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THOMAS KOSTEN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Psychiatry & Behavioral Sciences
DivisionPsychiatry & Behavioral Sciences
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    Collapse Overview 
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    Following a successful 25 year tenure as professor and chief of Psychiatry at Yale University and VA Connecticut, Dr. Kosten joined the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) in July 2006, bringing over 30 years of exemplary Federal service; the majority of which has been with the Department of Veterans Affairs. Over the period 2006-2011, Dr. Kosten served as the Research Director of the VA national Substance Use Disorders Quality Enhancement Research Initiative (QUERI) program, fully revitalizing a research-to-practice implementation program to provide proven, cutting-edge treatment to improve the lives of veteran populations across the VA health care system. With a joint appointment at Baylor College of Medicine (BCM), Dr. Kosten is the JH Waggoner Chair & Professor of Psychiatry, Pharmacology, Neuroscience and Immunology & Pathology. He is also vice-Chair for Psychiatry and Co-director of the Dan L. Duncan Institute for Clinical and Translational Research (ICTR) at Baylor College of Medicine. His other key appointments are Distinguished Professor of Psychiatry at Peking University Medical School and Professor of Epidemiology and of Behavioral Sciences at MD Anderson Cancer Prevention Center. He established the Division of Addictions Psychiatry at Baylor and Yale and directs their NIH Medications Development Center for substance abuse.

    A recognized leader in clinical and translational sciences, Dr. Kosten is a recent past recipient of a Research Scientist Award (1987-2010) from the National Institute of Health (NIH), he has served on national and international review groups for medications and vaccines development in substance abuse, and is credited with the development of several cutting-edge discoveries in medications for addictions. A former Congressional Fellow in the House of Representatives, Dr. Kosten has held visiting professorships in Germany, Spain, Greece, China and Canada. He is the founding vice-chair for Added Qualifications in Addiction Psychiatry of the American Board of Psychiatry and Neurology. He is a distinguished fellow in the American Psychiatric Association and fellow of the American College of Neuropsychopharmacology, past president of the American Academy of Addiction Psychiatry, and past president of the College on Problems of Drug Dependence (CPDD). He has received several prestigious awards for clinical research and for his work in vaccine pharmacotherapy for drug addictions, particularly in treating cocaine, methamphetamine, and opiate addictions. He is the current Editor for the American Journal on Addictions, past Editor for the American Journal of Drug and Alcohol Abuse, and serves on the board of several notable journals in substance abuse. Additionally, Dr. Kosten retains ongoing recognition in the Best Doctors in America® ranking, an honor reserved by only 5% of the nation’s doctors. As of 2012, for the 12th year in a row, he has been named by U.S. News & World Report as a Top Doc®, ranking him among the top 10% of psychiatrists in the region, and for the 9th consecutive year, in the top 1% of psychiatrists in the field of Addictions Medicine. He is a much sought-after expert both nationally and internationally in the field of addictions with appearances on National Geographic, Discovery Channel, and PBS as well as print, radio, and online publications that include WIRED, NPR, and the Wall Street Journal, among others.

    Dr. Kosten’s recent work includes serving on the National Academy of Sciences, Institute of Medicine (IOM) committee on vaccines for substance abuse. He also served on the recently concluded IOM’s Committee on Prevention, Diagnosis, Treatment, and Management of Substance Use Disorders in the U.S. Armed Forces, a congressional mandate via the National Defense Authorization Act for Fiscal Year 2010 (Public Law 111-84), to conduct an independent study on substance use disorders in the military.

    From his studies in substance dependence, post-traumatic stress disorder, and neuroimaging he has published over 600 papers, books and reviews. His medication contributions include a cocaine vaccine, immunotherapy for hallucinogens, buprenorphine for opioid dependence, disulfiram for cocaine dependence, vasodilators for cocaine induced cerebral perfusion defects, and combining medications with contingency management for opioid and cocaine dependence.

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    P50DA004060     (KOSTEN, THOMAS RICHARD)Aug 1, 1986 - Nov 30, 2000
    NIH/NIDA
    CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
    Role: Principal Investigator

    K02DA000112     (KOSTEN, THOMAS RICHARD)Mar 1, 1987 - Aug 31, 1997
    NIH/NIDA
    AGONIST TO ANTAGONIST--NEW APPROACHES
    Role: Principal Investigator

    R01DA004505     (KOSTEN, THOMAS RICHARD)Jul 1, 1987 - Jul 31, 1991
    NIH/NIDA
    PHARMACOTHERAPY OF IV COCAINE USE IN METHADONE PATIENTS
    Role: Principal Investigator

    R01DA005626     (ROUNSAVILLE, BRUCE)Aug 1, 1988 - May 31, 2007
    NIH/NIDA
    Pharmacotherapy for opioid and cocaine dependence
    Role: Co-Principal Investigator

    R18DA006190     (KOSTEN, THOMAS RICHARD)Sep 30, 1989 - Aug 31, 1994
    NIH/NIDA
    REDUCING AIDS RISKS
    Role: Principal Investigator

    C06DA007837     (KOSTEN, THOMAS RICHARD)Sep 30, 1991 - Sep 29, 1994
    NIH/NIDA
    THE YALE UNIVERSITY SUBSTANCE ABUSE RESEARCH CENTER
    Role: Principal Investigator

    S15DA008671     (KOSTEN, THOMAS RICHARD)Sep 15, 1993 - Aug 31, 1994
    NIH/NIDA
    SMALL INSTRUMENTATION GRANT
    Role: Principal Investigator

    R01DA008754     (AVANTS, SANDRA KELLY)Sep 30, 1993 - Dec 31, 2003
    NIH/NIDA
    REDUCING HIV RISK IN METHADONE-MAINTAINED PATIENTS
    Role: Co-Principal Investigator

    P50DA009250     (KOSTEN, THOMAS RICHARD)Sep 30, 1994 - Sep 30, 1999
    NIH/NIDA
    YALE MEDICATIONS DEVELOPMENT RESEARCH CENTER
    Role: Principal Investigator

    U19DA010946     (KOSTEN, THOMAS RICHARD)May 1, 1997 - Dec 31, 2005
    NIH/NIDA
    THERAPEUTIC COCAINE VACCINE
    Role: Principal Investigator

    R13DA012147     (KOSTEN, THOMAS RICHARD)Sep 5, 1998 - Aug 31, 2001
    NIH/NIDA
    9TH/13TH ANNUAL MEETING AND SYMPOSIUM
    Role: Principal Investigator

    P50DA012762     (KOSTEN, THOMAS RICHARD)Sep 30, 1999 - Feb 28, 2005
    NIH/NIDA
    COCAINE PHARMACOTHERAPIES FOR COMORBID POPULATIONS
    Role: Principal Investigator

    K05DA000454     (KOSTEN, THOMAS RICHARD)Apr 1, 2000 - Feb 28, 2011
    NIH/NIDA
    Comorbidity in Cocaine and Opioid Pharmacotherapy
    Role: Principal Investigator

    R13DA013380     (KOSTEN, THOMAS RICHARD)Sep 30, 2000 - Aug 31, 2002
    NIH/NIDA
    11TH - 15TH ANNUAL MEETINGS AND SYMPOSIA
    Role: Principal Investigator

    R01DA015477     (ROUNSAVILLE, BRUCE)Sep 27, 2002 - Jun 30, 2007
    NIH/NIDA
    Cocaine Vaccine for Methadone Maintained Patients
    Role: Co-Principal Investigator

    P50DA018197     (KOSTEN, THOMAS RICHARD)Sep 27, 2004 - May 31, 2014
    NIH/NIDA
    Stimulant Pharmacotherapy: Noradrenergic Targets
    Role: Principal Investigator

    R01DA018863     (KOSTEN, THOMAS RICHARD)Sep 28, 2004 - May 31, 2010
    NIH/NIDA
    Heroin Addiction Treatment: Naltrexone and Lofexidine
    Role: Principal Investigator

    U01MH079639     (KOSTEN, THOMAS RICHARD)Mar 1, 2007 - Feb 28, 2011
    NIH/NIMH
    Tropisetron with Risperidone for Schizophrenia
    Role: Principal Investigator

    R01DA025223     (KOSTEN, THOMAS RICHARD)Sep 15, 2008 - Jan 31, 2014
    NIH/NIDA
    Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
    Role: Principal Investigator

    U01DA023898     (ORSON, FRANK M)Aug 1, 2009 - Jul 31, 2012
    NIH/NIDA
    Developing Immunotherapeutics for Methamphetamine Abuse
    Role: Co-Principal Investigator

