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Vladimir V. Didenko

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurosurgery
DivisionNeurosurgery
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
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    R03AG022664     (DIDENKO, VLADIMIR V)Sep 30, 2003 - Aug 31, 2006
    NIH/NIA
    Free radicals detection in aging brain by fullerenes
    Role: Principal Investigator

    R21NS054855     (DIDENKO, VLADIMIR V)Mar 29, 2006 - Feb 28, 2009
    NIH/NINDS
    Detection of Topoisomerase II Mediated DNA Damage in Stroke
    Role: Principal Investigator

    R21EB006301     (DIDENKO, VLADIMIR V)Apr 1, 2006 - Mar 31, 2010
    NIH/NIBIB
    Semi-artificial nanomachines for detection of DNA damage and apoptosis
    Role: Principal Investigator

    R01NS062842     (DIDENKO, VLADIMIR V)Apr 1, 2009 - Mar 31, 2014
    NIH/NINDS
    Ligatable fluorescent probes using energy transfer for apoptosis detection
    Role: Principal Investigator

    R21NS064403     (DIDENKO, VLADIMIR V)Jun 15, 2009 - May 31, 2012
    NIH/NINDS
    Assay for dual detection of apoptosis
    Role: Principal Investigator

    R21CA178365     (DIDENKO, VLADIMIR V)Jul 1, 2013 - Jun 30, 2015
    NIH/NCI
    Apoptosis driven by elastase inhibitor: new approach to detection and study.
    Role: Principal Investigator

    R01NS082553     (DIDENKO, VLADIMIR V)Apr 1, 2014 - Mar 31, 2017
    NIH/NINDS
    FRET probes for analysis of serpin-mediated apoptosis in focal brain ischemia
    Role: Principal Investigator

    R21AR066931     (DIDENKO, VLADIMIR V)Jul 1, 2014 - May 31, 2016
    NIH/NIAMS
    APMV-topoisomerase assay for comprehensive assessment of efferocytosis in tissue
    Role: Principal Investigator

    R21EB022788     (DIDENKO, VLADIMIR V)Mar 1, 2017 - Dec 31, 2018
    NIH/NIBIB
    Express assay for specific fluorescence imaging of apoptosis via phosphatase-assisted topoligation.
    Role: Principal Investigator

