TitleAssociate Professor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Psychiatry & Behavioral Sciences
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor Emeritus
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology

    Collapse Research 
    Collapse research activities and funding
    R21DA020117     (KOSTEN, THERESE A)Jul 1, 2008 - Jun 30, 2012
    Sex Differences in Vulnerability to Cocaine Addiction
    Role: Co-Principal Investigator

    R03DA022266     (NIELSEN, DAVID ANDREW)Sep 25, 2006 - Aug 31, 2008
    DNA Methylation of Promoter CpG Dinucleotides in Opiate Addiction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, Brophy M, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, DeLisi LE, Kimbrel NA, Beckham JC, Swann AC, Kosten TR, Fanous AH, Cooperative Studies Program (CSP) #572, Aslan M, Harvey PD. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Mol Psychiatry. 2024 Mar 15. PMID: 38491344.
      Citations:    Fields:    
    2. Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann AC, Lipsky RK, Kosten TR, Aslan M, Harvey PD, Kimbrel NA, Beckham JC, Million Veteran Program (MVP)Cooperative Studies Program (CSP) #572. Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. JAMA Psychiatry. 2024 Feb 01; 81(2):188-197. PMID: 37938835; PMCID: PMC10633411.
      Citations:    Fields:    Translation:Humans
    3. Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Paige Harden K, Wilkinson A, Graham DP, Nielsen DA, Swann A, Lipsky RK, Kosten T, Aslan M, Harvey PD, Kimbrel NA, Beckham JC. Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. medRxiv. 2023 Jul 11. PMID: 37034805; PMCID: PMC10081391.
    4. Bolin PK, Nielsen EM, Nielsen DA, De La Garza R. Promoter region variant C-824T in the TH gene modulates the subjective effects of cocaine. Am J Addict. 2023 09; 32(5):506-509. PMID: 37337750.
      Citations:    Fields:    Translation:HumansCells
    5. Aloi MS, Poblete GF, Oldham J, Patriquin MA, Nielsen DA, Kosten TR, Salas R. miR-124-3p target genes identify globus pallidus role in suicide ideation recovery in borderline personality disorder. Npj Ment Health Res. 2023; 2(1):8. PMID: 37712050; PMCID: PMC10500603.
    6. Million Veteran Program (MVP), Cooperative Studies Program (CSP) #572, Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, Brophy M, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Pyarajan S, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, DeLisi LE, Kimbrel NA, Beckham JC, Swann AC, Kosten TR, Fanous AH, Aslan M, Harvey PD. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. medRxiv. 2023 Mar 08. PMID: 36945597; PMCID: PMC10029042.
    7. Nieto SJ, Harding MJ, Nielsen DA, Kosten TA. Paternal alcohol exposure has task- and sex-dependent behavioral effect in offspring. Alcohol Clin Exp Res. 2022 12; 46(12):2191-2202. PMID: 36281832.
      Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    8. Kosten TR, Domingo CB, Haile CN, Nielsen DA. A Clinical Trial of Entolimod a TLR-5 Adjuvant for Vaccines Using Diphtheria or Tetanus as Carrier Proteins. Vaccines (Basel). 2022 Sep 22; 10(10). PMID: 36298456; PMCID: PMC9611255.
    9. Poblete G, Nguyen T, Gosnell S, Sofela O, Patriquin M, Mathew SJ, Swann A, Nielsen DA, Kosten TR, Salas R. A Novel Approach to Link Genetics and Human MRI Identifies AKAP7-Dependent Subicular/Prefrontal Functional Connectivity as Altered in Suicidality. Chronic Stress (Thousand Oaks). 2022 Jan-Dec; 6:24705470221083700. PMID: 35340866; PMCID: PMC8941704.
    10. Nielsen DA, Walker R, Graham DP, Nielsen EM, Hamon SC, Hillhouse M, Shmueli-Blumberg D, Lawson WB, Shores-Wilson K, Settles-Reaves BD, Rotrosen J, Trivedi MH, Saxon AJ, Ling W, Kosten TR. Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene. Eur J Clin Pharmacol. 2022 Jun; 78(6):965-973. PMID: 35218405.
      Citations:    Fields:    Translation:Humans
    11. Graham DP, Harding MJ, Nielsen DA. Pharmacogenetics of Addiction Therapy. Methods Mol Biol. 2022; 2547:437-490. PMID: 36068473.