    DP1DA033502     (KOSTEN, THOMAS RICHARD)Sep 30, 2011 - Aug 31, 2016
    NIH/NIDA
    Human methamphetamine vaccine: Translational Avante Garde Award
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Deng H, Desai PV, Mohite S, Okusaga OO, Zhang XY, Nielsen DA, Kosten TR. Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users. J Stud Alcohol Drugs. 2019 Mar; 80(2):230-235. PMID: 31014468.
      View in: PubMed
    2. Yang F, Kosten TR. Psychopharmacology: neuroimmune signaling in psychiatric disease-developing vaccines against abused drugs using toll-like receptor agonists. Psychopharmacology (Berl). 2019 Feb 06. PMID: 30726515.
      View in: PubMed
    3. Yammine L, Kosten TR, Pimenova M, Schmitz JM. Cigarette smoking, type 2 diabetes mellitus, and glucagon-like peptide-1 receptor agonists as a potential treatment for smokers with diabetes: An integrative review. Diabetes Res Clin Pract. 2019 Mar; 149:78-88. PMID: 30735771.
      View in: PubMed
    4. Arora R, Haile CN, Kosten TA, Wu Y, Ramakrishnan M, Hawkins LD, Orson FM, Kosten TR. Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant. Am J Addict. 2019 Feb; 28(2):119-126. PMID: 30701618.
      View in: PubMed
    5. Kosten TR, Baxter LE. Review article: Effective management of opioid withdrawal symptoms: A gateway to opioid dependence treatment. Am J Addict. 2019 Feb; 28(2):55-62. PMID: 30701615.
      View in: PubMed
    6. Lake EP, Mitchell BG, Shorter DI, Kosten T, Domingo CB, Walder AM. Buprenorphine for the treatment of posttraumatic stress disorder. Am J Addict. 2019 Feb; 28(2):86-91. PMID: 30664299.
      View in: PubMed
    7. Curtis K, Stewart CJ, Robinson M, Molfese DL, Gosnell SN, Kosten TR, Petrosino JF, De La Garza R, Salas R. Insular Resting State Functional Connectivity is Associated with Gut Microbiota Diversity. Eur J Neurosci. 2018 Dec 16. PMID: 30554441.
      View in: PubMed
    8. Patel MM, Nielsen DA, Kosten TR, De La Garza R, Newton TF, Verrico CD. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. Am J Addict. 2018 10; 27(7):567-573. PMID: 30126012.
      View in: PubMed
    9. Deng H, Verrico CD, Kosten TR, Nielsen DA. Psychosis and synthetic cannabinoids. Psychiatry Res. 2018 10; 268:400-412. PMID: 30125871.
      View in: PubMed
    10. Carroll FI, Kosten TR, Buda JJ, Wang L, Walters BB. A Double-Blind, Placebo-Controlled Trial Demonstrating the Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336. Front Pharmacol. 2018; 9:712. PMID: 30042675.
      View in: PubMed
    11. Kosten TR, Domingo C. Editorial: A new partnership with the AAAP newsletter. Am J Addict. 2018 06; 27(4):257-258. PMID: 29873860.
      View in: PubMed
    12. Kosten TR, Graham DP, Nielsen DA. Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. JAMA Psychiatry. 2018 Jun 01; 75(6):642-648. PMID: 29710079.
      View in: PubMed
    13. Kosten TR, Graham DP, Nielsen DA. Opioid Use Disorder After Self-medicating Pain From Traumatic Brain Injury. JAMA Psychiatry. 2018 Jun 01; 75(6):649-650. PMID: 29710138.
      View in: PubMed
    14. Zhang L, Zheng H, Wu R, Zhu F, Kosten TR, Zhang XY, Zhao J. Minocycline adjunctive treatment to risperidone for negative symptoms in schizophrenia: Association with pro-inflammatory cytokine levels. Prog Neuropsychopharmacol Biol Psychiatry. 2018 07 13; 85:69-76. PMID: 29678772.
      View in: PubMed
    15. Bisaga A, Mannelli P, Yu M, Nangia N, Graham CE, Tompkins DA, Kosten TR, Akerman SC, Silverman BL, Sullivan MA. Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial. Drug Alcohol Depend. 2018 06 01; 187:171-178. PMID: 29674251.
      View in: PubMed
    16. Kosten T, Domingo C. Commentary. Am J Addict. 2018 Apr; 27(3):157. PMID: 29596723.
      View in: PubMed
    17. Bisaga A, Mannelli P, Sullivan MA, Vosburg SK, Compton P, Woody GE, Kosten TR. Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies. Am J Addict. 2018 04; 27(3):177-187. PMID: 29596725.
      View in: PubMed
    18. Zhang X, Nielsen DA, Domingo CB, Shorter DI, Nielsen EM, Kosten TR. Pharmacogenetics of Dopamine ß-Hydroxylase in cocaine dependence therapy with doxazosin. Addict Biol. 2019 May; 24(3):531-538. PMID: 29498170.
      View in: PubMed
    19. Yammine L, Kosten TR, Cinciripini PM, Green CE, Meininger JC, Minnix JA, Newton TF. Exenatide once weekly for smoking cessation: study protocol for a randomized clinical trial. Medicine (Baltimore). 2018 Jan; 97(2):e9567. PMID: 29480848.
      View in: PubMed
    20. Kosten TR, Domingo C. Editorial. Am J Addict. 2018 Jan; 27(1):5-6. PMID: 29283478.
      View in: PubMed
    21. Bashiri M, Mancino MJ, Stanick VA, Thostenson J, Kosten TR, Oliveto AH. Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials. Am J Addict. 2017 Dec; 26(8):807-814. PMID: 29115703.
      View in: PubMed
    22. Ma L, Steinberg JL, Cunningham KA, Bjork JM, Lane SD, Schmitz JM, Burroughs T, Narayana PA, Kosten TR, Bechara A, Moeller FG. Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder. Psychiatry Res Neuroimaging. 2018 01 30; 271:59-66. PMID: 29108734.
      View in: PubMed
    23. Heekin RD, Shorter D, Kosten TR. Current status and future prospects for the development of substance abuse vaccines. Expert Rev Vaccines. 2017 11; 16(11):1067-1077. PMID: 28918668.
      View in: PubMed
    24. Curtis K, Viswanath H, Velasquez KM, Molfese DL, Harding MJ, Aramayo E, Baldwin PR, Ambrosi E, Madan A, Patriquin M, Frueh BC, Fowler JC, Kosten TR, Nielsen DA, Salas R. Increased habenular connectivity in opioid users is associated with an a5 subunit nicotinic receptor genetic variant. Am J Addict. 2017 Oct; 26(7):751-759. PMID: 28857330.
      View in: PubMed
    25. Mathai DS, Holst M, Rodgman C, Haile CN, Keller J, Hussain MZ, Kosten TR, Newton TF, Verrico CD. Guanfacine Attenuates Adverse Effects of Dronabinol (THC) on Working Memory in Adolescent-Onset Heavy Cannabis Users: A Pilot Study. J Neuropsychiatry Clin Neurosci. 2018; 30(1):66-76. PMID: 28641496.
      View in: PubMed
    26. Zhao RJ, Sun W, Zhang LL, Bao YP, Huang L, Dong P, Zhou SJ, Wang ZQ, Kosten TR, Sun HQ. Psychopathology and personality traits associated with driving while intoxicated in Beijing, China: Implications for interventions. Am J Addict. 2017 Jun; 26(4):374-378. PMID: 28342226.
      View in: PubMed
    27. Ayanga D, Shorter D, Kosten TR. Update on pharmacotherapy for treatment of opioid use disorder. Expert Opin Pharmacother. 2016 Dec; 17(17):2307-2318. PMID: 27734745.
      View in: PubMed
    28. Mathai DS, Verrico CD, Shorter D, Coverdale JH, Kosten TR. "Just one bad high:" considering synthetic cannabinoid outcome expectancies in adolescents. Am J Addict. 2016 12; 25(8):620-622. PMID: 27749024.
      View in: PubMed
    29. Shorter D, Nielsen DA, Hamon SC, Nielsen EM, Kosten TR, Newton TF, De La Garza R. The a-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals. Pharmacogenet Genomics. 2016 09; 26(9):428-35. PMID: 27379509.
      View in: PubMed
    30. Verrico CD, Haile CN, De La Garza R, Grasing K, Kosten TR, Newton TF. Subjective and Cardiovascular Effects of Intravenous Methamphetamine during Perindopril Maintenance: A Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study. Int J Neuropsychopharmacol. 2016 07; 19(7). PMID: 27207905.
      View in: PubMed
    31. Kosten TR, Domingo C. Editorial. Am J Addict. 2016 06; 25(4):252-3. PMID: 27232764.
      View in: PubMed
    32. Li X, Shorter D, Kosten TR. Buprenorphine Prescribing: To Expand or Not to Expand. J Psychiatr Pract. 2016 05; 22(3):183-92. PMID: 27123798.
      View in: PubMed
    33. Kosten TR. An Opioid for Depression? Am J Psychiatry. 2016 05 01; 173(5):446-7. PMID: 27133402.
      View in: PubMed
    34. Gao Y, Zhou JJ, Zhu Y, Kosten T, Li DP. Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation. Neuroendocrinology. 2017; 104(2):194-208. PMID: 27077366.
      View in: PubMed
    35. An HM, Tan YL, Tan SP, Shi J, Wang ZR, Yang FD, Huang XF, Soars JC, Kosten TR, Zhang XY. Smoking and Serum Lipid Profiles in Schizophrenia. Neurosci Bull. 2016 Aug; 32(4):383-8. PMID: 27017941.
      View in: PubMed
    36. Xiu MH, Tian L, Chen S, Tan YL, Chen DC, Chen J, Chen N, De Yang F, Licinio J, Kosten TR, Soares JC, Zhang XY. Contribution of IL-10 and its -592 A/C polymorphism to cognitive functions in first-episode drug-naive schizophrenia. Brain Behav Immun. 2016 Oct; 57:116-124. PMID: 26971470.
      View in: PubMed
    37. Zhang XY, Tan YL, Chen DC, Tan SP, Malouta MZ, Bernard JD, Combs JL, Bhatti S, Davis MC, Kosten TR, Soares JC. Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population. Psychoneuroendocrinology. 2016 06; 68:140-7. PMID: 26974498.
      View in: PubMed
    38. Zhang XY, Fan FM, Chen DC, Tan YL, Tan SP, Hu K, Salas R, Kosten TR, Zunta-Soares G, Soares JC. Extensive white matter abnormalities and clinical symptoms in drug-naive patients with first-episode schizophrenia: a voxel-based diffusion tensor imaging study. J Clin Psychiatry. 2016 Feb; 77(2):205-11. PMID: 26761708.
      View in: PubMed
    39. Deng H, Wang J, Zhang X, Ma M, Domingo C, Sun H, Kosten T. Smoking reduction and quality of life in chronic patients with schizophrenia in a Chinese population--A pilot study. Am J Addict. 2016 Mar; 25(2):86-90. PMID: 26824336.
      View in: PubMed
    40. Sharp C, Fowler JC, Salas R, Nielsen D, Allen J, Oldham J, Kosten T, Mathew S, Madan A, Frueh BC, Fonagy P. Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings. Bull Menninger Clin. 2016; 80(3):187-212. PMID: 27583809.
      View in: PubMed
    41. Li X, Kosten T. Treating Addiction to Prescription Opioids. S D Med. 2016 Spec; No:64-67. PMID: 28817853.
      View in: PubMed
    42. Christodoulides N, De La Garza R, Simmons GW, McRae MP, Wong J, Newton TF, Kosten TR, Haque A, McDevitt JT. Next Generation Programmable Bio-Nano-Chip System for On-Site Detection in Oral Fluids. J Drug Abuse. 2015 Nov 23; 1(1):1-6. PMID: 26925466.
      View in: PubMed
    43. Shorter D, Hsieh J, Kosten TR. Pharmacologic management of comorbid post-traumatic stress disorder and addictions. Am J Addict. 2015 Dec; 24(8):705-12. PMID: 26587796.
      View in: PubMed
    44. Haile CN, Kosten TA, Shen XY, O'Malley PW, Winoske KJ, Kinsey BM, Wu Y, Huang Z, Lykissa ED, Naidu N, Cox JA, Arora R, Kosten TR, Orson FM. Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine. Am J Addict. 2015 Dec; 24(8):748-55. PMID: 26584468.
