NINO RAINUSSO

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    2007St.Baldrick's Foundation Fellowship, St.Baldrick's Foundation
    2009Young Investigator Award, American Society of Clinical Oncology
    2013St.Baldrick's Scholar Award, St.Baldrick's Foundation

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    I am physician scientist, who is interested in the role of cancer stem cells (CSCs) in tumorigenesis and chemotherapy resistance in pediatric sarcomas. I have conducted several studies aimed to characterize CSCs in pediatric bone tumors. For the past 5 years, I have been a member of the Osteosarcoma Research Program and the Musculoskeletal Tumor Clinic at Texas Children’s Cancer Center. I have successfully developed a patient derived tumor xenograft mouse model for pediatric sarcomas using tumor specimens obtained from patients treated in our institution.
    As a clinician, I’m also interested in the evaluation and prevention of the cardiotoxic effects caused by chemotherapy

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dasgupta A, Sierra L, Tsang SV, Kurenbekova L, Patel T, Rajapakshe K, Shuck RL, Rainusso N, Landesman Y, Unger T, Coarfa C, Yustein JT. Targeting PAK4 inhibits Ras-mediated signaling and multiple oncogenic pathways in high-risk Rhabdomyosarcoma. Cancer Res. 2020 Nov 09. PMID: 33168646.
      Citations:    Fields:    
    2. Loar RW, Colquitt JL, Rainusso NC, Gramatges MM, Liu AM, Noel CV, Tunuguntla HP, Lilje C, Pignatelli RH. Assessing the left atrium of childhood cancer survivors. Int J Cardiovasc Imaging. 2020 Aug 16. PMID: 32803485.
      Citations:    Fields:    
    3. Rainusso N, Gruner SE, Hernandez JA. Splenic embolization to continue chemotherapy in a child with hypersplenism-related thrombocytopenia. Pediatr Blood Cancer. 2021 Feb; 68(2):e28613. PMID: 32790133.
      Citations:    Fields:    
    4. Loar RW, Pignatelli RH, Tunuguntla HP, Rainusso NC, Gramatges MM, Plana JC, Noel CV. Improving reproducibility of left ventricular ejection fraction in pediatric oncology patients: less is more. Int J Cardiovasc Imaging. 2020 Oct; 36(10):1887-1895. PMID: 32488453.
      Citations:    Fields:    Translation:HumansPHPublic Health
    5. Young EP, Cheng WS, Bernhardt MB, Wang LL, Rainusso N, Foster JH. Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcoma. Pediatr Blood Cancer. 2020 04; 67(4):e28123. PMID: 31867853.
      Citations:    Fields:    Translation:Humans
    6. Nomura M, Rainusso N, Lee YC, Dawson B, Coarfa C, Han R, Larson JL, Shuck R, Kurenbekova L, Yustein JT. Tegavivint and the ß-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 11 01; 111(11):1216-1227. PMID: 30793158.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    7. Rainusso N, Seghers V, Egler R, Hicks J, Russell HV. Neuroblastoma of the Bone and Bone Marrow Without an Apparent Primary Site: Report of 4 Cases With Long-term Follow-up. Pediatr Dev Pathol. 2019 Jul-Aug; 22(4):329-333. PMID: 30600764.
      Citations:    Fields:    Translation:Humans
    8. Rainusso N, Cleveland H, Hernandez JA, Quintanilla NM, Hicks J, Vasudevan S, Marco RAW, Allen-Rhoades W, Wang LL, Yustein JT. Generation of patient-derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas. Pediatr Blood Cancer. 2019 04; 66(4):e27579. PMID: 30548185.
      Citations: 1     Fields:    Translation:Humans
    9. Allen-Rhoades W, Whittle SB, Rainusso N. Pediatric Solid Tumors in Children and Adolescents: An Overview. Pediatr Rev. 2018 Sep; 39(9):444-453. PMID: 30171055.
      Citations: 4     Fields:    Translation:Humans
    10. Fuja DG, Rainusso NC, Shuck RL, Kurenbekova L, Donehower LA, Yustein JT. Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma. Am J Cancer Res. 2018; 8(9):1752-1763. PMID: 30323968.
      Citations:    
    11. Allen-Rhoades W, Whittle SB, Rainusso N. Pediatric Solid Tumors of Infancy: An Overview. Pediatr Rev. 2018 Feb; 39(2):57-67. PMID: 29437125.
      Citations: 4     Fields:    Translation:Humans
    12. Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N. TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res. 2018 01 15; 78(2):489-500. PMID: 29183891.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    13. Mohan AC, Venkatramani R, Okcu MF, Nuchtern JG, Vasudevan SA, Mahajan A, Rainusso NC, Allen-Rhoades W, Chintagumpala M, Paulino AC. Local therapy to distant metastatic sites in stage IV rhabdomyosarcoma. Pediatr Blood Cancer. 2018 Feb; 65(2). PMID: 29049857.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    14. Dasgupta A, Trucco M, Rainusso N, Bernardi RJ, Shuck R, Kurenbekova L, Loeb DM, Yustein JT. Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties. Oncotarget. 2017 Sep 29; 8(44):77292-77308. PMID: 29100387.
      Citations: 7     Fields:    
    15. Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT. Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma. Genes Chromosomes Cancer. 2015 Dec; 54(12):796-808. PMID: 26355645.
      Citations: 5     Fields:    Translation:AnimalsCells
    16. Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, Gray T, Wu MF, Liu H, Hicks J, Rainusso N, Dotti G, Mei Z, Grilley B, Gee A, Rooney CM, Brenner MK, Heslop HE, Wels WS, Wang LL, Anderson P, Gottschalk S. Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma. J Clin Oncol. 2015 May 20; 33(15):1688-96. PMID: 25800760.
      Citations: 233     Fields:    Translation:HumansCellsCTClinical Trials
    17. Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT. Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma. Cancer Med. 2015 Jul; 4(7):977-88. PMID: 25784290.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    18. Rainusso N, Wang LL, Yustein JT. The adolescent and young adult with cancer: state of the art -- bone tumors. Curr Oncol Rep. 2013 Aug; 15(4):296-307. PMID: 23690089.
      Citations: 28     Fields:    Translation:Humans
    19. Chow KK, Naik S, Kakarla S, Brawley VS, Shaffer DR, Yi Z, Rainusso N, Wu MF, Liu H, Kew Y, Grossman RG, Powell S, Lee D, Ahmed N, Gottschalk S. T cells redirected to EphA2 for the immunotherapy of glioblastoma. Mol Ther. 2013 Mar; 21(3):629-37. PMID: 23070117.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    20. Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model. . 2011 Aug 15; 12(4):278-87. PMID: 21617384.
      Citations:    
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