    12. Longtain RB, Graham DP, Harding MJ, De La Garza Ii R, Nielsen DA. Methylation of the serotonin transporter gene moderates the depressive subjective effect of cocaine. Behav Brain Res. 2022 02 10; 418:113675. PMID: 34798166; PMCID: PMC8671356.
      Citations:    Fields:    Translation:HumansCells
    13. Nieto SJ, Haile CN, Quave CB, Harding MJ, Nielsen DA, Meisch RA, Kosten TA. Paternal alcohol exposure reduces acquisition of operant alcohol self-administration and affects Bdnf DNA methylation in male and female offspring. Addict Biol. 2022 01; 27(1):e13078. PMID: 34363290; PMCID: PMC8720057.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Thomas PS, Nielsen EM, Spellicy CJ, Harding MJ, Ye A, Patriquin M, Hamon SC, Kosten TR, Nielsen DA. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatr Genet. 2021 06 01; 31(3):88-94. PMID: 33953123; PMCID: PMC8108700.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    15. Jones CM, Korosh TC, Nielsen DR, Pfleger BF. Optimization of a T7-RNA polymerase system in Synechococcus sp. PCC 7002 mirrors the protein overproduction phenotype from E. coli BL21(DE3). Appl Microbiol Biotechnol. 2021 Feb; 105(3):1147-1158. PMID: 33443634; PMCID: PMC8351450.
      Citations:    Fields:    Translation:Cells
    16. Poblete GF, Gosnell SN, Meyer M, Fang M, Nguyen T, Patriquin MA, Nielsen D, Kosten T, Salas R. Process genes list: An approach to link genetics and human brain imaging. J Neurosci Methods. 2020 06 01; 339:108695. PMID: 32201351.
      Citations: 1     Fields:    Translation:Humans
    17. Shorter DI, Zhang X, Domingo CB, Nielsen EM, Kosten TR, Nielsen DA. Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant. Am J Drug Alcohol Abuse. 2020; 46(2):184-193. PMID: 31914324.
      Citations: 4     Fields:    Translation:Humans
    18. Kampangkaew JP, Spellicy CJ, Nielsen EM, Harding MJ, Ye A, Hamon SC, Kosten TR, Nielsen DA. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. Am J Addict. 2019 07; 28(4):311-317. PMID: 31087723; PMCID: PMC6591035.
      Citations: 4     Fields:    Translation:HumansCells
    19. Nielsen DA, Deng H, Patriquin MA, Harding MJ, Oldham J, Salas R, Fowler JC, Frueh BC. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. Eur Arch Psychiatry Clin Neurosci. 2020 Aug; 270(5):633-642. PMID: 30923939.
      Citations: 5     Fields:    Translation:Humans
    20. Deng H, Desai PV, Mohite S, Okusaga OO, Zhang XY, Nielsen DA, Kosten TR. Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users. J Stud Alcohol Drugs. 2019 03; 80(2):230-235. PMID: 31014468; PMCID: PMC6489549.
      Citations: 1     Fields:    Translation:Humans
    21. Patel MM, Nielsen DA, Kosten TR, De La Garza R, Newton TF, Verrico CD. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. Am J Addict. 2018 10; 27(7):567-573. PMID: 30126012.
      Citations: 5     Fields:    Translation:Humans
    22. Deng H, Verrico CD, Kosten TR, Nielsen DA. Psychosis and synthetic cannabinoids. Psychiatry Res. 2018 10; 268:400-412. PMID: 30125871.
      Citations: 11     Fields:    Translation:HumansAnimals
    23. Kosten TR, Graham DP, Nielsen DA. Opioid Use Disorder After Self-medicating Pain From Traumatic Brain Injury. JAMA Psychiatry. 2018 06 01; 75(6):649-650. PMID: 29710138.
      Citations: 1     Fields:    Translation:Humans
    24. Kosten TR, Graham DP, Nielsen DA. Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. JAMA Psychiatry. 2018 06 01; 75(6):642-648. PMID: 29710079.
      Citations:    Fields:    Translation:Humans
    25. Nielsen DA, Spellicy CJ, Harding MJ, Graham DP. Apolipoprotein E DNA methylation and posttraumatic stress disorder are associated with plasma ApoE level: A preliminary study. Behav Brain Res. 2019 01 01; 356:415-422. PMID: 29807071.