    R21NS101620     (DIDENKO, VLADIMIR V)Mar 15, 2017 - Feb 28, 2019
    NIH/NINDS
    Imaging mRNA turnover in P-bodies and its application to brain ischemia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Minchew CL, Didenko VV. Dual Detection of Nucleolytic and Proteolytic Markers of Lysosomal Cell Death: DNase II-Type Breaks and Cathepsin D. Methods Mol Biol. 2017; 1554:229-236. PMID: 28185196.
      View in: PubMed
    2. Hauser P, Wang S, Didenko VV. Apoptotic Bodies: Selective Detection in Extracellular Vesicles. Methods Mol Biol. 2017; 1554:193-200. PMID: 28185192.
      View in: PubMed
    3. Didenko VV. Express FRET Labeling and Analysis of Phagocytic Clearance. Methods Mol Biol. 2017; 1644:3-11. PMID: 28710749.
      View in: PubMed
    4. Minchew CL, Didenko VV. Quick Detection of DNase II-Type Breaks in Formalin-Fixed Tissue Sections. Methods Mol Biol. 2017; 1644:113-119. PMID: 28710757.
      View in: PubMed
    5. Didenko VV. Zebra Tail Amplification: Accelerated Detection of Apoptotic Blunt-Ended DNA Breaks by In Situ Ligation. Methods Mol Biol. 2017; 1644:167-177. PMID: 28710763.
      View in: PubMed
    6. Minchew CL, Didenko VV. Nanoblinker: Brownian motion powered bio-nanomachine for FRET detection of phagocytic phase of apoptosis. PLoS One. 2014; 9(9):e108734. PMID: 25268504.
      View in: PubMed
    7. Minchew CL, Didenko VV. Assessing phagocytic clearance of cell death in experimental stroke by ligatable fluorescent probes. J Vis Exp. 2014 May 27; (87). PMID: 24894100.
      View in: PubMed
    8. Didenko VV. Selective detection of phagocytic phase of apoptosis in fixed tissue sections. Methods Mol Biol. 2014; 1094:159-66. PMID: 24162987.
      View in: PubMed
    9. Minchew CL, Didenko VV. Selective transport of cationized fluorescent topoisomerase into nuclei of live cells for DNA damage studies. Methods Mol Biol. 2014; 1094:167-75. PMID: 24162988.
      View in: PubMed
    10. Minchew CL, Didenko VV. In vitro assembly of semi-artificial molecular machine and its use for detection of DNA damage. J Vis Exp. 2012 Jan 11; (59):e3628. PMID: 22258163.
      View in: PubMed
    11. Minchew CL, Didenko VV. Fluorescent probes detecting the phagocytic phase of apoptosis: enzyme-substrate complexes of topoisomerase and DNA. Molecules. 2011 Jun 03; 16(6):4599-614. PMID: 21642935.
      View in: PubMed
    12. Didenko VV. 5'OH DNA breaks in apoptosis and their labeling by topoisomerase-based approach. Methods Mol Biol. 2011; 682:77-87. PMID: 21057922.
      View in: PubMed
    13. Hornsby PJ, Didenko VV. In situ ligation: a decade and a half of experience. Methods Mol Biol. 2011; 682:49-63. PMID: 21057920.
      View in: PubMed
    14. Didenko VV. In situ ligation simplified: using PCR fragments for detection of double-strand DNA breaks in tissue sections. Methods Mol Biol. 2011; 682:65-75. PMID: 21057921.
      View in: PubMed
    15. Didenko VV. In situ labeling of DNA breaks and apoptosis by T7 DNA polymerase. Methods Mol Biol. 2011; 682:37-48. PMID: 21057919.
      View in: PubMed
    16. Didenko VV, Baskin DS. Horseradish peroxidase-driven fluorescent labeling of nanotubes with quantum dots. Biotechniques. 2006 Mar; 40(3):295-6, 298, 300-2. PMID: 16568818.
      View in: PubMed
    17. Didenko VV. Oscillating probe for dual detection of 5'PO4 and 5'OH DNA breaks in tissue sections. Methods Mol Biol. 2006; 335:59-69. PMID: 16785620.
      View in: PubMed
    18. Didenko VV, Ngo H, Baskin DS. Polyethyleneimine as a transmembrane carrier of fluorescently labeled proteins and antibodies. Anal Biochem. 2005 Sep 15; 344(2):168-73. PMID: 16095551.
      View in: PubMed
    19. Didenko VV, Moore VC, Baskin DS, Smalley RE. Visualization of individual single-walled carbon nanotubes by fluorescent polymer wrapping. Nano Lett. 2005 Aug; 5(8):1563-7. PMID: 16089489.
      View in: PubMed
    20. Didenko VV, Minchew CL, Shuman S, Baskin DS. Semi-artificial Fluorescent Molecular Machine for DNA Damage Detection. Nano Lett. 2004 Dec; 4(12):2461-6. PMID: 17330146.
