"Protein C Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)
| Descriptor ID |
D020151
|
| MeSH Number(s) |
C15.378.100.100.690 C15.378.147.880 C15.378.925.795 C16.320.099.690
|
| Concept/Terms |
Protein C Deficiency- Protein C Deficiency
- Hereditary Thrombophilia Due To Protein C Deficiency
- Deficiency, Protein C
- Deficiencies, Protein C
- Protein C Deficiencies
|
Below are MeSH descriptors whose meaning is more general than "Protein C Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Protein C Deficiency".
This graph shows the total number of publications written about "Protein C Deficiency" by people in this website by year, and whether "Protein C Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein C Deficiency" by people in Profiles.
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Dinarvand P, Moser KA. Protein C Deficiency. Arch Pathol Lab Med. 2019 10; 143(10):1281-1285.
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Findley T, Patel M, Chapman J, Brown D, Duncan AF. Acquired Versus Congenital Neonatal Purpura Fulminans: A Case Report and Literature Review. J Pediatr Hematol Oncol. 2018 11; 40(8):625-627.
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Manco-Johnson MJ, Bomgaars L, Palascak J, Shapiro A, Geil J, Fritsch S, Pavlova BG, Gelmont D. Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. Thromb Haemost. 2016 07 04; 116(1):58-68.
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Ding Q, Yang L, Dinarvand P, Wang X, Rezaie AR. Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood. 2015 Apr 09; 125(15):2428-34.
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Oo TH. The timing of thrombophilia testing is important: comment on "left main coronary artery thrombus resulting from combined protein C and S deficiency". Intern Med. 2013; 52(6):695.
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Sen K, Roy A. Management of neonatal purpura fulminans with severe protein C deficiency. Indian Pediatr. 2006 Jun; 43(6):542-5.
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Barton P, Kalil AC, Nadel S, Goldstein B, Okhuysen-Cawley R, Brilli RJ, Takano JS, Martin LD, Quint P, Yeh TS, Dalton HJ, Gessouron MR, Brown KE, Betts H, Levin M, Macias WL, Small DS, Wyss VL, Bates BM, Utterback BG, Giroir BP. Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis. Pediatrics. 2004 Jan; 113(1 Pt 1):7-17.
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Murin S, Marelich GP, Arroliga AC, Matthay RA. Hereditary thrombophilia and venous thromboembolism. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 1):1369-73.
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Olson JF, Steuber CP, Hawkins E, Mahoney DH. Functional deficiency of protein C associated with mesenteric venous thrombosis and splenic infarction. Am J Pediatr Hematol Oncol. 1991; 13(2):168-71.
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Kaufman PA, Jones RB, Greenberg CS, Peters WP. Autologous bone marrow transplantation and factor XII, factor VII, and protein C deficiencies. Report of a new association and its possible relationship to endothelial cell injury. Cancer. 1990 Aug 01; 66(3):515-21.