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WEIWEI DANG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
ORCID ORCID Icon0000-0002-6931-4636 Additional info
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


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    R01AG081347     (DANG, WEIWEI)Apr 1, 2023 - Mar 31, 2028
    NIH
    Molecular mechanisms of cellular response to age-associated chromatin changes
    Role: Principal Investigator
    R01AG081347     (DANG, WEIWEI)Apr 1, 2023 - Mar 31, 2028
    NIH
    Molecular mechanisms of cellular response to age-associated chromatin changes
    Role: Principal Investigator
    R03AG080423     (DANG, WEIWEI)Dec 1, 2022 - Nov 30, 2024
    NIH
    Developing and Validating a Novel Tau Toxicity Model in the Budding Yeast
    Role: Principal Investigator
    R03AG080423     (DANG, WEIWEI)Dec 1, 2022 - Nov 30, 2024
    NIH
    Developing and Validating a Novel Tau Toxicity Model in the Budding Yeast
    Role: Principal Investigator
    R01AG074540     (DANG, WEIWEI)Sep 5, 2021 - Aug 31, 2026
    NIH
    Lysosomal NADPH metabolism regulates proteostasis, aging and tauopathy
    Role: Principal Investigator
    R21AG064345     (DANG, WEIWEI)Jul 15, 2019 - Mar 31, 2021
    NIH
    Defining Periosteal Skeletal Stem Cell Heterogeneity and Age-associated Change
    Role: Principal Investigator
    R42AG058368     (JO, MYEONG CHAN)Sep 30, 2017 - May 31, 2021
    NIH
    Developing an automated yeast dissection system for aging research
    Role: Co-Principal Investigator
    R41AG058368     (JO, MYEONG CHAN)Sep 30, 2017 - Sep 29, 2018
    NIH
    Developing an automated yeast dissection system for aging research
    Role: Co-Principal Investigator
    R01AG052507     (DANG, WEIWEI)Sep 15, 2017 - Apr 30, 2022
    NIH
    Regulation of longevity through maintenance of transcription fidelity
    Role: Principal Investigator
    R56AG049714     (QIN, LIDONG)Sep 15, 2015 - Aug 31, 2017
    NIH
    Revolutionize Budding-Yeast-Based Aging Study by High-Throughput Lab-on-a-Chip Devices
    Role: Co-Principal Investigator
    R00AG037646     (DANG, WEIWEI)Mar 15, 2013 - Feb 28, 2017
    NIH
    Regulation of yeast cellular aging through chromatin and novel pathways
    Role: Principal Investigator
    K99AG037646     (DANG, WEIWEI)Aug 1, 2010 - Feb 28, 2013
    NIH
    Regulation of yeast cellular aging through chromatin and novel pathways
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sun L, McCauley BS, Liu H, Chen X, Dang W. Disruption of YY1-mediated super-enhancer-promoter looping drives transcriptomic changes during mammalian stem-cell aging. Res Sq. 2025 Jun 06. PMID: 40502787; PMCID: PMC12155207.
      Citations:    
    2. Cheng C, McCauley BS, Matulionis N, Vogelauer M, Camacho D, Christofk HR, Dang W, Irwin NAT, Kurdistani SK. Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae. Sci Adv. 2025 Apr 11; 11(15):eadv4082. PMID: 40215312; PMCID: PMC11988410.
      Citations:    Fields:    Translation:Animals
    3. Yu Y, Wang X, Fox J, Yu R, Thakre P, McCauley B, Nikoloutsos N, Yu Y, Li Q, Hastings PJ, Dang W, Chen K, Ira G. Yeast EndoG prevents genome instability by degrading extranuclear DNA species. Nat Commun. 2024 09 03; 15(1):7653. PMID: 39227600; PMCID: PMC11372161.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Yu Y, Wang X, Fox J, Yu R, Thakre P, McCauley B, Nikoloutsos N, Li Q, Hastings PJ, Dang W, Chen K, Ira G. Yeast EndoG prevents genome instability by degrading cytoplasmic DNA. Res Sq. 2024 Jan 05. PMID: 38260641; PMCID: PMC10802722.
      Citations:    
    5. Yu Y, Wang X, Fox J, Yu R, Thakre P, McCauley B, Nikoloutsos N, Li Q, Hastings PJ, Dang W, Chen K, Ira G. Yeast EndoG prevents genome instability by degrading cytoplasmic DNA. bioRxiv. 2023 Dec 13. PMID: 38168242; PMCID: PMC10760121.
      Citations:    
    6. Yu A, Yu R, Liu H, Ge C, Dang W. SIRT1 safeguards adipogenic differentiation by orchestrating anti-oxidative responses and suppressing cellular senescence. Geroscience. 2024 02; 46(1):1107-1127. PMID: 37420111; PMCID: PMC10828476.
      Citations:    Fields:    Translation:Animals
    7. McCauley BS, Dang W. Mammalian aging driven by transcription going awry. Trends Genet. 2023 10; 39(10):715-716. PMID: 37419698; PMCID: PMC10527280.
