Address2002 HOLCOMBE
Houston, TX 77030
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    R03DA022266     (NIELSEN, DAVID ANDREW)Sep 25, 2006 - Aug 31, 2008
    DNA Methylation of Promoter CpG Dinucleotides in Opiate Addiction
    Role: Principal Investigator

    R21DA020117     (KOSTEN, THERESE A)Jul 1, 2008 - Jun 30, 2012
    Sex Differences in Vulnerability to Cocaine Addiction
    Role: Co-Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nieto SJ, Haile CN, Quave CB, Harding MJ, Nielsen DA, Meisch RA, Kosten TA. Paternal alcohol exposure reduces acquisition of operant alcohol self-administration and affects Bdnf DNA methylation in male and female offspring. Addict Biol. 2021 Aug 06; e13078. PMID: 34363290.
      Citations:    Fields:    
    2. Thomas PS, Nielsen EM, Spellicy CJ, Harding MJ, Ye A, Patriquin M, Hamon SC, Kosten TR, Nielsen DA. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatr Genet. 2021 06 01; 31(3):88-94. PMID: 33953123.
      Citations:    Fields:    
    3. Jones CM, Korosh TC, Nielsen DR, Pfleger BF. Optimization of a T7-RNA polymerase system in Synechococcus sp. PCC 7002 mirrors the protein overproduction phenotype from E. coli BL21(DE3). Appl Microbiol Biotechnol. 2021 Feb; 105(3):1147-1158. PMID: 33443634.
      Citations:    Fields:    Translation:Cells
    4. Poblete GF, Gosnell SN, Meyer M, Fang M, Nguyen T, Patriquin MA, Nielsen D, Kosten T, Salas R. Process genes list: An approach to link genetics and human brain imaging. J Neurosci Methods. 2020 06 01; 339:108695. PMID: 32201351.
      Citations:    Fields:    Translation:Humans
    5. Shorter DI, Zhang X, Domingo CB, Nielsen EM, Kosten TR, Nielsen DA. Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant. Am J Drug Alcohol Abuse. 2020; 46(2):184-193. PMID: 31914324.
      Citations: 2     Fields:    Translation:Humans
    6. Kampangkaew JP, Spellicy CJ, Nielsen EM, Harding MJ, Ye A, Hamon SC, Kosten TR, Nielsen DA. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. Am J Addict. 2019 07; 28(4):311-317. PMID: 31087723.
      Citations: 3     Fields:    Translation:HumansCells
    7. Nielsen DA, Deng H, Patriquin MA, Harding MJ, Oldham J, Salas R, Fowler JC, Frueh BC. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. Eur Arch Psychiatry Clin Neurosci. 2020 Aug; 270(5):633-642. PMID: 30923939.
      Citations: 3     Fields:    Translation:Humans
    8. Deng H, Desai PV, Mohite S, Okusaga OO, Zhang XY, Nielsen DA, Kosten TR. Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users. J Stud Alcohol Drugs. 2019 03; 80(2):230-235. PMID: 31014468.
      Citations: 1     Fields:    Translation:Humans
    9. Patel MM, Nielsen DA, Kosten TR, De La Garza R, Newton TF, Verrico CD. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. Am J Addict. 2018 10; 27(7):567-573. PMID: 30126012.
      Citations: 2     Fields:    Translation:Humans
    10. Deng H, Verrico CD, Kosten TR, Nielsen DA. Psychosis and synthetic cannabinoids. Psychiatry Res. 2018 10; 268:400-412. PMID: 30125871.
      Citations: 8     Fields:    Translation:HumansAnimals
    11. Kosten TR, Graham DP, Nielsen DA. Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. JAMA Psychiatry. 2018 06 01; 75(6):642-648. PMID: 29710079.
      Citations:    Fields:    Translation:Humans
    12. Kosten TR, Graham DP, Nielsen DA. Opioid Use Disorder After Self-medicating Pain From Traumatic Brain Injury. JAMA Psychiatry. 2018 06 01; 75(6):649-650. PMID: 29710138.
