InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology

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    R21CA097762     (HURWITZ, RICHARD L)Jul 22, 2002 - Jun 30, 2005
    Gene Therapy for Retinoblastoma
    Role: Principal Investigator

    R01EY006656     (HURWITZ, RICHARD L)Jul 1, 1986 - Nov 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu A, Ildefonso CJ, Bond WS, Hurwitz MY, Hurwitz RL. Inhibitors of metalloprotease, ?-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication. PLoS One. 2020; 15(7):e0236175. PMID: 32697798; PMCID: PMC7375579.
      Citations:    Fields:    Translation:HumansCells
    2. George A, Dinu B, Estrada N, Minard CG, Hurwitz R, Mahoney DH, Yates AM, Vaughan M, Carmouche A, Airewele G, Kirk SE, Fasipe T, Uwaezuoke P, Ware RE. Novel dose escalation to predict treatment with hydroxyurea (NDEPTH): A randomized controlled trial of a dose-prediction equation to determine maximum tolerated dose of hydroxyurea in pediatric sickle cell disease. Am J Hematol. 2020 09; 95(9):E242-E244. PMID: 32472611.
      Citations:    Fields:    Translation:Humans
    3. Akinfenwa PY, Bond WS, Ildefonso CJ, Hurwitz MY, Hurwitz RL. Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways. J Biol Chem. 2017 09 01; 292(35):14381-14390. PMID: 28684419; PMCID: PMC5582833.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Bond WS, Akinfenwa PY, Perlaky L, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin. PLoS One. 2013; 8(6):e63519. PMID: 23826078; PMCID: PMC3691222.
      Citations: 9     Fields:    Translation:HumansCells
    5. Liu Z, Zhao X, Mao H, Baxter PA, Huang Y, Yu L, Wadhwa L, Su JM, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Hurwitz RL, Lau CC, Chintagumpala M, Blaney SM, Li XN. Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma. Neuro Oncol. 2013 Sep; 15(9):1173-85. PMID: 23658322; PMCID: PMC3748915.
      Citations: 41     Fields:    Translation:AnimalsCells
    6. Hurwitz RL. A new vision of mesenchymal stromal cells. Mol Ther. 2012 Nov; 20(11):2017-8. PMID: 23131854; PMCID: PMC3498812.
      Citations:    Fields:    Translation:HumansAnimals
    7. Ildefonso CJ, Bond WS, Al-Tawashi AR, Hurwitz MY, Hurwitz RL. The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression. J Biol Chem. 2012 Sep 21; 287(39):32697-707. PMID: 22865879; PMCID: PMC3463356.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells. Invest Ophthalmol Vis Sci. 2012 Jun 08; 53(7):3454-62. PMID: 22562503; PMCID: PMC4022423.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Bond WS, Wadhwa L, Perlaky L, Penland RL, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Establishment and propagation of human retinoblastoma tumors in immune deficient mice. J Vis Exp. 2011 Aug 04; (54). PMID: 21847079; PMCID: PMC3211116.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN. A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Neuro Oncol. 2011 Jan; 13(1):14-27. PMID: 21075780; PMCID: PMC3018906.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    11. Ildefonso CJ, Kong L, Leen A, Chai SJ, Petrochelli V, Chintagumpala M, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma. Mol Ther. 2010 Oct; 18(10):1885-90. PMID: 20606647; PMCID: PMC2951557.
      Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
    12. Wadhwa L, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus. Cancer Res. 2007 Nov 15; 67(22):10653-6. PMID: 18006805.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    13. Chintagumpala M, Chevez-Barrios P, Paysse EA, Plon SE, Hurwitz R. Retinoblastoma: review of current management. Oncologist. 2007 Oct; 12(10):1237-46. PMID: 17962617.
