"Zalcitabine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
| Descriptor ID |
D016047
|
| MeSH Number(s) |
D03.383.742.680.245.500.950 D13.570.230.329.950 D13.570.230.500.925 D13.570.685.245.500.950
|
| Concept/Terms |
Zalcitabine- Zalcitabine
- Dideoxycytidine
- 2',3'-Dideoxycytidine
- 2',3' Dideoxycytidine
- ddC (Antiviral)
|
Below are MeSH descriptors whose meaning is more general than "Zalcitabine".
Below are MeSH descriptors whose meaning is more specific than "Zalcitabine".
This graph shows the total number of publications written about "Zalcitabine" by people in this website by year, and whether "Zalcitabine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
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Below are the most recent publications written about "Zalcitabine" by people in Profiles.
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Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates. Antimicrob Agents Chemother. 1995 Dec; 39(12):2779-82.
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High-performance liquid chromatographic method for the analysis of 2',3'-dideoxycytidine in human plasma. J Chromatogr. 1990 Nov 16; 532(2):442-4.
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The disposition and metabolism of 2',3'-dideoxycytidine, an in vitro inhibitor of human T-lymphotrophic virus type III infectivity, in mice and monkeys. Drug Metab Dispos. 1987 Sep-Oct; 15(5):595-601.