      Citations: 1     Fields:    Translation:Humans
    13. Nielsen DA, Spellicy CJ, Harding MJ, Graham DP. Apolipoprotein E DNA methylation and posttraumatic stress disorder are associated with plasma ApoE level: A preliminary study. Behav Brain Res. 2019 01 01; 356:415-422. PMID: 29807071.
      Citations: 4     Fields:    Translation:HumansCells
    14. Wachman EM, Hayes MJ, Shrestha H, Nikita FNU, Nolin A, Hoyo L, Daigle K, Jones HE, Nielsen DA. Epigenetic variation in OPRM1 gene in opioid-exposed mother-infant dyads. Genes Brain Behav. 2018 09; 17(7):e12476. PMID: 29575474.
      Citations: 12     Fields:    Translation:HumansCells
    15. Zhang X, Nielsen DA, Domingo CB, Shorter DI, Nielsen EM, Kosten TR. Pharmacogenetics of Dopamine ß-Hydroxylase in cocaine dependence therapy with doxazosin. Addict Biol. 2019 05; 24(3):531-538. PMID: 29498170.
      Citations: 4     Fields:    Translation:Humans
    16. Deng H, Mohite S, Suchting R, Nielsen DA, Okusaga OO. Impact of synthetic cannabinoid use on hospital stay in patients with bipolar disorder versus schizophrenia, or other psychotic disorders. Psychiatry Res. 2018 03; 261:248-252. PMID: 29329043.
      Citations: 1     Fields:    Translation:Humans
    17. Patriquin MA, Hamon SC, Harding MJ, Nielsen EM, Newton TF, De La Garza R, Nielsen DA. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatr Genet. 2017 10; 27(5):178-186. PMID: 28590957.
      Citations: 2     Fields:    Translation:Humans
    18. Curtis K, Viswanath H, Velasquez KM, Molfese DL, Harding MJ, Aramayo E, Baldwin PR, Ambrosi E, Madan A, Patriquin M, Frueh BC, Fowler JC, Kosten TR, Nielsen DA, Salas R. Increased habenular connectivity in opioid users is associated with an a5 subunit nicotinic receptor genetic variant. Am J Addict. 2017 Oct; 26(7):751-759. PMID: 28857330.
      Citations: 7     Fields:    Translation:Humans
    19. Wachman EM, Hayes MJ, Sherva R, Brown MS, Shrestha H, Logan BA, Heller NA, Nielsen DA, Farrer LA. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. Am J Addict. 2017 Jan; 26(1):42-49. PMID: 27983768.
      Citations: 9     Fields:    Translation:Humans
    20. Shorter D, Nielsen DA, Hamon SC, Nielsen EM, Kosten TR, Newton TF, De La Garza R. The a-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals. Pharmacogenet Genomics. 2016 09; 26(9):428-35. PMID: 27379509.
      Citations:    Fields:    Translation:Humans
    21. Azadeh S, Hobbs BP, Ma L, Nielsen DA, Moeller FG, Baladandayuthapani V. INTEGRATIVE BAYESIAN ANALYSIS OF NEUROIMAGING-GENETIC DATA THROUGH HIERARCHICAL DIMENSION REDUCTION. Proc IEEE Int Symp Biomed Imaging. 2016 Apr; 2016:824-828. PMID: 27917260.
      Citations: 1     
    22. Nieto SJ, Patriquin MA, Nielsen DA, Kosten TA. Don't worry; be informed about the epigenetics of anxiety. Pharmacol Biochem Behav. 2016 Jul-Aug; 146-147:60-72. PMID: 27189589.
      Citations: 7     Fields:    Translation:HumansAnimals
    23. Cao B, Bauer IE, Sharma AN, Mwangi B, Frazier T, Lavagnino L, Zunta-Soares GB, Walss-Bass C, Glahn DC, Kapczinski F, Nielsen DA, Soares JC. Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. J Affect Disord. 2016 Jul 01; 198:198-205. PMID: 27018938.
      Citations: 20     Fields:    Translation:Humans
    24. Sharp C, Fowler JC, Salas R, Nielsen D, Allen J, Oldham J, Kosten T, Mathew S, Madan A, Frueh BC, Fonagy P. Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings. Bull Menninger Clin. 2016; 80(3):187-212. PMID: 27583809.