      Citations: 63     Fields:    Translation:Humans
    14. Higham-Kessler J, Reinert SE, Snodgrass WT, Hensle TW, Koyle MA, Hurwitz RS, Cendron M, Diamond DA, Caldamone AA. A review of failures of endoscopic treatment of vesicoureteral reflux with dextranomer microspheres. J Urol. 2007 Feb; 177(2):710-4; discussion 714-5. PMID: 17222662.
      Citations: 8     Fields:    Translation:Humans
    15. Chaudhuri SR, Mallam JN, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Mol Ther. 2007 Mar; 15(3):566-70. PMID: 17180120.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    16. Chong EM, Coffee RE, Chintagumpala M, Hurwitz RL, Hurwitz MY, Ch?vez-Barrios P. Extensively necrotic retinoblastoma is associated with high-risk prognostic factors. Arch Pathol Lab Med. 2006 Nov; 130(11):1669-72. PMID: 17076529.
      Citations: 10     Fields:    Translation:Humans
    17. Chintagumpala M, Mieler W, Paysse E, Boniuk M, Kozinetz C, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir. J Clin Oncol. 2005 Nov 01; 23(31):7927-35. PMID: 16258092.
      Citations: 46     Fields:    Translation:HumansCellsCTClinical Trials
    18. Mallam JN, Hurwitz MY, Mahoney T, Hurwitz RL, Ch?vez-Barrios P. Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1680-7. PMID: 15161826.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    19. Hurwitz RL, Boniuk M, Chintagumpala M, Hurwitz MY, Ch?vez-Barrios P. Retinoblastoma: from bench to bedside. Expert Rev Mol Med. 2003 Jan 07; 5(1):1-14. PMID: 14987394.
      Citations: 6     Fields:    Translation:HumansAnimals
    20. Hurwitz RL. Re.:"A Death in the Laboratory". Mol Ther. 2001 Jul; 4(1):4. PMID: 11472099.
      Citations:    Fields:    Translation:Humans
    21. Suber ML, Hurwitz MY, Hurwitz RL, Ch?vez-Barrios P. Immune consequences of intraocular administration of modified adenoviral vectors. Hum Gene Ther. 2001 May 01; 12(7):833-8. PMID: 11339899.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M, Brenner MK. Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes. Hum Gene Ther. 2001 Apr 10; 12(6):659-70. PMID: 11426465.
      Citations: 17     Fields:    Translation:HumansCells
    23. Hurwitz MY, Louie K, Marcus KT, Holcombe VN, Schafer P, Aguilar-Cordova CE, Hurwitz RL, Ch?vez-Barrios P. Metastatic and nonmetastatic models of retinoblastoma. Am J Pathol. 2000 Oct; 157(4):1405-12. PMID: 11021842; PMCID: PMC1850157.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    24. Hurwitz RL, Brenner MK, Poplack DG, Horowitz MC. Retinoblastoma treatment. Science. 1999 Jul 30; 285(5428):663-4. PMID: 10454919.
      Citations: 2     Fields:    Translation:Humans
    25. Hurwitz MY, Marcus KT, Louie K, Aguilar-Cordova E, Hurwitz RL, Ch?vez-Barrios P. Suicide gene therapy for treatment of retinoblastoma in a murine model. Hum Gene Ther. 1999 Feb 10; 10(3):441-8. PMID: 10048396.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B, Kylm? T. Cloning and analysis of the cDNA encoding the rod G-protein transduction alpha, beta1 and gamma1 subunits from the canine retina. Gene. 1997 Jul 01; 193(1):1-4. PMID: 9249060.
      Citations:    Fields:    Translation:AnimalsCells
    27. Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B, Kylm? T. Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog. Res Vet Sci. 1997 May-Jun; 62(3):293-6. PMID: 9300552.
      Citations:    Fields:    Translation:HumansAnimalsCells
    28. Murray JC, Hill RM, Hegemier S, Hurwitz RL. Lymphoblastic lymphoma following prenatal exposure to phenytoin. J Pediatr Hematol Oncol. 1996 May; 18(2):241-3. PMID: 8846150.