      View in: PubMed
    45. Zhang XY, Tan YL, Chen DC, Tan SP, Yang FD, Wu HE, Zunta-Soares GB, Huang XF, Kosten TR, Soares JC. Interaction of BDNF with cytokines in chronic schizophrenia. Brain Behav Immun. 2016 Jan; 51:169-75. PMID: 26407757.
      View in: PubMed
    46. Newton TF, Haile CN, Mahoney JJ, Shah R, Verrico CD, De La Garza R, Kosten TR. Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans. Psychiatry Res. 2015 Nov 30; 230(1):44-9. PMID: 26239766.
      View in: PubMed
    47. Brewer AJ, Nielsen DA, Spellicy CJ, Hamon SC, Gingrich J, Thompson-Lake DG, Nielsen EM, Mahoney JJ, Kosten TR, Newton TF, De La Garza R. Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenet Genomics. 2015 Jun; 25(6):296-304. PMID: 25850966.
      View in: PubMed
    48. Christodoulides N, De La Garza R, Simmons GW, McRae MP, Wong J, Newton TF, Smith R, Mahoney JJ, Hohenstein J, Gomez S, Floriano PN, Talavera H, Sloan DJ, Moody DE, Andrenyak DM, Kosten TR, Haque A, McDevitt JT. Application of programmable bio-nano-chip system for the quantitative detection of drugs of abuse in oral fluids. Drug Alcohol Depend. 2015 08 01; 153:306-13. PMID: 26048639.
      View in: PubMed
    49. Ma L, Steinberg JL, Cunningham KA, Lane SD, Bjork JM, Neelakantan H, Price AE, Narayana PA, Kosten TR, Bechara A, Moeller FG. Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls. Neuroimage Clin. 2015; 7:837-47. PMID: 26082893.
      View in: PubMed
    50. Sun Y, Zhao LY, Wang GB, Yue WH, He Y, Shu N, Lin QX, Wang F, Li JL, Chen N, Wang HM, Kosten TR, Feng JJ, Wang J, Tang YD, Liu SX, Deng GF, Diao GH, Tan YL, Han HB, Lin L, Shi J. ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers. Addict Biol. 2016 May; 21(3):657-66. PMID: 25708696.
      View in: PubMed
    51. Cui Y, Robinson JD, Engelmann JM, Lam CY, Minnix JA, Karam-Hage M, Wetter DW, Dani JA, Kosten TR, Cinciripini PM. Reinforcement sensitivity underlying treatment-seeking smokers' affect, smoking reinforcement motives, and affective responses. Psychol Addict Behav. 2015 Jun; 29(2):300-311. PMID: 25621416.
      View in: PubMed
    52. Buda JJ, Carroll FI, Kosten TR, Swearingen D, Walters BB. A Double-Blind, Placebo-Controlled Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of JDTic. Neuropsychopharmacology. 2015 Aug; 40(9):2059-65. PMID: 25628006.
      View in: PubMed
    53. Li QQ, Sun CY, Luo YX, Xue YX, Meng SQ, Xu LZ, Chen N, Deng JH, Zhai HF, Kosten TR, Shi J, Lu L, Sun HQ. A conjugate vaccine attenuates morphine- and heroin-induced behavior in rats. Int J Neuropsychopharmacol. 2014 Dec 07; 18(5). PMID: 25522425.
      View in: PubMed
    54. Thompson-Lake DG, Cooper KN, Mahoney JJ, Bordnick PS, Salas R, Kosten TR, Dani JA, De La Garza R. Withdrawal Symptoms and Nicotine Dependence Severity Predict Virtual Reality Craving in Cigarette-Deprived Smokers. Nicotine Tob Res. 2015 Jul; 17(7):796-802. PMID: 25475087.
      View in: PubMed
    55. Shorter D, Domingo CB, Kosten TR. Emerging drugs for the treatment of cocaine use disorder: a review of neurobiological targets and pharmacotherapy. Expert Opin Emerg Drugs. 2015 Mar; 20(1):15-29. PMID: 25425416.
      View in: PubMed
    56. Ma L, Steinberg JL, Cunningham KA, Lane SD, Kramer LA, Narayana PA, Kosten TR, Bechara A, Moeller FG. Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis. Brain Connect. 2015 Apr; 5(3):177-86. PMID: 25336321.
      View in: PubMed
    57. Kosten TA, Shen XY, Kinsey BM, Kosten TR, Orson FM. Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization. Am J Addict. 2014 Nov-Dec; 23(6):604-7. PMID: 25251469.
      View in: PubMed
    58. Li X, Shorter D, Kosten TR. Buprenorphine in the treatment of opioid addiction: opportunities, challenges and strategies. Expert Opin Pharmacother. 2014 Oct; 15(15):2263-75. PMID: 25171726.
      View in: PubMed
    59. Graham DP, Nielsen DA, Kosten TR, Davis LL, Hamner MB, Makotkine I, Yehuda R. Examining the utility of using genotype and functional biology in a clinical pharmacology trial: pilot testing dopamine ß-hydroxylase, norepinephrine, and post-traumatic stress disorder. Psychiatr Genet. 2014 Aug; 24(4):181-2. PMID: 24983834.
      View in: PubMed
    60. Ramakrishnan M, Kinsey BM, Singh RA, Kosten TR, Orson FM. Hapten optimization for cocaine vaccine with improved cocaine recognition. Chem Biol Drug Des. 2014 Sep; 84(3):354-63. PMID: 24803171.
      View in: PubMed
    61. Liu S, Green CE, Lane SD, Kosten TR, Moeller FG, Nielsen DA, Schmitz JM. The influence of dopamine ß-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. Pharmacogenet Genomics. 2014 Jul; 24(7):370-3. PMID: 24809448.
      View in: PubMed
    62. Orson FM, Wang R, Brimijoin S, Kinsey BM, Singh RA, Ramakrishnan M, Wang HY, Kosten TR. The future potential for cocaine vaccines. Expert Opin Biol Ther. 2014 Sep; 14(9):1271-83. PMID: 24835496.
      View in: PubMed
    63. Sun HQ, Chen HM, Yang FD, Lu L, Kosten TR. Epidemiological trends and the advances of treatments of amphetamine-type stimulants (ATS) in China. Am J Addict. 2014 May-Jun; 23(3):313-7. PMID: 24724890.
      View in: PubMed
    64. Kosten TR, Domingo CB, Shorter D, Orson F, Green C, Somoza E, Sekerka R, Levin FR, Mariani JJ, Stitzer M, Tompkins DA, Rotrosen J, Thakkar V, Smoak B, Kampman K. Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial. Drug Alcohol Depend. 2014 Jul 01; 140:42-7. PMID: 24793366.
      View in: PubMed
    65. Mancino MJ, McGaugh J, Chopra MP, Guise JB, Cargile C, Williams DK, Thostenson J, Kosten TR, Sanders N, Oliveto A. Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms. J Clin Psychopharmacol. 2014 Apr; 34(2):234-9. PMID: 24525654.
      View in: PubMed
    66. Kosten T, Domingo C, Orson F, Kinsey B. Vaccines against stimulants: cocaine and MA. Br J Clin Pharmacol. 2014 Feb; 77(2):368-74. PMID: 23509915.
      View in: PubMed
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    163. Chen DC, Wang J, Wang B, Yang SC, Zhang CX, Zheng YL, Li YL, Wang N, Yang KB, Xiu MH, Kosten TR, Zhang XY. Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypes. Psychopharmacology (Berl). 2009 Dec; 207(3):375-80. PMID: 19787338.
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    165. Stotts AL, Dodrill CL, Kosten TR. Opioid dependence treatment: options in pharmacotherapy. Expert Opin Pharmacother. 2009 Aug; 10(11):1727-40. PMID: 19538000.
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    166. Chen JX, Su YA, Wang SL, Bian QT, Liu YH, Wang N, Yang FD, Haile C, Kosten TR, Zhang XY. Aripiprazole treatment of risperidone-induced hyperprolactinemia. J Clin Psychiatry. 2009 Jul; 70(7):1058-9. PMID: 19653986.
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    167. Qiu HT, Meng HQ, Song C, Xiu MH, Chen DC, Zhu FY, Wu GY, Kosten TA, Kosten TR, Zhang XY. Association between monoamine oxidase (MAO)-A gene variants and schizophrenia in a Chinese population. Brain Res. 2009 Sep 01; 1287:67-73. PMID: 19573521.
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    168. Zhang XY, Chen DC, Xiu MH, Wang F, Qi LY, Sun HQ, Chen S, He SC, Wu GY, Haile CN, Kosten TA, Lu L, Kosten TR. The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients. Schizophr Res. 2009 Sep; 113(2-3):151-7. PMID: 19540723.
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    169. Qi LY, Xiu MH, Chen DC, Wang F, Kosten TA, Kosten TR, Zhang XY. Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. Neurosci Lett. 2009 Sep 22; 462(2):113-7. PMID: 19539717.
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    170. Zhang XY, Chen DC, Qi LY, Wang F, Xiu MH, Chen S, Wu GY, Kosten TA, Kosten TR. Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia. Psychopharmacology (Berl). 2009 Sep; 205(4):647-54. PMID: 19529921.
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    171. Shi J, Jun W, Zhao LY, Xue YX, Zhang XY, Kosten TR, Lu L. Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts. Eur J Pharmacol. 2009 Aug 01; 615(1-3):108-12. PMID: 19470385.
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    172. Orson FM, Kinsey BM, Singh RA, Wu Y, Kosten TR. Vaccines for cocaine abuse. Hum Vaccin. 2009 Apr; 5(4):194-9. PMID: 19276665.
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    173. Zhang XY, Zhou DF, Qi LY, Chen S, Cao LY, Chen DC, Xiu MH, Wang F, Wu GY, Lu L, Kosten TA, Kosten TR. Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics. Psychopharmacology (Berl). 2009 May; 204(1):177-84. PMID: 19139851.
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    174. Li SX, Shi J, Epstein DH, Wang X, Zhang XL, Bao YP, Zhang D, Zhang XY, Kosten TR, Lu L. Circadian alteration in neurobiology during 30 days of abstinence in heroin users. Biol Psychiatry. 2009 May 15; 65(10):905-12. PMID: 19135652.
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    175. Shi J, Li SX, Zhang XL, Wang X, Le Foll B, Zhang XY, Kosten TR, Lu L. Time-dependent neuroendocrine alterations and drug craving during the first month of abstinence in heroin addicts. Am J Drug Alcohol Abuse. 2009; 35(5):267-72. PMID: 19591065.
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    176. Sofuoglu M, Poling J, Hill K, Kosten T. Atomoxetine attenuates dextroamphetamine effects in humans. Am J Drug Alcohol Abuse. 2009; 35(6):412-6. PMID: 20014909.
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    177. Castells X, Kosten TR, Capellà D, Vidal X, Colom J, Casas M. Efficacy of opiate maintenance therapy and adjunctive interventions for opioid dependence with comorbid cocaine use disorders: A systematic review and meta-analysis of controlled clinical trials. Am J Drug Alcohol Abuse. 2009; 35(5):339-49. PMID: 20180662.
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    178. Lu L, Wang X, Kosten TR. Stereotactic neurosurgical treatment of drug addiction. Am J Drug Alcohol Abuse. 2009; 35(6):391-3. PMID: 20014906.
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    179. Sun HQ, Guo S, Chen DF, Jiang ZN, Liu Y, Di XL, Yang FD, Zhang XY, Kosten TR, Lu L. Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers. Am J Drug Alcohol Abuse. 2009; 35(3):183-8. PMID: 19462302.
