WEIWEI DANG

Title	Assistant Professor
Institution	Baylor College of Medicine
Department	Department of Molecular & Human Genetics
Address	One Baylor Plaza Houston, TX 77030
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Other Positions


Title	Assistant Professor
Institution	Baylor College of Medicine
Department	Huffington Center on Aging
Division	Huffington Ctr on Aging

Affiliation

groups

Dr. Shaulsky's Group (Member)

Research

research activities and funding

K99AG037646 (DANG, WEIWEI)Aug 1, 2010 - Feb 28, 2013 NIH Regulation of yeast cellular aging through chromatin and novel pathways Role: Principal Investigator

R00AG037646 (DANG, WEIWEI)Mar 15, 2013 - Feb 28, 2017 NIH Regulation of yeast cellular aging through chromatin and novel pathways Role: Principal Investigator

R56AG049714 (QIN, LIDONG)Sep 15, 2015 - Aug 31, 2017 NIH Revolutionize Budding-Yeast-Based Aging Study by High-Throughput Lab-on-a-Chip Devices Role: Co-Principal Investigator

R01AG052507 (DANG, WEIWEI)Sep 15, 2017 - Apr 30, 2022 NIH Regulation of longevity through maintenance of transcription fidelity Role: Principal Investigator

R41AG058368 (JO, MYEONG CHAN)Sep 30, 2017 - Sep 29, 2018 NIH Developing an automated yeast dissection system for aging research Role: Co-Principal Investigator

R42AG058368 (JO, MYEONG CHAN)Sep 30, 2017 - May 31, 2021 NIH Developing an automated yeast dissection system for aging research Role: Co-Principal Investigator

R21AG064345 (DANG, WEIWEI)Jul 15, 2019 - Mar 31, 2021 NIH Defining Periosteal Skeletal Stem Cell Heterogeneity and Age-associated Change Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Sun Y, Yu R, Guo HB, Qin H, Dang W. A quantitative yeast aging proteomics analysis reveals novel aging regulators. Geroscience. 2021 Jul 09. PMID: 34241809.

Citations: Fields:
Ger Geriatrics
McCauley BS, Dang W. Loosening chromatin and dysregulated transcription: a perspective on cryptic transcription during mammalian aging. Brief Funct Genomics. 2021 May 28. PMID: 34050364.

Citations: Fields:
Gen Genetics
Yu R, Cao X, Sun L, Zhu JY, Wasko BM, Liu W, Crutcher E, Liu H, Jo MC, Qin L, Kaeberlein M, Han Z, Dang W. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nat Commun. 2021 03 31; 12(1):1981. PMID: 33790287.

Citations: Fields:
Bio Biology Sci Science
Translation:Animals Cells
Guo HB, Ghafari M, Dang W, Qin H. Protein interaction potential landscapes for yeast replicative aging. Sci Rep. 2021 03 30; 11(1):7143. PMID: 33785798.

Citations: Fields:
Sci Science
Ghafari M, Clark J, Guo HB, Yu R, Sun Y, Dang W, Qin H. Complementary performances of convolutional and capsule neural networks on classifying microfluidic images of dividing yeast cells. PLoS One. 2021; 16(3):e0246988. PMID: 33730031.

Citations: Fields:
Med Medicine (General)Sci Science
Translation:Animals
Liu L, Yan Z, Osia BA, Twarowski J, Sun L, Kramara J, Lee RS, Kumar S, Elango R, Li H, Dang W, Ira G, Malkova A. Tracking break-induced replication shows that it stalls at roadblocks. Nature. 2021 Feb; 590(7847):655-659. PMID: 33473214.

Citations: 4 Fields:
Sci Science
Sun L, Dang W. SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery. Protein Cell. 2020 07; 11(7):469-471. PMID: 32435977.

Citations: Fields:
Bio Biochemistry Cel Cell Biology
Translation:Humans Cells
Huang B, Zhong D, Zhu J, An Y, Gao M, Zhu S, Dang W, Wang X, Yang B, Xie Z. Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines. Aging Cell. 2020 04; 19(4):e13129. PMID: 32157780.

Citations: 3 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Moruno-Manchon JF, Lejault P, Wang Y, McCauley B, Honarpisheh P, Morales Scheihing DA, Singh S, Dang W, Kim N, Urayama A, Zhu L, Monchaud D, McCullough LD, Tsvetkov AS. Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons. Elife. 2020 02 11; 9. PMID: 32043463.

Citations: 9 Fields:
Bio Biology
Translation:Humans Animals Cells
Yu R, McCauley B, Dang W. Loss of chromatin structural integrity is a source of stress during aging. Hum Genet. 2020 Mar; 139(3):371-380. PMID: 31900586.

Citations: 1 Fields:
Gen Genetics
Translation:Humans Animals Cells
Yu R, Jo MC, Dang W. Measuring the Replicative Lifespan of Saccharomyces cerevisiae Using the HYAA Microfluidic Platform. Methods Mol Biol. 2020; 2144:1-6. PMID: 32410020.

Citations: 1 Fields:
Mol Molecular Biology
Translation:Animals Cells
Yu A, Zhou R, Xia B, Dang W, Yang Z, Chen X. NAMPT maintains mitochondria content via NRF2-PPARa/AMPKa pathway to promote cell survival under oxidative stress. Cell Signal. 2020 02; 66:109496. PMID: 31816398.