      Citations: 3     Fields:    Translation:Humans
    29. Kommonen B, Kylma T, Cohen RJ, Penn JS, Paulin L, Hurwitz M, Hurwitz RL. Elevation of cGMP with normal expression and activity of rod cGMP-PDE in photoreceptor degenerate labrador retrievers. Ophthalmic Res. 1996; 28(1):19-28. PMID: 8726673.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Carcamo B, Hurwitz MY, Craft CM, Hurwitz RL. The mammalian pineal expresses the cone but not the rod cyclic GMP phosphodiesterase. J Neurochem. 1995 Sep; 65(3):1085-92. PMID: 7643086.
      Citations: 4     Fields:    Translation:AnimalsCells
    31. Srivastava D, Hurwitz RL, Fox DA. Lead- and calcium-mediated inhibition of bovine rod cGMP phosphodiesterase: interactions with magnesium. Toxicol Appl Pharmacol. 1995 Sep; 134(1):43-52. PMID: 7676457.
      Citations:    Fields:    Translation:AnimalsCells
    32. Srivastava D, Fox DA, Hurwitz RL. Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase. Biochem J. 1995 Jun 01; 308 ( Pt 2):653-8. PMID: 7772055; PMCID: PMC1136976.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Fox DA, Srivastava D, Hurwitz RL. Lead-induced alterations in rod-mediated visual functions and cGMP metabolism: new insights. Neurotoxicology. 1994; 15(3):503-12. PMID: 7854584.
      Citations: 2     Fields:    Translation:AnimalsCells
    34. Suber ML, Pittler SJ, Qin N, Wright GC, Holcombe V, Lee RH, Craft CM, Lolley RN, Baehr W, Hurwitz RL. Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):3968-72. PMID: 8387203; PMCID: PMC46427.
      Citations: 72     Fields:    Translation:AnimalsCells
    35. Morad AB, Steuber CP, Mahoney DH, Hurwitz RL. Hypoplastic anemia in an infant with human immunodeficiency virus (HIV) infection. Am J Hematol. 1993 Feb; 42(2):236. PMID: 8438892.
      Citations: 1     Fields:    Translation:Humans
    36. Kazazian HH, Dowling CE, Hurwitz RL, Coleman M, Stopeck A, Adams JG. Dominant thalassemia-like phenotypes associated with mutations in exon 3 of the beta-globin gene. Blood. 1992 Jun 01; 79(11):3014-8. PMID: 1586746.
      Citations: 12     Fields:    Translation:HumansCells
    37. Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W. Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. J Biol Chem. 1992 Mar 25; 267(9):6257-62. PMID: 1372902.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    38. Hayani A, Mahoney DH, Hawkins HK, Steuber CP, Hurwitz R, Fernbach DJ. Soft-tissue sarcomas other than rhabdomyosarcoma in children. Med Pediatr Oncol. 1992; 20(2):114-8. PMID: 1734215.
      Citations: 6     Fields:    Translation:Humans
    39. Chintagumpala MM, Hurwitz RL, Moake JL, Mahoney DH, Steuber CP. Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von Willebrand factor multimers during remission. J Pediatr. 1992 Jan; 120(1):49-53. PMID: 1731024.
      Citations: 2     Fields:    Translation:Humans
    40. Booth DP, Hurwitz RL, Lolley RN. Phosphodiesterase of cone photoreceptors from the lizard, Anolis carolinensis. J Neurochem. 1991 Jun; 56(6):1949-56. PMID: 1851207.
      Citations: 1     Fields:    Translation:AnimalsCells
    41. Hurwitz R, Holcombe V. Affinity purification of the photoreceptor cGMP-gated cation channel. J Biol Chem. 1991 May 05; 266(13):7975-7. PMID: 1850731.