      Citations: 2     Fields:    Translation:Humans
    25. Azadeh S, Hobbs BP, Ma L, Nielsen DA, Gerard Moeller F, Baladandayuthapani V. Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence. Neuroimage. 2016 Jan 15; 125:813-824. PMID: 26484829.
      Citations: 2     Fields:    Translation:Humans
    26. Liu S, Maili L, Lane SD, Schmitz JM, Spellicy CJ, Cunningham KA, Moeller FG, Nielsen DA. Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity. Psychiatr Genet. 2015 Oct; 25(5):213-4. PMID: 26110342.
      Citations: 3     Fields:    Translation:HumansCells
    27. Patriquin MA, Bauer IE, Soares JC, Graham DP, Nielsen DA. Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatr Genet. 2015 Oct; 25(5):181-93. PMID: 26146874.
      Citations: 14     Fields:    Translation:Humans
    28. Bauer IE, Graham DP, Soares JC, Nielsen DA. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. 2015; 16(11):1307-14. PMID: 26265436.
      Citations: 9     Fields:    Translation:Humans
    29. Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Variations in opioid receptor genes in neonatal abstinence syndrome. Drug Alcohol Depend. 2015 Oct 01; 155:253-9. PMID: 26233486.
      Citations: 16     Fields:    Translation:Humans
    30. Brewer AJ, Nielsen DA, Spellicy CJ, Hamon SC, Gingrich J, Thompson-Lake DG, Nielsen EM, Mahoney JJ, Kosten TR, Newton TF, De La Garza R. Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenet Genomics. 2015 Jun; 25(6):296-304. PMID: 25850966.
      Citations: 8     Fields:    Translation:Humans
    31. Bauer IE, Soares JC, Nielsen DA. The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. Am J Addict. 2015 Jan; 24(1):15-23. PMID: 25823631.
      Citations: 11     Fields:    Translation:Humans
    32. Peterson ED, Ho PM, Barton M, Beam C, Burgess LH, Casey DE, Drozda JP, Fonarow GC, Goff D, Grady KL, King DE, King ML, Masoudi FA, Nielsen DR, Stanko S. ACC/AHA/AACVPR/AAFP/ANA concepts for clinician-patient shared accountability in performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. J Am Coll Cardiol. 2014 Nov 18-25; 64(20):2133-45. PMID: 25439761.
      Citations: 2     Fields:    Translation:Humans
    33. Peterson ED, Ho PM, Barton M, Beam C, Burgess LH, Casey DE, Drozda JP, Fonarow GC, Goff D, Grady KL, King DE, King ML, Masoudi FA, Nielsen DR, Stanko S. ACC/AHA/AACVPR/AAFP/ANA concepts for clinician-patient shared accountability in performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circulation. 2014 Nov 25; 130(22):1984-94. PMID: 25366994.
      Citations: 7     Fields:    Translation:Humans
    34. Graham DP, Nielsen DA, Kosten TR, Davis LL, Hamner MB, Makotkine I, Yehuda R. Examining the utility of using genotype and functional biology in a clinical pharmacology trial: pilot testing dopamine ß-hydroxylase, norepinephrine, and post-traumatic stress disorder. Psychiatr Genet. 2014 Aug; 24(4):181-2. PMID: 24983834.
      Citations: 4     Fields:    Translation:Humans
    35. Wachman EM, Hayes MJ, Lester BM, Terrin N, Brown MS, Nielsen DA, Davis JM. Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. J Pediatr. 2014 Sep; 165(3):472-8. PMID: 24996986.
      Citations: 32     Fields:    Translation:HumansCells
    36. Liu S, Green CE, Lane SD, Kosten TR, Moeller FG, Nielsen DA, Schmitz JM. The influence of dopamine ß-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. Pharmacogenet Genomics. 2014 Jul; 24(7):370-3. PMID: 24809448.
      Citations: 6     Fields:    Translation:Humans
    37. Kosten TA, Nielsen DA. Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum. Int J Dev Neurosci. 2014 Aug; 36:5-12. PMID: 24721039.