      Citations:    Fields:    Translation:AnimalsCells
    8. McCauley BS, Dang W. Loosening chromatin and dysregulated transcription: a perspective on cryptic transcription during mammalian aging. Brief Funct Genomics. 2022 01 25; 21(1):56-61. PMID: 34050364; PMCID: PMC8789305.
      Citations:    Fields:    Translation:AnimalsCells
    9. McCauley BS, Sun L, Yu R, Lee M, Liu H, Leeman DS, Huang Y, Webb AE, Dang W. Altered Chromatin States Drive Cryptic Transcription in Aging Mammalian Stem Cells. Nat Aging. 2021 08; 1(8):684-697. PMID: 34746802; PMCID: PMC8570536.
      Citations: 2     
    10. Sun Y, Yu R, Guo HB, Qin H, Dang W. A quantitative yeast aging proteomics analysis reveals novel aging regulators. Geroscience. 2021 10; 43(5):2573-2593. PMID: 34241809; PMCID: PMC8599547.
      Citations: 1     Fields:    Translation:Animals
    11. Yu R, Cao X, Sun L, Zhu JY, Wasko BM, Liu W, Crutcher E, Liu H, Jo MC, Qin L, Kaeberlein M, Han Z, Dang W. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nat Commun. 2021 03 31; 12(1):1981. PMID: 33790287; PMCID: PMC8012573.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Guo HB, Ghafari M, Dang W, Qin H. Protein interaction potential landscapes for yeast replicative aging. Sci Rep. 2021 03 30; 11(1):7143. PMID: 33785798; PMCID: PMC8010020.
      Citations: 2     Fields:    Translation:Animals
    13. Ghafari M, Clark J, Guo HB, Yu R, Sun Y, Dang W, Qin H. Complementary performances of convolutional and capsule neural networks on classifying microfluidic images of dividing yeast cells. PLoS One. 2021; 16(3):e0246988. PMID: 33730031; PMCID: PMC7968698.
      Citations:    Fields:    Translation:Animals
    14. Liu L, Yan Z, Osia BA, Twarowski J, Sun L, Kramara J, Lee RS, Kumar S, Elango R, Li H, Dang W, Ira G, Malkova A. Tracking break-induced replication shows that it stalls at roadblocks. Nature. 2021 02; 590(7847):655-659. PMID: 33473214; PMCID: PMC8219245.
      Citations: 17     Fields:    Translation:AnimalsCells
    15. Sun L, Dang W. SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery. Protein Cell. 2020 07; 11(7):469-471. PMID: 32435977; PMCID: PMC7305289.
      Citations: 2     Fields:    Translation:HumansCells
    16. Huang B, Zhong D, Zhu J, An Y, Gao M, Zhu S, Dang W, Wang X, Yang B, Xie Z. Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines. Aging Cell. 2020 04; 19(4):e13129. PMID: 32157780; PMCID: PMC7189995.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    17. Moruno-Manchon JF, Wang Y, McCauley B, Honarpisheh P, Morales Scheihing DA, Singh S, Dang W, Kim N, Urayama A, Zhu L, McCullough LD, Tsvetkov AS, Lejault P, Monchaud D. Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons. Elife. 2020 02 11; 9. PMID: 32043463; PMCID: PMC7012600.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    18. Yu R, McCauley B, Dang W. Loss of chromatin structural integrity is a source of stress during aging. Hum Genet. 2020 Mar; 139(3):371-380. PMID: 31900586; PMCID: PMC8011432.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Yu R, Jo MC, Dang W. Measuring the Replicative Lifespan of Saccharomyces cerevisiae Using the HYAA Microfluidic Platform. Methods Mol Biol. 2020; 2144:1-6. PMID: 32410020; PMCID: PMC8629154.
      Citations: 1     Fields:    Translation:AnimalsCells
    20. Yu A, Zhou R, Xia B, Dang W, Yang Z, Chen X. NAMPT maintains mitochondria content via NRF2-PPARa/AMPKa pathway to promote cell survival under oxidative stress. Cell Signal. 2020 02; 66:109496. PMID: 31816398.
      Citations: 8     Fields:    Translation:HumansCells
    21. Yu R, Sun L, Sun Y, Han X, Qin L, Dang W. Cellular response to moderate chromatin architectural defects promotes longevity. Sci Adv. 2019 07; 5(7):eaav1165. PMID: 31309140; PMCID: PMC6620092.
      Citations: 7     Fields:    Translation:AnimalsCells
    22. Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V, Yang JN. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 04 18; 177(3):622-638.e22. PMID: 31002797; PMCID: PMC6499390.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    23. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 02 21; 73(4):684-698.e8. PMID: 30773298; PMCID: PMC6688479.
      Citations: 38     Fields:    Translation:HumansCells
    24. Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560; PMCID: PMC6156608.
      Citations: 16     Fields:    Translation:AnimalsCells
    25. Sun L, Yu R, Dang W. Chromatin Architectural Changes during Cellular Senescence and Aging. Genes (Basel). 2018 Apr 16; 9(4). PMID: 29659513; PMCID: PMC5924553.