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    180. Lu L, Liu Y, Zhu W, Shi J, Liu Y, Ling W, Kosten TR. Traditional medicine in the treatment of drug addiction. Am J Drug Alcohol Abuse. 2009; 35(1):1-11. PMID: 19152199.
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    181. Haile CN, Kosten TR, Kosten TA. Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. Am J Drug Alcohol Abuse. 2009; 35(3):161-77. PMID: 19462300.
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    182. Xiu MH, Chen S, Wang F, Cao LY, Qi LY, Chen DC, Wu GY, Lu L, Kosten TA, Kosten TR, Zhang XY. Altered interleukin-3 serum levels in drug-naïve and neuroleptic-treated schizophrenic patients. Schizophr Res. 2008 Dec; 106(2-3):369-70. PMID: 18838250.
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    183. Chen DC, Qi LY, Xiu MH, Cao LY, Wang F, Chen S, Wu GY, Kosten TA, Kosten TR, Zhang XY. Elevated serum levels of tumor necrosis factor-alpha in clozapine-associated obesity in chronic schizophrenia. Schizophr Res. 2008 Dec; 106(2-3):367-8. PMID: 18835132.
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    184. Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. Substance abuse vaccines. Ann N Y Acad Sci. 2008 Oct; 1141:257-69. PMID: 18991962.
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    185. Ren ZY, Zhang XL, Liu Y, Zhao LY, Shi J, Bao Y, Zhang XY, Kosten TR, Lu L. Diurnal variation in cue-induced responses among protracted abstinent heroin users. Pharmacol Biochem Behav. 2009 Jan; 91(3):468-72. PMID: 18809427.
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    186. Zhang XY, Cao LY, Song C, Wu GY, Chen DC, Qi LY, Wang F, Xiu MH, Chen S, Zhang Y, Lu L, Kosten TA, Kosten TR. Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics. Psychopharmacology (Berl). 2008 Dec; 201(3):383-9. PMID: 18719893.
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    187. Mooney ME, Poling J, Gonzalez G, Gonsai K, Kosten T, Sofuoglu M. Preliminary study of buprenorphine and bupropion for opioid-dependent smokers. Am J Addict. 2008 Jul-Aug; 17(4):287-92. PMID: 18612883.
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    188. Sun S, Wang F, Wei J, Cao LY, Qi LY, Xiu MH, Chen S, Li XH, Kosten TA, Kosten TR, Zhang XY. Association between interleukin-6 receptor polymorphism and patients with schizophrenia. Schizophr Res. 2008 Jul; 102(1-3):346-7. PMID: 18508242.
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    189. Sun S, Wang F, Wei J, Cao LY, Wu GY, Lu L, Kosten TA, Kosten TR, Zhang XY. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. Neurosci Lett. 2008 Jul 25; 440(1):35-7. PMID: 18547720.
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    190. Wang F, Xiu MH, Zhou DF, Cao LY, Wu GY, Kosten TA, Kosten TR, Zhang XY. The CCR5 32-bp deletion allele is rare in a Chinese population. Schizophr Res. 2008 Apr; 101(1-3):341-3. PMID: 18295459.
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    191. Kosten TA, Zhang XY. Sex differences in non-reinforced responding for cocaine. Am J Drug Alcohol Abuse. 2008; 34(4):473-88. PMID: 18584577.
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    192. Haile CN, Kosten TA, Kosten TR. Pharmacogenetic treatments for drug addiction: alcohol and opiates. Am J Drug Alcohol Abuse. 2008; 34(4):355-81. PMID: 18584566.
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    193. Li SX, Li J, Epstein DH, Zhang XY, Kosten TR, Lu L. Serum cortisol secretion during heroin abstinence is elevated only nocturnally. Am J Drug Alcohol Abuse. 2008; 34(3):321-8. PMID: 18428074.
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    194. Kosten TR, Gardner TJ. New hot topics sections: 1. China's new march forward in addiction treatment: methadone for the masses. 2. Issues in formulating DSM V. Am J Drug Alcohol Abuse. 2008; 34(2):123-6. PMID: 18293228.
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    195. Zhang XY, Zhou DF, Wu GY, Cao LY, Tan YL, Haile CN, Li J, Lu L, Kosten TA, Kosten TR. BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. Neuropsychopharmacology. 2008 Aug; 33(9):2200-5. PMID: 17987059.
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    196. Sofuoglu M, Poling J, Gonzalez G, Gonsai K, Oliveto A, Kosten TR. Progesterone effects on cocaine use in male cocaine users maintained on methadone: a randomized, double-blind, pilot study. Exp Clin Psychopharmacol. 2007 Oct; 15(5):453-60. PMID: 17924779.
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    197. Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. The future of vaccines in the management of addictive disorders. Curr Psychiatry Rep. 2007 Oct; 9(5):381-7. PMID: 17915077.
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    198. Wang ZR, Zhou DF, Cao LY, Tan YL, Zhang XY, Li J, Lu L, Wu GY, Kosten TA, Kosten TR. Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia. Schizophr Res. 2007 Dec; 97(1-3):299-301. PMID: 17869486.
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    199. Li W, Wei J, Zhou DF, Tan YL, Cao YL, Zhang XY, Wu G, Kosten TA, Kosten TR. Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population. Schizophr Res. 2007 Dec; 97(1-3):297-8. PMID: 17669628.
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    200. Zhang XY, Tan YL, Zhou DF, Haile CN, Cao LY, Xu Q, Shen Y, Kosten TA, Kosten TR. Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. J Clin Psychopharmacol. 2007 Jun; 27(3):246-51. PMID: 17502770.
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    201. Poling J, Pruzinsky R, Kosten TR, Gonsai K, Sofuoglu M, Gonzalez G, Oliveto A. Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients. Am J Addict. 2007 May-Jun; 16(3):187-94. PMID: 17612822.
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    202. Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Haile CN, Kosten TA, Kosten TR. Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. J Clin Psychiatry. 2007 May; 68(5):754-60. PMID: 17503985.
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    203. Kleber HD, Weiss RD, Anton RF, George TP, Greenfield SF, Kosten TR, O'Brien CP, Rounsaville BJ, Strain EC, Ziedonis DM, Hennessy G, Connery HS, McIntyre JS, Charles SC, Anzia DJ, Cook IA, Finnerty MT, Johnson BR, Nininger JE, Summergrad P, Woods SM, Yager J, Pyles R, Cross CD, Peele R, Shemo JP, Lurie L, Walker RD, Barnovitz MA, Gray SH, Saxena S, Tonnu T, Kunkle R, Albert AB, Fochtmann LJ, Hart C, Regier D. Treatment of patients with substance use disorders, second edition. American Psychiatric Association. Am J Psychiatry. 2007 Apr; 164(4 Suppl):5-123. PMID: 17569411.
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    205. Martell BA, O'Connor PG, Kerns RD, Becker WC, Morales KH, Kosten TR, Fiellin DA. Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. Ann Intern Med. 2007 Jan 16; 146(2):116-27. PMID: 17227935.
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    206. Guo S, Chen DF, Zhou DF, Sun HQ, Wu GY, Haile CN, Kosten TA, Kosten TR, Zhang XY. Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. Psychopharmacology (Berl). 2007 Mar; 190(4):449-56. PMID: 17206495.
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    207. Lane SD, Moeller FG, Steinberg JL, Buzby M, Kosten TR. Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty. Am J Drug Alcohol Abuse. 2007; 33(5):717-26. PMID: 17891664.
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    208. Kosten TR. Pharmacotherapy for addictions: partnering with contingency management. Am J Drug Alcohol Abuse. 2007; 33(3):341-2. PMID: 17613962.
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    209. Poling J, Kosten TR, Sofuoglu M. Treatment outcome predictors for cocaine dependence. Am J Drug Alcohol Abuse. 2007; 33(2):191-206. PMID: 17497542.
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    210. Gardner TJ, Kosten TR. Human laboratory and neuroimaging studies in substance use disorders: developing new treatment approaches. Am J Drug Alcohol Abuse. 2007; 33(6):765-7. PMID: 17994472.
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    211. Brown AE, Pavlik VN, Shegog R, Whitney SN, Friedman LC, Romero C, Davis GC, Cech I, Kosten TR, Volk RJ. Association of spirituality and sobriety during a behavioral spirituality intervention for Twelve Step (TS) recovery. Am J Drug Alcohol Abuse. 2007; 33(4):611-7. PMID: 17668347.
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    212. Gardner TJ, Kosten TR. Therapeutic options and challenges for substances of abuse. Dialogues Clin Neurosci. 2007; 9(4):431-45. PMID: 18286802.
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    213. Gardner TJ, Kosten TR. Pharmacotherapeutic environments for substance use disorders. Am J Drug Alcohol Abuse. 2007; 33(5):627-9. PMID: 17891655.
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    214. Sinha R, Kimmerling A, Doebrick C, Kosten TR. Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings. Psychopharmacology (Berl). 2007 Mar; 190(4):569-74. PMID: 17136399.
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    216. Haile CN, Kosten TR, Kosten TA. Genetics of dopamine and its contribution to cocaine addiction. Behav Genet. 2007 Jan; 37(1):119-45. PMID: 17063402.
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    217. González G, Desai R, Sofuoglu M, Poling J, Oliveto A, Gonsai K, Kosten TR. Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. Drug Alcohol Depend. 2007 Feb 23; 87(1):1-9. PMID: 16930857.
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    218. Kosten TR, Scanley BE, Tucker KA, Oliveto A, Prince C, Sinha R, Potenza MN, Skudlarski P, Wexler BE. Cue-induced brain activity changes and relapse in cocaine-dependent patients. Neuropsychopharmacology. 2006 Mar; 31(3):644-50. PMID: 16123763.
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    219. Sofuoglu M, Kosten TR. Emerging pharmacological strategies in the fight against cocaine addiction. Expert Opin Emerg Drugs. 2006 Mar; 11(1):91-8. PMID: 16503828.
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    220. Li CS, Kosten TR, Sinha R. Antisocial personality and stress-induced brain activation in cocaine-dependent patients. Neuroreport. 2006 Feb 27; 17(3):243-7. PMID: 16462591.
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    221. Poling J, Oliveto A, Petry N, Sofuoglu M, Gonsai K, Gonzalez G, Martell B, Kosten TR. Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population. Arch Gen Psychiatry. 2006 Feb; 63(2):219-28. PMID: 16461866.
