TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
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    1. Budai, M.M., Li, M., Kodali, S., Chen, M., and Wang, J. Regulation of Mitochondrial Homeostasis and Metabolic Programming in Memory B cells by Mitophagy. 2022; 1(1):165-169. View Publication.
    2. Chen M, Li M, Budai MM, Rice AP, Kimata JT, Mohan M, Wang J. Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies. J Leukoc Biol. 2022 Mar 31. PMID: 35362118.
      Citations:    Fields:    
    3. Kodali S, Li M, Budai MM, Chen M, Wang J. Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy. J Immunol. 2022 03 01; 208(5):1085-1098. PMID: 35101890.
      Citations:    Fields:    Translation:AnimalsCells
    4. Khan A, Sayedahmed EE, Singh VK, Mishra A, Dorta-Estremera S, Nookala S, Canaday DH, Chen M, Wang J, Sastry KJ, Mittal SK, Jagannath C. A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice. Cell Rep Med. 2021 08 17; 2(8):100372. PMID: 34467249.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Jang A, Sharp R, Wang JM, Feng Y, Wang J, Chen M. Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus. Front Immunol. 2021; 12:701066. PMID: 34335611.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Li M, Liu W, Bauch T, Graviss EA, Arduino RC, Kimata JT, Chen M, Wang J. Clearance of HIV infection by selective elimination of host cells capable of producing HIV. Nat Commun. 2020 08 13; 11(1):4051. PMID: 32792548.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Gupta SS, Wang J, Chen M. Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections. Front Immunol. 2020; 11:1013. PMID: 32670270.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    8. Zhang J, Kodali S, Chen M, Wang J. Maintenance of Germinal Center B Cells by Caspase-9 through Promotion of Apoptosis and Inhibition of Necroptosis. J Immunol. 2020 07 01; 205(1):113-120. PMID: 32434938.
      Citations: 2     Fields:    Translation:AnimalsCells
    9. Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW, Wang J, Chen M. NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells. Cell Rep. 2019 11 12; 29(7):1862-1877.e7. PMID: 31722203.
      Citations: 8     Fields:    Translation:AnimalsCells
    10. Hong MJ, Gu BH, Madison MC, Landers C, Tung HY, Kim M, Yuan X, You R, Machado AA, Gilbert BE, Soroosh P, Elloso M, Song L, Chen M, Corry DB, Diehl G, Kheradmand F. Protective role of ?d T cells in cigarette smoke and influenza infection. Mucosal Immunol. 2018 05; 11(3):894-908. PMID: 29091081.
      Citations: 19     Fields:    Translation:AnimalsCells
    11. Chen M, Kodali S, Jang A, Kuai L, Wang J. Requirement for autophagy in the long-term persistence but not initial formation of memory B cells. J Immunol. 2015 Mar 15; 194(6):2607-15. PMID: 25672753.
      Citations: 31     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Wang J, Chen M. . Autophagy in Host Defense Against Viruses. Autophagy Networks in Inflammation. 2015; 185-199.
    13. Chen M, Hong MJ, Sun H, Wang L, Shi X, Gilbert BE, Corry DB, Kheradmand F, Wang J. Essential role for autophagy in the maintenance of immunological memory against influenza infection. Nat Med. 2014 May; 20(5):503-10. PMID: 24747745.
      Citations: 96     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Sun H, Wang L, Wang J, Chen M. Role of Nix in the Maturation of Erythroid Cells through Mitochondrial Autophagy. Autophagy: Cancer, other Pathologies, Inflammation, Immunity, Infection and Aging. 2014; 127-137.
    15. Chen M, Huang L, Wang J. Analyses of programmed cell death in dendritic cells. Methods Mol Biol. 2013; 979:51-63. PMID: 23397388.
      Citations:    Fields:    Translation:AnimalsCells
    16. Guerrero AD, Welschhans RL, Chen M, Wang J. Cleavage of anti-apoptotic Bcl-2 family members after TCR stimulation contributes to the decision between T cell activation and apoptosis. J Immunol. 2013 Jan 01; 190(1):168-73. PMID: 23203923.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    17. Guerrero AD, Schmitz I, Chen M, Wang J. Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage. J Clin Cell Immunol. 2012 Aug 09; 3(3). PMID: 23539542.
      Citations: 11     
    18. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
      Citations: 1739     Fields:    Translation:HumansAnimals
    19. Chen M, Wang J. Regulation of Immune Responses by Spontaneous and T cell-mediated Dendritic Cell Death. J Clin Cell Immunol. 2011 Dec 11; S3. PMID: 22468233.
      Citations: 4     
    20. Chen M, Felix K, Wang J. Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation. Blood. 2012 Jan 05; 119(1):127-36. PMID: 22042696.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    21. Chen M, Felix K, Wang J. Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol. 2011 Dec 01; 187(11):5684-92. PMID: 22031758.
      Citations: 8     Fields:    Translation:AnimalsCells
    22. Chen M, Wang J. Programmed cell death of dendritic cells in immune regulation. Immunol Rev. 2010 Jul; 236:11-27. PMID: 20636805.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    23. Chen M, Sandoval H, Wang J. Selective mitochondrial autophagy during erythroid maturation. Autophagy. 2008 Oct; 4(7):926-8. PMID: 18716457.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    24. Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. Essential role for Nix in autophagic maturation of erythroid cells. Nature. 2008 Jul 10; 454(7201):232-5. PMID: 18454133.
