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EDWARD COOPER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
Address6501 Fannin St
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    R13NS095592     (COOPER, EDWARD C)Sep 21, 2015 - Sep 20, 2016
    NIH
    KCNQ2 Epileptic Encephalopathy: Overcoming Hurdles to Effective Disease-Modifying Therapy
    Role: Principal Investigator
    R21NS055765     (COOPER, EDWARD C)Sep 15, 2006 - Apr 30, 2010
    NIH
    KCNQ channel opener efficacy for neonatal seizures
    Role: Principal Investigator
    R01NS049119     (COOPER, EDWARD C)Jul 1, 2004 - Jan 31, 2019
    NIH
    KCNQ2/3 channels in neonatal-onset epilepsy and encephalopathy
    Role: Principal Investigator
    R21NS042100     (COOPER, EDWARD C)Sep 15, 2001 - Aug 31, 2005
    NIH
    Proteomic Dissection of M-channel Phosphorylation
    Role: Principal Investigator
    K08NS001755     (COOPER, EDWARD C)Aug 1, 1994 - Jul 31, 1999
    NIH
    MODULATION OF HIPPOCAMPAL K+ CHANNELS BY PHOSPHORYLATION
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abreo TJ, Thompson EC, Madabushi A, Soh H, Varghese N, Vanoye CG, Springer K, Park KL, Johnson J, Sims S, Ji Z, Chavez AG, Jankovic MJ, Habte B, Zuberi A, Lutz C, Wang Z, Krishnan V, Dudler L, Einsele-Scholz S, Noebels JL, George AL, Maheshwari A, Tzingounis AV, Cooper EC, Abreo TJ, Thompson EC, Madabushi A, Soh H, Varghese N, Vanoye CG, Springer K, Park KL, Johnson J, Sims S, Ji Z, Chavez AG, Jankovic MJ, Habte B, Zuberi A, Lutz C, Wang Z, Krishnan V, Dudler L, Einsele-Scholz S, Noebels JL, George AL, Maheshwari A, Tzingounis AV, Cooper EC, Abreo TJ, Abreo TJ. Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy. bioRxiv. 2024 Feb 08. PMID: 38260608; PMCID: PMC10802467.
      Citations:    
    2. Bayat A, Iavarone S, Miceli F, Jakobsen AV, Johannesen KM, Nikanorova M, Ploski R, Szymanska K, Flamini R, Cooper EC, Weckhuysen S, Taglialatela M, M?ller RS. Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment. Neurotherapeutics. 2024 Jan; 21(1):e00296. PMID: 38241158; PMCID: PMC10903081.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Mazzaferro S, Msekela DJ, Cooper EC, Maheshwari A, Sine SM. Genetic Variant in Nicotinic Receptor a4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening. Int J Mol Sci. 2022 Oct 12; 23(20). PMID: 36292983; PMCID: PMC9602795.
      Citations:    Fields:    Translation:Cells
    4. Miceli F, Millevert C, Soldovieri MV, Mosca I, Ambrosino P, Carotenuto L, Schrader D, Lee HK, Riviello J, Hong W, Risen S, Emrick L, Amin H, Edery P, de Bellescize J, Michaud V, Van-Gils J, Goizet C, Willemsen MH, Kleefstra T, Bayat A, Devinsky O, Sands T, Korenke GC, Mefford HC, Brilstra E, Lesca G, Milh M, Cooper EC, Taglialatela M, Ville D, M?ller RS, Kluger G, Weckhuysen S. KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism. EBioMedicine. 2022 Jul; 81:104130. PMID: 35780567; PMCID: PMC9254340.
      Citations:    Fields:    Translation:Humans
    5. Jing J, Dunbar C, Sonesra A, Chavez A, Park S, Yang R, Soh H, Lee M, Tzingounis AV, Cooper EC, Jiang X, Maheshwari A. Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine. Exp Neurol. 2022 09; 355:114141. PMID: 35691372; PMCID: PMC9899633.
      Citations:    Fields:    Translation:AnimalsCells
    6. Vanoye CG, Desai RR, Ji Z, Adusumilli S, Jairam N, Ghabra N, Joshi N, Fitch E, Helbig KL, McKnight D, Lindy AS, Zou F, Helbig I, Cooper EC, George AL. High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity. JCI Insight. 2022 03 08; 7(5). PMID: 35104249; PMCID: PMC8983144.
