TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

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    R01EB013584     (YEN, LAISING LEWIS)Aug 1, 2011 - Jul 31, 2016
    Harnessing the power of RNA sensor for imaging molecular signatures in vivo
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Luo L, Jea JD, Wang Y, Chao PW, Yen L. Control of mammalian gene expression by modulation of polyA signal cleavage at 5' UTR. Nat Biotechnol. 2024 Jan 02. PMID: 38168982.
      Citations: 1     Fields:    
    2. Gupta SK, Yen L. Chimeric RNA Design Principles for RNA-Mediated Gene Fusion. Cells. 2022 03 16; 11(6). PMID: 35326453; PMCID: PMC8947500.
      Citations:    Fields:    Translation:Animals
    3. Gupta SK, Jea JD, Yen L. RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. PLoS Genet. 2021 12; 17(12):e1009985. PMID: 34928964; PMCID: PMC8722726.
      Citations: 1     Fields:    Translation:HumansCells
    4. Chen YJ, Chen CY, Mai TL, Chuang CF, Chen YC, Gupta SK, Yen L, Wang YD, Chuang TJ. Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism. Genome Res. 2020 03; 30(3):375-391. PMID: 32127416; PMCID: PMC7111521.
      Citations: 22     Fields:    Translation:HumansCells
    5. Gupta SK, Jea JD, Yen L. Validating Gene Fusion as the Source of Chimeric RNAs. Methods Mol Biol. 2020; 2079:187-207. PMID: 31728972.
      Citations:    Fields:    Translation:Humans
    6. Gupta SK, Luo L, Yen L. RNA-mediated gene fusion in mammalian cells. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12295-E12304. PMID: 30538195; PMCID: PMC6310785.
      Citations: 13     Fields:    Translation:HumansCells
    7. Joseph NA, Chiou SH, Lung Z, Yang CL, Lin TY, Chang HW, Sun HS, Gupta SK, Yen L, Wang SD, Chow KC. The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells. J Hematol Oncol. 2018 05 31; 11(1):74. PMID: 29855336; PMCID: PMC5984410.
      Citations: 30     Fields:    Translation:HumansCells
    8. Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS, Tsai SJ. Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer Res. 2017 05 01; 77(9):2339-2350. PMID: 28249903; PMCID: PMC5910173.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    9. Jijakli K, Khraiwesh B, Fu W, Luo L, Alzahmi A, Koussa J, Chaiboonchoe A, Kirmizialtin S, Yen L, Salehi-Ashtiani K. The in vitro selection world. Methods. 2016 08 15; 106:3-13. PMID: 27312879.
      Citations: 14     Fields:    
    10. Kannan K, Kordestani GK, Galagoda A, Coarfa C, Yen L. Aberrant MUC1-TRIM46-KRTCAP2 Chimeric RNAs in High-Grade Serous Ovarian Carcinoma. Cancers (Basel). 2015 Oct 19; 7(4):2083-93. PMID: 26492273; PMCID: PMC4695878.
      Citations: 6     
    11. Kannan K, Coarfa C, Chao PW, Luo L, Wang Y, Brinegar AE, Hawkins SM, Milosavljevic A, Matzuk MM, Yen L. Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1272-7. PMID: 25733895; PMCID: PMC4371965.
      Citations: 17     Fields:    Translation:HumansCells
    12. Kannan K, Coarfa C, Rajapakshe K, Hawkins SM, Matzuk MM, Milosavljevic A, Yen L. CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet. 2014 Mar; 10(3):e1004216. PMID: 24675677; PMCID: PMC3967933.
      Citations: 26     Fields:    Translation:Humans
    13. Zhang H, Lin W, Kannan K, Luo L, Li J, Chao PW, Wang Y, Chen YP, Gu J, Yen L. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Oncotarget. 2013 Nov; 4(11):2135-43. PMID: 24243830; PMCID: PMC3875775.
      Citations: 16     Fields:    Translation:HumansCells
    14. Wu CC, Kannan K, Lin S, Yen L, Milosavljevic A. Identification of cancer fusion drivers using network fusion centrality. Bioinformatics. 2013 May 01; 29(9):1174-81. PMID: 23505294; PMCID: PMC3634186.
      Citations: 16     Fields:    Translation:HumansCells
    15. Kannan K, Wang L, Wang J, Ittmann MM, Li W, Yen L. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9172-7. PMID: 21571633; PMCID: PMC3107329.
      Citations: 98     Fields:    Translation:HumansCells
    16. Wang L, Xi Y, Yu J, Dong L, Yen L, Li W. A statistical method for the detection of alternative splicing using RNA-seq. PLoS One. 2010 Jan 08; 5(1):e8529. PMID: 20072613; PMCID: PMC2798953.
      Citations: 19     Fields:    Translation:Cells
    17. Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods Mol Biol. 2009; 540:335-47. PMID: 19381571.
      Citations: 1     Fields:    Translation:HumansCells
    18. Link KH, Guo L, Ames TD, Yen L, Mulligan RC, Breaker RR. Engineering high-speed allosteric hammerhead ribozymes. Biol Chem. 2007 Aug; 388(8):779-86. PMID: 17655496.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    19. Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006 May; 12(5):797-806. PMID: 16556935; PMCID: PMC1440893.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    20. Yen L, Svendsen J, Lee JS, Gray JT, Magnier M, Baba T, D'Amato RJ, Mulligan RC. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature. 2004 Sep 23; 431(7007):471-6. PMID: 15386015.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    21. Yen L, Gonzalez-Zulueta M, Feldman A, Yuan Y, Fryer H, Dawson T, Dawson V, Kalb RG. Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA. J Neurochem. 2001 Mar; 76(5):1386-94. PMID: 11238723.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Yen L, Strittmatter SM, Kalb RG. Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA. Ann Neurol. 1999 Sep; 46(3):366-73. PMID: 10482267.
      Citations: 16     Fields:    Translation:HumansCells
    23. Jakowec MW, Yen L, Kalb RG. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience. 1995 Aug; 67(4):909-20. PMID: 7675213.
      Citations: 32     Fields:    Translation:AnimalsCells
    24. Yen L, Sibley JT, Constantine-Paton M. Analysis of synaptic distribution within single retinal axonal arbors after chronic NMDA treatment. J Neurosci. 1995 Jun; 15(6):4712-25. PMID: 7540683; PMCID: PMC6577734.
      Citations: 11     Fields:    Translation:AnimalsCells
    25. . Neuroscientist. Recovery from spinal cord injury: New approaches. 1995; 1:321.
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