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    223. Sofuoglu M, Poling J, Gonzalez G, Gonsai K, Kosten T. Cocaine withdrawal symptoms predict medication response in cocaine users. Am J Drug Alcohol Abuse. 2006; 32(4):617-27. PMID: 17127550.
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    224. Sofuoglu M, Poling J, Mitchell E, Kosten TR. Tiagabine affects the subjective responses to cocaine in humans. Pharmacol Biochem Behav. 2005 Nov; 82(3):569-73. PMID: 16332385.
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    225. Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE. Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology (Berl). 2005 Dec; 183(2):171-80. PMID: 16163517.
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    227. Kosten T, Owens SM. Immunotherapy for the treatment of drug abuse. Pharmacol Ther. 2005 Oct; 108(1):76-85. PMID: 16023218.
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    228. Oliveto A, Poling J, Sevarino KA, Gonsai KR, McCance-Katz EF, Stine SM, Kosten TR. Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients. Drug Alcohol Depend. 2005 Aug 01; 79(2):157-65. PMID: 16002025.
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    229. Martell BA, Mitchell E, Poling J, Gonsai K, Kosten TR. Vaccine pharmacotherapy for the treatment of cocaine dependence. Biol Psychiatry. 2005 Jul 15; 58(2):158-64. PMID: 16038686.
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    230. Kosten TR. What are America's opportunities for harm reduction strategies in opiate dependence? Am J Addict. 2005 Jul-Sep; 14(4):307-10. PMID: 16188710.
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    234. Schottenfeld RS, Chawarski MC, Pakes JR, Pantalon MV, Carroll KM, Kosten TR. Methadone versus buprenorphine with contingency management or performance feedback for cocaine and opioid dependence. Am J Psychiatry. 2005 Feb; 162(2):340-9. PMID: 15677600.
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    237. Sofuoglu M, Kosten TR. Novel approaches to the treatment of cocaine addiction. CNS Drugs. 2005; 19(1):13-25. PMID: 15651902.
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    243. Sofuoglu M, Mitchell E, Kosten TR. Effects of progesterone treatment on cocaine responses in male and female cocaine users. Pharmacol Biochem Behav. 2004 Aug; 78(4):699-705. PMID: 15301924.
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    244. Oliveto A, Poling J, Kosten TR, Gonsai K. Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure. Eur J Pharmacol. 2004 May 03; 491(2-3):157-68. PMID: 15140632.
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    246. Gonzalez G, Oliveto A, Kosten TR. Combating opiate dependence: a comparison among the available pharmacological options. Expert Opin Pharmacother. 2004 Apr; 5(4):713-25. PMID: 15102558.
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    247. Haney M, Kosten TR. Therapeutic vaccines for substance dependence. Expert Rev Vaccines. 2004 Feb; 3(1):11-8. PMID: 14761239.
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    248. West JC, Kosten TR, Wilk J, Svikis D, Triffleman E, Rae DS, Narrow WE, Duffy FF, Regier DA. Challenges in increasing access to buprenorphine treatment for opiate addiction. Am J Addict. 2004; 13 Suppl 1:S8-16. PMID: 15204672.
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    250. Kosten TR, Fiellin DA. Buprenorphine for office-based practice: consensus conference overview. Am J Addict. 2004; 13 Suppl 1:S1-7. PMID: 15204671.
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    251. Haile CN, During MJ, Jatlow PI, Kosten TR, Kosten TA. Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats. Biol Psychiatry. 2003 Nov 01; 54(9):915-21. PMID: 14573319.
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    252. Gonzalez G, Sevarino K, Sofuoglu M, Poling J, Oliveto A, Gonsai K, George TP, Kosten TR. Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study. Addiction. 2003 Nov; 98(11):1625-32. PMID: 14616189.
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    257. Reid MC, Tinetti ME, O'Connor PG, Kosten TR, Concato J. Measuring alcohol consumption among older adults: a comparison of available methods. Am J Addict. 2003 May-Jun; 12(3):211-9. PMID: 12851017.
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    258. Kosten TR, O'Connor PG. Management of drug and alcohol withdrawal. N Engl J Med. 2003 May 01; 348(18):1786-95. PMID: 12724485.
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    267. Kosten TR, Oliveto A, Sevarino KA, Gonsai K, Feingold A. Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug Alcohol Depend. 2002 Apr 01; 66(2):173-80. PMID: 11906804.
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    270. George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. Effects of smoking abstinence on visuospatial working memory function in schizophrenia. Neuropsychopharmacology. 2002 Jan; 26(1):75-85. PMID: 11751034.
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    271. Feingold A, Oliveto A, Schottenfeld R, Kosten TR. Utility of crossover designs in clinical trials: efficacy of desipramine vs. placebo in opioid-dependent cocaine abusers. Am J Addict. 2002; 11(2):111-23. PMID: 12028741.
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    272. Gonzalez G, Oliveto A, Kosten TR. Treatment of heroin (diamorphine) addiction: current approaches and future prospects. Drugs. 2002; 62(9):1331-43. PMID: 12076182.
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    273. Kosten TR, Gorelick DA. The Lexington narcotic farm. Am J Psychiatry. 2002 Jan; 159(1):22. PMID: 11772684.
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    274. Gottschalk PC, Kosten TR. Isradipine enhancement of cerebral blood flow in abstinent cocaine abusers with and without chronic perfusion deficits. Am J Addict. 2002; 11(3):200-8. PMID: 12202012.
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    275. Jacobsen LK, Southwick SM, Kosten TR. Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. Am J Psychiatry. 2001 Aug; 158(8):1184-90. PMID: 11481147.
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    276. Fiellin DA, Rosenheck RA, Kosten TR. Office-based treatment for opioid dependence: reaching new patient populations. Am J Psychiatry. 2001 Aug; 158(8):1200-4. PMID: 11481150.
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    277. Rosenheck R, Kosten T. Buprenorphine for opiate addiction: potential economic impact. Drug Alcohol Depend. 2001 Aug 01; 63(3):253-62. PMID: 11418229.
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    278. Oliveto A, McCance-Katz FE, Singha A, Petrakis I, Hameedi F, Kosten TR. Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers. Drug Alcohol Depend. 2001 Jul 01; 63(2):155-67. PMID: 11376920.
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    279. McCance-Katz EF, Kosten TA, Kosten TR. Going from the bedside back to the bench with ecopipam: a new strategy for cocaine pharmacotherapy development. Psychopharmacology (Berl). 2001 Jun; 155(4):327-9. PMID: 11441421.
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    280. Petry NM, Petrakis I, Trevisan L, Wiredu G, Boutros NN, Martin B, Kosten TR. Contingency management interventions: from research to practice. Am J Psychiatry. 2001 May; 158(5):694-702. PMID: 11329388.
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    281. D'Souza DC, Kosten TR. Cannabinoid antagonists: a treatment in search of an illness. Arch Gen Psychiatry. 2001 Apr; 58(4):330-1. PMID: 11296092.
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    282. Stine SM, Grillon CG, Morgan CA, Kosten TR, Charney DS, Krystal JH. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology (Berl). 2001 Mar; 154(3):274-81. PMID: 11351934.
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    283. Jacobsen LK, Giedd JN, Kreek MJ, Gottschalk C, Kosten TR. Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. Drug Alcohol Depend. 2001 Mar 01; 62(1):49-56. PMID: 11173167.
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    285. Sernyak MJ, Kosten TR, Fontana A, Rosenheck R. Neuroleptic use in the treatment of Post-Traumatic Stress Disorder. Psychiatr Q. 2001; 72(3):197-213. PMID: 11467155.
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    286. McCance-Katz EF, Rainey PM, Friedland G, Kosten TR, Jatlow P. Effect of opioid dependence pharmacotherapies on zidovudine disposition. Am J Addict. 2001; 10(4):296-307. PMID: 11783744.
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    287. Singha AK, McCance-Katz EF, Petrakis I, Kosten TR, Oliveto A. Sex differences in self-reported and physiological response to oral cocaine and placebo in humans. Am J Drug Alcohol Abuse. 2000 Nov; 26(4):643-57. PMID: 11097197.
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    288. George TP, Ziedonis DM, Feingold A, Pepper WT, Satterburg CA, Winkel J, Rounsaville BJ, Kosten TR. Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia. Am J Psychiatry. 2000 Nov; 157(11):1835-42. PMID: 11058482.
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    289. Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. Prediction of dopamine transporter binding availability by genotype: a preliminary report. Am J Psychiatry. 2000 Oct; 157(10):1700-3. PMID: 11007732.
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    290. Avants SK, Margolin A, Holford TR, Kosten TR. A randomized controlled trial of auricular acupuncture for cocaine dependence. Arch Intern Med. 2000 Aug 14-28; 160(15):2305-12. PMID: 10927727.
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    291. Kosten TR, Fontana A, Sernyak MJ, Rosenheck R. Benzodiazepine use in posttraumatic stress disorder among veterans with substance abuse. J Nerv Ment Dis. 2000 Jul; 188(7):454-9. PMID: 10919705.
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    292. Jacobsen LK, Staley JK, Malison RT, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB. Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients. Am J Psychiatry. 2000 Jul; 157(7):1134-40. PMID: 10873923.
