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WEIWEI DANG

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    K99AG037646     (DANG, WEIWEI)Aug 1, 2010 - Feb 28, 2013
    NIH/NIA
    Regulation of yeast cellular aging through chromatin and novel pathways
    Role: Principal Investigator

    R00AG037646     (DANG, WEIWEI)Mar 15, 2013 - Feb 29, 2016
    NIH/NIA
    Regulation of yeast cellular aging through chromatin and novel pathways
    Role: Principal Investigator

    R56AG049714     (QIN, LIDONG)Sep 15, 2015 - Aug 31, 2016
    NIH/NIA
    Revolutionize Budding-Yeast-Based Aging Study by High-Throughput Lab-on-a-Chip Devices
    Role: Co-Principal Investigator

    R01AG052507     (DANG, WEIWEI)Sep 15, 2017 - Apr 30, 2022
    NIH/NIA
    Regulation of longevity through maintenance of transcription fidelity
    Role: Principal Investigator

    R41AG058368     (JO, MYEONG CHAN)Sep 30, 2017 - Sep 30, 2018
    NIH/NIA
    Developing an automated yeast dissection system for aging research
    Role: Co-Principal Investigator

    R42AG058368     (JO, MYEONG CHAN)Sep 30, 2017 - May 31, 2020
    NIH/NIA
    Developing an automated yeast dissection system for aging research
    Role: Co-Principal Investigator

    R21AG064345     (DANG, WEIWEI)Jul 15, 2019 - Mar 31, 2021
    NIH/NIA
    Defining Periosteal Skeletal Stem Cell Heterogeneity and Age-associated Change
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yu R, Sun L, Sun Y, Han X, Qin L, Dang W. Cellular response to moderate chromatin architectural defects promotes longevity. Sci Adv. 2019 Jul; 5(7):eaav1165. PMID: 31309140.
      View in: PubMed
    2. Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 Apr 18; 177(3):622-638.e22. PMID: 31002797.
      View in: PubMed
    3. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 02 21; 73(4):684-698.e8. PMID: 30773298.
      View in: PubMed
    4. Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560.
      View in: PubMed
    5. Sun L, Yu R, Dang W. Chromatin Architectural Changes during Cellular Senescence and Aging. Genes (Basel). 2018 Apr 16; 9(4). PMID: 29659513.
      View in: PubMed
    6. Yu A, Dang W. Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications. Mol Cell Endocrinol. 2017 Nov 05; 455:75-82. PMID: 28392411.
      View in: PubMed
    7. Molina-Serrano D, Schiza V, Demosthenous C, Stavrou E, Oppelt J, Kyriakou D, Liu W, Zisser G, Bergler H, Dang W, Kirmizis A. Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Rep. 2016 12; 17(12):1829-1843. PMID: 27799288.
      View in: PubMed
    8. Yu R, Dang W. Gearing up for survival - HSP-containing granules accumulate in quiescent cells and promote survival. Microb Cell. 2016 Mar 06; 3(3):95-96. PMID: 28362009.
      View in: PubMed
    9. Jo MC, Liu W, Gu L, Dang W, Qin L. High-throughput analysis of yeast replicative aging using a microfluidic system. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9364-9. PMID: 26170317.
      View in: PubMed
    10. Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes Dev. 2015 Jul 01; 29(13):1362-76. PMID: 26159996.
      View in: PubMed
    11. Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of organometallic S6K1 inhibitors. J Med Chem. 2015 Jan 08; 58(1):305-14. PMID: 25356520.
      View in: PubMed
    12. McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep. 2014 Jul 24; 8(2):477-86. PMID: 25043177.
      View in: PubMed
    13. Dang W. The controversial world of sirtuins. Drug Discov Today Technol. 2014 Jun; 12:e9-e17. PMID: 25027380.
      View in: PubMed
    14. McCauley BS, Dang W. Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta. 2014 Dec; 1839(12):1454-62. PMID: 24859460.
      View in: PubMed
    15. Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metab. 2014 Jun 03; 19(6):952-66. PMID: 24814484.
      View in: PubMed
    16. Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Sirtuins in yeast: phenotypes and tools. Methods Mol Biol. 2013; 1077:11-37. PMID: 24014397.
      View in: PubMed
    17. Edwards CR, Dang W, Berger SL. Histone H4 lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing. Biochemistry. 2011 Dec 06; 50(48):10473-83. PMID: 21985125.
      View in: PubMed
    18. Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW, Thibault P, Verreault A, Johnson FB, Berger SL, Sternglanz R, McMahon SB, Côté J, Marmorstein R. MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2012 Jan 04; 31(1):58-70. PMID: 22020126.
      View in: PubMed
    19. Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, Johnson FB. Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. EMBO J. 2010 Jan 06; 29(1):158-70. PMID: 19875981.
      View in: PubMed
    20. Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K, Marmorstein R. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem. 2009 Oct 01; 17(19):7031-41. PMID: 19734050.
      View in: PubMed
    21. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature. 2009 Jun 11; 459(7248):802-7. PMID: 19516333.
      View in: PubMed
    22. Lin YY, Lu JY, Zhang J, Walter W, Dang W, Wan J, Tao SC, Qian J, Zhao Y, Boeke JD, Berger SL, Zhu H. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar 20; 136(6):1073-84. PMID: 19303850.
      View in: PubMed
    23. Dang W, Bartholomew B. Domain architecture of the catalytic subunit in the ISW2-nucleosome complex. Mol Cell Biol. 2007 Dec; 27(23):8306-17. PMID: 17908792.
      View in: PubMed
    24. Dang W, Kagalwala MN, Bartholomew B. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. J Biol Chem. 2007 Jul 06; 282(27):19418-25. PMID: 17491017.
      View in: PubMed
    25. Dang W, Kagalwala MN, Bartholomew B. Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA. Mol Cell Biol. 2006 Oct; 26(20):7388-96. PMID: 17015471.
      View in: PubMed
    26. Kagalwala MN, Glaus BJ, Dang W, Zofall M, Bartholomew B. Topography of the ISW2-nucleosome complex: insights into nucleosome spacing and chromatin remodeling. EMBO J. 2004 May 19; 23(10):2092-104. PMID: 15131696.
      View in: PubMed
    27. Liu Ying, Zheng Junheng, Dang Weiwei, Ren Hongwei, Yu Meimin and Ru Binggen . The study of direct ELISA and competitive ELISA for rabbit metallothionein: correlation of induction with zinc. Analusis. 2000; 28(5):361-366.
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