Citations: 5 Fields:
Cel Cell Biology
Translation:Humans Cells
Yu R, Sun L, Sun Y, Han X, Qin L, Dang W. Cellular response to moderate chromatin architectural defects promotes longevity. Sci Adv. 2019 07; 5(7):eaav1165. PMID: 31309140.

Citations: 4 Fields:
Sci Science
Translation:Animals Cells
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 04 18; 177(3):622-638.e22. PMID: 31002797.

Citations: 45 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 02 21; 73(4):684-698.e8. PMID: 30773298.

Citations: 26 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560.

Citations: 9 Fields:
Sci Science
Translation:Animals Cells
Sun L, Yu R, Dang W. Chromatin Architectural Changes during Cellular Senescence and Aging. Genes (Basel). 2018 Apr 16; 9(4). PMID: 29659513.

Citations: 16 Fields:
Gen Genetics
Yu A, Dang W. Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications. Mol Cell Endocrinol. 2017 Nov 05; 455:75-82. PMID: 28392411.

Citations: 8 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Molina-Serrano D, Schiza V, Demosthenous C, Stavrou E, Oppelt J, Kyriakou D, Liu W, Zisser G, Bergler H, Dang W, Kirmizis A. Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Rep. 2016 12; 17(12):1829-1843. PMID: 27799288.

Citations: 13 Fields:
Mol Molecular Biology
Translation:Animals Cells
Yu R, Dang W. Gearing up for survival - HSP-containing granules accumulate in quiescent cells and promote survival. Microb Cell. 2016 Mar 06; 3(3):95-96. PMID: 28362009.

Citations:
Jo MC, Liu W, Gu L, Dang W, Qin L. High-throughput analysis of yeast replicative aging using a microfluidic system. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9364-9. PMID: 26170317.

Citations: 49 Fields:
Sci Science
Translation:Animals
Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev. 2015 Jul 01; 29(13):1362-76. PMID: 26159996.

Citations: 74 Fields:
Mol Molecular Biology
Translation:Animals Cells
Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of organometallic S6K1 inhibitors. J Med Chem. 2015 Jan 08; 58(1):305-14. PMID: 25356520.

Citations: 3 Fields:
Che Chemistry
Translation:Humans Cells
McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep. 2014 Jul 24; 8(2):477-86. PMID: 25043177.

Citations: 26 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Dang W. The controversial world of sirtuins. Drug Discov Today Technol. 2014 Jun; 12:e9-e17. PMID: 25027380.

Citations: 32 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Animals
McCauley BS, Dang W. Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta. 2014 Dec; 1839(12):1454-62. PMID: 24859460.

Citations: 20 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals Cells
Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metab. 2014 Jun 03; 19(6):952-66. PMID: 24814484.

Citations: 38 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods Mol Biol. 2013; 1077:11-37. PMID: 24014397.

Citations: 2 Fields:
Mol Molecular Biology
Translation:Animals
Edwards CR, Dang W, Berger SL. Histone H4 lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing. Biochemistry. 2011 Dec 06; 50(48):10473-83. PMID: 21985125.

Citations: 9 Fields:
Bio Biochemistry
Translation:Animals Cells
Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW, Thibault P, Verreault A, Johnson FB, Berger SL, Sternglanz R, McMahon SB, Côté J, Marmorstein R. MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2012 Jan 04; 31(1):58-70. PMID: 22020126.

Citations: 60 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Humans Cells
Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, Johnson FB. Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. EMBO J. 2010 Jan 06; 29(1):158-70. PMID: 19875981.

Citations: 27 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Animals Cells
Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K, Marmorstein R. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem. 2009 Oct 01; 17(19):7031-41. PMID: 19734050.

Citations: 5 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans
Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature. 2009 Jun 11; 459(7248):802-7. PMID: 19516333.

Citations: 265 Fields:
Sci Science
Translation:Animals Cells
Lin YY, Lu JY, Zhang J, Walter W, Dang W, Wan J, Tao SC, Qian J, Zhao Y, Boeke JD, Berger SL, Zhu H. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar 20; 136(6):1073-84. PMID: 19303850.

Citations: 153 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Dang W, Bartholomew B. Domain architecture of the catalytic subunit in the ISW2-nucleosome complex. Mol Cell Biol. 2007 Dec; 27(23):8306-17. PMID: 17908792.

Citations: 62 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Dang W, Kagalwala MN, Bartholomew B. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. J Biol Chem. 2007 Jul 06; 282(27):19418-25. PMID: 17491017.

Citations: 16 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Dang W, Kagalwala MN, Bartholomew B. Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA. Mol Cell Biol. 2006 Oct; 26(20):7388-96. PMID: 17015471.

Citations: 50 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Kagalwala MN, Glaus BJ, Dang W, Zofall M, Bartholomew B. Topography of the ISW2-nucleosome complex: insights into nucleosome spacing and chromatin remodeling. EMBO J. 2004 May 19; 23(10):2092-104. PMID: 15131696.

Citations: 72 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Humans Cells
Liu Ying, Zheng Junheng, Dang Weiwei, Ren Hongwei, Yu Meimin and Ru Binggen . The study of direct ELISA and competitive ELISA for rabbit metallothionein: correlation of induction with zinc. Analusis. 2000; 28(5):361-366. View Publication.