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    293. George TP, Chawarski MC, Pakes J, Carroll KM, Kosten TR, Schottenfeld RS. Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. Biol Psychiatry. 2000 Jun 15; 47(12):1080-6. PMID: 10862808.
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    295. Farren CK, Hameedi FA, Rosen MA, Woods S, Jatlow P, Kosten TR. Significant interaction between clozapine and cocaine in cocaine addicts. Drug Alcohol Depend. 2000 May 01; 59(2):153-63. PMID: 10891628.
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    296. Sevarino KA, Oliveto A, Kosten TR. Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development. Ann N Y Acad Sci. 2000; 909:51-87. PMID: 10911924.
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    297. Gottschalk PC, Jacobsen LK, Kosten TR. Current concepts in pharmacotherapy of substance abuse. Curr Psychiatry Rep. 1999 Dec; 1(2):172-8. PMID: 11122921.
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    298. Singha AK, McCance-Katz EF, Heck SA, Kosten TR, Oliveto A. Individual differences in humans responding under a cocaine discrimination procedure: discriminators versus nondiscriminators. Exp Clin Psychopharmacol. 1999 Nov; 7(4):391-8. PMID: 10609974.
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    299. Oliveto AH, Feingold A, Schottenfeld R, Jatlow P, Kosten TR. Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. Arch Gen Psychiatry. 1999 Sep; 56(9):812-20. PMID: 12884887.
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    303. Kosten TR. Images in psychiatry. Marie Nyswander, 1919-1986. Am J Psychiatry. 1998 Dec; 155(12):1766. PMID: 9842790.
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    305. Rosen MI, Pearsall HR, Kosten TR. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug Alcohol Depend. 1998 Oct 01; 52(2):173-6. PMID: 9800147.
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    306. McCance-Katz EF, Kosten TR, Jatlow P. Disulfiram effects on acute cocaine administration. Drug Alcohol Depend. 1998 Sep 01; 52(1):27-39. PMID: 9788003.
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    311. Kosten TR. Addiction as a brain disease. Am J Psychiatry. 1998 Jun; 155(6):711-3. PMID: 9619141.
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    312. Oliveto AH, Rosen MI, Kosten TA, Hameedi FA, Woods SW, Kosten TR. Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure. Exp Clin Psychopharmacol. 1998 May; 6(2):169-78. PMID: 9608349.
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    313. Avants SK, Margolin A, DePhilippis D, Kosten TR. A comprehensive pharmacologic-psychosocial treatment program for HIV-seropositive cocaine- and opioid-dependent patients. Preliminary findings. J Subst Abuse Treat. 1998 May-Jun; 15(3):261-5. PMID: 9633038.
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    317. Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology. 1998 Mar; 18(3):135-74. PMID: 9471114.
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    318. Bowers MB, Malison RT, Seibyl JP, Kosten TR. Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal. Biol Psychiatry. 1998 Feb 15; 43(4):278-81. PMID: 9513737.
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    319. Margolin A, Avants SK, DePhilippis D, Kosten TR. A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients. Am J Drug Alcohol Abuse. 1998 Feb; 24(1):85-101. PMID: 9513631.
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    320. O'Connor PG, Kosten TR. Rapid and ultrarapid opioid detoxification techniques. JAMA. 1998 Jan 21; 279(3):229-34. PMID: 9438745.
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    321. Oliveto AH, Farren C, Kosten TR. Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study. Am J Addict. 1998; 7(4):272-82. PMID: 9809131.
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    322. Kosten TR. The pharmacotherapy of relapse prevention using anticonvulsants. Am J Addict. 1998; 7(3):205-9. PMID: 9702288.
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    324. Kosten TR. Pharmacotherapy of cerebral ischemia in cocaine dependence. Drug Alcohol Depend. 1998 Jan 01; 49(2):133-44. PMID: 9543650.
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    325. Kosten TR, Rosen MI, McMahon TL, Bridge TP, O'Malley SS, Pearsall R, O'Connor PG. Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T. Am J Drug Alcohol Abuse. 1997 Nov; 23(4):543-53. PMID: 9366972.
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    327. Avants SK, Margolin A, McMahon TJ, Kosten TR. Association between self-report of cognitive impairment, HIV status, and cocaine use in a sample of cocaine-dependent methadone-maintained patients. Addict Behav. 1997 Sep-Oct; 22(5):599-611. PMID: 9347062.
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    329. Stine SM, Krystal JH, Petrakis IL, Jatlow PI, Heninger GR, Kosten TR, Charney DS. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biol Psychiatry. 1997 Aug 01; 42(3):181-90. PMID: 9232210.
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    330. Warner EA, Kosten TR, O'Connor PG. Pharmacotherapy for opioid and cocaine abuse. Med Clin North Am. 1997 Jul; 81(4):909-25. PMID: 9222260.
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    334. Manji H, Chen G, Potter W, Kosten TR. Guanine nucleotide binding proteins in opioid-dependent patients. Biol Psychiatry. 1997 Jan 15; 41(2):130-4. PMID: 9018382.
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    335. Kosten TR, Ziedonis DM. Substance abuse and schizophrenia: editors' introduction. Schizophr Bull. 1997; 23(2):181-6. PMID: 9165628.
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    337. van Dyck CH, McMahon TJ, Rosen MI, O'Malley SS, O'Connor PG, Lin CH, Pearsall HR, Woods SW, Kosten TR. Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study. J Neuropsychiatry Clin Neurosci. 1997; 9(1):29-36. PMID: 9017526.
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    339. Wallace EA, Wisniewski G, Zubal G, vanDyck CH, Pfau SE, Smith EO, Rosen MI, Sullivan MC, Woods SW, Kosten TR. Acute cocaine effects on absolute cerebral blood flow. Psychopharmacology (Berl). 1996 Nov; 128(1):17-20. PMID: 8944401.
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    340. Margolin A, Avants SK, Kosten TR. Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients. Am J Drug Alcohol Abuse. 1996 Aug; 22(3):377-88. PMID: 8841686.
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    344. Rosen MI, McMahon TJ, Hameedi FA, Pearsall HR, Woods SW, Kreek MJ, Kosten TR. Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. J Pharmacol Exp Ther. 1996 Mar; 276(3):1128-35. PMID: 8786543.
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    351. McCance EF, Price LH, Kosten TR, Jatlow PI. Cocaethylene: pharmacology, physiology and behavioral effects in humans. J Pharmacol Exp Ther. 1995 Jul; 274(1):215-23. PMID: 7616402.
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    360. Lago JA, Kosten TR. Stimulant withdrawal. Addiction. 1994 Nov; 89(11):1477-81. PMID: 7841859.
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    373. Satel SL, Kosten TR, Schuckit MA, Fischman MW. Should protracted withdrawal from drugs be included in DSM-IV? Am J Psychiatry. 1993 May; 150(5):695-704. PMID: 8097618.
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    374. Kosten TR. Clinical and research perspectives on cocaine abuse: the pharmacotherapy of cocaine abuse. NIDA Res Monogr. 1993; 135:48-56. PMID: 8289903.
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    375. McCance-Katz EF, Price LH, McDougle CJ, Kosten TR, Black JE, Jatlow PI. Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacology (Berl). 1993; 111(1):39-46. PMID: 7870932.
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    376. Margolin A, Chang P, Avants SK, Kosten TR. Effects of sham and real auricular needling: implications for trials of acupuncture for cocaine addiction. Am J Chin Med. 1993; 21(2):103-11. PMID: 8237887.
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    377. Kosten TA, Gawin FH, Kosten TR, Rounsaville BJ. Gender differences in cocaine use and treatment response. J Subst Abuse Treat. 1993 Jan-Feb; 10(1):63-6. PMID: 8450576.
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    378. Kosten TR, Morgan CM, Falcione J, Schottenfeld RS. Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. Arch Gen Psychiatry. 1992 Nov; 49(11):894-8. PMID: 1444728.
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    379. Kosten TR, Morgan C, Kreek MJ. Beta endorphin levels during heroin, methadone, buprenorphine, and naloxone challenges: preliminary findings. Biol Psychiatry. 1992 Sep 15; 32(6):523-8. PMID: 1445968.
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    380. McDougle CJ, Price LH, Palumbo JM, Kosten TR, Heninger GR, Kleber HD. Dopaminergic responsivity during cocaine abstinence: a pilot study. Psychiatry Res. 1992 Jul; 43(1):77-85. PMID: 1359594.
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    381. Stine SM, Kosten TR. Use of drug combinations in treatment of opioid withdrawal. J Clin Psychopharmacol. 1992 Jun; 12(3):203-9. PMID: 1629388.
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    382. Closser MH, Kosten TR. Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics. Recent Dev Alcohol. 1992; 10:115-28. PMID: 1317046.
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    383. Kosten TR. Pharmacological approaches to cocaine dependence. Clin Neuropharmacol. 1992; 15 Suppl 1 Pt A:70A-71A. PMID: 1498999.
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    384. Nigam R, Schottenfeld R, Kosten TR. Treatment of dual diagnosis patients: a relapse prevention group approach. J Subst Abuse Treat. 1992; 9(4):305-9. PMID: 1362227.
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    385. Kosten TR, Rosen MI, Schottenfeld R, Ziedonis D. Buprenorphine for cocaine and opiate dependence. Psychopharmacol Bull. 1992; 28(1):15-9. PMID: 1609037.
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    386. Kosten TR, Morgan C, Kleber HD. Phase II clinical trials of buprenorphine: detoxification and induction onto naltrexone. NIDA Res Monogr. 1992; 121:101-19. PMID: 1406906.
