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GAD SHAULSKY

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
AddressMolecular and Human Genetics
One Baylor Plaza - S930
Houston TX 77030
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    Collapse Research 
    Collapse research activities and funding
    T32GM008307     (SHAULSKY, GAD)Jul 1, 1990 - Jun 30, 2021
    NIH/NIGMS
    Program in Human and Molecular Genetics
    Role: Principal Investigator

    R21AA012381     (SHAULSKY, GAD)Mar 1, 2000 - Feb 28, 2002
    NIH/NIAAA
    MECHANISMS OF ETHANOL TOXICITY IN DICTYOSTELIUM
    Role: Principal Investigator

    P01HD039691     (KUSPA, ADAM)Jun 19, 2001 - Apr 30, 2017
    NIH/NICHD
    Functional Genomics of Dictyostelium
    Role: Co-Principal Investigator

    R21HD055923     (SHAULSKY, GAD)Aug 1, 2007 - Jul 31, 2009
    NIH/NICHD
    Genetic Analysis of Dedifferentiation
    Role: Principal Investigator

    R01GM084992     (SHAULSKY, GAD)Sep 30, 2009 - Aug 31, 2017
    NIH/NIGMS
    The Molecular Basis of Allorecognition in Social Amoeba
    Role: Principal Investigator

    R01GM098276     (SHAULSKY, GAD)May 1, 2012 - Apr 30, 2015
    NIH/NIGMS
    The role of kin-recognition in social evolution
    Role: Principal Investigator

    R35GM118016     (SHAULSKY, GAD)May 12, 2016 - Apr 30, 2021
    NIH/NIGMS
    The molecular basis of allorecognition and its roles in development and evolution of the social amoeba D. discoideum
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rubin M, Miller AD, Katoh-Kurasawa M, Dinh C, Kuspa A, Shaulsky G. Cooperative predation in the social amoebae Dictyostelium discoideum. PLoS One. 2019; 14(1):e0209438. PMID: 30625171.
      View in: PubMed
    2. Chen X, Köllner TG, Shaulsky G, Jia Q, Dickschat JS, Gershenzon J, Chen F. Diversity and Functional Evolution of Terpene Synthases in Dictyostelid Social Amoebae. Sci Rep. 2018 Sep 25; 8(1):14361. PMID: 30254228.
      View in: PubMed
    3. Swatson WS, Katoh-Kurasawa M, Shaulsky G, Alexander S. Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum. PLoS One. 2017; 12(11):e0187562. PMID: 29135990.
      View in: PubMed
    4. Hirose S, Chen G, Kuspa A, Shaulsky G. The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition. J Cell Sci. 2017 Dec 01; 130(23):4002-4012. PMID: 29038229.
      View in: PubMed
    5. Stajdohar M, Rosengarten RD, Kokosar J, Jeran L, Blenkus D, Shaulsky G, Zupan B. dictyExpress: a web-based platform for sequence data management and analytics in Dictyostelium and beyond. BMC Bioinformatics. 2017 Jun 02; 18(1):291. PMID: 28578698.
      View in: PubMed
    6. Rosengarten RD, Santhanam B, Kokosar J, Shaulsky G. The Long Noncoding RNA Transcriptome of Dictyostelium discoideum Development. G3 (Bethesda). 2017 02 09; 7(2):387-398. PMID: 27932387.
      View in: PubMed
    7. Hirose, S. Chen, G. Kuspa, A. Shaulsky, G. The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition. J Cell Sci. 2017; 130(23):4002-4012.
    8. Chen X, Köllner TG, Jia Q, Norris A, Santhanam B, Rabe P, Dickschat JS, Shaulsky G, Gershenzon J, Chen F. Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12132-12137. PMID: 27790999.
      View in: PubMed
    9. Li CL, Santhanam B, Webb AN, Zupan B, Shaulsky G. Gene discovery by chemical mutagenesis and whole-genome sequencing in Dictyostelium. Genome Res. 2016 09; 26(9):1268-76. PMID: 27307293.
      View in: PubMed
    10. Katoh-Kurasawa M, Santhanam B, Shaulsky G. The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium. J Cell Sci. 2016 Mar 09. PMID: 26962009.
      View in: PubMed
    11. Žitnik M, Nam EA, Dinh C, Kuspa A, Shaulsky G, Zupan B. Gene Prioritization by Compressive Data Fusion and Chaining. PLoS Comput Biol. 2015 Oct; 11(10):e1004552. PMID: 26465776.
