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LAISING YEN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionPathology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01EB013584     (YEN, LAISING LEWIS)Aug 1, 2011 - Jul 31, 2015
    NIH/NIBIB
    Harnessing the power of RNA sensor for imaging molecular signatures in vivo
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gupta SK, Luo L, Yen L. RNA-mediated gene fusion in mammalian cells. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12295-E12304. PMID: 30538195.
      View in: PubMed
    2. Joseph NA, Chiou SH, Lung Z, Yang CL, Lin TY, Chang HW, Sun HS, Gupta SK, Yen L, Wang SD, Chow KC. The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells. J Hematol Oncol. 2018 05 31; 11(1):74. PMID: 29855336.
      View in: PubMed
    3. Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS, Tsai SJ. Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer Res. 2017 05 01; 77(9):2339-2350. PMID: 28249903.
      View in: PubMed
    4. Jijakli K, Khraiwesh B, Fu W, Luo L, Alzahmi A, Koussa J, Chaiboonchoe A, Kirmizialtin S, Yen L, Salehi-Ashtiani K. The in vitro selection world. Methods. 2016 08 15; 106:3-13. PMID: 27312879.
      View in: PubMed
    5. Kannan K, Kordestani GK, Galagoda A, Coarfa C, Yen L. Aberrant MUC1-TRIM46-KRTCAP2 Chimeric RNAs in High-Grade Serous Ovarian Carcinoma. Cancers (Basel). 2015 Oct 19; 7(4):2083-93. PMID: 26492273.
      View in: PubMed
    6. Kannan K, Coarfa C, Chao PW, Luo L, Wang Y, Brinegar AE, Hawkins SM, Milosavljevic A, Matzuk MM, Yen L. Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1272-7. PMID: 25733895.
      View in: PubMed
    7. Kannan K, Coarfa C, Rajapakshe K, Hawkins SM, Matzuk MM, Milosavljevic A, Yen L. CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet. 2014 Mar; 10(3):e1004216. PMID: 24675677.
      View in: PubMed
    8. Zhang H, Lin W, Kannan K, Luo L, Li J, Chao PW, Wang Y, Chen YP, Gu J, Yen L. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Oncotarget. 2013 Nov; 4(11):2135-43. PMID: 24243830.
      View in: PubMed
    9. Wu CC, Kannan K, Lin S, Yen L, Milosavljevic A. Identification of cancer fusion drivers using network fusion centrality. Bioinformatics. 2013 May 01; 29(9):1174-81. PMID: 23505294.
      View in: PubMed
    10. Kannan K, Wang L, Wang J, Ittmann MM, Li W, Yen L. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9172-7. PMID: 21571633.
      View in: PubMed
    11. Wang L, Xi Y, Yu J, Dong L, Yen L, Li W. A statistical method for the detection of alternative splicing using RNA-seq. PLoS One. 2010 Jan 08; 5(1):e8529. PMID: 20072613.
      View in: PubMed
    12. Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods Mol Biol. 2009; 540:335-47. PMID: 19381571.
      View in: PubMed
    13. Link KH, Guo L, Ames TD, Yen L, Mulligan RC, Breaker RR. Engineering high-speed allosteric hammerhead ribozymes. Biol Chem. 2007 Aug; 388(8):779-86. PMID: 17655496.
      View in: PubMed
    14. Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006 May; 12(5):797-806. PMID: 16556935.
      View in: PubMed
    15. Yen L, Svendsen J, Lee JS, Gray JT, Magnier M, Baba T, D'Amato RJ, Mulligan RC. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature. 2004 Sep 23; 431(7007):471-6. PMID: 15386015.
      View in: PubMed
    16. Yen L, Gonzalez-Zulueta M, Feldman A, Yuan Y, Fryer H, Dawson T, Dawson V, Kalb RG. Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA. J Neurochem. 2001 Mar; 76(5):1386-94. PMID: 11238723.
      View in: PubMed
    17. Carystinos GD, Alaoui-Jamali MA, Phipps J, Yen L, Batist G. Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells. Cancer Chemother Pharmacol. 2001; 47(2):126-32. PMID: 11269738.
      View in: PubMed
    18. Yen L, Strittmatter SM, Kalb RG. Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA. Ann Neurol. 1999 Sep; 46(3):366-73. PMID: 10482267.
      View in: PubMed
    19. Jakowec MW, Yen L, Kalb RG. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience. 1995 Aug; 67(4):909-20. PMID: 7675213.
      View in: PubMed
    20. Yen L, Sibley JT, Constantine-Paton M. Analysis of synaptic distribution within single retinal axonal arbors after chronic NMDA treatment. J Neurosci. 1995 Jun; 15(6):4712-25. PMID: 7540683.
      View in: PubMed
    21. Yen, L. and R.G. Kalb. . Neuroscientist. Recovery from spinal cord injury: New approaches. 1995; 1:321.
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