      Citations: 25     Fields:    
    26. Yu A, Dang W. Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications. Mol Cell Endocrinol. 2017 Nov 05; 455:75-82. PMID: 28392411; PMCID: PMC7951659.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    27. Molina-Serrano D, Schiza V, Demosthenous C, Stavrou E, Oppelt J, Kyriakou D, Liu W, Dang W, Kirmizis A, Zisser G, Bergler H. Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Rep. 2016 12; 17(12):1829-1843. PMID: 27799288; PMCID: PMC5167350.
      Citations: 20     Fields:    Translation:AnimalsCells
    28. Yu R, Dang W. Gearing up for survival - HSP-containing granules accumulate in quiescent cells and promote survival. Microb Cell. 2016 Mar 06; 3(3):95-96. PMID: 28362009; PMCID: PMC5349018.
      Citations:    
    29. Jo MC, Liu W, Gu L, Dang W, Qin L. High-throughput analysis of yeast replicative aging using a microfluidic system. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9364-9. PMID: 26170317; PMCID: PMC4522780.
      Citations: 62     Fields:    Translation:Animals
    30. Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev. 2015 Jul 01; 29(13):1362-76. PMID: 26159996; PMCID: PMC4511212.
      Citations: 94     Fields:    Translation:AnimalsCells
    31. Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of organometallic S6K1 inhibitors. J Med Chem. 2015 Jan 08; 58(1):305-14. PMID: 25356520; PMCID: PMC4289024.
      Citations: 6     Fields:    Translation:HumansCells
    32. McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep. 2014 Jul 24; 8(2):477-86. PMID: 25043177; PMCID: PMC4284099.
      Citations: 32     Fields:    Translation:AnimalsCells
    33. Dang W. The controversial world of sirtuins. Drug Discov Today Technol. 2014 Jun; 12:e9-e17. PMID: 25027380; PMCID: PMC4101544.
      Citations: 42     Fields:    Translation:HumansAnimals
    34. McCauley BS, Dang W. Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta. 2014 Dec; 1839(12):1454-62. PMID: 24859460; PMCID: PMC4240748.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    35. Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metab. 2014 Jun 03; 19(6):952-66. PMID: 24814484; PMCID: PMC4106248.
      Citations: 43     Fields:    Translation:AnimalsCells
    36. Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods Mol Biol. 2013; 1077:11-37. PMID: 24014397.
      Citations: 2     Fields:    Translation:Animals
    37. Edwards CR, Dang W, Berger SL. Histone H4 lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing. Biochemistry. 2011 Dec 06; 50(48):10473-83. PMID: 21985125; PMCID: PMC3697087.
      Citations: 12     Fields:    Translation:AnimalsCells
    38. Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW, Thibault P, Verreault A, Johnson FB, Berger SL, Sternglanz R, McMahon SB, Marmorstein R, C?t? J. MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2012 Jan 04; 31(1):58-70. PMID: 22020126; PMCID: PMC3252582.
      Citations: 65     Fields:    Translation:HumansCells
    39. Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, Johnson FB. Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. EMBO J. 2010 Jan 06; 29(1):158-70. PMID: 19875981; PMCID: PMC2808364.
      Citations: 30     Fields:    Translation:AnimalsCells
    40. Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K, Marmorstein R. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem. 2009 Oct 01; 17(19):7031-41. PMID: 19734050; PMCID: PMC2929362.
      Citations: 5     Fields:    Translation:Humans
    41. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature. 2009 Jun 11; 459(7248):802-7. PMID: 19516333; PMCID: PMC2702157.
      Citations: 299     Fields:    Translation:AnimalsCells
    42. Lin YY, Lu JY, Zhang J, Walter W, Dang W, Wan J, Tao SC, Qian J, Zhao Y, Boeke JD, Berger SL, Zhu H. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar 20; 136(6):1073-84. PMID: 19303850; PMCID: PMC2696288.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    43. Dang W, Bartholomew B. Domain architecture of the catalytic subunit in the ISW2-nucleosome complex. Mol Cell Biol. 2007 Dec; 27(23):8306-17. PMID: 17908792; PMCID: PMC2169183.
      Citations: 65     Fields:    Translation:AnimalsCells
    44. Dang W, Kagalwala MN, Bartholomew B. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. J Biol Chem. 2007 Jul 06; 282(27):19418-25. PMID: 17491017.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    45. Dang W, Kagalwala MN, Bartholomew B. Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA. Mol Cell Biol. 2006 Oct; 26(20):7388-96. PMID: 17015471; PMCID: PMC1636884.
      Citations: 52     Fields:    Translation:AnimalsCells
    46. Kagalwala MN, Glaus BJ, Dang W, Zofall M, Bartholomew B. Topography of the ISW2-nucleosome complex: insights into nucleosome spacing and chromatin remodeling. EMBO J. 2004 May 19; 23(10):2092-104. PMID: 15131696; PMCID: PMC424408.
      Citations: 78     Fields:    Translation:HumansCells
    47. Liu Ying, Zheng Junheng, DANG Weiwei, Ren Hongwei, Yu Meimin and Ru Binggen . The study of direct ELISA and competitive ELISA for rabbit metallothionein: correlation of induction with zinc. Analusis. 2000; 28(5):361-366. View Publication.
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