      View in: PubMed
    12. Hirose S, Santhanam B, Katoh-Kurosawa M, Shaulsky G, Kuspa A. Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum. Development. 2015 Oct 15; 142(20):3561-70. PMID: 26395484; PMCID: PMC4631765 [Available on 10/15/16].
    13. Li CL, Chen G, Webb AN, Shaulsky G. Altered N-glycosylation modulates TgrB1- and TgrC1-mediated development but not allorecognition in Dictyostelium. J Cell Sci. 2015 Nov 01; 128(21):3990-6. PMID: 26359303; PMCID: PMC4647166 [Available on 11/01/16].
    14. Santhanam B, Cai H, Devreotes PN, Shaulsky G, Katoh-Kurasawa M. The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium. Nat Commun. 2015 Jul 06; 6:7551. PMID: 26144553; PMCID: PMC4506546.
    15. Ostrowski EA, Shen Y, Tian X, Sucgang R, Jiang H, Qu J, Katoh-Kurasawa M, Brock DA, Dinh C, Lara-Garduno F, Lee SL, Kovar CL, Dinh HH, Korchina V, Jackson L, Patil S, Han Y, Chaboub L, Shaulsky G, Muzny DM, Worley KC, Gibbs RA, Richards S, Kuspa A, Strassmann JE, Queller DC. Genomic signatures of cooperation and conflict in the social amoeba. Curr Biol. 2015 Jun 15; 25(12):1661-5. PMID: 26051890; PMCID: PMC4591038.
    16. Rosengarten RD, Beltran PR, Shaulsky G. A deep coverage Dictyostelium discoideum genomic DNA library replicates stably in Escherichia coli. Genomics. 2015 Oct; 106(4):249-55. PMID: 26028264; PMCID: PMC4575855 [Available on 10/01/16].
    17. Ho HI, Shaulsky G. Temporal regulation of kin recognition maintains recognition-cue diversity and suppresses cheating. Nat Commun. 2015 May 28; 6:7144. PMID: 26018043.
      View in: PubMed
    18. Wang Y, Shaulsky G. TgrC1 Has Distinct Functions in Dictyostelium Development and Allorecognition. PLoS One. 2015; 10(4):e0124270. PMID: 25894230; PMCID: PMC4404348.
    19. Rosengarten RD, Santhanam B, Fuller D, Katoh-Kurasawa M, Loomis WF, Zupan B, Shaulsky G. Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum. BMC Genomics. 2015 Apr 13; 16:294. PMID: 25887420; PMCID: PMC4403905.
    20. Miranda ER, Nam EA, Kuspa A, Shaulsky G. The ABC transporter, AbcB3, mediates cAMP export in D. discoideum development. Dev Biol. 2015 Jan 15; 397(2):203-11. PMID: 25448698; PMCID: PMC4277735.
    21. Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, Walhout AJM, Bouget FY, Ratsch G, Larrondo LF, Ecker JR, Hughes TR. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11; 158(6):1431-1443. PMID: 25215497; PMCID: PMC4163041.
    22. Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science. 2014 Mar 21; 343(6177):1249531. PMID: 24653039; PMCID: PMC4061987.
    23. Miranda ER, Zhuchenko O, Toplak M, Santhanam B, Zupan B, Kuspa A, Shaulsky G. ABC transporters in Dictyostelium discoideum development. PLoS One. 2013; 8(8):e70040. PMID: 23967067; PMCID: PMC3743828.
    24. Ho HI, Hirose S, Kuspa A, Shaulsky G. Kin recognition protects cooperators against cheaters. Curr Biol. 2013 Aug 19; 23(16):1590-5. PMID: 23910661; PMCID: PMC3759992.
    25. Nasser W, Santhanam B, Miranda ER, Parikh A, Juneja K, Rot G, Dinh C, Chen R, Zupan B, Shaulsky G, Kuspa A. Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions. Curr Biol. 2013 May 20; 23(10):862-72. PMID: 23664307; PMCID: PMC3914002.
    26. Santorelli LA, Kuspa A, Shaulsky G, Queller DC, Strassmann JE. A new social gene in Dictyostelium discoideum, chtB. BMC Evol Biol. 2013 Jan 09; 13:4. PMID: 23298336; PMCID: PMC3559258.
    27. Miranda ER, Rot G, Toplak M, Santhanam B, Curk T, Shaulsky G, Zupan B. Transcriptional profiling of Dictyostelium with RNA sequencing. Methods Mol Biol. 2013; 983:139-71. PMID: 23494306; PMCID: PMC3892559.
