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BINOY SHIVANNA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
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    Collapse Biography 
    Collapse education and training
    Mysore Medical College, Mysore, IndiaM.B.B.S03/1994Medicine
    Mysore Medical College, Mysore, IndiaM.D.06/1997Pediatrics
    Lokamanya Tilak Municipal Medical College, Mumbai, IndiaD.M.06/2002Neonatology
    Royal North Shore Hospital, Sydney, AustraliaFellowship06/2005Neonatology
    Newark Beth Israel Medical Center, New Jersey, U.S.Residency06/2007Pediatrics
    Baylor College of Medicine, Houston, U.S.Fellowship06/2010Neonatology
    Baylor College of Medicine, Houston, U.S.PhD01/2016Clinical Scientist Development Program
    Collapse awards and honors
    2007Pediatric Resident of the Year, Newark Beth Israel Medical Center, Newark, NJ
    2009Fellows Day - Award for Best Poster Presentation of Research, Department of Pediatrics, Baylor College of Medicine, Houston, TX
    2009Young Investigator Award, AAP Section on Perinatal Pediatrics at National Conference, American Academy of Pediatrics
    2009Texas Pediatrics Society Fellow Electronic Poster Contest, Texas Pediatric Society
    2010Fellows Day - Award for Best Poster Presentation of Research, Department of Pediatrics, Baylor College of Medicine, Houston, TX
    2010Arnold J. Rudolph Award for Outstanding Teaching, Patient Care, and Scientific Inquiry, Section of Neonatology, Baylor College of Medicine, Houston, TX
    2011Young Investigator Award, Southern Society of Pediatric Research Regional meeting, Southern Society of Pediatric Research
    2012Young Faculty Award, Southern Society of Pediatric Research
    2013Young Faculty Award, Southern Society of Pediatric Research
    2013John R. Kelsey, Jr. Student Speaker Award, Graduate Student Symposium, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX
    2014Young Faculty Award, Southern Society of Pediatric Research
    2015Young Faculty Award, Southern Society of Pediatric Research
    2015Pediatric Scientific Abstract Award, American Thoracic Society

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R03HD103823     (SHIVANNA, BINOY)Mar 8, 2021 - May 31, 2023
    NIH
    Regulatory T cells and Inflammatory Injury of the Developing Murine Lungs
    Role: Principal Investigator
    R01HL139594     (SHIVANNA, BINOY)Sep 1, 2018 - Jul 31, 2023
    NIH
    Mechanistic Roles of Adrenomedullin and its Signaling Receptors in Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension
    Role: Principal Investigator
    K08HD073323     (SHIVANNA, BINOY)Aug 20, 2013 - Jun 30, 2019
    NIH
    Modulation of Neonatal Hyperoxic Lung Injury by the Aryl Hydrocarbon Receptor
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gilley J, Hanneman SK, Ottosen MJ, Shivanna B, Keswani S. Endothelial-to-Mesenchymal Transition in Human and Murine Models of Congenital Diaphragmatic Hernia. Neonatology. 2024 Apr 08; 1-7. PMID: 38588643.
      Citations:    
    2. El-Saie A, Shivanna B. Apnea of prematurity: when is the right time to stimulate? Pediatr Res. 2024 Apr 04. PMID: 38575693.
      Citations:    Fields:    
    3. Thapa S, Shankar N, Shrestha AK, Civunigunta M, Gaikwad AS, Shivanna B. Amphiregulin Exerts Proangiogenic Effects in Developing Murine Lungs. Antioxidants (Basel). 2024 Jan 08; 13(1). PMID: 38247502; PMCID: PMC10812697.
      Citations:    
    4. Young KC, Schmidt AF, Tan AW, Sbragia L, Elsaie A, Shivanna B. Pathogenesis and Physiologic Mechanisms of Neonatal Pulmonary Hypertension: Preclinical Studies. Clin Perinatol. 2024 Mar; 51(1):21-43. PMID: 38325942.
      Citations:    Fields:    Translation:Humans
    5. El-Saie A, Varghese NP, Webb MK, Villafranco N, Gandhi B, Guaman MC, Shivanna B. Bronchopulmonary dysplasia - associated pulmonary hypertension: An updated review. Semin Perinatol. 2023 10; 47(6):151817. PMID: 37783579; PMCID: PMC10843293.