      Citations: 5     Fields:    Translation:HumansCells
    26. Zhang X, Nielsen DA, Domingo CB, Shorter DI, Nielsen EM, Kosten TR. Pharmacogenetics of Dopamine ?-Hydroxylase in cocaine dependence therapy with doxazosin. Addict Biol. 2019 05; 24(3):531-538. PMID: 29498170; PMCID: PMC6119656.
      Citations: 4     Fields:    Translation:Humans
    27. Deng H, Mohite S, Suchting R, Nielsen DA, Okusaga OO. Impact of synthetic cannabinoid use on hospital stay in patients with bipolar disorder versus schizophrenia, or other psychotic disorders. Psychiatry Res. 2018 03; 261:248-252. PMID: 29329043.
      Citations: 2     Fields:    Translation:Humans
    28. Patriquin MA, Hamon SC, Harding MJ, Nielsen EM, Newton TF, De La Garza R, Nielsen DA. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatr Genet. 2017 10; 27(5):178-186. PMID: 28590957; PMCID: PMC5572746.
      Citations: 3     Fields:    Translation:Humans
    29. Curtis K, Viswanath H, Velasquez KM, Molfese DL, Harding MJ, Aramayo E, Baldwin PR, Ambrosi E, Madan A, Patriquin M, Frueh BC, Fowler JC, Kosten TR, Nielsen DA, Salas R. Increased habenular connectivity in opioid users is associated with an a5 subunit nicotinic receptor genetic variant. Am J Addict. 2017 Oct; 26(7):751-759. PMID: 28857330; PMCID: PMC5745069.
      Citations: 8     Fields:    Translation:Humans
    30. Wachman EM, Hayes MJ, Sherva R, Brown MS, Shrestha H, Logan BA, Heller NA, Nielsen DA, Farrer LA. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. Am J Addict. 2017 Jan; 26(1):42-49. PMID: 27983768; PMCID: PMC5206487.
      Citations: 12     Fields:    Translation:Humans
    31. Shorter D, Nielsen DA, Hamon SC, Nielsen EM, Kosten TR, Newton TF, De La Garza R. The a-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals. Pharmacogenet Genomics. 2016 09; 26(9):428-35. PMID: 27379509; PMCID: PMC4970930.
      Citations: 2     Fields:    Translation:Humans
    32. Nieto SJ, Patriquin MA, Nielsen DA, Kosten TA. Don't worry; be informed about the epigenetics of anxiety. Pharmacol Biochem Behav. 2016 Jul-Aug; 146-147:60-72. PMID: 27189589; PMCID: PMC4939112.
      Citations: 8     Fields:    Translation:HumansAnimals
    33. Cao B, Bauer IE, Sharma AN, Mwangi B, Frazier T, Lavagnino L, Zunta-Soares GB, Walss-Bass C, Glahn DC, Kapczinski F, Nielsen DA, Soares JC. Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. J Affect Disord. 2016 Jul 01; 198:198-205. PMID: 27018938; PMCID: PMC5214589.
      Citations: 24     Fields:    Translation:Humans
    34. Sharp C, Fowler JC, Salas R, Nielsen D, Allen J, Oldham J, Kosten T, Mathew S, Madan A, Frueh BC, Fonagy P. Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings. Bull Menninger Clin. 2016; 80(3):187-212. PMID: 27583809.
      Citations: 2     Fields:    Translation:Humans
    35. Azadeh S, Hobbs BP, Ma L, Nielsen DA, Gerard Moeller F, Baladandayuthapani V. Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence. Neuroimage. 2016 Jan 15; 125:813-824. PMID: 26484829; PMCID: PMC5042574.
      Citations: 3     Fields:    Translation:Humans
    36. Liu S, Maili L, Lane SD, Schmitz JM, Spellicy CJ, Cunningham KA, Moeller FG, Nielsen DA. Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity. Psychiatr Genet. 2015 Oct; 25(5):213-4. PMID: 26110342; PMCID: PMC4549162.
      Citations: 3     Fields:    Translation:HumansCells
    37. Patriquin MA, Bauer IE, Soares JC, Graham DP, Nielsen DA. Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatr Genet. 2015 Oct; 25(5):181-93. PMID: 26146874; PMCID: PMC4549168.
      Citations: 16     Fields:    Translation:Humans
    38. Bauer IE, Graham DP, Soares JC, Nielsen DA. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. 2015; 16(11):1307-14. PMID: 26265436; PMCID: PMC4573253.