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    387. Chang G, Carroll KM, Behr HM, Kosten TR. Improving treatment outcome in pregnant opiate-dependent women. J Subst Abuse Treat. 1992; 9(4):327-30. PMID: 1479630.
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    388. Krystal JH, McDougle CJ, Kosten TR, Price LH, Aghajanian GK, Charney DS. Baclofen-assisted detoxification from opiates. A pilot study. J Subst Abuse Treat. 1992; 9(2):139-42. PMID: 1324986.
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    389. Kosten TA, Bianchi MS, Kosten TR. The predictive validity of the dependence syndrome in opiate abusers. Am J Drug Alcohol Abuse. 1992; 18(2):145-56. PMID: 1562012.
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    390. Kosten TR, Kosten TA, Rounsaville BJ. Alcoholism and depressive disorders in opioid addicts and their family members. Compr Psychiatry. 1991 Nov-Dec; 32(6):521-7. PMID: 1778079.
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    391. Kosten TA, Kosten TR. Pharmacological blocking agents for treating substance abuse. J Nerv Ment Dis. 1991 Oct; 179(10):583-92. PMID: 1919542.
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    392. Ziedonis DM, Kosten TR. Pharmacotherapy improves treatment outcome in depressed cocaine addicts. J Psychoactive Drugs. 1991 Oct-Dec; 23(4):417-25. PMID: 1813613.
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    393. Kosten TR, Rounsaville BJ, Kosten TA, Merikangas K. Gender differences in the specificity of alcoholism transmission among the relatives of opioid addicts. J Nerv Ment Dis. 1991 Jul; 179(7):392-400. PMID: 1869867.
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    394. Kosten TR, Frank JB, Dan E, McDougle CJ, Giller EL. Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. J Nerv Ment Dis. 1991 Jun; 179(6):366-70. PMID: 2051152.
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    395. Kosten TR, Morgan C, Kleber HD. Treatment of heroin addicts using buprenorphine. Am J Drug Alcohol Abuse. 1991 Jun; 17(2):119-28. PMID: 1862786.
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    396. Rosen MI, Kosten TR. Buprenorphine: beyond methadone? Hosp Community Psychiatry. 1991 Apr; 42(4):347-9. PMID: 2050347.
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    397. Kosten TR. Medications development and the war on drugs: victims of the Gulf war? Biol Psychiatry. 1991 Mar 15; 29(6):521-3. PMID: 2054428.
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    398. Mason JW, Kosten TR, Giller EL. Multidimensional hormonal discrimination of paranoid schizophrenic from bipolar manic patients. Biol Psychiatry. 1991 Mar 01; 29(5):457-66. PMID: 2018819.
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    399. Rounsaville BJ, Kosten TR, Weissman MM, Prusoff B, Pauls D, Anton SF, Merikangas K. Psychiatric disorders in relatives of probands with opiate addiction. Arch Gen Psychiatry. 1991 Jan; 48(1):33-42. PMID: 1984760.
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    400. Woods SW, O'Malley SS, Martini BL, McDougle CJ, Price LH, Krystal JH, Hoffer PB, Kosten TR. SPECT regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: preliminary results. Prog Neuropsychopharmacol Biol Psychiatry. 1991; 15(5):649-62. PMID: 1956993.
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    401. Ziedonis DM, Kosten TR. Depression as a prognostic factor for pharmacological treatment of cocaine dependence. Psychopharmacol Bull. 1991; 27(3):337-43. PMID: 1775608.
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    402. Kosten TR. Client issues in drug abuse treatment: addressing multiple drug abuse. NIDA Res Monogr. 1991; 106:136-51. PMID: 1922284.
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    403. Kosten TR, Wahby V, Giller E, Mason J. The dexamethasone suppression test and thyrotropin-releasing hormone stimulation test in posttraumatic stress disorder. Biol Psychiatry. 1990 Oct 15; 28(8):657-64. PMID: 2122916.
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    404. Kosten TR, Gawin FH, Morgan C, Nelson JC, Jatlow P. Desipramine and its 2-hydroxy metabolite in patients taking or not taking methadone. Am J Psychiatry. 1990 Oct; 147(10):1379-80. PMID: 2400009.
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    405. Kosten TR. Neurobiology of abused drugs. Opioids and stimulants. J Nerv Ment Dis. 1990 Apr; 178(4):217-27. PMID: 2156952.
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    406. Frank JB, Kosten TR, Giller EL. Antidepressants in the treatment of PTSD. Am J Psychiatry. 1990 Feb; 147(2):260. PMID: 2301678.
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    407. Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. Opioid antagonist challenges in buprenorphine maintained patients. Drug Alcohol Depend. 1990 Feb; 25(1):73-8. PMID: 2323312.
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    408. Kosten TA, Kosten TR, Rounsaville BJ. Cocaine symptoms are predicted by familial psychopathology. NIDA Res Monogr. 1990; 105:603-4. PMID: 1876139.
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    409. Kosten TA, Kosten TR. The dependence syndrome concept as applied to alcohol and other substances of abuse. Recent Dev Alcohol. 1990; 8:47-68. PMID: 2185524.
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    410. Diakogiannis IA, Steinberg M, Kosten TR. Mazindol treatment of cocaine abuse. A double-blind investigation. NIDA Res Monogr. 1990; 105:514. PMID: 1876105.
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    411. Kosten TR, Morgan C, Kosten TA. Depressive symptoms during buprenorphine treatment of opioid abusers. J Subst Abuse Treat. 1990; 7(1):51-4. PMID: 2313769.
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    412. Kosten TR, Bryant K, Rounsaville BJ. The SCID: a clinical instrument for assessing psychiatric disorders. NIDA Res Monogr. 1990; 105:213-9. PMID: 1876002.
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    413. Kosten TR, Gawin FH, Morgan C, Nelson JC, Jatlow P. Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse. Am J Drug Alcohol Abuse. 1990; 16(3-4):329-36. PMID: 2288330.
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    414. Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. Rapid detoxification from opioid dependence. Am J Psychiatry. 1989 Oct; 146(10):1349. PMID: 2675644.
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    415. Kosten TA, Kosten TR. Cocaine abuse and opioid withdrawal. Lancet. 1989 Jul 15; 2(8655):165-6. PMID: 2567937.
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    416. Kosten TR. Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments. J Nerv Ment Dis. 1989 Jul; 177(7):379-89. PMID: 2664072.
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    417. Mason JW, Kennedy JL, Kosten TR, Giller EL. Serum thyroxine levels in schizophrenic and affective disorder diagnostic subgroups. J Nerv Ment Dis. 1989 Jun; 177(6):351-8. PMID: 2723624.
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    418. Gawin FH, Kleber HD, Byck R, Rounsaville BJ, Kosten TR, Jatlow PI, Morgan C. Desipramine facilitation of initial cocaine abstinence. Arch Gen Psychiatry. 1989 Feb; 46(2):117-21. PMID: 2492422.
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    419. Kosten TA, Kosten TR, Rounsaville BJ. Personality disorders in opiate addicts show prognostic specificity. J Subst Abuse Treat. 1989; 6(3):163-8. PMID: 2795705.
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    420. Southwick S, Mason JW, Giller EL, Kosten TR. Serum thyroxine change and clinical recovery in psychiatric inpatients. Biol Psychiatry. 1989 Jan; 25(1):67-74. PMID: 2912510.
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    421. Kosten TR, Morgan CJ, Kleber HD. Buprenorphine treatment of cocaine abuse. NIDA Res Monogr. 1989; 95:461. PMID: 2641031.
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    422. Gawin FH, Morgan C, Kosten TR, Kleber HD. Double-blind evaluation of the effect of acute amantadine on cocaine craving. Psychopharmacology (Berl). 1989; 97(3):402-3. PMID: 2497490.
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    423. Kosten TR, Rounsaville BJ, Foley SH. Inpatient vs. outpatient cocaine abuse treatments. NIDA Res Monogr. 1989; 95:312-3. PMID: 2640976.
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    424. Kosten TR, Kleber HD, Morgan C. Role of opioid antagonists in treating intravenous cocaine abuse. Life Sci. 1989; 44(13):887-92. PMID: 2927249.
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    425. Jacobsen LK, Kosten TR. Naloxone challenge as a biological predictor of treatment outcome in opiate addicts. Am J Drug Alcohol Abuse. 1989; 15(4):355-66. PMID: 2596440.
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    426. Kosten TA, Jacobsen LK, Kosten TR. Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria. Am J Drug Alcohol Abuse. 1989; 15(3):237-50. PMID: 2763981.
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    427. Frank JB, Kosten TR, Giller EL, Dan E. A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder. Am J Psychiatry. 1988 Oct; 145(10):1289-91. PMID: 3048121.
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    428. Mason JW, Giller EL, Kosten TR, Harkness L. Elevation of urinary norepinephrine/cortisol ratio in posttraumatic stress disorder. J Nerv Ment Dis. 1988 Aug; 176(8):498-502. PMID: 3404142.
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    429. Vining E, Kosten TR, Kleber HD. Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. Br J Addict. 1988 May; 83(5):567-75. PMID: 3382815.
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    430. Kosten TR, Rounsaville BJ, Kleber HD. Antecedents and consequences of cocaine abuse among opioid addicts. A 2.5-year follow-up. J Nerv Ment Dis. 1988 Mar; 176(3):176-81. PMID: 3343591.
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    431. Mason JW, Giller EL, Kosten TR. Serum testosterone differences between patients with schizophrenia and those with affective disorder. Biol Psychiatry. 1988 Feb 15; 23(4):357-66. PMID: 3342266.
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    432. Kosten TR, Rounsaville BJ. Suicidality among opioid addicts: 2.5 year follow-up. Am J Drug Alcohol Abuse. 1988; 14(3):357-69. PMID: 3189257.
