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ALADIN M BORIEK

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Pulmonary
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


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    R01HL046230     (BORIEK, ALADIN MOHAMED)Apr 1, 1991 - Mar 31, 2004
    NIH/NHLBI
    RESPIRATORY SYSTEM MECHANICS
    Role: Principal Investigator

    R29HL054198     (BORIEK, ALADIN MOHAMED)Jun 1, 1996 - May 31, 2000
    NIH/NHLBI
    MICROMECHANICS OF RESPIRATORY MUSCLES
    Role: Principal Investigator

    R01HL063134     (BORIEK, ALADIN M)Mar 1, 2001 - Jun 30, 2010
    NIH/NHLBI
    Physiology of Respiratory Muscle Micromechanics
    Role: Principal Investigator

    R01HL072839     (BORIEK, ALADIN M)Aug 1, 2004 - Jul 31, 2009
    NIH/NHLBI
    Engineering Approach to the Ventilatory Pump
    Role: Principal Investigator

    R25HL108853     (BORIEK, ALADIN M)Jun 15, 2011 - Mar 31, 2022
    NIH/NHLBI
    Short-Term Research Education Program to Increase Diversity in Health-Related Research (STREPID, R25)
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Diaz AA, Martinez CH, Harmouche R, Young TP, McDonald ML, Ross JC, Han ML, Bowler R, Make B, Regan EA, Silverman EK, Crapo J, Boriek AM, Kinney GL, Hokanson JE, Estepar RSJ, Washko GR. Pectoralis muscle area and mortality in smokers without airflow obstruction. Respir Res. 2018 04 10; 19(1):62. PMID: 29636050.
      View in: PubMed
    2. Parulekar AD, Martinez C, Tsai CL, Locantore N, Atik M, Yohannes AM, Kao CC, Al-Azzawi H, Mohsin A, Wise RA, Foreman MG, Demeo DL, Regan EA, Make BJ, Boriek AM, Wiener LE, Hanania NA. Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts. J Am Med Dir Assoc. 2017 Dec 01; 18(12):1063-1068. PMID: 29169736.
      View in: PubMed
    3. Pardo PS, Lopez MA, Mohamed JS, Boriek AM. Anisotropic mechanosensitive pathways in the diaphragm and their implications in muscular dystrophies. J Muscle Res Cell Motil. 2017 12; 38(5-6):437-446. PMID: 28986699.
      View in: PubMed
    4. Boriek AM, Lopez MA, Velasco C, Bakir AA, Frolov A, Wynd S, Babb TG, Hanania NA, Hoffman EA, Sharafkhaneh A. Obesity modulates diaphragm curvature in subjects with and without COPD. Am J Physiol Regul Integr Comp Physiol. 2017 Nov 01; 313(5):R620-R629. PMID: 28903915.
      View in: PubMed
    5. Pardo PS, Hajira A, Boriek AM, Mohamed JS. MicroRNA-434-3p regulates age-related apoptosis through eIF5A1 in the skeletal muscle. Aging (Albany NY). 2017 03 22; 9(3):1012-1029. PMID: 28331100.
      View in: PubMed
    6. Greybeck B, Lu R, Ramanujam A, Adeyeye M, Wettergreen M, Wynd S, Boriek AM. Regional diaphragm volume displacement is heterogeneous in dogs. Am J Physiol Regul Integr Comp Physiol. 2017 03 01; 312(3):R443-R450. PMID: 28100474.
      View in: PubMed
    7. Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack MC, Hansel NN. Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD. Chest. 2017 Jan; 151(1):68-77. PMID: 27568229.
      View in: PubMed
    8. Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galbán CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK. Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 15; 194(2):178-84. PMID: 26808615.
      View in: PubMed
    9. Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J, Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL. Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 07; 13(7):1016-25. PMID: 27158740.
      View in: PubMed
    10. Mohamed JS, Hajira A, Lopez MA, Boriek AM. Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy. J Biol Chem. 2015 Oct 09; 290(41):24986-5011. PMID: 26272747.
      View in: PubMed
    11. Mohamed JS, Hajira A, Pardo PS, Boriek AM. MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1a network in skeletal muscle. Diabetes. 2014 May; 63(5):1546-59. PMID: 24757201.
      View in: PubMed
    12. Mohamed JS, Lopez MA, Cox GA, Boriek AM. Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction. J Biol Chem. 2013 Aug 23; 288(34):24560-8. PMID: 23824195.