      Citations: 9     Fields:    Translation:Humans
    39. Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Variations in opioid receptor genes in neonatal abstinence syndrome. Drug Alcohol Depend. 2015 Oct 01; 155:253-9. PMID: 26233486; PMCID: PMC4581974.
      Citations: 17     Fields:    Translation:Humans
    40. Brewer AJ, Nielsen DA, Spellicy CJ, Hamon SC, Gingrich J, Thompson-Lake DG, Nielsen EM, Mahoney JJ, Kosten TR, Newton TF, De La Garza R. Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenet Genomics. 2015 Jun; 25(6):296-304. PMID: 25850966; PMCID: PMC4414865.
      Citations: 11     Fields:    Translation:Humans
    41. Bauer IE, Soares JC, Nielsen DA. The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. Am J Addict. 2015 Jan; 24(1):15-23. PMID: 25823631.
      Citations: 15     Fields:    Translation:Humans
    42. Peterson ED, Ho PM, Barton M, Beam C, Burgess LH, Casey DE, Drozda JP, Fonarow GC, Goff D, Grady KL, King DE, King ML, Masoudi FA, Nielsen DR, Stanko S. ACC/AHA/AACVPR/AAFP/ANA concepts for clinician-patient shared accountability in performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circulation. 2014 Nov 25; 130(22):1984-94. PMID: 25366994; PMCID: PMC4500543.
      Citations: 8     Fields:    Translation:Humans
    43. Peterson ED, Ho PM, Barton M, Beam C, Burgess LH, Casey DE, Drozda JP, Fonarow GC, Goff D, Grady KL, King DE, King ML, Masoudi FA, Nielsen DR, Stanko S. ACC/AHA/AACVPR/AAFP/ANA concepts for clinician-patient shared accountability in performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. J Am Coll Cardiol. 2014 Nov 18-25; 64(20):2133-45. PMID: 25439761; PMCID: PMC4476791.
      Citations: 2     Fields:    Translation:Humans
    44. Graham DP, Nielsen DA, Kosten TR, Davis LL, Hamner MB, Makotkine I, Yehuda R. Examining the utility of using genotype and functional biology in a clinical pharmacology trial: pilot testing dopamine ?-hydroxylase, norepinephrine, and post-traumatic stress disorder. Psychiatr Genet. 2014 Aug; 24(4):181-2. PMID: 24983834; PMCID: PMC4080201.
      Citations: 4     Fields:    Translation:Humans
    45. Liu S, Green CE, Lane SD, Kosten TR, Moeller FG, Nielsen DA, Schmitz JM. The influence of dopamine ?-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. Pharmacogenet Genomics. 2014 Jul; 24(7):370-3. PMID: 24809448.
      Citations: 10     Fields:    Translation:Humans
    46. Wachman EM, Hayes MJ, Lester BM, Terrin N, Brown MS, Nielsen DA, Davis JM. Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. J Pediatr. 2014 Sep; 165(3):472-8. PMID: 24996986; PMCID: PMC4145036.
      Citations: 37     Fields:    Translation:HumansCells
    47. Kosten TA, Nielsen DA. Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum. Int J Dev Neurosci. 2014 Aug; 36:5-12. PMID: 24721039; PMCID: PMC4101021.
      Citations: 14     Fields:    Translation:AnimalsCells
    48. Frazier TW, Youngstrom EA, Frankel BA, Zunta-Soares GB, Sanches M, Escamilla M, Nielsen DA, Soares JC. Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes. Brain Behav. 2014 May; 4(3):418-30. PMID: 24944871; PMCID: PMC4055192.
      Citations: 10     Fields:    Translation:Humans
    49. Nielsen DA, Nielsen EM, Dasari T, Spellicy CJ. Pharmacogenetics of addiction therapy. Methods Mol Biol. 2014; 1175:589-624. PMID: 25150877.
      Citations: 5     Fields:    Translation:HumansAnimals
    50. Nielsen DA, Hamon SC, Kosten TR. The ?-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial. Psychiatr Genet. 2013 Dec; 23(6):225-32. PMID: 23995774; PMCID: PMC3885873.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    51. Darter BJ, Nielsen DH, Yack HJ, Janz KF. Home-based treadmill training to improve gait performance in persons with a chronic transfemoral amputation. Arch Phys Med Rehabil. 2013 Dec; 94(12):2440-2447. PMID: 23954560; PMCID: PMC4005601.
