACOSTA S, Villamizar V. Finite difference on grids with nearly uniform cell area and line spacing for the wave equation on complex domains. Journal of Computational and Applied Mathematics. 2010; 234(6):1970-1979. View Publication.
    71. Villamizar V, ACOSTA S. Generation of smooth grids with line control for scattering from multiple obstacles. Mathematics and Computers in Simulation. 2009; 79(8):2506-2520. View Publication.
    72. Villamizar V, ACOSTA S. Elliptic grids with nearly uniform cell area and line spacing. Electronic Transactions on Numerical Analysis. 2009; 34:59-75. View Publication.
    73. ACOSTA S, Acosta P. Numerical wave scattering taking account of energy dissipation and media stiffness. SIAM Undergraduate Research Online. 2008; 1(2):100-119. View Publication.
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