      View in: PubMed
    13. Pardo PS, Boriek AM. An autoregulatory loop reverts the mechanosensitive Sirt1 induction by EGR1 in skeletal muscle cells. Aging (Albany NY). 2012 Jul; 4(7):456-61. PMID: 22820707.
      View in: PubMed
    14. Shardonofsky FR, Moore J, Schwartz RJ, Boriek AM. Airways in smooth muscle a-actin null mice experience a compensatory mechanism that modulates their contractile response. J Appl Physiol (1985). 2012 Mar; 112(5):898-903. PMID: 22134689.
      View in: PubMed
    15. Mohamed JS, Boriek AM. Loss of desmin triggers mechanosensitivity and up-regulation of Ankrd1 expression through Akt-NF-?B signaling pathway in smooth muscle cells. FASEB J. 2012 Feb; 26(2):757-65. PMID: 22085644.
      View in: PubMed
    16. Mohamed JS, Hajira A, Li Z, Paulin D, Boriek AM. Desmin regulates airway smooth muscle hypertrophy through early growth-responsive protein-1 and microRNA-26a. J Biol Chem. 2011 Dec 16; 286(50):43394-404. PMID: 21903578.
      View in: PubMed
    17. De Troyer A, Boriek AM. Mechanics of the respiratory muscles. Compr Physiol. 2011 Jul; 1(3):1273-300. PMID: 23733642.
      View in: PubMed
    18. Pardo PS, Boriek AM. The physiological roles of Sirt1 in skeletal muscle. Aging (Albany NY). 2011 Apr; 3(4):430-7. PMID: 21483036.
      View in: PubMed
    19. Greybeck BJ, Wettergreen M, Hubmayr RD, Boriek AM. Diaphragm curvature modulates the relationship between muscle shortening and volume displacement. Am J Physiol Regul Integr Comp Physiol. 2011 Jul; 301(1):R76-82. PMID: 21430079.
      View in: PubMed
    20. Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26; 56(18):1493-502. PMID: 20951326.
      View in: PubMed
    21. Pardo PS, Mohamed JS, Lopez MA, Boriek AM. Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response. J Biol Chem. 2011 Jan 28; 286(4):2559-66. PMID: 20971845.
      View in: PubMed
    22. Chu I, Fernandez C, Rodowicz KA, Lopez MA, Lu R, Hubmayr RD, Boriek AM. Diaphragm muscle shortening modulates kinematics of lower rib cage in dogs. Am J Physiol Regul Integr Comp Physiol. 2010 Dec; 299(6):R1456-62. PMID: 20739605.
      View in: PubMed
    23. Mohamed JS, Lopez MA, Boriek AM. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3ß. J Biol Chem. 2010 Sep 17; 285(38):29336-47. PMID: 20525681.
      View in: PubMed
    24. Mohamed JS, Boriek AM. Stretch augments TGF-beta1 expression through RhoA/ROCK1/2, PTK, and PI3K in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010 Sep; 299(3):L413-24. PMID: 20511342.
      View in: PubMed
    25. Mohamed JS, Lopez MA, Cox GA, Boriek AM. Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 2010 Sep; 24(9):3330-40. PMID: 20442316.
      View in: PubMed
    26. Moulik M, Vatta M, Witt SH, Arola AM, Murphy RT, McKenna WJ, Boriek AM, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA. ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 2009 Jul 21; 54(4):325-33. PMID: 19608030.
      View in: PubMed
    27. Lopez MA, Pardo PS, Cox GA, Boriek AM. Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttnmdm) model. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1092-102. PMID: 18753318.
      View in: PubMed
    28. Pardo PS, Lopez MA, Boriek AM. FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump. Am J Physiol Cell Physiol. 2008 Apr; 294(4):C1056-66. PMID: 18272820.
      View in: PubMed
    29. Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J. Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. J Biol Chem. 2007 Nov 23; 282(47):34268-75. PMID: 17878168.
      View in: PubMed
    30. Sharafkhaneh A, Babb TG, Officer TM, Hanania NA, Sharafkhaneh H, Boriek AM. The confounding effects of thoracic gas compression on measurement of acute bronchodilator response. Am J Respir Crit Care Med. 2007 Feb 15; 175(4):330-5. PMID: 17110648.
      View in: PubMed
    31. Boriek AM, Black B, Hubmayr R, Wilson TA. Length and curvature of the dog diaphragm. J Appl Physiol (1985). 2006 Sep; 101(3):794-8. PMID: 16902068.