      Citations: 12     Fields:    Translation:Humans
    52. Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Pharmacogenet Genomics. 2013 Jul; 23(7):333-40. PMID: 23635803; PMCID: PMC5396392.
      Citations: 12     Fields:    Translation:Humans
    53. Graham DP, Helmer DA, Harding MJ, Kosten TR, Petersen NJ, Nielsen DA. Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans. J Psychiatr Res. 2013 Jun; 47(6):835-42. PMID: 23478049; PMCID: PMC3643301.
      Citations: 19     Fields:    Translation:Humans
    54. Kosten TA, Huang W, Nielsen DA. Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats. Dev Psychobiol. 2014 Apr; 56(3):392-406. PMID: 23460384.
      Citations: 29     Fields:    Translation:AnimalsCells
    55. Kosten TR, Domingo CB, Hamon SC, Nielsen DA. DBH gene as predictor of response in a cocaine vaccine clinical trial. Neurosci Lett. 2013 Apr 29; 541:29-33. PMID: 23458673; PMCID: PMC3631430.
      Citations: 11     Fields:    Translation:Humans
    56. Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. Front Psychiatry. 2012; 3:109. PMID: 23335901; PMCID: PMC3544007.
      Citations: 3     
    57. Haile CN, De La Garza R, Mahoney JJ, Nielsen DA, Kosten TR, Newton TF. The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. PLoS One. 2012; 7(11):e47702. PMID: 23144826; PMCID: PMC3493584.
      Citations: 14     Fields:    Translation:Humans
    58. Kosten TR, Wu G, Huang W, Harding MJ, Hamon SC, Lappalainen J, Nielsen DA. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine ?-hydroxylase. Biol Psychiatry. 2013 Feb 01; 73(3):219-24. PMID: 22906516; PMCID: PMC3514624.
      Citations: 44     Fields:    Translation:Humans
    59. Nielsen DA, Utrankar A, Reyes JA, Simons DD, Kosten TR. Epigenetics of drug abuse: predisposition or response. Pharmacogenomics. 2012 Jul; 13(10):1149-60. PMID: 22909205; PMCID: PMC3463407.
      Citations: 37     Fields:    Translation:HumansCells
    60. Nielsen DA, Huang W, Hamon SC, Maili L, Witkin BM, Fox RG, Cunningham KA, Moeller FG. Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. Front Psychiatry. 2012; 3:60. PMID: 22712019; PMCID: PMC3374938.
      Citations: 16     
    61. Nielsen DA, Kreek MJ. Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug Alcohol Depend. 2012 Jun; 123 Suppl 1:S33-41. PMID: 22542464; PMCID: PMC3689423.
      Citations: 13     Fields:    Translation:Humans
    62. Nielsen DA, Ho A, Bahl A, Varma P, Kellogg S, Borg L, Kreek MJ. Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls. Drug Alcohol Depend. 2012 Jul 01; 124(1-2):113-20. PMID: 22265192; PMCID: PMC3372650.
      Citations: 26     Fields:    Translation:Humans
    63. Hao Y, Huang W, Nielsen DA, Kosten TA. Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Front Psychiatry. 2011; 2:21. PMID: 21629839; PMCID: PMC3098712.
      Citations: 28     
    64. Yuferov V, Nielsen DA, Levran O, Randesi M, Hamon S, Ho A, Morgello S, Kreek MJ. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenet Genomics. 2011 Apr; 21(4):185-96. PMID: 20808262; PMCID: PMC3017726.
      Citations: 22     Fields:    Translation:HumansCells
    65. Nielsen DA, Ji F, Yuferov V, Ho A, He C, Ott J, Kreek MJ. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatr Genet. 2010 Oct; 20(5):207-14. PMID: 20520587; PMCID: PMC3832188.
      Citations: 33     Fields:    Translation:Humans
    66. Rouault M, Nielsen DA, Ho A, Kreek MJ, Yuferov V. Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addict Biol. 2011 Apr; 16(2):334-46. PMID: 20731629; PMCID: PMC2995810.
      Citations: 16     Fields:    Translation:HumansCells
    67. Briant JA, Nielsen DA, Proudnikov D, Londono D, Ho A, Ott J, Kreek MJ. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Psychiatr Genet. 2010 Apr; 20(2):65-72. PMID: 20032820; PMCID: PMC3832186.
