Small Molecule Libraries

"Small Molecule Libraries" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Descriptor ID	D054852
MeSH Number(s)	D27.720.470.765
Concept/Terms	Small Molecule Libraries Small Molecule Libraries Libraries, Small Molecule Molecule Libraries, Small Molecular Libraries, Small Libraries, Small Molecular Small Molecular Libraries Chemical Libraries Libraries, Chemical

Below are MeSH descriptors whose meaning is more general than "Small Molecule Libraries".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Small Molecule Libraries [D27.720.470.765]

Below are MeSH descriptors whose meaning is related to "Small Molecule Libraries".

Below are MeSH descriptors whose meaning is more specific than "Small Molecule Libraries".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Small Molecule Libraries" by people in this website by year, and whether "Small Molecule Libraries" was a major or minor topic of these publications.

Bar chart showing 90 publications over 14 distinct years, with a maximum of 11 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2009	1	2	3
2010	3	1	4
2011	2	3	5
2012	7	3	10
2013	9	2	11
2014	6	2	8
2015	4	5	9
2016	6	3	9
2017	1	3	4
2018	4	4	8
2019	7	1	8
2020	6	2	8
2021	1	1	2

Below are the most recent publications written about "Small Molecule Libraries" by people in Profiles.

Zhao N, Powell RT, Yuan X, Bae G, Roarty KP, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition. Nat Commun. 2021 07 12; 12(1):4262.

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Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186.

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Boyd SR, Chang L, Rezende W, Raji IO, Kandel P, Holmes SL, Young DW. Design and Applications of Bifunctional Small Molecules in Biology. Biochim Biophys Acta Proteins Proteom. 2021 01; 1869(1):140534.

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Dawadi S, Simmons N, Miklossy G, Bohren KM, Faver JC, Ucisik MN, Nyshadham P, Yu Z, Matzuk MM. Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library. Proc Natl Acad Sci U S A. 2020 07 21; 117(29):16782-16789.

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Wang Z, Hausmann S, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK. SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Cancer Cell. 2020 06 08; 37(6):834-849.e13.

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Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. Cell Chem Biol. 2020 06 18; 27(6):708-718.e10.

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Borowiak M, Küllmer F, Gegenfurtner F, Peil S, Nasufovic V, Zahler S, Thorn-Seshold O, Trauner D, Arndt HD. Optical Manipulation of F-Actin with Photoswitchable Small Molecules. J Am Chem Soc. 2020 05 20; 142(20):9240-9249.

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Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T. Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. ACS Infect Dis. 2020 05 08; 6(5):1214-1227.

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Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020 04 17; 15(4):1036-1049.

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Chen YC, Faver JC, Ku AF, Miklossy G, Riehle K, Bohren KM, Ucisik MN, Matzuk MM, Yu Z, Simmons N. C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis. Bioconjug Chem. 2020 03 18; 31(3):770-780.

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