      Citations:    Fields:    Translation:Humans
    6. Shankar N, Thapa S, Shrestha AK, Sarkar P, Gaber MW, Barrios R, Shivanna B. Hyperoxia Disrupts Lung Lymphatic Homeostasis in Neonatal Mice. Antioxidants (Basel). 2023 Mar 02; 12(3). PMID: 36978868; PMCID: PMC10045755.
      Citations:    
    7. Menon RT, Thapa S, Shrestha AK, Barrios R, Shivanna B. Extracellular Signal-Regulated Kinase 1 Alone Is Dispensable for Hyperoxia-Mediated Alveolar and Pulmonary Vascular Simplification in Neonatal Mice. Antioxidants (Basel). 2022 Jun 08; 11(6). PMID: 35740027; PMCID: PMC9219973.
      Citations:    
    8. El Saie A, Fu C, Grimm SL, Robertson MJ, Hoffman K, Putluri V, Ambati CSR, Putluri N, Shivanna B, Coarfa C, Pammi M. Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia. Pediatr Res. 2022 12; 92(6):1580-1589. PMID: 35338351; PMCID: PMC9509498.
      Citations:    Fields:    
    9. Shivanna B, Chu C, Moorthy B. The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? Int J Mol Sci. 2022 Jan 28; 23(3). PMID: 35163440; PMCID: PMC8836075.
      Citations: 2     Fields:    Translation:HumansAnimals
    10. Kalikkot Thekkeveedu R, El-Saie A, Prakash V, Katakam L, Shivanna B. Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies. J Clin Med. 2022 Jan 22; 11(3). PMID: 35160009; PMCID: PMC8836835.
      Citations:    
    11. Elsaie A, Menon RT, Shrestha AK, Gowda SH, Varghese NP, Barrios RJ, Blanco CL, Konduri GG, Shivanna B. Endothelial Adenosine Monophosphate-Activated Protein Kinase-Alpha1 Deficiency Potentiates Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension. Antioxidants (Basel). 2021 Nov 29; 10(12). PMID: 34943016; PMCID: PMC8750184.
      Citations: 1     
    12. Shrestha AK, Menon RT, Yallampalli C, Barrios R, Shivanna B. Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice. Am J Pathol. 2021 12; 191(12):2080-2090. PMID: 34508690; PMCID: PMC8647431.
      Citations:    Fields:    Translation:Animals
    13. Shrestha AK, Menon RT, El-Saie A, Barrios R, Reynolds C, Shivanna B. Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs. Am J Physiol Lung Cell Mol Physiol. 2020 12 01; 319(6):L981-L996. PMID: 32901520; PMCID: PMC7792686.
      Citations: 4     Fields:    Translation:Animals
    14. El-Saie A, Shivanna B. Novel Strategies to Reduce Pulmonary Hypertension in Infants With Bronchopulmonary Dysplasia. Front Pediatr. 2020; 8:201. PMID: 32457857; PMCID: PMC7225259.
      Citations: 3     
    15. Menon RT, Shrestha AK, Barrios R, Reynolds C, Shivanna B. Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice. Int J Mol Sci. 2020 Mar 31; 21(7). PMID: 32244398; PMCID: PMC7177249.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    16. Menon RT, Shrestha AK, Reynolds CL, Barrios R, Caron KM, Shivanna B. Adrenomedullin Is Necessary to Resolve Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension?in Mice. Am J Pathol. 2020 03; 190(3):711-722. PMID: 32093901; PMCID: PMC7074343.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    17. Xiong T, Kulkarni M, Gokulakrishnan G, Shivanna B, Pammi M. Natriuretic peptides in bronchopulmonary dysplasia: a systematic review. J Perinatol. 2020 04; 40(4):607-615. PMID: 31925319.
      Citations: 4     Fields:    Translation:Humans
    18. Shivanna B, Gowda S, Welty SE, Barrington KJ, Pammi M. Prostanoids and their analogues for the treatment of pulmonary hypertension in neonates. Cochrane Database Syst Rev. 2019 10 01; 10:CD012963. PMID: 31573068; PMCID: PMC6771085.
