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PAULA HERTEL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    U01DK103149     (SHNEIDER, BENJAMIN L)Sep 10, 2014 - May 31, 2024
    NIH
    BCM/TCH CHOLESTATIC LIVER DISEASE CONSORTIUM
    Role: Co-Principal Investigator
    U01-DK061718     (HERTEL, PAULA M.)Feb 23, 2010 - Jun 30, 2024
    NIH/NIDDK
    Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
    Role: Principal Investigator (subcontract)

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ma M, Ganapathi M, Zheng Y, Tan KL, Kanca O, Bove KE, Quintanilla N, Sag SO, Temel SG, LeDuc CA, McPartland AJ, Pereira EM, Shen Y, Hagen J, Thomas CP, Galv?n NTN, Pan X, Lu S, Rosenfeld JA, Calame DG, Wangler MF, Lupski JR, Pehlivan D, Hertel PM, Chung WK, Bellen HJ. Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Genet Med. 2024 Mar 21; 101125. PMID: 38522068.
      Citations:    Fields:    
    2. Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Nutrition assessment and MASH severity in children using the Healthy Eating Index. Hepatol Commun. 2023 Dec 01; 7(12). PMID: 38055641; PMCID: PMC10984667.
      Citations:    Fields:    Translation:Humans
    3. Wang A, Blackford AL, Behling C, Wilson LA, Newton KP, Xanthakos SA, Fishbein MH, Vos MB, Mouzaki M, Molleston JP, Jain AK, Hertel P, Harlow Adams K, Schwimmer JB, NASH CRN, Wang A, Blackford AL, Behling C, Wilson LA, Newton KP, Xanthakos SA, Fishbein MH, Vos MB, Mouzaki M, Molleston JP, Jain AK, Hertel P, Harlow Adams K, Schwimmer JB. Development of Fibro-PeN, a clinical prediction model for moderate-to-severe fibrosis in children with nonalcoholic fatty liver disease. Hepatology. 2023 Oct 23. PMID: 37870272.
      Citations:    Fields:    
    4. Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J, Rosenthal P, Bull L, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C, Kohli R, Wang L, Soufi N, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer JP, Abramowsky C, McFall J, Shneider BL, Harpavat S, Hertel P, Leung D, Tessier M, Schady D, Cavallo L, Olvera D, Banks C, Tsai C, Thompson R, Doo E, Hoofnagle J, Sherker A, Torrance R, Hall S, Magee J, Merion R, Spino C, Ye W, Childhood Liver Disease Research Network. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. Hepatology. 2023 02 01; 77(2):530-545. PMID: 36069569; PMCID: PMC10151059.
      Citations:    
    5. Hassan S, Hertel P. Overview of Progressive Familial Intrahepatic Cholestasis. Clin Liver Dis. 2022 08; 26(3):371-390. PMID: 35868680.
      Citations:    Fields:    Translation:Humans
    6. Woreta TA, Van Natta ML, Lazo M, Krishnan A, Neuschwander-Tetri BA, Loomba R, Mae Diehl A, Abdelmalek MF, Chalasani N, Gawrieh S, Dasarathy S, Vuppalanchi R, Siddiqui MS, Kowdley KV, McCullough A, Terrault NA, Behling C, Kleiner DE, Fishbein M, Hertel P, Wilson LA, Mitchell EP, Miriel LA, Clark JM, Tonascia J, Sanyal AJ, NASH Clinical Research Network. Validation of the accuracy of the FAST? score for detecting patients with at-risk nonalcoholic steatohepatitis (NASH) in a North American cohort and comparison to other non-invasive algorithms. PLoS One. 2022; 17(4):e0266859. PMID: 35427375; PMCID: PMC9012361.
      Citations: 1     Fields:    Translation:Humans
    7. Vos MB, Van Natta ML, Blondet NM, Dasarathy S, Fishbein M, Hertel P, Jain AK, Karpen SJ, Lavine JE, Mohammad S, Miriel LA, Molleston JP, Mouzaki M, Sanyal A, Sharkey EP, Schwimmer JB, Tonascia J, Wilson LA, Xanthakos SA, NASH Clinical Research Network. Randomized placebo-controlled trial of losartan for pediatric NAFLD. Hepatology. 2022 08; 76(2):429-444. PMID: 35133671; PMCID: PMC9288975.