      Citations: 11     Fields:    Translation:AnimalsCells
    38. Frazier TW, Youngstrom EA, Frankel BA, Zunta-Soares GB, Sanches M, Escamilla M, Nielsen DA, Soares JC. Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes. Brain Behav. 2014 May; 4(3):418-30. PMID: 24944871.
      Citations: 6     Fields:    Translation:Humans
    39. Spellicy CJ, Harding MJ, Hamon SC, Mahoney JJ, Reyes JA, Kosten TR, Newton TF, De La Garza R, Nielsen DA. A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. Genes Brain Behav. 2014 Jul; 13(6):559-64. PMID: 24528631.
      Citations: 4     Fields:    Translation:Humans
    40. Anastasio NC, Liu S, Maili L, Swinford SE, Lane SD, Fox RG, Hamon SC, Nielsen DA, Cunningham KA, Moeller FG. Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity. Transl Psychiatry. 2014 Mar 11; 4:e369. PMID: 24618688.
      Citations: 20     Fields:    Translation:HumansAnimals
    41. Nielsen DA, Nielsen EM, Dasari T, Spellicy CJ. Pharmacogenetics of addiction therapy. Methods Mol Biol. 2014; 1175:589-624. PMID: 25150877.
      Citations: 3     Fields:    Translation:HumansAnimals
    42. Nielsen DA, Hamon SC, Kosten TR. The ?-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial. Psychiatr Genet. 2013 Dec; 23(6):225-32. PMID: 23995774.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    43. Darter BJ, Nielsen DH, Yack HJ, Janz KF. Home-based treadmill training to improve gait performance in persons with a chronic transfemoral amputation. Arch Phys Med Rehabil. 2013 Dec; 94(12):2440-2447. PMID: 23954560.
      Citations: 11     Fields:    Translation:Humans
    44. Shorter D, Nielsen DA, Huang W, Harding MJ, Hamon SC, Kosten TR. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and a1A-adrenoceptor gene variation. Eur Neuropsychopharmacol. 2013 Nov; 23(11):1401-7. PMID: 23849431.
      Citations: 9     Fields:    Translation:Humans
    45. Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Pharmacogenet Genomics. 2013 Jul; 23(7):333-40. PMID: 23635803.
      Citations: 10     Fields:    Translation:Humans
    46. Graham DP, Helmer DA, Harding MJ, Kosten TR, Petersen NJ, Nielsen DA. Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans. J Psychiatr Res. 2013 Jun; 47(6):835-42. PMID: 23478049.
      Citations: 16     Fields:    Translation:Humans
    47. Kosten TA, Huang W, Nielsen DA. Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats. Dev Psychobiol. 2014 Apr; 56(3):392-406. PMID: 23460384.
      Citations: 27     Fields:    Translation:AnimalsCells
    48. Kosten TR, Domingo CB, Hamon SC, Nielsen DA. DBH gene as predictor of response in a cocaine vaccine clinical trial. Neurosci Lett. 2013 Apr 29; 541:29-33. PMID: 23458673.
      Citations: 8     Fields:    Translation:Humans
    49. Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. Front Psychiatry. 2012; 3:109. PMID: 23335901.
      Citations: 2     
    50. Haile CN, De La Garza R, Mahoney JJ, Nielsen DA, Kosten TR, Newton TF. The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. PLoS One. 2012; 7(11):e47702. PMID: 23144826.
      Citations: 14     Fields:    Translation:Humans
    51. Nielsen DA, Harding MJ, Hamon SC, Huang W, Kosten TR. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Genes Brain Behav. 2012 Nov; 11(8):1001-8. PMID: 22925276.
      Citations: 10     Fields:    Translation:Humans
    52. Kosten TR, Wu G, Huang W, Harding MJ, Hamon SC, Lappalainen J, Nielsen DA. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine ß-hydroxylase. Biol Psychiatry. 2013 Feb 01; 73(3):219-24. PMID: 22906516.
