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Last Name

Binoy Shivanna

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
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    Collapse Biography 
    Collapse education and training
    Mysore Medical College, Mysore, IndiaM.B.B.S03/1994Medicine
    Mysore Medical College, Mysore, IndiaM.D.06/1997Pediatrics
    Lokamanya Tilak Municipal Medical College, Mumbai, IndiaD.M.06/2002Neonatology
    Royal North Shore Hospital, Sydney, AustraliaFellowship06/2005Neonatology
    Newark Beth Israel Medical Center, New Jersey, U.S.Residency06/2007Pediatrics
    Baylor College of Medicine, Houston, U.S.Fellowship06/2010Neonatology
    Baylor College of Medicine, Houston, U.S.PhD01/2016Clinical Scientist Development Program
    Collapse awards and honors
    2007Pediatric Resident of the Year, Newark Beth Israel Medical Center, Newark, NJ
    2009Fellows Day - Award for Best Poster Presentation of Research, Department of Pediatrics, Baylor College of Medicine, Houston, TX
    2009Young Investigator Award, AAP Section on Perinatal Pediatrics at National Conference, American Academy of Pediatrics
    2009Texas Pediatrics Society Fellow Electronic Poster Contest, Texas Pediatric Society
    2010Fellows Day - Award for Best Poster Presentation of Research, Department of Pediatrics, Baylor College of Medicine, Houston, TX
    2010Arnold J. Rudolph Award for Outstanding Teaching, Patient Care, and Scientific Inquiry, Section of Neonatology, Baylor College of Medicine, Houston, TX
    2011Young Investigator Award, Southern Society of Pediatric Research Regional meeting, Southern Society of Pediatric Research
    2012Young Faculty Award, Southern Society of Pediatric Research
    2013Young Faculty Award, Southern Society of Pediatric Research
    2013John R. Kelsey, Jr. Student Speaker Award, Graduate Student Symposium, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX
    2014Young Faculty Award, Southern Society of Pediatric Research
    2015Young Faculty Award, Southern Society of Pediatric Research
    2015Pediatric Scientific Abstract Award, American Thoracic Society

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    K08HD073323     (SHIVANNA, BINOY)Aug 20, 2013 - Jun 30, 2018
    Modulation of Neonatal Hyperoxic Lung Injury by the Aryl Hydrocarbon Receptor
    Role: Principal Investigator