      Citations:    Fields:    Translation:Humans
    8. Hertel PM, Hawthorne K, Kim S, Finegold MJ, Shneider BL, Squires JE, Gupta NA, Bull LN, Murray KF, Kerkar N, Ng VL, Molleston JP, Bezerra JA, Loomes KM, Taylor SA, Schwarz KB, Turmelle YP, Rosenthal P, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study. J Pediatr Gastroenterol Nutr. 2021 10 01; 73(4):478-484. PMID: 34310436; PMCID: PMC8448404.
      Citations:    Fields:    Translation:Humans
    9. Hertel PM, Bull LN, Thompson RJ, Goodrich NP, Ye W, Magee JC, Squires RH, Bass LM, Heubi JE, Kim GE, Ranganathan S, Schwarz KB, Bozic MA, Horslen SP, Clifton MS, Turmelle YP, Suchy FJ, Superina RA, Wang KS, Loomes KM, Kamath BM, Sokol RJ, Shneider BL, Childhood Liver Disease Research Network (ChiLDReN). Mutation Analysis and Disease Features at Presentation in a Multi-Center Cohort of Children With Monogenic Cholestasis. J Pediatr Gastroenterol Nutr. 2021 08 01; 73(2):169-177. PMID: 34016879; PMCID: PMC8373673.
      Citations: 2     Fields:    Translation:Humans
    10. Dokic Y, Albahrani Y, Phung T, Patel K, de Guzman M, Hertel P, Hunt R. Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis: Hepatic disease in a child with a novel pathogenic variant of FAM111B. JAAD Case Rep. 2020 Dec; 6(12):1217-1220. PMID: 33294546; PMCID: PMC7701006.
      Citations: 2     
    11. Alfaro-Cruz LM, Barton KR, Hertel PM, Carter BA, Bergner EM, Garcia-Prats JA, Mehollin-Ray AR, Fishman DS. "TPN-oma": A Rare Complication of Lipid Extravasation With Umbilical Venous Catheterization Misplacement. J Pediatr Gastroenterol Nutr. 2020 04; 70(4):e84. PMID: 32205554.
      Citations:    Fields:    Translation:Humans
    12. Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider BL, Rosenthal P, Hertel PM, Karpen SJ, Molleston JP, Murray KF, Schwarz KB, Squires RH, Teckman J, Turmelle YP, Alonso EM, Sherker AH, Magee JC, Sokol RJ, Childhood Liver Disease Research Network. Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology. 2019 01; 69(1):245-257. PMID: 30063078; PMCID: PMC6324969.
      Citations: 11     Fields:    Translation:Humans
    13. Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC, ChiLDReN Network. Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. J Pediatr. 2018 11; 202:179-185.e4. PMID: 30244988; PMCID: PMC6365098.
      Citations: 7     Fields:    Translation:Humans
    14. Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr. 2018 05; 196:139-147.e3. PMID: 29519540; PMCID: PMC5924604.
      Citations: 5     Fields:    Translation:Humans
    15. Zhou Y, Hertel P, Cu J. Case 5: Large Amounts of Urine Bilirubin on Urine Dipstick in a 14-year-old Girl. Pediatr Rev. 2017 Sep; 38(9):440. PMID: 28864738.
      Citations:    Fields:    Translation:Humans
    16. Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL, Childhood Liver Disease Research Network (ChiLDReN). Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2017 05; 65(5):1645-1654. PMID: 28027587; PMCID: PMC5397365.
      Citations: 18     Fields:    Translation:Humans
    17. Sacchet MD, Levy BJ, Hamilton JP, Maksimovskiy A, Hertel PT, Joormann J, Anderson MC, Wagner AD, Gotlib IH. Cognitive and neural consequences of memory suppression in major depressive disorder. Cogn Affect Behav Neurosci. 2017 02; 17(1):77-93. PMID: 27649971; PMCID: PMC5272890.
      Citations: 9     Fields:    Translation:Humans
    18. Ramraj R, Finegold MJ, Brandt ML, Hertel PM, Fallon SC, Shepherd RW, Shneider BL, Harpavat S. Newborn Direct or Conjugated Bilirubin Measurements As a Potential Screen for Biliary Atresia. J Pediatr Gastroenterol Nutr. 2016 06; 62(6):799-803. PMID: 26720765.
      Citations: 17     Fields:    Translation:HumansPHPublic Health
    19. Mouzaki M, Bass LM, Sokol RJ, Piccoli DA, Quammie C, Loomes KM, Heubi JE, Hertel PM, Scheenstra R, Furuya K, Kutsch E, Spinner NB, Robbins KN, Venkat V, Rosenthal P, Beyene J, Baker A, Kamath BM. Early life predictive markers of liver disease outcome in an International, Multicentre Cohort of children with Alagille syndrome. Liver Int. 2016 05; 36(5):755-60. PMID: 26201540; PMCID: PMC5401769.