      Citations: 5     Fields:    
    19. Shrestha AK, Bettini ML, Menon RT, Gopal VYN, Huang S, Edwards DP, Pammi M, Barrios R, Shivanna B. Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L229-L244. PMID: 30307313; PMCID: PMC6383495.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. Pammi M, Lal CV, Wagner BD, Mourani PM, Lohmann P, Luna RA, Sisson A, Shivanna B, Hollister EB, Abman SH, Versalovic J, Connett GJ, Bhandari V, Ambalavanan N. Airway Microbiome and Development of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review. J Pediatr. 2019 01; 204:126-133.e2. PMID: 30297287.
      Citations: 25     Fields:    Translation:Humans
    21. Shrestha AK, Menon RT, Shivanna B. Leflunomide attenuates oxidative stress in fetal human lung endothelial cells via superoxide dismutase 2 and catalase. Biochem Biophys Res Commun. 2018 09 10; 503(3):2009-2014. PMID: 30077371; PMCID: PMC6119491.
      Citations: 1     Fields:    Translation:HumansCells
    22. Shrestha AK, Gopal VYN, Menon RT, Hagan JL, Huang S, Shivanna B. Lung omics signatures in a bronchopulmonary dysplasia and pulmonary hypertension-like murine model. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L734-L741. PMID: 30047283; PMCID: PMC6295503.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Menon RT, Shrestha AK, Barrios R, Shivanna B. Hyperoxia Disrupts Extracellular Signal-Regulated Kinases 1/2-Induced Angiogenesis in the Developing Lungs. Int J Mol Sci. 2018 May 20; 19(5). PMID: 29783779; PMCID: PMC5983575.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    24. Akkinapally S, Hundalani SG, Kulkarni M, Fernandes CJ, Cabrera AG, Shivanna B, Pammi M. Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions. Cochrane Database Syst Rev. 2018 02 27; 2:CD011417. PMID: 29486048; PMCID: PMC6491149.
      Citations: 11     Fields:    Translation:Humans
    25. Menon RT, Shrestha AK, Reynolds CL, Barrios R, Shivanna B. Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice. Int J Biochem Cell Biol. 2018 01; 94:119-124. PMID: 29223466; PMCID: PMC5745292.
      Citations: 14     Fields:    Translation:Animals
    26. Kalikkot Thekkeveedu R, Guaman MC, Shivanna B. Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology. Respir Med. 2017 Nov; 132:170-177. PMID: 29229093; PMCID: PMC5729938.
      Citations: 93     Fields:    Translation:Humans
    27. Menon RT, Shrestha AK, Shivanna B. Hyperoxia exposure disrupts adrenomedullin signaling in newborn mice: Implications for lung development in premature infants. Biochem Biophys Res Commun. 2017 06 03; 487(3):666-671. PMID: 28438602; PMCID: PMC5497733.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    28. Shrestha AK, Patel A, Menon RT, Jiang W, Wang L, Moorthy B, Shivanna B. Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice. Biochem Biophys Res Commun. 2017 03 25; 485(1):195-200. PMID: 28192119; PMCID: PMC5367632.
      Citations: 1     Fields:    Translation:AnimalsCells
    29. Patel A, Zhang S, Shrestha AK, Maturu P, Moorthy B, Shivanna B. Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway. Toxicol Appl Pharmacol. 2016 Nov 15; 311:26-33. PMID: 27725188; PMCID: PMC5089963.
      Citations: 6     Fields:    Translation:HumansCells
    30. Reynolds CL, Zhang S, Shrestha AK, Barrios R, Shivanna B. Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: a step toward preventing chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2016; 11:1597-605. PMID: 27478373; PMCID: PMC4951055.
      Citations: 16     Fields:    Translation:Animals
    31. Shivanna B, Maity S, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Belmont J, Coarfa C, Moorthy B. Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia. Toxicol Sci. 2016 07; 152(1):155-68. PMID: 27103661; PMCID: PMC4922543.
      Citations: 11     Fields:    Translation:HumansCells
    32. Zhang S, Patel A, Moorthy B, Shivanna B. Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2. Biochem Biophys Res Commun. 2015 Nov 13; 467(2):282-7. PMID: 26441083; PMCID: PMC4618076.