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    433. Kosten TR, Kleber HD. Buprenorphine detoxification from opioid dependence: a pilot study. Life Sci. 1988; 42(6):635-41. PMID: 3276999.
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    434. Kosten TR, Kleber HD. Rapid death during cocaine abuse: a variant of the neuroleptic malignant syndrome? Am J Drug Alcohol Abuse. 1988; 14(3):335-46. PMID: 3055940.
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    435. Kosten TR, Kleber HD. Differential diagnosis of psychiatric comorbidity in substance abusers. J Subst Abuse Treat. 1988; 5(4):201-6. PMID: 3216436.
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    436. Kosten TR, Rounsaville BJ, Babor TF, Spitzer RL, Williams JB. Substance-use disorders in DSM-III-R. Evidence for the dependence syndrome across different psychoactive substances. Br J Psychiatry. 1987 Dec; 151:834-43. PMID: 2901887.
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    437. Kosten TR, Schumann B, Wright D, Carney MK, Gawin FH. A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients. J Clin Psychiatry. 1987 Nov; 48(11):442-4. PMID: 3680185.
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    438. Kosten TR, Kreek MJ, Swift C, Carney MK, Ferdinands L. Beta endorphin levels in CSF during methadone maintenance. Life Sci. 1987 Aug 31; 41(9):1071-6. PMID: 2956475.
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    439. Rounsaville BJ, Kosten TR, Williams JB, Spitzer RL. A field trial of DSM-III-R psychoactive substance dependence disorders. Am J Psychiatry. 1987 Mar; 144(3):351-5. PMID: 3826436.
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    440. Kosten TR, Rounsaville BJ, Kleber HD. A 2.5-year follow-up of cocaine use among treated opioid addicts. Have our treatments helped? Arch Gen Psychiatry. 1987 Mar; 44(3):281-4. PMID: 3827521.
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    441. Jacobs SC, Mason J, Kosten TR, Kasl SV, Ostfeld AM, Wahby V. Urinary free cortisol and separation anxiety early in the course of bereavement and threatened loss. Biol Psychiatry. 1987 Feb; 22(2):148-52. PMID: 3814667.
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    442. Rounsaville BJ, Kosten TR, Kleber HD. The antecedents and benefits of achieving abstinence in opioid addicts: a 2.5-year follow-up study. Am J Drug Alcohol Abuse. 1987; 13(3):213-29. PMID: 3687888.
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    443. Kosten TR, Rounsaville BJ. Source of income as a predictor in opioid addicts: 2.5 year follow-up. NIDA Res Monogr. 1987; 76:196-9. PMID: 3125447.
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    444. Kosten TR, Jalali B, Steidl JH, Kleber HD. Relationship of marital structure and interactions to opiate abuse relapse. Am J Drug Alcohol Abuse. 1987; 13(4):387-99. PMID: 3687898.
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    445. Kosten TR, Rounsaville BJ, Babor TF, Spitzer RL, Williams JB. The dependence syndrome across different psychoactive substances: revised DSM-III. NIDA Res Monogr. 1987; 76:255-8. PMID: 3125454.
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    446. Kosten TR, Mason JW, Giller EL, Ostroff RB, Harkness L. Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder. Psychoneuroendocrinology. 1987; 12(1):13-20. PMID: 3588809.
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    447. Kosten TR, Rounsaville BJ, Kleber HD. Multidimensionality and prediction of treatment outcome in opioid addicts: 2.5-year follow-up. Compr Psychiatry. 1987 Jan-Feb; 28(1):3-13. PMID: 3802797.
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    448. Kosten TR, Rounsaville BJ, Kleber HD. Predictors of 2.5-year outcome in opioid addicts: pretreatment source of income. Am J Drug Alcohol Abuse. 1987; 13(1-2):19-32. PMID: 3687883.
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    449. Kosten TR, Forrest JN. Treatment of severe lithium-induced polyuria with amiloride. Am J Psychiatry. 1986 Dec; 143(12):1563-8. PMID: 3538913.
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    450. Rounsaville BJ, Kosten TR, Kleber HD. Long-term changes in current psychiatric diagnoses of treated opiate addicts. Compr Psychiatry. 1986 Sep-Oct; 27(5):480-98. PMID: 3757496.
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    451. Kosten TR, Rounsaville BJ. Psychopathology in opioid addicts. Psychiatr Clin North Am. 1986 Sep; 9(3):515-32. PMID: 3774603.
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    452. Rounsaville BJ, Kosten TR, Weissman MM, Kleber HD. Prognostic significance of psychopathology in treated opiate addicts. A 2.5-year follow-up study. Arch Gen Psychiatry. 1986 Aug; 43(8):739-45. PMID: 3729668.
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    453. Kosten TR, Kreek MJ, Ragunath J, Kleber HD. A preliminary study of beta endorphin during chronic naltrexone maintenance treatment in ex-opiate addicts. Life Sci. 1986 Jul 07; 39(1):55-9. PMID: 2941636.
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    454. Rounsaville BJ, Kosten TR, Weissmann MM, Kleber HD. A 2.5-year follow-up of short-term interpersonal psychotherapy in methadone-maintained opiate addicts. Compr Psychiatry. 1986 May-Jun; 27(3):201-10. PMID: 3709134.
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    455. Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L. Urinary free-cortisol levels in posttraumatic stress disorder patients. J Nerv Ment Dis. 1986 Mar; 174(3):145-9. PMID: 3950596.
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    456. Kosten TR, Kreek MJ, Ragunath J, Kleber HD. Cortisol levels during chronic naltrexone maintenance treatment in ex-opiate addicts. Biol Psychiatry. 1986 Feb; 21(2):217-20. PMID: 3947698.
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    457. Jacobs SC, Mason JW, Kosten TR, Wahby V, Kasl SV, Ostfeld AM. Bereavement and catecholamines. J Psychosom Res. 1986; 30(4):489-96. PMID: 3761233.
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    458. Kosten TR, Rounsaville BJ, Kleber HD. A 2.5 year follow-up of treatment retention and reentry among opioid addicts. J Subst Abuse Treat. 1986; 3(3):181-9. PMID: 3806731.
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    459. Kosten TR. Diagnosing depression with the DST and TRH in cocaine and opioid abusers. J Subst Abuse Treat. 1986; 3(1):47-9. PMID: 3090273.
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    460. Kosten TR, Hogan I, Jalali B, Steidl J, Kleber HD. The effect of multiple family therapy on addict family functioning: a pilot study. Adv Alcohol Subst Abuse. 1986; 5(3):51-62. PMID: 3728193.
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    461. Kosten TR, Gawin FH, Rounsaville BJ, Kleber HD. Abuse of cocaine with opioids: psychological aspects of treatment. NIDA Res Monogr. 1986; 67:278-82. PMID: 3092078.
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    462. Kosten TR, Kreek MJ, Ragunath J, Kleber HD. Chronic naltrexone effect on cortisol. NIDA Res Monogr. 1986; 67:362-5. PMID: 3092091.
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    463. Kosten TR, Gawin FH, Rounsaville BJ, Kleber HD. Cocaine abuse among opioid addicts: demographic and diagnostic factors in treatment. Am J Drug Alcohol Abuse. 1986; 12(1-2):1-16. PMID: 3788892.
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    464. Kosten TR, Rounsaville BJ, Kleber HD. Parental alcoholism in opioid addicts. J Nerv Ment Dis. 1985 Aug; 173(8):461-9. PMID: 4020363.
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    465. Kosten TR, Rounsaville BJ, Kleber HD. Ethnic and gender differences among opiate addicts. Int J Addict. 1985 Aug; 20(8):1143-62. PMID: 4077316.
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    466. Kleber HD, Kosten TR, Gaspari J, Topazian M. Nontolerance to the opioid antagonism of naltrexone. Biol Psychiatry. 1985 Jan; 20(1):66-72. PMID: 2981129.
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    467. Kosten TR, Rounsaville BJ, Kleber HD. Comparison of clinician ratings to self reports of withdrawal during clonidine detoxification of opiate addicts. Am J Drug Alcohol Abuse. 1985; 11(1-2):1-10. PMID: 3904410.
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    468. Kosten TR, Rounsaville BJ, Kleber HD. Relationship of depression to clonidine detoxification of opiate addicts. Compr Psychiatry. 1984 Sep-Oct; 25(5):503-8. PMID: 6488761.
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    469. Kosten TR, Kleber HD. Strategies to improve compliance with narcotic antagonists. Am J Drug Alcohol Abuse. 1984; 10(2):249-66. PMID: 6475891.
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    470. Kosten TR, Novak P, Kleber HD. Perceived marital and family environment of opiate addicts. Am J Drug Alcohol Abuse. 1984; 10(4):491-501. PMID: 6534181.
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    471. Kosten TR, Rounsaville BJ, Merikangas KR, Prusoff BA, Kleber HD. The relationship of the Maudsley Personality Inventory to depression in addicts. Compr Psychiatry. 1983 Nov-Dec; 24(6):535-42. PMID: 6653096.
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    472. Kosten TR, Jalali B, Hogan I, Kleber HD. Family denial as a prognostic factor in opiate addict treatment outcome. J Nerv Ment Dis. 1983 Oct; 171(10):611-6. PMID: 6619824.
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    473. Kosten TR, Rounsaville BJ, Kleber HD. Concurrent validity of the addiction severity index. J Nerv Ment Dis. 1983 Oct; 171(10):606-10. PMID: 6619823.
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    474. Kosten TR, Rounsaville BJ, Kleber HD. Relationship of depression to psychosocial stressors in heroin addicts. J Nerv Ment Dis. 1983 Feb; 171(2):97-104. PMID: 6822825.
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    475. Kosten TR, Rounsaville BJ, Kleber HD. DSM-III personality disorders in opiate addicts. Compr Psychiatry. 1982 Nov-Dec; 23(6):572-81. PMID: 7160176.
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    476. Kosten TR, Jalali B, Kleber HD. Complementary marital roles of male heroin addicts: evolution and intervention tactics. Am J Drug Alcohol Abuse. 1982-1983; 9(2):155-69. PMID: 7171079.
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