      Citations: 38     Fields:    Translation:Humans
    53. Nielsen DA, Utrankar A, Reyes JA, Simons DD, Kosten TR. Epigenetics of drug abuse: predisposition or response. Pharmacogenomics. 2012 Jul; 13(10):1149-60. PMID: 22909205.
      Citations: 31     Fields:    Translation:HumansCells
    54. Nielsen DA, Huang W, Hamon SC, Maili L, Witkin BM, Fox RG, Cunningham KA, Moeller FG. Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. Front Psychiatry. 2012; 3:60. PMID: 22712019.
      Citations: 12     
    55. Nielsen DA, Kreek MJ. Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug Alcohol Depend. 2012 Jun; 123 Suppl 1:S33-41. PMID: 22542464.
      Citations: 12     Fields:    Translation:Humans
    56. Nielsen DA, Ho A, Bahl A, Varma P, Kellogg S, Borg L, Kreek MJ. Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls. Drug Alcohol Depend. 2012 Jul 01; 124(1-2):113-20. PMID: 22265192.
      Citations: 22     Fields:    Translation:Humans
    57. Hao Y, Huang W, Nielsen DA, Kosten TA. Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Front Psychiatry. 2011; 2:21. PMID: 21629839.
      Citations: 26     
    58. Yuferov V, Nielsen DA, Levran O, Randesi M, Hamon S, Ho A, Morgello S, Kreek MJ. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenet Genomics. 2011 Apr; 21(4):185-96. PMID: 20808262.
      Citations: 18     Fields:    Translation:HumansCells
    59. Nielsen DA, Ji F, Yuferov V, Ho A, He C, Ott J, Kreek MJ. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatr Genet. 2010 Oct; 20(5):207-14. PMID: 20520587.
      Citations: 30     Fields:    Translation:Humans
    60. Rouault M, Nielsen DA, Ho A, Kreek MJ, Yuferov V. Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addict Biol. 2011 Apr; 16(2):334-46. PMID: 20731629.
      Citations: 14     Fields:    Translation:HumansCells
    61. Briant JA, Nielsen DA, Proudnikov D, Londono D, Ho A, Ott J, Kreek MJ. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Psychiatr Genet. 2010 Apr; 20(2):65-72. PMID: 20032820.
      Citations: 6     Fields:    Translation:HumansCells
    62. Nielsen DA, Hamon S, Yuferov V, Jackson C, Ho A, Ott J, Kreek MJ. Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum Genet. 2010 Jun; 127(6):639-49. PMID: 20237803.
      Citations: 25     Fields:    Translation:HumansCells
    63. Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci. 2010 Feb; 1187:184-207. PMID: 20201854.
      Citations: 43     Fields:    Translation:Humans
    64. Yuferov V, Ji F, Nielsen DA, Levran O, Ho A, Morgello S, Shi R, Ott J, Kreek MJ. A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. Neuropsychopharmacology. 2009 Apr; 34(5):1185-97. PMID: 18923396.
      Citations: 37     Fields:    Translation:Humans
    65. Oosterhuis BE, LaForge KS, Proudnikov D, Ho A, Nielsen DA, Gianotti R, Barral S, Gordon D, Leal SM, Ott J, Kreek MJ. Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 05; 147B(6):793-8. PMID: 18270997.
      Citations: 12     Fields:    Translation:Humans
    66. Kreek MJ, Schlussman SD, Reed B, Zhang Y, Nielsen DA, Levran O, Zhou Y, Butelman ER. Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology. 2009; 56 Suppl 1:32-43. PMID: 18725235.
      Citations: 16     Fields:    Translation:HumansAnimals
    67. Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology. 2009 Mar; 34(4):867-73. PMID: 18650805.
      Citations: 56     Fields:    Translation:HumansCells
    68. Levran O, Londono D, O'Hara K, Nielsen DA, Peles E, Rotrosen J, Casadonte P, Linzy S, Randesi M, Ott J, Adelson M, Kreek MJ. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav. 2008 Oct; 7(7):720-9. PMID: 18518925.
      Citations: 111     Fields:    Translation:Humans
    69. Nielsen DA, Ji F, Yuferov V, Ho A, Chen A, Levran O, Ott J, Kreek MJ. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Mol Psychiatry. 2008 Apr; 13(4):417-28. PMID: 18195715.