    28. Huang E, Talukder S, Hughes TR, Curk T, Zupan B, Shaulsky G, Katoh-Kurasawa M. BzpF is a CREB-like transcription factor that regulates spore maturation and stability in Dictyostelium. Dev Biol. 2011 Oct 01; 358(1):137-46. PMID: 21810415; PMCID: PMC3180911.
    29. Phillips JE, Huang E, Shaulsky G, Gomer RH. The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium. PLoS One. 2011; 6(7):e21765. PMID: 21760904; PMCID: PMC3131300.
    30. Hirose S, Benabentos R, Ho HI, Kuspa A, Shaulsky G. Self-recognition in social amoebae is mediated by allelic pairs of tiger genes. Science. 2011 Jul 22; 333(6041):467-70. PMID: 21700835; PMCID: PMC3142563.
    31. Loomis WF, Shaulsky G. Developmental changes in transcriptional profiles. Dev Growth Differ. 2011 May; 53(4):567-75. PMID: 21447097.
      View in: PubMed
    32. Sucgang R, Kuo A, Tian X, Salerno W, Parikh A, Feasley CL, Dalin E, Tu H, Huang E, Barry K, Lindquist E, Shapiro H, Bruce D, Schmutz J, Salamov A, Fey P, Gaudet P, Anjard C, Babu MM, Basu S, Bushmanova Y, van der Wel H, Katoh-Kurasawa M, Dinh C, Coutinho PM, Saito T, Elias M, Schaap P, Kay RR, Henrissat B, Eichinger L, Rivero F, Putnam NH, West CM, Loomis WF, Chisholm RL, Shaulsky G, Strassmann JE, Queller DC, Kuspa A, Grigoriev IV. Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biol. 2011; 12(2):R20. PMID: 21356102; PMCID: PMC3188802.
    33. Parikh A, Huang E, Dinh C, Zupan B, Kuspa A, Subramanian D, Shaulsky G. New components of the Dictyostelium PKA pathway revealed by Bayesian analysis of expression data. BMC Bioinformatics. 2010 Mar 31; 11:163. PMID: 20356373; PMCID: PMC2873529.
    34. Parikh A, Miranda ER, Katoh-Kurasawa M, Fuller D, Rot G, Zagar L, Curk T, Sucgang R, Chen R, Zupan B, Loomis WF, Kuspa A, Shaulsky G. Conserved developmental transcriptomes in evolutionarily divergent species. Genome Biol. 2010; 11(3):R35. PMID: 20236529; PMCID: PMC2864575.
    35. Khare A, Shaulsky G. Cheating by exploitation of developmental prestalk patterning in Dictyostelium discoideum. PLoS Genet. 2010 Feb 26; 6(2):e1000854. PMID: 20195510; PMCID: PMC2829058.
    36. Khare A, Santorelli LA, Strassmann JE, Queller DC, Kuspa A, Shaulsky G. Cheater-resistance is not futile. Nature. 2009 Oct 15; 461(7266):980-2. PMID: 19794414.
      View in: PubMed
    37. Rot G, Parikh A, Curk T, Kuspa A, Shaulsky G, Zupan B. dictyExpress: a Dictyostelium discoideum gene expression database with an explorative data analysis web-based interface. BMC Bioinformatics. 2009 Aug 25; 10:265. PMID: 19706156; PMCID: PMC2738683.
    38. Ostrowski EA, Shaulsky G. Learning to get along despite struggling to get by. Genome Biol. 2009; 10(5):218. PMID: 19519929; PMCID: PMC2718508.
    39. Benabentos R, Hirose S, Sucgang R, Curk T, Katoh M, Ostrowski EA, Strassmann JE, Queller DC, Zupan B, Shaulsky G, Kuspa A. Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium. Curr Biol. 2009 Apr 14; 19(7):567-72. PMID: 19285397; PMCID: PMC2694408.
    40. Ostrowski EA, Katoh M, Shaulsky G, Queller DC, Strassmann JE. Kin discrimination increases with genetic distance in a social amoeba. PLoS Biol. 2008 Nov 25; 6(11):e287. PMID: 19067487.
      View in: PubMed
    41. Fey P, Gaudet P, Curk T, Zupan B, Just EM, Basu S, Merchant SN, Bushmanova YA, Shaulsky G, Kibbe WA, Chisholm RL. dictyBase--a Dictyostelium bioinformatics resource update. Nucleic Acids Res. 2009 Jan; 37(Database issue):D515-9. PMID: 18974179.