    R01HL139594     (SHIVANNA, BINOY)Sep 1, 2018 - Jul 31, 2023
    Mechanistic Roles of Adrenomedullin and its Signaling Receptors in Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xiong T, Kulkarni M, Gokulakrishnan G, Shivanna B, Pammi M. Natriuretic peptides in bronchopulmonary dysplasia: a systematic review. J Perinatol. 2020 Jan 10. PMID: 31925319.
      View in: PubMed
    2. Shivanna B, Gowda S, Welty SE, Barrington KJ, Pammi M. Prostanoids and their analogues for the treatment of pulmonary hypertension in neonates. Cochrane Database Syst Rev. 2019 Oct 01; 10:CD012963. PMID: 31573068.
      View in: PubMed
    3. Shrestha AK, Bettini ML, Menon RT, Gopal VYN, Huang S, Edwards DP, Pammi M, Barrios R, Shivanna B. Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L229-L244. PMID: 30307313.
      View in: PubMed
    4. Pammi M, Lal CV, Wagner BD, Mourani PM, Lohmann P, Luna RA, Sisson A, Shivanna B, Hollister EB, Abman SH, Versalovic J, Connett GJ, Bhandari V, Ambalavanan N. Airway Microbiome and Development of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review. J Pediatr. 2019 01; 204:126-133.e2. PMID: 30297287.
      View in: PubMed
    5. Shrestha AK, Menon RT, Shivanna B. Leflunomide attenuates oxidative stress in fetal human lung endothelial cells via superoxide dismutase 2 and catalase. Biochem Biophys Res Commun. 2018 09 10; 503(3):2009-2014. PMID: 30077371.
      View in: PubMed
    6. Shrestha AK, Gopal VYN, Menon RT, Hagan JL, Huang S, Shivanna B. Lung omics signatures in a bronchopulmonary dysplasia and pulmonary hypertension-like murine model. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L734-L741. PMID: 30047283.
      View in: PubMed
    7. Menon RT, Shrestha AK, Barrios R, Shivanna B. Hyperoxia Disrupts Extracellular Signal-Regulated Kinases 1/2-Induced Angiogenesis in the Developing Lungs. Int J Mol Sci. 2018 May 20; 19(5). PMID: 29783779.
      View in: PubMed
    8. Akkinapally S, Hundalani SG, Kulkarni M, Fernandes CJ, Cabrera AG, Shivanna B, Pammi M. Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions. Cochrane Database Syst Rev. 2018 02 27; 2:CD011417. PMID: 29486048.
      View in: PubMed
    9. Menon RT, Shrestha AK, Reynolds CL, Barrios R, Shivanna B. Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice. Int J Biochem Cell Biol. 2018 01; 94:119-124. PMID: 29223466.
      View in: PubMed
    10. Kalikkot Thekkeveedu R, Guaman MC, Shivanna B. Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology. Respir Med. 2017 Nov; 132:170-177. PMID: 29229093.
      View in: PubMed
    11. Menon RT, Shrestha AK, Shivanna B. Hyperoxia exposure disrupts adrenomedullin signaling in newborn mice: Implications for lung development in premature infants. Biochem Biophys Res Commun. 2017 06 03; 487(3):666-671. PMID: 28438602.
      View in: PubMed
    12. Shrestha AK, Patel A, Menon RT, Jiang W, Wang L, Moorthy B, Shivanna B. Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice. Biochem Biophys Res Commun. 2017 03 25; 485(1):195-200. PMID: 28192119.
      View in: PubMed
    13. Patel A, Zhang S, Shrestha AK, Maturu P, Moorthy B, Shivanna B. Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway. Toxicol Appl Pharmacol. 2016 Nov 15; 311:26-33. PMID: 27725188.
      View in: PubMed
    14. Reynolds CL, Zhang S, Shrestha AK, Barrios R, Shivanna B. Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: a step toward preventing chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2016; 11:1597-605. PMID: 27478373.
      View in: PubMed
    15. Shivanna B, Maity S, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Belmont J, Coarfa C, Moorthy B. Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia. Toxicol Sci. 2016 07; 152(1):155-68. PMID: 27103661.
      View in: PubMed
    16. Zhang S, Patel A, Moorthy B, Shivanna B. Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2. Biochem Biophys Res Commun. 2015 Nov 13; 467(2):282-7. PMID: 26441083.
      View in: PubMed
    17. Patel A, Zhang S, Moorthy B, Shivanna B. Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia. Pharm Anal Acta. 2015 Oct; 6(10). PMID: 26779382.
      View in: PubMed
    18. Patel A, Zhang S, Paramahamsa M, Jiang W, Wang L, Moorthy B, Shivanna B. Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor. Drug Metab Dispos. 2015 Dec; 43(12):1966-70. PMID: 26417045.
      View in: PubMed
    19. Shivanna B, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Moorthy B. Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice. Toxicol Sci. 2015 Nov; 148(1):276-87. PMID: 26272953.
      View in: PubMed
    20. Zhang S, Patel A, Moorthy B, Shivanna B. Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):1048-1053. PMID: 26196743.
      View in: PubMed
    21. Zhang S, Patel A, Chu C, Jiang W, Wang L, Welty SE, Moorthy B, Shivanna B. Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB. Toxicol Appl Pharmacol. 2015 Jul 15; 286(2):92-101. PMID: 25831079.
      View in: PubMed
    22. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282.
      View in: PubMed
    23. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714.
      View in: PubMed
    24. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529.
      View in: PubMed
    25. Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince LS, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013 Jun; 34(6):801-11. PMID: 23505205.
      View in: PubMed
    26. Shivanna B, Rios D, Rossano J, Fernandes CJ, Pammi M. Vasopressin and its analogues for the treatment of refractory hypotension in neonates. Cochrane Database Syst Rev. 2013 Mar 28; (3):CD009171. PMID: 23543571.
      View in: PubMed
    27. Shivanna B, Zhang W, Jiang W, Welty SE, Couroucli XI, Wang L, Moorthy B. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol. 2013 Mar 15; 267(3):209-17. PMID: 23337360.
      View in: PubMed
    28. Shivanna B, Chu C, Welty SE, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor. Free Radic Biol Med. 2011 Nov 15; 51(10):1910-7. PMID: 21906671.
      View in: PubMed
    29. Shivanna B, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2011 Oct; 339(1):106-14. PMID: 21768223.
      View in: PubMed
    30. Joshi AA, Bradoo RA, Kadam S, Binoy S, Mondkar J, Kalgutkar A. Tracheal agenesis. Indian J Otolaryngol Head Neck Surg. 2005 Apr; 57(2):141-2. PMID: 23120152.
      View in: PubMed
    31. Kadam S, Binoy S, Kanbur W, Mondkar JA, Fernandez A. Feasibility of kangaroo mother care in Mumbai. Indian J Pediatr. 2005 Jan; 72(1):35-8. PMID: 15684446.
      View in: PubMed
    32. Mohapatra A, Sankaranarayanan K, Kadam SS, Binoy S, Kanbur WA, Mondkar JA. Congenital rickets. J Trop Pediatr. 2003 04; 49(2):126-7. PMID: 12729298.
      View in: PubMed
    33. Mohapatra A, Binoy S, Mondkar J . Journal of Neonatology. Placental blood transfusion: An alternate source for transfusion. 2003; (17):45-52.
    34. Mondkar J, Binoy S, Fernandez A . Journal of Neonatology. Pharmacological Principles in the Newborn. 2002; (16):4-10.
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