      Citations: 42     Fields:    Translation:HumansCells
    70. Nielsen DA, Barral S, Proudnikov D, Kellogg S, Ho A, Ott J, Kreek MJ. TPH2 and TPH1: association of variants and interactions with heroin addiction. Behav Genet. 2008 Mar; 38(2):133-50. PMID: 18181017.
      Citations: 23     Fields:    Translation:Humans
    71. Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem. 2007 Oct; 103(1):77-87. PMID: 17877633.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    72. Nielsen DA, Leidner M, Haynes C, Krauthammer M, Kreek MJ. The BiolAD-DB system : an informatics system for clinical and genetic data. Mol Diagn Ther. 2007; 11(1):15-9. PMID: 17286447.
      Citations: 1     Fields:    Translation:Humans
    73. Osguthorpe JD, Nielsen DR. Otitis externa: Review and clinical update. Am Fam Physician. 2006 Nov 01; 74(9):1510-6. PMID: 17111889.
      Citations: 19     Fields:    Translation:Humans
    74. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci. 2005 Nov; 8(11):1450-7. PMID: 16251987.
      Citations: 326     Fields:    Translation:HumansAnimals
    75. Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev. 2005 Mar; 57(1):1-26. PMID: 15734726.
      Citations: 110     Fields:    Translation:Humans
    76. Yuferov V, Nielsen D, Butelman E, Kreek MJ. Microarray studies of psychostimulant-induced changes in gene expression. Addict Biol. 2005 Mar; 10(1):101-18. PMID: 15849024.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    77. Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics. 2004 Dec; 14(12):793-804. PMID: 15608558.
      Citations: 40     Fields:    Translation:HumansCells
    78. Kreek MJ, Nielsen DA, LaForge KS. Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Med. 2004; 5(1):85-108. PMID: 15001815.
      Citations: 41     Fields:    Translation:HumansAnimals
    79. Roy A, Rylander G, Forslund K, Asberg M, Mazzanti CM, Goldman D, Nielsen DA. Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims. Neuropsychobiology. 2001; 43(4):233-6. PMID: 11340361.
      Citations: 8     Fields:    Translation:Humans
    80. Nielsen DA, Mazzanti CM, Linnoila M, Goldman D. Serotonin transporter genotype and seasonal variation in serotonin function. Neuropsychopharmacology. 1999 May; 20(5):507-8. PMID: 26468552.
      Citations:    Fields:    Translation:Humans
    81. Han L, Nielsen DA, Rosenthal NE, Jefferson K, Kaye W, Murphy D, Altemus M, Humphries J, Cassano G, Rotondo A, Virkkunen M, Linnoila M, Goldman D. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biol Psychiatry. 1999 Mar 01; 45(5):615-9. PMID: 10088048.
      Citations: 11     Fields:    Translation:Humans
    82. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry. 1998 Jul; 55(7):593-602. PMID: 9672049.
      Citations: 37     Fields:    Translation:Humans
    83. New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. Am J Med Genet. 1998 Feb 07; 81(1):13-7. PMID: 9514581.
      Citations: 21     Fields:    Translation:Humans
    84. Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am J Psychiatry. 1997 Oct; 154(10):1451-3. PMID: 9326831.
      Citations: 15     Fields:    Translation:Humans
    85. Rotondo A, Nielsen DA, Nakhai B, Hulihan-Giblin B, Bolos A, Goldman D. Agonist-promoted down-regulation and functional desensitization in two naturally occurring variants of the human serotonin1A receptor. Neuropsychopharmacology. 1997 Jul; 17(1):18-26. PMID: 9194046.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    86. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D. Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Brain Res Mol Brain Res. 1997 Apr; 45(1):145-8. PMID: 9105682.
      Citations: 20     Fields:    Translation:HumansCells
    87. Jönsson EG, Goldman D, Spurlock G, Gustavsson JP, Nielsen DA, Linnoila M, Owen MJ, Sedvall GC. Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Eur Arch Psychiatry Clin Neurosci. 1997; 247(6):297-302. PMID: 9477008.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    88. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. TPH replication study: not! Arch Gen Psychiatry. 1996 Oct; 53(10):964-5. PMID: 8857875.