      Citations: 3     Fields:    Translation:AnimalsCells
    42. Hurwitz RL, Bogenmann E, Font RL, Holcombe V, Clark D. Expression of the functional cone phototransduction cascade in retinoblastoma. J Clin Invest. 1990 Jun; 85(6):1872-8. PMID: 2161431; PMCID: PMC296653.
      Citations: 10     Fields:    Translation:HumansCells
    43. Hurwitz RL, Hirsch KM, Clark DJ, Holcombe VN, Hurwitz MY. Induction of a calcium/calmodulin-dependent phosphodiesterase during phytohemagglutinin-stimulated lymphocyte mitogenesis. J Biol Chem. 1990 May 25; 265(15):8901-7. PMID: 2160471.
      Citations: 5     Fields:    Translation:AnimalsCells
    44. Hurwitz RL, Mahoney DH, Armstrong DL, Browder TM. Reversible encephalopathy and seizures as a result of conventional vincristine administration. Med Pediatr Oncol. 1988; 16(3):216-9. PMID: 3164090.
      Citations: 7     Fields:    Translation:Humans
    45. Lee RH, Lieberman BS, Hurwitz RL, Lolley RN. Phosphodiesterase-probes show distinct defects in rd mice and Irish setter dog disorders. Invest Ophthalmol Vis Sci. 1985 Nov; 26(11):1569-79. PMID: 2997075.
      Citations: 5     Fields:    Translation:AnimalsCells
    46. Hurwitz RL, Bunt-Milam AH, Chang ML, Beavo JA. cGMP phosphodiesterase in rod and cone outer segments of the retina. J Biol Chem. 1985 Jan 10; 260(1):568-73. PMID: 2981219.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    47. Hurwitz RL, Bunt-Milam AH, Beavo JA. Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesterase. J Biol Chem. 1984 Jul 10; 259(13):8612-8. PMID: 6330115.
      Citations: 12     Fields:    Translation:AnimalsCells
    48. Hurwitz RL, Beavo JA. Immunotitration analysis of the rod outer segment phosphodiesterase. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 17:239-48. PMID: 6203341.
      Citations: 5     Fields:    Translation:AnimalsCells
    49. Hurwitz RL, Hansen RS, Harrison SA, Martins TJ, Mumby MC, Beavo JA. Immunologic approaches to the study of cyclic nucleotide phosphodiesterases. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 16:89-106. PMID: 6326539.
      Citations: 1     Fields:    Translation:AnimalsCells
    50. Beavo JA, Hansen RS, Harrison SA, Hurwitz RL, Martins TJ, Mumby MC. Identification and properties of cyclic nucleotide phosphodiesterases. Mol Cell Endocrinol. 1982 Nov-Dec; 28(3):387-410. PMID: 6185373.
      Citations: 28     Fields:    Translation:AnimalsCells
    51. Hozier J, Lindquist L, Hurwitz R, LeBien T, Kersey J. Evolution of cultured leukemic cell lines monitored by chromosomal and immunologic analysis. Int J Cancer. 1980 Sep 15; 26(3):281-4. PMID: 6945291.
      Citations: 1     Fields:    Translation:HumansCells
    52. Hurwitz RL, Schreinemachers D, Kersey JH. Elimination of platelets from mononuclear cell preparations using heat-killed yeast. Exp Hematol. 1979 Feb; 7(2):81-6. PMID: 371975.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    53. Hurwitz R, Hozier J, LeBien T, Minowada J, Gajl-Peczalska K, Kubonishi I, Kersey J. Characterization of a leukemic cell line of the pre-B phenotype. Int J Cancer. 1979 Feb; 23(2):174-80. PMID: 83966.
      Citations: 59     Fields:    Translation:HumansCells
    54. LeBien TW, Hurwitz RL, Kersey JH. Characterization of a xenoantiserum produced against three molar KCl-solubilized antigens obtained from a non-T, non-B (pre-B) acute lymphoblastic leukemia cell line. J Immunol. 1979 Jan; 122(1):82-8. PMID: 310838.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
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