      View in: PubMed
    32. Shardonofsky FR, Capetanaki Y, Boriek AM. Desmin modulates lung elastic recoil and airway responsiveness. Am J Physiol Lung Cell Mol Physiol. 2006 May; 290(5):L890-6. PMID: 16387753.
      View in: PubMed
    33. Hwang W, Carvalho JC, Tarlovsky I, Boriek AM. Passive mechanics of canine internal abdominal muscles. J Appl Physiol (1985). 2005 May; 98(5):1829-35. PMID: 15829719.
      View in: PubMed
    34. Hwang W, Kelly NG, Boriek AM. Passive mechanics of muscle tendinous junction of canine diaphragm. J Appl Physiol (1985). 2005 Apr; 98(4):1328-33. PMID: 15772060.
      View in: PubMed
    35. Boriek AM, Hwang W, Trinh L, Rodarte JR. Shape and tension distribution of the active canine diaphragm. Am J Physiol Regul Integr Comp Physiol. 2005 Apr; 288(4):R1021-7. PMID: 15793029.
      View in: PubMed
    36. Lopez MA, Mayer U, Hwang W, Taylor T, Hashmi MA, Jannapureddy SR, Boriek AM. Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragm. Am J Physiol Cell Physiol. 2005 Feb; 288(2):C282-9. PMID: 15643051.
      View in: PubMed
    37. Kumar A, Murphy R, Robinson P, Wei L, Boriek AM. Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-kappaB transcription factor. FASEB J. 2004 Oct; 18(13):1524-35. PMID: 15466361.
      View in: PubMed
    38. Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-kappaB: its role in health and disease. J Mol Med (Berl). 2004 Jul; 82(7):434-48. PMID: 15175863.
      View in: PubMed
    39. Sharafkhaneh A, Officer TM, Goodnight-White S, Rodarte JR, Boriek AM. Novel method for measuring effects of gas compression on expiratory flow. Am J Physiol Regul Integr Comp Physiol. 2004 Aug; 287(2):R479-84. PMID: 15117729.
      View in: PubMed
    40. Kumar A, Khandelwal N, Malya R, Reid MB, Boriek AM. Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers. FASEB J. 2004 Jan; 18(1):102-13. PMID: 14718391.
      View in: PubMed
    41. Kumar A, Lnu S, Malya R, Barron D, Moore J, Corry DB, Boriek AM. Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma. FASEB J. 2003 Oct; 17(13):1800-11. PMID: 14519659.
      View in: PubMed
    42. Foster PP, Boriek AM, Butler BD, Gernhardt ML, Bové AA. Patent foramen ovale and paradoxical systemic embolism: a bibliographic review. Aviat Space Environ Med. 2003 Jun; 74(6 Pt 2):B1-64. PMID: 12830848.
      View in: PubMed
    43. Jannapureddy SR, Patel ND, Hwang W, Boriek AM. Genetic Models in Applied Physiology. Merosin deficiency leads to alterations in passive and active skeletal muscle mechanics. J Appl Physiol (1985). 2003 Jun; 94(6):2524-33; discussion 2523. PMID: 12736195.
      View in: PubMed
    44. Patel ND, Jannapureddy SR, Hwang W, Chaudhry I, Boriek AM. Altered muscle force and stiffness of skeletal muscles in alpha-sarcoglycan-deficient mice. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C962-8. PMID: 12620894.
      View in: PubMed
    45. Kumar A, Knox AJ, Boriek AM. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J Biol Chem. 2003 May 23; 278(21):18868-76. PMID: 12637525.
      View in: PubMed
    46. Kyckelhahn BA, Nason PB, Tidball JG, Boriek AM. Kinematic modeling of single muscle fiber during diaphragm shortening. J Biomech. 2003 Mar; 36(3):457-61. PMID: 12594994.
      View in: PubMed
    47. Kumar A, Boriek AM. Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy. FASEB J. 2003 Mar; 17(3):386-96. PMID: 12631578.
      View in: PubMed
    48. Kumar A, Chaudhry I, Reid MB, Boriek AM. Distinct signaling pathways are activated in response to mechanical stress applied axially and transversely to skeletal muscle fibers. J Biol Chem. 2002 Nov 29; 277(48):46493-503. PMID: 12221078.
      View in: PubMed
    49. Boriek AM, Ortize J, Zhu D. Fiber architecture of canine abdominal muscles. J Appl Physiol (1985). 2002 Feb; 92(2):725-35. PMID: 11796687.
      View in: PubMed
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