      Citations: 517     Fields:    Translation:AnimalsCells
    25. Guerrero AD, Chen M, Wang J. Delineation of the caspase-9 signaling cascade. Apoptosis. 2008 Jan; 13(1):177-86. PMID: 17899380.
      Citations: 20     Fields:    Translation:HumansCells
    26. Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem. 2007 Nov 16; 282(46):33888-33895. PMID: 17893147.
      Citations: 41     Fields:    Translation:HumansCells
    27. Chen M, Huang L, Shabier Z, Wang J. Regulation of the lifespan in dendritic cell subsets. Mol Immunol. 2007 Apr; 44(10):2558-65. PMID: 17267035.
      Citations: 37     Fields:    Translation:AnimalsCells
    28. Chen M, Huang L, Wang J. Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood. 2007 May 15; 109(10):4360-7. PMID: 17227827.
      Citations: 53     Fields:    Translation:AnimalsCells
    29. Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ, Wang J. Dendritic cell apoptosis in the maintenance of immune tolerance. Science. 2006 Feb 24; 311(5764):1160-4. PMID: 16497935.
      Citations: 133     Fields:    Translation:AnimalsCells
    30. Roberts JL, Lengi A, Brown SM, Chen M, Zhou YJ, O'Shea JJ, Buckley RH. Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. Blood. 2004 Mar 15; 103(6):2009-18. PMID: 14615376.
      Citations: 34     Fields:    Translation:HumansCells
    31. Aringer M, Hofmann SR, Frucht DM, Chen M, Centola M, Morinobu A, Visconti R, Kastner DL, Smolen JS, O'Shea JJ. Characterization and analysis of the proximal Janus kinase 3 promoter. J Immunol. 2003 Jun 15; 170(12):6057-64. PMID: 12794134.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    32. Chen M, Orozco A, Spencer DM, Wang J. Activation of initiator caspases through a stable dimeric intermediate. J Biol Chem. 2002 Dec 27; 277(52):50761-7. PMID: 12399450.
      Citations: 22     Fields:    Translation:HumansCells
    33. Chen M, Wang J. Initiator caspases in apoptosis signaling pathways. Apoptosis. 2002 Aug; 7(4):313-9. PMID: 12101390.
      Citations: 116     Fields:    Translation:AnimalsCells
    34. Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, Geahlen RL, Candotti F, Gadina M, Changelian PS, O'Shea JJ. Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell. 2001 Nov; 8(5):959-69. PMID: 11741532.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    35. Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K. STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett. 2000 Jul 14; 477(1-2):55-61. PMID: 10899310.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    36. Chen M, Cheng A, Candotti F, Zhou YJ, Hymel A, Fasth A, Notarangelo LD, O'Shea JJ. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol Cell Biol. 2000 Feb; 20(3):947-56. PMID: 10629052.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    37. Lu W, Lo SY, Chen M, Wu Kj, Fung YK, Ou JH. Activation of p53 tumor suppressor by hepatitis C virus core protein. Virology. 1999 Nov 10; 264(1):134-41. PMID: 10544138.
      Citations: 32     Fields:    Translation:HumansCells
    38. Chen E, Gadina M, Chen M, O'Shea JJ. Advances in cytokine signaling: the role of Jaks and STATs. Transplant Proc. 1999 May; 31(3):1482-7. PMID: 10330976.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    39. Cacalano NA, Migone TS, Bazan F, Hanson EP, Chen M, Candotti F, O'Shea JJ, Johnston JA. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain. EMBO J. 1999 Mar 15; 18(6):1549-58. PMID: 10075926.
      Citations: 25     Fields:    Translation:HumansCells
    40. Aringer M, Cheng A, Nelson JW, Chen M, Sudarshan C, Zhou YJ, O'Shea JJ. Janus kinases and their role in growth and disease. Life Sci. 1999; 64(24):2173-86. PMID: 10374907.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    41. Chen EH, Gadina M, Galon J, Chen M, O'Shea JJ. Not just another meeting: the coming of age of JAKs and STATs. Immunol Today. 1998 Aug; 19(8):338-41. PMID: 9709499.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    42. Zhou YJ, Hanson EP, Chen YQ, Magnuson K, Chen M, Swann PG, Wange RL, Changelian PS, O'Shea JJ. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13850-5. PMID: 9391116.
      Citations: 34     Fields:    Translation:AnimalsCells
    43. Chen M, Cheng A, Chen YQ, Hymel A, Hanson EP, Kimmel L, Minami Y, Taniguchi T, Changelian PS, O'Shea JJ. The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6910-5. PMID: 9192665.
      Citations: 45     Fields:    Translation:AnimalsCells
    44. Buckwold VE, Chen M, Ou JH. Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1997 Jan 20; 227(2):515-8. PMID: 9018153.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    45. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol. 1996 Sep; 70(9):5845-51. PMID: 8709203.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    46. Chen M, Ou JH. Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1995 Dec 01; 214(1):198-206. PMID: 8525615.
      Citations: 9     Fields:    Translation:HumansCells
    47. Lu CC, Chen M, Ou JH, Yen TS. Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology. 1995 Feb 01; 206(2):1155-8. PMID: 7856091.
      Citations: 12     Fields:    Translation:HumansCells
    48. Chen M, Hieng S, Qian X, Costa R, Ou JH. Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3. Virology. 1994 Nov 15; 205(1):127-32. PMID: 7975208.
      Citations: 27     Fields:    Translation:HumansCells
    49. Guo W, Chen M, Yen TS, Ou JH. Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol Cell Biol. 1993 Jan; 13(1):443-8. PMID: 8417343.
      Citations: 44     Fields:    Translation:HumansCells
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