      View in: PubMed
    42. Santorelli LA, Thompson CR, Villegas E, Svetz J, Dinh C, Parikh A, Sucgang R, Kuspa A, Strassmann JE, Queller DC, Shaulsky G. Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae. Nature. 2008 Feb 28; 451(7182):1107-10. PMID: 18272966.
      View in: PubMed
    43. Katoh M, Chen G, Roberge E, Shaulsky G, Kuspa A. Developmental commitment in Dictyostelium discoideum. Eukaryot Cell. 2007 Nov; 6(11):2038-45. PMID: 17905919; PMCID: PMC2168402.
    44. Van Driessche N, Alexander H, Min J, Kuspa A, Alexander S, Shaulsky G. Global transcriptional responses to cisplatin in Dictyostelium discoideum identify potential drug targets. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15406-11. PMID: 17878305; PMCID: PMC2000517.
    45. Shaulsky G, Kessin RH. The cold war of the social amoebae. Curr Biol. 2007 Aug 21; 17(16):R684-92. PMID: 17714662.
      View in: PubMed
    46. Mendoza MC, Booth EO, Shaulsky G, Firtel RA. MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis. Mol Cell Biol. 2007 May; 27(10):3817-27. PMID: 17353263; PMCID: PMC1899987.
    47. Mehdiabadi NJ, Jack CN, Farnham TT, Platt TG, Kalla SE, Shaulsky G, Queller DC, Strassmann JE. Social evolution: kin preference in a social microbe. Nature. 2006 Aug 24; 442(7105):881-2. PMID: 16929288.
      View in: PubMed
    48. Khare A, Shaulsky G. First among equals: competition between genetically identical cells. Nat Rev Genet. 2006 Jul; 7(7):577-83. PMID: 16702983.
      View in: PubMed
    49. Chubb JR, Bloomfield G, Xu Q, Kaller M, Ivens A, Skelton J, Turner BM, Nellen W, Shaulsky G, Kay RR, Bickmore WA, Singer RH. Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase. Dev Biol. 2006 Apr 15; 292(2):519-32. PMID: 16469305.
      View in: PubMed
    50. Huang E, Blagg SL, Keller T, Katoh M, Shaulsky G, Thompson CR. bZIP transcription factor interactions regulate DIF responses in Dictyostelium. Development. 2006 Feb; 133(3):449-58. PMID: 16410410.
      View in: PubMed
    51. Katoh M, Curk T, Xu Q, Zupan B, Kuspa A, Shaulsky G. Developmentally regulated DNA methylation in Dictyostelium discoideum. Eukaryot Cell. 2006 Jan; 5(1):18-25. PMID: 16400165; PMCID: PMC1360260.
    52. Song J, Xu Q, Olsen R, Loomis WF, Shaulsky G, Kuspa A, Sucgang R. Comparing the Dictyostelium and Entamoeba genomes reveals an ancient split in the Conosa lineage. PLoS Comput Biol. 2005 Dec; 1(7):e71. PMID: 16362072; PMCID: PMC1314882.
    53. Booth EO, Van Driessche N, Zhuchenko O, Kuspa A, Shaulsky G. Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes. Bioinformatics. 2005 Dec 15; 21(24):4371-7. PMID: 16234315.
      View in: PubMed
    54. Juvan P, Demsar J, Shaulsky G, Zupan B. GenePath: from mutations to genetic networks and back. Nucleic Acids Res. 2005 Jul 01; 33(Web Server issue):W749-52. PMID: 15980576; PMCID: PMC1160187.
    55. Van Driessche N, Demsar J, Booth EO, Hill P, Juvan P, Zupan B, Kuspa A, Shaulsky G. Epistasis analysis with global transcriptional phenotypes. Nat Genet. 2005 May; 37(5):471-7. PMID: 15821735.
      View in: PubMed
    56. Xu Q, Shaulsky G. GOAT: An R Tool for Analysing Gene Ontologytrade mark Term Enrichment. Appl Bioinformatics. 2005; 4(4):281-3. PMID: 16309346.
      View in: PubMed
    57. Faix J, Kreppel L, Shaulsky G, Schleicher M, Kimmel AR. A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res. 2004 Oct 26; 32(19):e143. PMID: 15507682; PMCID: PMC528815.
    58. Foster KR, Shaulsky G, Strassmann JE, Queller DC, Thompson CR. Pleiotropy as a mechanism to stabilize cooperation. Nature. 2004 Oct 07; 431(7009):693-6. PMID: 15470429.