      Citations: 14     Fields:    Translation:Humans
    20. Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN), Teckman JH. Baseline Analysis of a Young a-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015 Jul; 61(1):94-101. PMID: 25651489; PMCID: PMC4692167.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    21. Zhou S, Hertel PM, Finegold MJ, Wang L, Kerkar N, Wang J, Wong LJ, Plon SE, Sambrotta M, Foskett P, Niu Z, Thompson RJ, Knisely AS. Hepatocellular carcinoma associated with tight-junction protein 2 deficiency. Hepatology. 2015 Dec; 62(6):1914-6. PMID: 25921221; PMCID: PMC4626433.
      Citations: 22     Fields:    Translation:Humans
    22. Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Magee JC, Childhood Liver Disease Research Network (ChiLDReN). Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome. J Pediatr. 2015 Aug; 167(2):390-6.e3. PMID: 26059338; PMCID: PMC4516587.
      Citations: 6     Fields:    Translation:Humans
    23. Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE, Childhood Liver Disease Research and Education Network, Venkat VL. Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia. J Pediatr Gastroenterol Nutr. 2014 Dec; 59(6):702-7. PMID: 25419594; PMCID: PMC4243585.
      Citations: 7     Fields:    Translation:Humans
    24. Tibesar E, Karwowski C, Hertel P, Scheimann A, Karnsakul W. Two Cases of Progressive Familial Intrahepatic Cholestasis Type 2 Presenting with Severe Coagulopathy without Jaundice. Case Rep Pediatr. 2014; 2014:185923. PMID: 24991443; PMCID: PMC4060322.
      Citations:    
    25. Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ, Childhood Liver Disease Research and Education Network (ChiLDREN). Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014 May 07; 311(17):1750-9. PMID: 24794368; PMCID: PMC4303045.
      Citations: 54     Fields:    Translation:Humans
    26. Mor N, Hertel P, Ngo TA, Shachar T, Redak S. Interpretation bias characterizes trait rumination. J Behav Ther Exp Psychiatry. 2014 Mar; 45(1):67-73. PMID: 24001990.
      Citations: 5     Fields:    Translation:Humans
    27. Hertel PM, Crawford SE, Bessard BC, Estes MK. Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles. Vaccine. 2013 Nov 19; 31(48):5778-84. PMID: 23887039; PMCID: PMC3883562.
      Citations: 2     Fields:    Translation:Animals
    28. Hertel PM, Estes MK. Rotavirus and biliary atresia: can causation be proven? Curr Opin Gastroenterol. 2012 Jan; 28(1):10-7. PMID: 22123643; PMCID: PMC8883795.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    29. Patel NC, Hertel PM, Hanson IC, Krance RA, Crawford SE, Estes M, Paul ME. Chronic rotavirus infection in an infant with severe combined immunodeficiency: successful treatment by hematopoietic stem cell transplantation. Clin Immunol. 2012 Mar; 142(3):399-401. PMID: 22244360; PMCID: PMC3932121.
      Citations: 6     Fields:    Translation:HumansCells
    30. Hertel PM, Crawford SE, Finegold MJ, Estes MK. Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia. Virology. 2011 Sep 01; 417(2):281-92. PMID: 21742364; PMCID: PMC3170515.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    31. Patel NC, Hertel PM, Estes MK, de la Morena M, Petru AM, Noroski LM, Revell PA, Hanson IC, Paul ME, Rosenblatt HM, Abramson SL. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. N Engl J Med. 2010 Jan 28; 362(4):314-9. PMID: 20107217; PMCID: PMC4103739.
      Citations: 61     Fields:    Translation:HumansCells
    32. Venkateswaran L, Scaglia F, McLin V, Hertel P, Shchelochkov OA, Karpen S, Mahoney D, Yee DL. Ornithine transcarbamylase deficiency: a possible risk factor for thrombosis. Pediatr Blood Cancer. 2009 Jul; 53(1):100-2. PMID: 19343772; PMCID: PMC4869977.
      Citations: 5     Fields:    Translation:Humans
    33. Hertel PM, Chacko SK, Pal S, Sunehag AL, Haymond MW. Subcutaneous infusion and capillary "finger stick" sampling of stable isotope tracer in metabolic studies. Pediatr Res. 2006 Nov; 60(5):597-601. PMID: 16988196.
      Citations:    Fields:    Translation:Humans
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