      Citations:    Fields:    Translation:Humans
    89. Henley WN, Schuebel KE, Nielsen DA. Limitations imposed by heteroduplex formation on quantitative RT-PCR. Biochem Biophys Res Commun. 1996 Sep 04; 226(1):113-7. PMID: 8806600.
      Citations: 7     Fields:    Translation:AnimalsCells
    90. Schuebel KE, Bustelo XR, Nielsen DA, Song BJ, Barbacid M, Goldman D, Lee IJ. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene. 1996 Jul 18; 13(2):363-71. PMID: 8710375.
      Citations: 49     Fields:    Translation:AnimalsCells
    91. McCarthy MM, Nielsen DA, Goldman D. Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain. Regul Pept. 1995 Oct 20; 59(2):163-70. PMID: 8584751.
      Citations:    Fields:    Translation:AnimalsCells
    92. Virkkunen M, Goldman D, Nielsen DA, Linnoila M. Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. J Psychiatry Neurosci. 1995 Jul; 20(4):271-5. PMID: 7544158.
      Citations: 38     Fields:    Translation:Humans
    93. Nielsen DA, Novoradovsky A, Goldman D. SSCP primer design based on single-strand DNA structure predicted by a DNA folding program. Nucleic Acids Res. 1995 Jun 25; 23(12):2287-91. PMID: 7610057.
      Citations: 7     Fields:    Translation:HumansCells
    94. Nakhai B, Nielsen DA, Linnoila M, Goldman D. Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochem Biophys Res Commun. 1995 May 16; 210(2):530-6. PMID: 7755630.
      Citations: 9     Fields:    Translation:HumansCells
    95. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry. 1994 Jan; 51(1):34-8. PMID: 7506517.
      Citations: 38     Fields:    Translation:Humans
    96. Linnoila M, Virkkunen M, George T, Eckardt M, Higley JD, Nielsen D, Goldman D. Serotonin, violent behavior and alcohol. EXS. 1994; 71:155-63. PMID: 7518265.
      Citations: 8     Fields:    Translation:HumansAnimals
    97. Nielsen DA, Dean M, Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am J Hum Genet. 1992 Dec; 51(6):1366-71. PMID: 1463016.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    98. Nielsen DA, Shapiro DJ. Insights into hormonal control of messenger RNA stability. Mol Endocrinol. 1990 Jul; 4(7):953-7. PMID: 2284008.
      Citations: 21     Fields:    Translation:AnimalsCells
    99. Nielsen DA, Shapiro DJ. Estradiol and estrogen receptor-dependent stabilization of a minivitellogenin mRNA lacking 5,100 nucleotides of coding sequence. Mol Cell Biol. 1990 Jan; 10(1):371-6. PMID: 2294409.
      Citations: 11     Fields:    Translation:AnimalsCells
    100. Nielsen DA, Chang TC, Shapiro DJ. A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells. Anal Biochem. 1989 May 15; 179(1):19-23. PMID: 2757194.
      Citations: 20     Fields:    Translation:AnimalsCells
    101. Shapiro DJ, Barton MC, McKearin DM, Chang TC, Lew D, Blume J, Nielsen DA, Gould L. Estrogen regulation of gene transcription and mRNA stability. Recent Prog Horm Res. 1989; 45:29-58; discussion 58-64. PMID: 2682843.
      Citations: 7     Fields:    Translation:AnimalsCells
    102. Welsh M, Weber T, Wrange O, Nielsen DA, Matthieu M, Steiner DF. Regulation of insulin gene expression by dexamethasone, Ca2+ and a phorbol ester. Biomed Biochim Acta. 1988; 47(4-5):299-303. PMID: 3071361.