      Citations: 4     Fields:    Translation:HumansCells
    33. Patel A, Zhang S, Moorthy B, Shivanna B. Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia. Pharm Anal Acta. 2015 Oct; 6(10). PMID: 26779382; PMCID: PMC4712726.
      Citations: 5     
    34. Patel A, Zhang S, Paramahamsa M, Jiang W, Wang L, Moorthy B, Shivanna B. Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor. Drug Metab Dispos. 2015 Dec; 43(12):1966-70. PMID: 26417045; PMCID: PMC4658494.
      Citations: 3     Fields:    Translation:Animals
    35. Shivanna B, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Moorthy B. Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice. Toxicol Sci. 2015 Nov; 148(1):276-87. PMID: 26272953; PMCID: PMC4635634.
      Citations: 15     Fields:    Translation:HumansAnimals
    36. Zhang S, Patel A, Moorthy B, Shivanna B. Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):1048-1053. PMID: 26196743; PMCID: PMC4558361.
      Citations: 9     Fields:    Translation:HumansCells
    37. Zhang S, Patel A, Chu C, Jiang W, Wang L, Welty SE, Moorthy B, Shivanna B. Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB. Toxicol Appl Pharmacol. 2015 Jul 15; 286(2):92-101. PMID: 25831079; PMCID: PMC4458211.
      Citations: 29     Fields:    Translation:HumansCells
    38. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282; PMCID: PMC4418801.
      Citations: 18     Fields:    Translation:AnimalsCells
    39. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714; PMCID: PMC4200035.
      Citations: 25     Fields:    Translation:AnimalsCells
    40. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529; PMCID: PMC4169345.
      Citations: 14     Fields:    Translation:Animals
    41. Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince LS, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 Jun; 34(6):801-11. PMID: 23505205; PMCID: PMC3663886.
      Citations: 48     Fields:    Translation:HumansCells
    42. Shivanna B, Rios D, Rossano J, Fernandes CJ, Pammi M. Vasopressin and its analogues for the treatment of refractory hypotension in neonates. Cochrane Database Syst Rev. 2013 Mar 28; (3):CD009171. PMID: 23543571.
      Citations: 9     Fields:    Translation:Humans
    43. Shivanna B, Zhang W, Jiang W, Welty SE, Couroucli XI, Wang L, Moorthy B. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol. 2013 Mar 15; 267(3):209-17. PMID: 23337360; PMCID: PMC3582791.
      Citations: 27     Fields:    Translation:Animals
    44. Chu C, Welty SE, Jiang W, Wang L, Couroucli XI, Moorthy B, Shivanna B. Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor. Free Radic Biol Med. 2011 Nov 15; 51(10):1910-7. PMID: 21906671; PMCID: PMC3901644.
      Citations: 22     Fields:    Translation:HumansCells
    45. Shivanna B, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2011 Oct; 339(1):106-14. PMID: 21768223; PMCID: PMC3186283.
      Citations: 19     Fields:    Translation:AnimalsCells
    46. Joshi AA, Bradoo RA, Kadam S, Binoy S, Mondkar J, Kalgutkar A. Tracheal agenesis. Indian J Otolaryngol Head Neck Surg. 2005 Apr; 57(2):141-2. PMID: 23120152; PMCID: PMC3450959.
      Citations:    
    47. Kadam S, Binoy S, Kanbur W, Mondkar JA, Fernandez A. Feasibility of kangaroo mother care in Mumbai. Indian J Pediatr. 2005 Jan; 72(1):35-8. PMID: 15684446.
      Citations: 22     Fields:    Translation:Humans
    48. Mohapatra A, Sankaranarayanan K, Kadam SS, Binoy S, Kanbur WA, Mondkar JA. Congenital rickets. J Trop Pediatr. 2003 04; 49(2):126-7. PMID: 12729298.
      Citations: 11     Fields:    Translation:Humans
    49. . Journal of Neonatology. Placental blood transfusion: An alternate source for transfusion. 2003; (17):45-52.
    50. . Journal of Neonatology. Pharmacological Principles in the Newborn. 2002; (16):4-10.
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