      View in: PubMed
    21. Baskin DS, Ngo H, Didenko VV. Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts. Toxicol Sci. 2003 Aug; 74(2):361-8. PMID: 12773768.
      View in: PubMed
    22. Didenko VV, Ngo H, Baskin DS. Early necrotic DNA degradation: presence of blunt-ended DNA breaks, 3' and 5' overhangs in apoptosis, but only 5' overhangs in early necrosis. Am J Pathol. 2003 May; 162(5):1571-8. PMID: 12707041.
      View in: PubMed
    23. Didenko VV, Ngo H, Minchew CL, Boudreaux DJ, Widmayer MA, Baskin DS. Visualization of irreparable ischemic damage in brain by selective labeling of double strand blunt-ended DNA breaks. Mol Med. 2002 Dec; 8(12):818-23. PMID: 12606816.
      View in: PubMed
    24. Didenko VV, Ngo H, Minchew CL, Boudreaux DJ, Widmayer MA, Baskin DS. Caspase-3-dependent and -independent apoptosis in focal brain ischemia. Mol Med. 2002 Jul; 8(7):347-52. PMID: 12393932.
      View in: PubMed
    25. Didenko VV, Ngo HN, Minchew C, Baskin DS. Apoptosis of T lymphocytes invading glioblastomas multiforme: a possible tumor defense mechanism. J Neurosurg. 2002 Mar; 96(3):580-4. PMID: 11883844.
      View in: PubMed
    26. Didenko VV. Early shape-shifting FRET probe. Biotechniques. 2002 Feb; 32(2):272. PMID: 11848401.
      View in: PubMed
    27. Hornsby PJ, Didenko VV. In situ DNA ligation as a method for labeling apoptotic cells in tissue sections. An overview. Methods Mol Biol. 2002; 203:133-41. PMID: 12073437.
      View in: PubMed
    28. Didenko VV, Ngo H, Baskin DS. In situ detection of double-strand DNA breaks with terminal 5'OH groups. Methods Mol Biol. 2002; 203:153-9. PMID: 12073439.
      View in: PubMed
    29. Didenko VV. Detection of specific double-strand DNA breaks and apoptosis in situ using T4 DNA ligase. Methods Mol Biol. 2002; 203:143-51. PMID: 12073438.
      View in: PubMed
    30. Didenko VV. DNA probes using fluorescence resonance energy transfer (FRET): designs and applications. Biotechniques. 2001 Nov; 31(5):1106-16, 1118, 1120-1. PMID: 11730017.
      View in: PubMed
    31. Didenko VV, Boudreaux DJ, Baskin DS. Substantial background reduction in ligase-based apoptosis detection using newly designed hairpin oligonucleotide probes. Biotechniques. 1999 Dec; 27(6):1130-2. PMID: 10631490.
      View in: PubMed
    32. Didenko VV, Wang X, Yang L, Hornsby PJ. DNA damage and p21(WAF1/CIP1/SDI1) in experimental injury of the rat adrenal cortex and trauma-associated damage of the human adrenal cortex. J Pathol. 1999 Sep; 189(1):119-26. PMID: 10451498.
      View in: PubMed
    33. Bozkurt B, Kribbs SB, Clubb FJ, Michael LH, Didenko VV, Hornsby PJ, Seta Y, Oral H, Spinale FG, Mann DL. Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circulation. 1998 Apr 14; 97(14):1382-91. PMID: 9577950.
      View in: PubMed
    34. Didenko VV, Tunstead JR, Hornsby PJ. Biotin-labeled hairpin oligonucleotides: probes to detect double-strand breaks in DNA in apoptotic cells. Am J Pathol. 1998 Apr; 152(4):897-902. PMID: 9546350.
      View in: PubMed
    35. Didenko VV, Hornsby PJ. Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis. J Cell Biol. 1996 Dec; 135(5):1369-76. PMID: 8947557.
      View in: PubMed
    36. Didenko VV, Hornsby PJ. A quantitative luminescence assay for nonradioactive nucleic acid probes. J Histochem Cytochem. 1996 Jun; 44(6):657-60. PMID: 8666750.
      View in: PubMed
    37. Didenko VV, Wang X, Yang L, Hornsby PJ. Expression of p21(WAF1/CIP1/SDI1) and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury. J Clin Invest. 1996 Apr 01; 97(7):1723-31. PMID: 8601638.
      View in: PubMed
    38. Yang L, Didenko VV, Noda A, Bilyeu TA, Darlington DJ, Smith JR, Hornsby PJ. Increased expression of p21Sdi1 in adrenocortical cells when they are placed in culture. Exp Cell Res. 1995 Nov; 221(1):126-31. PMID: 7589237.
      View in: PubMed
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