TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    R01CA058541     (JAVIER, RONALD T.)Jan 1, 1993 - Nov 30, 2014
    Mechanisms of the Adenovirus E4-ORF1 Oncoprotein
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kong K, Kumar M, Taruishi M, Javier RT. Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression. J Virol. 2015 Nov; 89(21):10774-85. PMID: 26269183; PMCID: PMC4621122.
      Citations: 6     Fields:    Translation:HumansCells
    2. Kumar M, Kong K, Javier RT. Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins. J Virol. 2014 Dec; 88(24):14268-77. PMID: 25253337; PMCID: PMC4249130.
      Citations: 10     Fields:    Translation:HumansCells
    3. Kong K, Kumar M, Taruishi M, Javier RT. The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase. PLoS Pathog. 2014 May; 10(5):e1004102. PMID: 24788832; PMCID: PMC4006922.
      Citations: 20     Fields:    Translation:HumansCells
    4. Irvin-Wilson CV, Newberg JY, Kong K, Javier RT, Marriott SJ. High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells. Viruses. 2011 12; 3(12):2396-411. PMID: 22355445; PMCID: PMC3280515.
      Citations:    Fields:    Translation:HumansCells
    5. Golebiewski L, Liu H, Javier RT, Rice AP. The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions. J Virol. 2011 Oct; 85(20):10639-48. PMID: 21849460; PMCID: PMC3187509.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    6. Javier RT, Rice AP. Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J Virol. 2011 Nov; 85(22):11544-56. PMID: 21775458; PMCID: PMC3209276.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    7. Liu H, Golebiewski L, Dow EC, Krug RM, Javier RT, Rice AP. The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. J Virol. 2010 Nov; 84(21):11164-74. PMID: 20702615; PMCID: PMC2953166.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    8. Javier RT. Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene. 2008 Nov 24; 27(55):7031-46. PMID: 19029943; PMCID: PMC3501650.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    9. Javier RT, Butel JS. The history of tumor virology. Cancer Res. 2008 Oct 01; 68(19):7693-706. PMID: 18829521; PMCID: PMC3501656.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    10. Chung SH, Frese KK, Weiss RS, Prasad BV, Javier RT. A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles. J Virol. 2007 May; 81(9):4787-97. PMID: 17314165; PMCID: PMC1900153.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Gregorc U, Ivanova S, Thomas M, Guccione E, Glaunsinger B, Javier R, Turk V, Banks L, Turk B. Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Apoptosis. 2007 Feb; 12(2):343-54. PMID: 17191119; PMCID: PMC3501654.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    12. Frese KK, Latorre IJ, Chung SH, Caruana G, Bernstein A, Jones SN, Donehower LA, Justice MJ, Garner CC, Javier RT. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J. 2006 Mar 22; 25(6):1406-17. PMID: 16511562; PMCID: PMC1422156.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    13. Latorre IJ, Roh MH, Frese KK, Weiss RS, Margolis B, Javier RT. Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci. 2005 Sep 15; 118(Pt 18):4283-93. PMID: 16141229; PMCID: PMC3471650.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    14. Singh D, Solan JL, Taffet SM, Javier R, Lampe PD. Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J Biol Chem. 2005 Aug 26; 280(34):30416-21. PMID: 15980428; PMCID: PMC3501655.
      Citations: 65     Fields:    Translation:AnimalsCells
    15. Lee OK, Frese KK, James JS, Chadda D, Chen ZH, Javier RT, Cho KO. Discs-Large and Strabismus are functionally linked to plasma membrane formation. Nat Cell Biol. 2003 Nov; 5(11):987-93. PMID: 14562058; PMCID: PMC3471657.
      Citations: 39     Fields:    Translation:AnimalsCells
    16. Frese KK, Lee SS, Thomas DL, Latorre IJ, Weiss RS, Glaunsinger BA, Javier RT. Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Oncogene. 2003 Feb 06; 22(5):710-21. PMID: 12569363; PMCID: PMC3501958.
      Citations: 47     Fields:    Translation:Animals
    17. Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J. 2002 Feb 01; 361(Pt 3):525-36. PMID: 11802782; PMCID: PMC1222335.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
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