      Citations: 7     Fields:    Translation:HumansCells
    68. Nielsen DA, Hamon S, Yuferov V, Jackson C, Ho A, Ott J, Kreek MJ. Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum Genet. 2010 Jun; 127(6):639-49. PMID: 20237803; PMCID: PMC3739429.
      Citations: 28     Fields:    Translation:HumansCells
    69. Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci. 2010 Feb; 1187:184-207. PMID: 20201854; PMCID: PMC3769182.
      Citations: 44     Fields:    Translation:Humans
    70. Yuferov V, Ji F, Nielsen DA, Levran O, Ho A, Morgello S, Shi R, Ott J, Kreek MJ. A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. Neuropsychopharmacology. 2009 Apr; 34(5):1185-97. PMID: 18923396; PMCID: PMC2778041.
      Citations: 38     Fields:    Translation:Humans
    71. Oosterhuis BE, LaForge KS, Proudnikov D, Ho A, Nielsen DA, Gianotti R, Barral S, Gordon D, Leal SM, Ott J, Kreek MJ. Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 05; 147B(6):793-8. PMID: 18270997; PMCID: PMC2909109.
      Citations: 12     Fields:    Translation:Humans
    72. Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology. 2009 Mar; 34(4):867-73. PMID: 18650805; PMCID: PMC2778040.
      Citations: 63     Fields:    Translation:HumansCells
    73. Nielsen DA, Barral S, Proudnikov D, Kellogg S, Ho A, Ott J, Kreek MJ. TPH2 and TPH1: association of variants and interactions with heroin addiction. Behav Genet. 2008 Mar; 38(2):133-50. PMID: 18181017.
      Citations: 25     Fields:    Translation:Humans
    74. Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem. 2007 Oct; 103(1):77-87. PMID: 17877633.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    75. Nielsen DA, Leidner M, Haynes C, Krauthammer M, Kreek MJ. The BiolAD-DB system : an informatics system for clinical and genetic data. Mol Diagn Ther. 2007; 11(1):15-9. PMID: 17286447.
      Citations: 1     Fields:    Translation:Humans
    76. Osguthorpe JD, Nielsen DR. Otitis externa: Review and clinical update. Am Fam Physician. 2006 Nov 01; 74(9):1510-6. PMID: 17111889.
      Citations: 20     Fields:    Translation:Humans
    77. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci. 2005 Nov; 8(11):1450-7. PMID: 16251987.
      Citations: 356     Fields:    Translation:HumansAnimals
    78. Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev. 2005 Mar; 57(1):1-26. PMID: 15734726.
      Citations: 117     Fields:    Translation:Humans
    79. Yuferov V, Nielsen D, Butelman E, Kreek MJ. Microarray studies of psychostimulant-induced changes in gene expression. Addict Biol. 2005 Mar; 10(1):101-18. PMID: 15849024.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    80. Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics. 2004 Dec; 14(12):793-804. PMID: 15608558; PMCID: PMC6141019.
      Citations: 42     Fields:    Translation:HumansCells
    81. Kreek MJ, Nielsen DA, LaForge KS. Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Med. 2004; 5(1):85-108. PMID: 15001815.
      Citations: 47     Fields:    Translation:HumansAnimals
    82. Henley WN, Schuebel KE, Nielsen DA. Limitations imposed by heteroduplex formation on quantitative RT-PCR. Biochem Biophys Res Commun. 1996 Sep 04; 226(1):113-7. PMID: 8806600.
      Citations: 7     Fields:    Translation:AnimalsCells
    83. Schuebel KE, Bustelo XR, Nielsen DA, Song BJ, Barbacid M, Goldman D, Lee IJ. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene. 1996 Jul 18; 13(2):363-71. PMID: 8710375.
      Citations: 53     Fields:    Translation:AnimalsCells
    84. Linnoila M, Virkkunen M, George T, Eckardt M, Higley JD, Nielsen D, Goldman D. Serotonin, violent behavior and alcohol. EXS. 1994; 71:155-63. PMID: 7518265.
      Citations: 11     Translation:HumansAnimals
    85. Nielsen DA, Shapiro DJ. Insights into hormonal control of messenger RNA stability. Mol Endocrinol. 1990 Jul; 4(7):953-7. PMID: 2284008.