      Citations: 2     Fields:    Translation:Humans
    7. Cooper EC, Abreo T, Tran B. KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist. Neuron. 2022 01 19; 110(2):178-180. PMID: 35051360.
      Citations: 1     Fields:    Translation:HumansCells
    8. Tran B, Ji ZG, Xu M, Tsuchida TN, Cooper EC. Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP2 Interaction. Front Physiol. 2020; 11:1144. PMID: 33041849; PMCID: PMC7518097.
      Citations: 1     
    9. Miceli F, Carotenuto L, Barrese V, Soldovieri MV, Heinzen EL, Mandel AM, Lippa N, Bier L, Goldstein DB, Cooper EC, Taglialatela M, Sands TT, Cilio MR. A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by ?-Hydroxybutyrate. Front Physiol. 2020; 11:1040. PMID: 33013448; PMCID: PMC7498716.
      Citations: 1     
    10. Goto A, Ishii A, Shibata M, Ihara Y, Cooper EC, Hirose S. Characteristics of KCNQ2 variants causing either benign neonatal epilepsy or developmental and epileptic encephalopathy. Epilepsia. 2019 09; 60(9):1870-1880. PMID: 31418850.
      Citations: 16     Fields:    Translation:Humans
    11. Soldovieri MV, Ambrosino P, Mosca I, Miceli F, Franco C, Canzoniero LMT, Kline-Fath B, Cooper EC, Venkatesan C, Taglialatela M. Epileptic Encephalopathy In A Patient With A Novel Variant In The Kv7.2 S2 Transmembrane Segment: Clinical, Genetic, and Functional Features. Int J Mol Sci. 2019 Jul 10; 20(14). PMID: 31295832; PMCID: PMC6678645.
      Citations: 6     Fields:    Translation:HumansCells
    12. Sands TT, Miceli F, Lesca G, Beck AE, Sadleir LG, Arrington DK, Lauritano A, Nappi P, Soldovieri MV, Scheffer IE, Mefford HC, Stong N, Heinzen EL, Goldstein DB, Perez AG, Kossoff EH, Stocco A, Sullivan JA, Shashi V, Gerard B, Francannet C, Bisgaard AM, Willems M, Vitobello A, Thakkar K, Rajan DS, Barkovich AJ, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR, Sch?newolf-Greulich B, Moutton S, T?mer Z, Rivier F. Autism and developmental disability caused by KCNQ3 gain-of-function variants. Ann Neurol. 2019 08; 86(2):181-192. PMID: 31177578.
      Citations: 18     Fields:    Translation:HumansCells
    13. Mulkey SB, Ben-Zeev B, Nicolai J, Carroll JL, Jiang YH, Joshi N, Kelly M, Koolen DA, Mikati MA, Park K, Pearl PL, Scheffer IE, Spillmann RC, Taglialatela M, Vieker S, Weckhuysen S, Cooper EC, Cilio MR, Gr?nborg S. Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. Epilepsia. 2017 03; 58(3):436-445. PMID: 28139826; PMCID: PMC5339037.
      Citations: 25     Fields:    Translation:Humans
    14. Millichap JJ, Miceli F, De Maria M, Keator C, Joshi N, Tran B, Soldovieri MV, Ambrosino P, Shashi V, Mikati MA, Cooper EC, Taglialatela M. Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia. 2017 01; 58(1):e10-e15. PMID: 27861786; PMCID: PMC5219941.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    15. Millichap JJ, Park KL, Tsuchida T, Ben-Zeev B, Carmant L, Flamini R, Joshi N, Levisohn PM, Marsh E, Nangia S, Narayanan V, Ortiz-Gonzalez XR, Patterson MC, Pearl PL, Porter B, Ramsey K, McGinnis EL, Taglialatela M, Tracy M, Tran B, Venkatesan C, Weckhuysen S, Cooper EC. KCNQ2 encephalopathy: Features, mutational hot spots, and ezogabine treatment of 11 patients. Neurol Genet. 2016 Oct; 2(5):e96. PMID: 27602407; PMCID: PMC4995058.
      Citations: 59     
    16. Xu M, Cooper EC. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. J Biol Chem. 2015 Jul 03; 290(27):16619-32. PMID: 25998125; PMCID: PMC4505415.