      Citations: 6     Fields:    Translation:AnimalsCells
    103. Shapiro DJ, Blume JE, Nielsen DA. Regulation of messenger RNA stability in eukaryotic cells. Bioessays. 1987 May; 6(5):221-6. PMID: 3606588.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    104. Steiner DF, Chan SJ, Welsh JM, Nielsen D, Michael J, Tager HS, Rubenstein AH. Models of peptide biosynthesis: the molecular and cellular basis of insulin production. Clin Invest Med. 1986 Nov; 9(4):328-36. PMID: 3542328.
      Citations: 4     Fields:    Translation:Cells
    105. Nielsen DA, Shapiro DJ. Preparation of capped RNA transcripts using T7 RNA polymerase. Nucleic Acids Res. 1986 Jul 25; 14(14):5936. PMID: 3526287.
      Citations: 45     Fields:    Translation:Cells
    106. Welsh M, Nielsen DA, MacKrell AJ, Steiner DF. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J Biol Chem. 1985 Nov 05; 260(25):13590-4. PMID: 3902821.
      Citations: 76     Fields:    Translation:AnimalsCells
    107. Nielsen DA, Welsh M, Casadaban MJ, Steiner DF. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. J Biol Chem. 1985 Nov 05; 260(25):13585-9. PMID: 2997172.
      Citations: 53     Fields:    Translation:AnimalsCells
    108. Nielsen DR, Larsen J, Pedersen IM, Starup J. [Hirsutism treated with cyproterone acetate and ethinyl estradiol. Influence on androgens in the serum and urine and on urinary cortisol]. Ugeskr Laeger. 1985 Aug 12; 147(33):2589-93. PMID: 2933857.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    109. Pedersen IM, Nielsen DR, Larsen J, Starup J. [Hirsutism treated with cyproterone acetate and ethinyl estradiol. Evaluation of the clinical effect]. Ugeskr Laeger. 1985 Aug 12; 147(33):2594-6. PMID: 2933858.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    110. Larsen J, Buus O, Nielsen DR, Pedersen IM, Starup J. [Androgens in the serum in normal and hirsute women]. Ugeskr Laeger. 1985 Aug 12; 147(33):2586-9. PMID: 4071689.
      Citations:    Fields:    Translation:Humans
    111. Nielsen DA, Chou J, MacKrell AJ, Casadaban MJ, Steiner DF. Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5198-202. PMID: 6310564.
      Citations: 56     Fields:    Translation:AnimalsCells
    112. Nielsen DA, Lernmark A, Berelowitz M, Bloom GD, Steiner DF. Sorting of pancreatic islet cell subpopulations by light scattering using a fluorescence-activated cell sorter. Diabetes. 1982 Apr; 31(4 Pt 1):299-306. PMID: 6130019.
      Citations: 13     Fields:    Translation:AnimalsCells
    113. Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. Expression of major histocompatibility antigens on pancreatic islet cells. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6456-60. PMID: 7031653.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    114. Lernmark A, Nielsen DA, Nielsen O, Larsen JK. Light scattering analysis of rat and mouse islet cells in the fluorescence-activated cell sorter. Ups J Med Sci. 1981; 86(2):119-24. PMID: 7034342.
      Citations: 2     Fields:    Translation:AnimalsCells
    115. Steiner DF, Patzelt C, Chan SJ, Quinn PS, Tager HS, Nielsen D, Lernmark A, Noyes BE, Agarwal KL, Gabbay KH, Rubenstein AH. Formation of biologically active peptides. Proc R Soc Lond B Biol Sci. 1980 Oct 29; 210(1178):45-59. PMID: 6107930.
      Citations: 2     Fields:    Translation:Cells
    116. Lernmark A, Nielsen DA, Parman AU, Sehlin J, Steiner DF, Täljedal IB. Cation-activated phosphatase activities in islet cell plasma membrane preparations. Horm Metab Res Suppl. 1980; Suppl 10:55-61. PMID: 6256271.
      Citations: 1     Fields:    Translation:AnimalsCells
    117. Lernmark A, Nielsen DA, Steiner DF. Cation-dependent phosphatase activites in a rat pancreatic islet plasma membrane fraction prepared by one-step gradient centrifugation. J Supramol Struct. 1978; 9(3):327-36. PMID: 34753.
      Citations:    Fields:    Translation:AnimalsCells
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