Last Name


TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
ROOM 530.01
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Maturu P, Wei-Liang Y, Androutsopoulos VP, Jiang W, Wang L, Tsatsakis AM, Couroucli XI. Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD). Food Chem Toxicol. 2018 Apr; 114:23-33. PMID: 29432836.
      View in: PubMed
    2. Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI. ß-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. Toxicol Appl Pharmacol. 2018 Jan 15; 339:133-142. PMID: 29180065.
      View in: PubMed
    3. Jiang W, Maturu P, Liang YW, Wang L, Lingappan K, Couroucli X. Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice. Biochem Biophys Res Commun. 2018 01 01; 495(1):408-413. PMID: 29101037.
      View in: PubMed
    4. Coarfa C, Zhang Y, Maity S, Perera D, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K. Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 17; ajplung.00230.2017. PMID: 28818871.
      View in: PubMed
    5. Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B. Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Sci Rep. 2017 Apr 04; 7(1):642. PMID: 28377578.
      View in: PubMed
    6. Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI. Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal ?-napthoflavone (BNF) administration: Implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Sci. 2017 Feb 13. PMID: 28201809.
      View in: PubMed
    7. Couroucli XI, Placencia JL, Cates LA, Suresh GK. Should we still use vitamin A to prevent bronchopulmonary dysplasia? J Perinatol. 2016 Aug; 36(8):581-5. PMID: 27228508.
      View in: PubMed
    8. Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016 May 25. PMID: 27235555.
      View in: PubMed
    9. Couroucli XI. Vitamin A deficiency in adolescents: rare or underdiagnosed? Lancet. 2016 Jan 2; 387(10013):94. PMID: 26766347.
      View in: PubMed
    10. Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015 May 4; 331:14-23. PMID: 25703676; PMCID: PMC4406849.
    11. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282; PMCID: PMC4418801.
    12. Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B. Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PLoS One. 2014; 9(7):e101581. PMID: 25003466; PMCID: PMC4086819.
    13. Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun. 2014 Aug 8; 450(4):1345-50. PMID: 24997337; PMCID: PMC4216694.
    14. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714; PMCID: PMC4200035.
    15. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529; PMCID: PMC4169345.
    16. Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol Appl Pharmacol. 2013 Oct 15; 272(2):281-90. PMID: 23792423; PMCID: PMC4201582.
    17. Shivanna B, Zhang W, Jiang W, Welty SE, Couroucli XI, Wang L, Moorthy B. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol. 2013 Mar 15; 267(3):209-17. PMID: 23337360; PMCID: PMC3582791.
    18. Zhou GD, Zhu H, Phillips TD, Wang J, Wang SZ, Wang F, Amendt BA, Couroucli XI, Donnelly KC, Moorthy B. Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One. 2011; 6(10):e26589. PMID: 22066002; PMCID: PMC3204992.
    19. Shivanna B, Chu C, Welty SE, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor. Free Radic Biol Med. 2011 Nov 15; 51(10):1910-7. PMID: 21906671; PMCID: PMC3901644.
    20. Shivanna B, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2011 Oct; 339(1):106-14. PMID: 21768223; PMCID: PMC3186283.
    21. Couroucli XI, Liang YH, Jiang W, Wang L, Barrios R, Yang P, Moorthy B. Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Appl Pharmacol. 2011 Oct 15; 256(2):83-94. PMID: 21745492; PMCID: PMC3196339.
    22. Jiang W, Couroucli XI, Wang L, Barrios R, Moorthy B. Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo. Biochem Biophys Res Commun. 2011 Apr 1; 407(1):79-85. PMID: 21362406; PMCID: PMC3123253.
    23. Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, Moorthy B. Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther. 2010 Nov; 335(2):369-79. PMID: 20732958; PMCID: PMC2967398.
    24. Bhakta KY, Jiang W, Couroucli XI, Fazili IS, Muthiah K, Moorthy B. Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury. Toxicol Appl Pharmacol. 2008 Dec 1; 233(2):169-78. PMID: 18824009; PMCID: PMC2646384.
    25. Moorthy B, Muthiah K, Fazili IS, Kondraganti SR, Wang L, Couroucli XI, Jiang W. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1071-7. PMID: 17276403.
      View in: PubMed
    26. Couroucli XI, Wei YH, Jiang W, Muthiah K, Evey LW, Barrios R, Moorthy B. Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat: implications for lung injury. Pediatr Res. 2006 Mar; 59(3):401-6. PMID: 16492979.
      View in: PubMed
    27. Couroucli XI, Liang YW, Jiang W, Barrios R, Moorthy B. Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2006 Jun; 317(3):946-54. PMID: 16497785.
      View in: PubMed
    28. Sinha A, Muthiah K, Jiang W, Couroucli X, Barrios R, Moorthy B. Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone. Toxicol Sci. 2005 Sep; 87(1):204-12. PMID: 15958656.
      View in: PubMed
    29. Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, Yu L, Avery SE, Moorthy B. Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury. J Pharmacol Exp Ther. 2004 Aug; 310(2):512-9. PMID: 15123765.
      View in: PubMed
    30. Couroucli XI, Welty SE, Geske RS, Moorthy B. Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury. Mol Pharmacol. 2002 Mar; 61(3):507-15. PMID: 11854430.
      View in: PubMed
    31. Couroucli XI, Welty SE, Ramsay PL, Wearden ME, Fuentes-Garcia FJ, Ni J, Jacobs TN, Towbin JA, Bowles NE. Detection of microorganisms in the tracheal aspirates of preterm infants by polymerase chain reaction: association of adenovirus infection with bronchopulmonary dysplasia. Pediatr Res. 2000 Feb; 47(2):225-32. PMID: 10674351.
      View in: PubMed
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