      Citations: 32     Fields:    Translation:HumansCells
    17. Hirst CS, Foong JP, Stamp LA, Fegan E, Dent S, Cooper EC, Lomax AE, Anderson CR, Bornstein JC, Young HM, McKeown SJ. Ion channel expression in the developing enteric nervous system. PLoS One. 2015; 10(3):e0123436. PMID: 25798587; PMCID: PMC4370736.
      Citations: 4     Fields:    Translation:AnimalsCells
    18. Martinello K, Huang Z, Lujan R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM. Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron. 2015 Jan 21; 85(2):346-63. PMID: 25578363; PMCID: PMC4306544.
      Citations: 45     Fields:    Translation:AnimalsCells
    19. Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014 Dec; 17(12):1673-81. PMID: 25362471; PMCID: PMC4260775.
      Citations: 45     Fields:    Translation:AnimalsCells
    20. Ho TS, Zollinger DR, Chang KJ, Xu M, Cooper EC, Stankewich MC, Bennett V, Rasband MN. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014 Dec; 17(12):1664-72. PMID: 25362473; PMCID: PMC4271271.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    21. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-11544. PMID: 24627475; PMCID: PMC4036288.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    22. Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MH. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014 Mar 05; 34(10):3719-32. PMID: 24599470; PMCID: PMC3942587.
      Citations: 78     Fields:    Translation:AnimalsCells
    23. Kole MH, Cooper EC. Axonal Kv7.2/7.3 channels: caught in the act. Channels (Austin). 2014; 8(4):288-9. PMID: 25171180; PMCID: PMC5210507.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Cooper EA, Edelman JJ, Black D, Brereton RJ, Ross DE, Bannon PG, Wilson MK, Vallely MP. Anaortic off-pump coronary artery bypass grafting in the elderly and very elderly. Heart Lung Circ. 2013 Dec; 22(12):989-95. PMID: 23827207.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    25. Millichap JJ, Cooper EC. KCNQ2 Potassium Channel Epileptic Encephalopathy Syndrome: Divorce of an Electro-Mechanical Couple? Epilepsy Curr. 2012 Jul; 12(4):150-2. PMID: 22936888; PMCID: PMC3423209.
      Citations: 9     
    26. Cooper EC. Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons. Semin Cell Dev Biol. 2011 Apr; 22(2):185-92. PMID: 20940059; PMCID: PMC3070838.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    27. Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar; 65(3):326-36. PMID: 19334075; PMCID: PMC2666110.
      Citations: 27     Fields:    Translation:Animals
    28. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC. Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet. 2008 Dec; 4(12):e1000317. PMID: 19112491; PMCID: PMC2597720.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    29. Jin Z, Liang GH, Cooper EC, Jarlebark L. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea. Audiol Neurootol. 2009; 14(2):98-105. PMID: 18827480; PMCID: PMC3030994.
      Citations: 8     Fields:    Translation:AnimalsCells
    30. Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7869-74. PMID: 18515424; PMCID: PMC2408483.
      Citations: 140     Fields:    Translation:AnimalsCells
    31. Cooper EC. Exploiting the other inhibitory ion: KCNQ potassium channels and regulation of excitability in developing and mature brain. Epilepsy Curr. 2006 Jul-Aug; 6(4):133-5. PMID: 17260036; PMCID: PMC1783435.
      Citations:    
    32. Pan Z, Kao T, Horvath Z, Lemos J, Sul JY, Cranstoun SD, Bennett V, Scherer SS, Cooper EC. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006 Mar 08; 26(10):2599-613. PMID: 16525039; PMCID: PMC6675151.
      Citations: 270     Fields:    Translation:HumansAnimalsCells
    33. Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17828-33. PMID: 16319223; PMCID: PMC1297712.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    34. Kleopa KA, Cooper EC, Scherer SS, Devaux JJ. KCNQ2 is a nodal K+ channel. J Neurosci. 2004 Feb 04; 24(5):1236-44. PMID: 14762142; PMCID: PMC6793582.
      Citations: 205     Fields:    Translation:HumansAnimalsCells
    35. Cooper EC, Jan LY. M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol. 2003 Apr; 60(4):496-500. PMID: 12707061.
      Citations: 54     Fields:    Translation:Humans
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