      View in: PubMed
    59. Xu Q, Ibarra M, Mahadeo D, Shaw C, Huang E, Kuspa A, Cotter D, Shaulsky G. Transcriptional transitions during Dictyostelium spore germination. Eukaryot Cell. 2004 Oct; 3(5):1101-10. PMID: 15470238; PMCID: PMC522591.
    60. Curk T, Demsar J, Xu Q, Leban G, Petrovic U, Bratko I, Shaulsky G, Zupan B. Microarray data mining with visual programming. Bioinformatics. 2005 Feb 01; 21(3):396-8. PMID: 15308546.
      View in: PubMed
    61. Maeda M, Lu S, Shaulsky G, Miyazaki Y, Kuwayama H, Tanaka Y, Kuspa A, Loomis WF. Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science. 2004 May 07; 304(5672):875-8. PMID: 15131307.
      View in: PubMed
    62. Chen G, Shaulsky G, Kuspa A. Tissue-specific G1-phase cell-cycle arrest prior to terminal differentiation in Dictyostelium. Development. 2004 Jun; 131(11):2619-30. PMID: 15128662.
      View in: PubMed
    63. Katoh M, Shaw C, Xu Q, Van Driessche N, Morio T, Kuwayama H, Obara S, Urushihara H, Tanaka Y, Shaulsky G. An orderly retreat: Dedifferentiation is a regulated process. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7005-10. PMID: 15103019; PMCID: PMC406456.
    64. Thompson CR, Fu Q, Buhay C, Kay RR, Shaulsky G. A bZIP/bRLZ transcription factor required for DIF signaling in Dictyostelium. Development. 2004 Feb; 131(3):513-23. PMID: 14729573.
      View in: PubMed
    65. Kibler K, Svetz J, Nguyen TL, Shaw C, Shaulsky G. A cell-adhesion pathway regulates intercellular communication during Dictyostelium development. Dev Biol. 2003 Dec 15; 264(2):506-21. PMID: 14651934.
      View in: PubMed
    66. Zupan B, Bratko I, Demsar J, Juvan P, Curk T, Borstnik U, Beck JR, Halter J, Kuspa A, Shaulsky G. GenePath: a system for inference of genetic networks and proposal of genetic experiments. Artif Intell Med. 2003 Sep-Oct; 29(1-2):107-30. PMID: 12957783.
      View in: PubMed
    67. Kibler K, Nguyen TL, Svetz J, Van Driessche N, Ibarra M, Thompson C, Shaw C, Shaulsky G. A novel developmental mechanism in Dictyostelium revealed in a screen for communication mutants. Dev Biol. 2003 Jul 15; 259(2):193-208. PMID: 12871696.
      View in: PubMed
    68. Good JR, Cabral M, Sharma S, Yang J, Van Driessche N, Shaw CA, Shaulsky G, Kuspa A. TagA, a putative serine protease/ABC transporter of Dictyostelium that is required for cell fate determination at the onset of development. Development. 2003 Jul; 130(13):2953-65. PMID: 12756178.
      View in: PubMed
    69. Sucgang R, Chen G, Liu W, Lindsay R, Lu J, Muzny D, Shaulsky G, Loomis W, Gibbs R, Kuspa A. Sequence and structure of the extrachromosomal palindrome encoding the ribosomal RNA genes in Dictyostelium. Nucleic Acids Res. 2003 May 01; 31(9):2361-8. PMID: 12711681; PMCID: PMC154234.
    70. Zupan B, Demsar J, Bratko I, Juvan P, Halter JA, Kuspa A, Shaulsky G. GenePath: a system for automated construction of genetic networks from mutant data. Bioinformatics. 2003 Feb 12; 19(3):383-9. PMID: 12584124.
      View in: PubMed
    71. Shaulsky G, Loomis WF. Gene expression patterns in Dictyostelium using microarrays. Protist. 2002 Jun; 153(2):93-8. PMID: 12125760.
      View in: PubMed
    72. Van Driessche N, Shaw C, Katoh M, Morio T, Sucgang R, Ibarra M, Kuwayama H, Saito T, Urushihara H, Maeda M, Takeuchi I, Ochiai H, Eaton W, Tollett J, Halter J, Kuspa A, Tanaka Y, Shaulsky G. A transcriptional profile of multicellular development in Dictyostelium discoideum. Development. 2002 Apr; 129(7):1543-52. PMID: 11923193.
      View in: PubMed
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