      Citations: 21     Fields:    Translation:AnimalsCells
    86. Nielsen DA, Shapiro DJ. Estradiol and estrogen receptor-dependent stabilization of a minivitellogenin mRNA lacking 5,100 nucleotides of coding sequence. Mol Cell Biol. 1990 Jan; 10(1):371-6. PMID: 2294409; PMCID: PMC360757.
      Citations: 11     Fields:    Translation:AnimalsCells
    87. Nielsen DA, Chang TC, Shapiro DJ. A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells. Anal Biochem. 1989 May 15; 179(1):19-23. PMID: 2757194.
      Citations: 19     Fields:    Translation:AnimalsCells
    88. Shapiro DJ, Barton MC, McKearin DM, Chang TC, Lew D, Blume J, Nielsen DA, Gould L. Estrogen regulation of gene transcription and mRNA stability. Recent Prog Horm Res. 1989; 45:29-58; discussion 58-64. PMID: 2682843.
      Citations: 7     Fields:    Translation:AnimalsCells
    89. Welsh M, Weber T, Wrange O, Nielsen DA, Matthieu M, Steiner DF. Regulation of insulin gene expression by dexamethasone, Ca2+ and a phorbol ester. Biomed Biochim Acta. 1988; 47(4-5):299-303. PMID: 3071361.
      Citations: 7     Fields:    Translation:AnimalsCells
    90. Shapiro DJ, Blume JE, Nielsen DA. Regulation of messenger RNA stability in eukaryotic cells. Bioessays. 1987 May; 6(5):221-6. PMID: 3606588.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    91. Steiner DF, Chan SJ, Welsh JM, Nielsen D, Michael J, Tager HS, Rubenstein AH. Models of peptide biosynthesis: the molecular and cellular basis of insulin production. Clin Invest Med. 1986 Nov; 9(4):328-36. PMID: 3542328.
      Citations: 4     Fields:    Translation:Cells
    92. Nielsen DA, Shapiro DJ. Preparation of capped RNA transcripts using T7 RNA polymerase. Nucleic Acids Res. 1986 Jul 25; 14(14):5936. PMID: 3526287; PMCID: PMC311604.
      Citations: 47     Fields:    Translation:Cells
    93. Nielsen DA, Chou J, MacKrell AJ, Casadaban MJ, Steiner DF. Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proc Natl Acad Sci U S A. 1983 Sep; 80(17):5198-202. PMID: 6310564; PMCID: PMC384219.
      Citations: 57     Fields:    Translation:AnimalsCells
    94. Nielsen DA, Lernmark A, Berelowitz M, Bloom GD, Steiner DF. Sorting of pancreatic islet cell subpopulations by light scattering using a fluorescence-activated cell sorter. Diabetes. 1982 Apr; 31(4 Pt 1):299-306. PMID: 6130019.
      Citations: 15     Fields:    Translation:AnimalsCells
    95. Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. Expression of major histocompatibility antigens on pancreatic islet cells. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6456-60. PMID: 7031653; PMCID: PMC349058.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    96. Lernmark A, Nielsen DA, Nielsen O, Larsen JK. Light scattering analysis of rat and mouse islet cells in the fluorescence-activated cell sorter. Ups J Med Sci. 1981; 86(2):119-24. PMID: 7034342.
      Citations: 2     Fields:    Translation:AnimalsCells
    97. Steiner DF, Patzelt C, Chan SJ, Quinn PS, Tager HS, Nielsen D, Lernmark A, Noyes BE, Agarwal KL, Gabbay KH, Rubenstein AH. Formation of biologically active peptides. Proc R Soc Lond B Biol Sci. 1980 Oct 29; 210(1178):45-59. PMID: 6107930.
      Citations: 3     Fields:    Translation:Cells
    98. Lernmark A, Nielsen DA, Parman AU, Sehlin J, Steiner DF, T?ljedal IB. Cation-activated phosphatase activities in islet cell plasma membrane preparations. Horm Metab Res Suppl. 1980; Suppl 10:55-61. PMID: 6256271.
      Citations: 1     Fields:    Translation:AnimalsCells
    99. Lernmark A, Nielsen DA, Steiner DF. Cation-dependent phosphatase activites in a rat pancreatic islet plasma membrane fraction prepared by one-step gradient centrifugation. J Supramol Struct. 1978; 9(3):327-36. PMID: 34753.
      Citations:    Fields:    Translation:AnimalsCells
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